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This meeting took place in 2004



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Cardiac Development and Congenital Heart Disease (X4)


Organizer(s) Deepak Srivastava and Nadia A. Rosenthal
March 7—12, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 24, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 7, 2004

Sponsored in part by the Director's Sponsor Fund


Summary of Meeting:
Congenital heart disease (CHD) is the most common birth defect and the leading non-infectious killer of children in the first year of life. CHD represents abnormalities of heart formation in utero. Recent advances in understanding the molecular bases for heart formation and the recognition of cross-species conservation of regulatory pathways make a Keystone Symposium on this topic timely. The prospect of combining the advances in cardiogenesis with a theme of congenital heart defects offers an opportunity to focus basic science on efforts to understand and prevent heart disease in children. In addition, basic mechanisms of cardiogenesis may be applied to efforts of tissue engineering to construct new valves, vessels or other specific cardiac structures as multi-disciplinary fields mature. Although there are some other conferences that address overlapping issues, the most similar is the Weinstein Cardiovascular Development Conference. A Keystone Symposium on this topic will greatly enhance the focus on heart development and related disease and would allow the leaders in the field to congregate at one meeting. This will provide a unique opportunity for trainees to interact with senior investigators and should spur future collaborations between investigators. Upon completion of this conference, participants should be able to: - Understand the embryologic and molecular underpinnings of heart formation as they relate to congenital heart defects, which is the leading non-infectious cause of death in the first year of life. - Appreciate advances in understanding genetic mutations that lead to defects of heart development in humans with particular attention to mechanisms of gene function. - Explore signaling and transcriptional pathways that guide early cardiac specification and later steps of cardiac morphogenesis in a region-specific manner. - Understand the contribution of cardiac neural crest cells to the heart and the genes responsible for proper cardiac migration and differentiation of this unique lineage of cells. - Stimulate new avenues of research to address the molecular basis of cell movement during critical migration steps essential for remodeling of the developing heart. - Stimulate new avenues of research to incorporate advances in cardiac development into new knowledge regarding the etiology and prevention of congenital heart disease in children.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 7

15:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—19:30
Orientation

Grays/Longs Peak
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Christine E. Seidman, Harvard Medical School, USA

James A. Spudich, Stanford University, USA
The Myosin Family of Molecular Motors: Diversity of Function and Mechanism


MONDAY, MARCH 8

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Cardiac Specification
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Manfred Frasch, Mount Sinai School of Medicine, USA
Induction and Function of T-Box Genes during Cardiac and Visceral Muscle Specification in Drosophila

Andrew B. Lassar, Harvard Medical School, USA
Signaling Pathways that Regulate Heart Formation

* Mark Mercola, Stanford University, USA
Molecular Relays for Heart Induction: Identification of Proteins that Act Downstream of Wnt Antagonists and Notch to Regulate Cardiac Cell Fate

Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Transcriptional Control of Cardiac Chamber Formation

Ching-Pin Chang, Indiana University, USA
Short Talk: Repression of VEGF Expression by NFAT Underlies Initiation of Heart Valve Morphogenesis

08:00—11:00
Sarcomere Proteins and Hypertrophy
Meeting has ended...abstracts no longer viewable online.

Grays
Jonathan G. Seidman, Harvard Medical School, USA
Hypertrophic Cardiomyopathy in Mice and Man

Neal D. Epstein, National Institutes of Health, USA
The Role of Myosin Light Chain Phosphorylation in Regulating the Cardiac Stretch-Activation Response

* Leslie A. Leinwand, University of Colorado Boulder, USA
Molecular Mechanisms of Cardiac Adaptations

Deborah L. Yelon, University of California, San Diego, USA
Primary and Secondary Effects of Chamber-Specific Myosin Heavy Chain Defects in Zebrafish

Sharlene M. Day, University of Michigan, USA
Short Talk: Transgenic and Gene Transfer-Based Expression of Cardiac Troponin I Mutant A164H Increases Myofilament Calcium Sensitivity Under Acidic Conditions

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Cross Species Approach to Cardiac Development and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jonathan G. Seidman, Harvard Medical School, USA

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Transcriptional Regulation in Cardiac Development and Disease

* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease

Christine E. Seidman, Harvard Medical School, USA
Deciphering Genetic Remodeling of the Human Heart in Zebrafish

Karl Ludwig Laugwitz, Technical University Munich, Germany
Short Talk: Identification, Renewal and Differentiation of Postnatal is l1+ Cardioblasts

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, MARCH 9

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Cardiac Patterning and Chamber Formation
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Antoon F.M. Moorman, University of Amsterdam, Netherlands
Development of the Building Plan of the Heart

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiovascular Development in Zebrafish

Margaret E. Buckingham, Institut Pasteur, France
The Origin of Myocardial Cells and their Oriented Cell Growth during Heart Morphogenesis

Jonathan A. Epstein, University of Pennsylvania, USA
The Homeodomain Only Protein, Hop, in Development, Hypertrophy and Heart Failure

Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Notch Promotes Epithelial-Mesenchymal Transition during Cardiac Development and Oncogenic Transformation

08:00—11:15
Electrophophysiologic Disorders
Meeting has ended...abstracts no longer viewable online.

Grays
Kenneth R. Chien, Karolinska Institutet, Sweden
Cardiomyopathy, Conduction, and Cardioblasts: New Genetic Insights and Model Systems

J. Kevin Donahue, Johns Hopkins University, USA
Gene Therapy for Cardiac Arrhythmias

* Glenn I. Fishman, New York University School of Medicine, USA
Modeling the Conduction System

D. Woodrow Benson, Cincinnati Children's Hospital, USA
Genetic Origins of Cardiac Arrhythmias in the Young

Sameer S. Chopra, Vanderbilt University School of Medicine, USA
Short Talk: The Zebrafish as a Model for the Functional Analysis of Cardiac Sodium Channel alpha and beta Subunits

Antoinette Groenewegen, , Netherlands
Short Talk: Association of Human Connexin40 Gene Polymorphisms with Atrial Vulnerability for Initiation of Idiopathic Atrial Fibrillation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Congenital Heart Disease/Genetics of Pediatric Heart Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Christine E. Seidman, Harvard Medical School, USA

Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Genetics of Pediatric Cardiomyopathies and CHD

Vidu Garg, Ohio State University/Nationwide Children's Hospital, USA
The Role of GATA4 in Congenital Heart Disease

Cecilia W. Lo, University of Pittsburgh, USA
ENU Mutagenesis and Mouse Mutations Causing Congenital Heart Defects

Jean-Jacques Schott, INSERM, France
Short Talk: Genetics of Valvular Diseases

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, MARCH 10

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Cardiac Regeneration (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Michael D. Schneider, Imperial College London, UK
Cardiac Progenitor Cells from Adult Myocardium

Bernardo Nadal-Ginard, New York Medical College, USA
Cardiac Stem Cells and Myocardial Regeneration

* Nadia A. Rosenthal, The Jackson Laboratory, USA
Growth Factor Enhancement of Cardiac Regeneration

Stefanie Dimmeler, University of Frankfurt, Germany
Circulating Progenitor Cells for Vasculogenesis and Cardiac Regeneration

Ellen Heber-Katz, Lankenau Institute for Medical Research, USA
Short Talk: MRL Mouse Heart Healing Using Bone Marrow Chimeras Shows Host Dominance

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Pharyngeal Arch and Neural Crest Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Erik N. Meyers, Duke University Medical Center, USA
Fgf8 Signaling in Cardiovascular Development

Antonio Baldini, Institute of Genetics and Biophysics, Italy
Dissection of the Cardiovascular Phenotype in Mouse Models of DiGeorge Syndrome

* Margaret L. Kirby, Duke University Medical Center, USA
Collaboration of Cardiac Neural Crest and Caudal Pharynx is Needed for Patterning the Preseptation Arterial Pole

Aaron D. Gitler, Stanford University School of Medicine, USA
Short Talk: PlexinD1 is a Novel Endothelial-Specific Semaphorin Receptor Essential for Outflow Tract Septation and Aortic Arch Artery Patterning

17:00—19:15
Signaling in Cardiac Remodeling
Meeting has ended...abstracts no longer viewable online.

Grays
Richard T. Lee, Harvard University, USA
Mechanotransduction and Two Interesting Puzzles in Cardiomyopathy

Rhonda Bassel-Duby, University of Texas Southwestern Medical Center, USA
Control of Muscle Growth and Remodeling by Calcium-Dependent Signaling

* R. Sanders Williams, Duke University Medical Center, USA
Calcium Regulated Gene Transcription in Myocyte Remodeling

Miei Shimura, Yokosuka City Hospital, Japan
Short Talk: Sarcalumenin, a Sarcoplasmic Reticulum Luminal Ca2+ Binding Protein Plays an Important Role in Maintaining Cardiac Function

Jonathan A. Stiber, Duke University, USA
Short Talk: Homer Proteins Influence Muscle Remodeling Through the Calcineurin Signaling Pathway

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, MARCH 11

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Signaling Pathways in Cardiac Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetic Control of Cardiac Development and Aging

* H. Joseph Joseph Yost, University of Utah, USA
Cell Signaling in Cardiac Left-Right Development

Martina Brueckner, Yale University School of Medicine, USA
Cilia are at the Heart of the Development of Left-Right Asymmetry

Tom Gridley, The Jackson Laboratory, USA
Notch Signaling in Cardiovascular Development and Disease

Deborah L. Yelon, University of California, San Diego, USA
Short Talk: Retinoic Acid Signaling Restricts the Cardiac Progenitor Pool

08:00—11:15
Pathways to Dilated Cardiomyopathy
Meeting has ended...abstracts no longer viewable online.

Grays
* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
A Unifying Principle Underlying Cardiac Arrhythmias and Heart Failure

Luisa Mestroni, University of Colorado Denver-AMC, USA
Genotype/Phenotype Correlations in Dilated Cardiomyopathy

Kevin P. Campbell, University of Iowa, USA
Dystroglycan, Dysferlin and Cardiomyopathy

Elizabeth M. McNally, Northwestern University, USA
Genetic Diversity in Cardiomyopathy

David H. MacLennan, University of Toronto, Canada
Short Talk: Identification of Biochemical Adaptations in Hyper- or Hypocontractile Hearts from Phospholamban Mutant Mice by Expression Proteomics

Charles Redwood, University of Oxford, UK
Short Talk: Dilated Cardiomyopathy-Causing Mutations in Troponin T, Troponin C and alpha-Tropomyosin Reduce Ca2+-Sensitivity and Maximum Activation

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Transcriptional Circuits in Cardiomyocyte Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Robert J. Schwartz, Texas A&M University, USA
Serum Response Factor a Master Cardiogenic Regulatory Platform and a Novel Phosphorylatable Gene Switch Target

William T. Pu, Children's Hospital, Harvard Medical School, USA
Regulation of Heart Development by GATA4: Distinct Functional Requirements in the Endocardium and Myocardium

Robert A. Schulz, University of Texas MD Anderson Cancer Center, USA
Transcriptional Control of Heart Morphogenesis in Drosophila

17:00—19:15
Models of Human Heart Disease
Meeting has ended...abstracts no longer viewable online.

Grays
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
Novel Insights into Pathogenesis and Therapy of Marfan Syndrome

Craig T. Basson, Weill Medical College of Cornell University, USA
Molecular Genetic Mechanisms Underlying PKA-Dependent Cardiac Tumorigenesis

* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
The Desmin-Related Cardiomyopathies: Form and Function

Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration

19:00—20:00
Social Hour

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, MARCH 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD046201-01




We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676