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This meeting took place in 2004



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Mouse Models of Human Cancer (B7)


Organizer(s) Allan Balmain and Tyler Jacks
February 17—22, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 24, 2003

Sponsored by Novartis Pharmaceuticals Corporation

Summary of Meeting:
The main theme of the meeting will be the exploration, using the best mouse models of the major human cancers, of questions related to the target cells for tumor development, the genetic basis to tumor susceptibility, sequential somatic genetic changes during tumor initiation promotion and progression, comparative mouse-human cancer genetics, the role of stromal/accessory cells, the immune response and cancer, and approaches to early detection using imaging or surrogate markers. A major objective will be to emphasize the parallels between mouse models and human cancers, and the advantages of these models to address questions related not only to the basic biology, but also to more practical aspects of gene discovery and therapy. Two of the sessions will be on the functions of stromal/endothelial/immune cells in cancer development to explore non-cell autonomous effects in tumor growth.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 17

15:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Refreshments

Shavano Peak Foyer
19:15—19:30
Orientation

Red Cloud
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Tyler Jacks, Massachusetts Institute of Technology, USA

J. Michael Bishop, University of California, San Francisco, USA
Mouse Models Rule

Harold E. Varmus, Weill Cornell Medical College, USA
Making Mouse Models is Not the Same as Using Them: What We Should be Learning


WEDNESDAY, FEBRUARY 18

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Comparative Mouse-Human Cancer Genetics
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Jeffrey E. Green, National Cancer Institute, National Institutes of Health, USA
Genomic Approaches to Define the Molecular Anatomy of Mouse Mammary Cancer Models and Their Relationship to Human Breast Cancer

Donna G. Albertson, University of California, San Francisco, USA
Genomic Alterations in Mouse and Human Cancers

* Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Modeling Cancer and Cancer Genomes in the Mouse

Tyler Jacks, Massachusetts Institute of Technology, USA
Modeling Lung Cancer in the Mouse

E. Alejandro Sweet-Cordero, Stanford University, USA
Short Talk

Alan R. Clarke, Cardiff University, UK
Short Talk: Investigating the Functional Requirement for Apc through Conditional Deletion in the Mouse

Matthias Hebrok, University of California, San Francisco, USA
Short Talk: Embryonic Signaling Pathways in Pancreatic Cancer

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Stem Cells and Cancer
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Elaine V. Fuchs, HHMI/Rockefeller University, USA
Stem Cell Lineages of the Skin

Fiona M. Watt, King's College London School of Medicine, UK
Contribution of Stem Cells and Differentiated Cells to Tumors of the Epidermis

Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
New Insights into Progenitor Cells of the GI Tract: Less Clandestine in the Intestine

William M. Keyes, Cold Spring Harbor Laboratory, USA
Short Talk: P63 Ablation Activates Key Cellular Processes during Epidermal Morphogenesis

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

THURSDAY, FEBRUARY 19

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:30
Genetic Basis of Cancer Susceptibility
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Beverly A. Mock, NCI, National Institutes of Health, USA
Compound Defects in Cancer Susceptibility Genes Contribute to Plasmacytomagenesis

Allan Balmain, University of California, San Francisco, USA
Germline and Somatic Mutations in Mouse Models of Human Cancer

* William F. Dove, University of Wisconsin-Madison, USA
From the Apc-Min Mouse Model to Genes and Molecules Involved in Human Colon Cancer

David W. Threadgill, University of North Carolina at Chapel Hill, USA
Mouse Strain-Dependent Susceptibility to Colorectal Cancer and Colonization by the Gastrointestinal Flora

Lynn M. Matrisian, Vanderbilt University School of Medicine, USA
Mouse Models in Translational Research

Andrea I. McClatchey, Massachusetts General Hospital, USA
Short Talk: A Mouse Model of Stem Cell Derived Liver Cancer

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Tumor Imaging and Early Detection
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA

Christopher H. Contag, Institute for Quantitative Health Sciences and Engineering, USA
Advancing Mouse Models in-vivo Dynamic Imaging Systems

Natasha Grant Deane, Vanderbilt University Medical Center, USA
Short Talk: The Use of High Field MRI to Detect and Characterize Cancer Progression in Experimental Mouse Livers

Leonard Hofstra, Maastricht University Hospital, Netherlands
Short Talk: Molecular Imaging of Apoptosis

Byron C. Hann, University of California, San Francisco, USA
Short Talk: A Murine Model for Rapid and Sensitive in vivo Tumor Detection

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Bioluminescent Imaging of Molecular Pathways Relevant to Cancer

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

FRIDAY, FEBRUARY 20

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:30
Genetically Engineered Models of Human Cancer. Session Sponsored in part by GenPath Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Utility of Mouse Models for Human Cancer

Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Spain
Engineering Mouse Models for Target Validation in Cancer: Cyclin-Dependent Kinases and their Inhibitors

Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Modeling Cancer Mechanisms in the Mouse

* Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
Germline Mutations in the p53/Mdm2 Pathway and Cancer Development

Christopher J. Kemp, Fred Hutchinson Cancer Research Center, USA
The Genetics and Biology of Tumor Suppression by p27/Kip1

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Stromal Cells and Tumor Development
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Non-Mutagenic Actions of Radiation Carcinogenesis in Mouse and Human Mammary Models

Gerald R. Cunha, University of California, San Francisco, USA
Stromal Cell Control of Prostate Cancer Progression

Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
The Dual Functions of AP-1 (Fos/Jun) in Cancer Development

Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Short Talk: Real-Time Imaging of Mammary Carcinoma Progression

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

SATURDAY, FEBRUARY 21

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Experimental Therapeutics Using Engineered Mouse Models
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Douglas Hanahan, ISREC, Switzerland
Angiogenesis Inhibitors in Cancer Therapy

Johanna A. Joyce, University of Lausanne, Switzerland
Short Talk

Eric Holland, Memorial Sloan-Kettering Cancer Center, USA
Mouse Models of Glioma Formation and Maintenance

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Linking Cancer Genetics to Cancer Therapy in Mouse Models

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Pokemon: The Birth and Raise of a Cancer Gene

Pernilla Roswall, Uppsala University, Sweden
Short Talk: Tumor Stroma as a Target for Therapy: Effects of TGF-beta Inhibition in Experimental Thyroid Carcinoma

Stephen N. Jones, University of Massachusetts Medical School, USA
Short Talk: Wnt5a Inhibits B Cell Proliferation and Functions as a Tumor Suppressor in Hematopoietic Tissue

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Analysis of Regulatory Networks in Cancer Biology
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Allan Balmain, University of California, San Francisco, USA

Zoltan N. Oltvai, University of Pittsburgh Medical School, USA
Organization of Cellular Networks

Luk Van Parijs, Massachusetts Institute of Technology, USA
Novel Tumor Suppressor Genes Revealed by a Mammalian RNA Interference Screen

Kent W. Hunter, National Institutes of Health, USA
Integrating "omic" Technologies to Interrogate the Molecular Basis of Mammary Tumor Metastasis

19:00—20:00
Social Hour

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

SUNDAY, FEBRUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

AVEO Pharmaceuticals, Inc.
Cell Signaling Technology, Inc.

Novartis Pharmaceuticals Corporation

Cell Signaling Technology, Inc.

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