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This meeting took place in 2004



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Structural Genomics (Z1)


Organizer(s) Stephen K. Burley, Jeffrey B. Bonanno and Ian A. Wilson
April 13—19, 2004
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 15, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 13, 2004

Supported by Keystone Symposia


Summary of Meeting:
Upon completion of this conference, participants should appreciate and understand: - Appreciate the challenge of selecting structural genomics targets that will both increase our knowledge of the protein structure universe and enhance biomedical research. - Understand automated approaches to high-throughput sample preparation for solution NMR spectroscopy and X-ray crystallography. - Identify strategies for automated data reduction, structure determination, refinement, and PDB deposition. - Learn approaches to functional annotation of new protein structures that incorporate information from phylogeny, gene expression profiling, protein-protein interaction maps, gene knockout studies, and biochemical/biophysical analyses. - Understand the role of high-throughput structural studies of protein-ligand complexes in drug discovery.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, APRIL 13

15:00—19:00
Registration

Ballroom Lobby
18:15—19:15
Refreshments

Ballroom Mezzanine
19:15—19:30
Orientation

Ballroom
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Kurt Wüthrich, ETH Zürich, Switzerland
Structural Biology and Proteomics using Solution NMR

* Stephen K. Burley, Rutgers University, USA

Stephen C. Harrison, Harvard Medical School, USA
Assembling Structures


WEDNESDAY, APRIL 14

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby/Eagles Nest
08:00—11:00
Bioinformatics/Target Selection
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
Andrej Sali, University of California, San Francisco, USA
Modeling the Structure of Proteins and Macromolecular Assemblies

* Janet M. Thornton, European Bioinformatics Institute, UK
From Structure to Function

Juswinder Singh, Celgene Corporation, USA
A Classification of Disulfide Space and Its Role in Protein Structure and Function

Steven E. Brenner, University of California, Berkeley, USA
The Pfam 5000: Implications of Target Selection for Structural Genomics


Following Session is for Frontiers in Structural Biology (Z2)

08:00—11:00
Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Patricia A. Jennings, University of California, San Diego, USA

Donald M. Engelman, Yale University, USA
Folding and Evolution of Membrane Proteins

Charles R. Sanders, Vanderbilt University School of Medicine, USA
Membrane Protein Folding, Misfolding, and Disease

William M. Clemons, Harvard University Medical School, USA
X-ray Structure of a Protein-Conducting Channel

Werner Kühlbrandt, Max-Planck-Institute of Biophysics, Germany
Electron Microscopy of Membrane Transport Proteins

Yafei Huang, New York University Medical Center, USA
Short Talk: Structure and Mechanism of the Glycerol-3-Phosphate Transporter

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Wasatch/Superior/Superior Lobby
13:00—22:00
Poster Viewing

Wasatch/Superior/Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—18:50
Pushing the Limits in Structural Biology I (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom
* David A. Agard, University of California, San Francisco, USA

Brian T. Chait, Rockefeller University, USA
New Approaches for the Study of Protein Complexes

Barry Honig, Columbia University / HHMI, USA
Pushing the Limits of Computational Structural Biology

Ad Bax, NIDDK, National Institutes of Health, USA
Weak Alignment NMR: How Detailed a View Can We Get?

18:50—19:00
NIH Protein Structure Initiative
Meeting has ended...abstracts no longer viewable online.

Ballroom
John C. Norvell, NIGMS, National Institutes of Health, USA

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
19:30—22:00
Poster Session 1

Wasatch/Superior/Superior Lobby

THURSDAY, APRIL 15

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby/Eagles Nest
08:00—11:00
Molecular Biology/ Protein Expression/Purification I
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Spencer Emtage, SGX Pharmaceuticals, Inc., USA

Scott A. Lesley, Genomics Institute of the Novartis Research Foundation, USA
A Multi-Tiered Approach to Structural Genomics

Kenneth H. Lundstrom, BioXtal, Inc., Switzerland
Structural Genomics on Membrane Proteins - The MEPNET Approach

Glen A. Evans, Egea BioSciences, Inc., USA
Application of Gene Synthesis in Pharmacuetical Development

Gerald W. Becker, Roche Diagnostics, USA
Cell Free Protein Expression Systems for Structural Biology


Following Session is for Frontiers in Structural Biology (Z2)

08:00—11:00
Signaling at the Membrane
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Charles R. Sanders, Vanderbilt University School of Medicine, USA

Patricia A. Jennings, University of California, San Diego, USA
Structure and Mechanism of Kinases and Anchoring Proteins

Wendell A. Lim, University of California, San Francisco, USA
The Logic of Signaling Switches and Scaffolds

Daniel J. Leahy, Johns Hopkins School of Medicine, USA
Conformational Change in ErbB Receptor Signaling

K. Christopher Garcia, Stanford University School of Medicine, USA
Unraveling the Mechanisms of Neurotrophin Receptor Signaling

Douglas M. Freymann, Northwestern University, USA
Short Talk: Structure of the Homo-Heterodimeric GTPase Core of the SRP Targeting Complex

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Molecular Biology/ Protein Expression/Purification II
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
Spencer Emtage, SGX Pharmaceuticals, Inc., USA
A Modular Automation Platform for Large-Scale Production of Eukaryotic Proteins

* Cheryl Arrowsmith, University of Toronto, Canada
Structural Proteomics: Structural Biology on a Genome Wide Scale

Geoffrey Waldo, Los Alamos National Laboratory, USA
Progress on High Throughput Folding Interference Reporters and Directed Evolution/New Protein tagging an Detection Systems Using GFP Microdomains


Following Session is for Frontiers in Structural Biology (Z2)

17:00—19:00
Macromolecular Interactions I
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* William I. Weis, Stanford University, USA

G. Marius Clore, NIDDK, National Institutes of Health, USA
Insights into Recognition in Transient Protein-Protein Complexes

Wei Yang, NIDDK, National Institutes of Health, USA
Insights into the Mechanism of DNA Polymerase

Sepideh Khorasanizadeh, Sanford Burnham Prebys Medical Discovery Institute, USA
Recognition of Lysine-Methylated Histone Tails by the Chromodomain

Josep Rizo, University of Texas Southwestern Medical Center, USA
Short Talk: Mad Conformational Signaling in the Mitotic Spindle Checkpoint

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
20:00—22:10
Workshop: Graduate Student/Postdoctoral Presentations

Ballroom 1
* Jeffrey B. Bonanno, Albert Einstein College of Medicine, USA

Mark A. DePristo, Harvard University, USA
Heterogeneity and Inaccuracy in Protein Structures Solved by X-ray Crystallography

Maria Dolores Díaz, University of Washington, USA
Cytochrome P450 Homotropic Cooperativity as Probed by Heteronuclear NMR

Celia W. Goulding, University of California, Irvine, USA
Discovery of Heme Uptake Pathway in M. tuberculosis

Marek Grabowski, University of Virginia, USA
The Structural Genomics Experimental Pipeline: Insights from Global Target Lists

Izabela Katarzyna Janda, University of Virginia, USA
Protein Crystallization by Surface Entropy Reduction Approach

Piotr Lasota, University of Virginia, USA
Small Scale Automation on the Bench

Lynsey A. Mack, University of Edinburgh, Scotland
Studies of Extremophilic SSB Proteins

Dierk Niessing, Ulm University, Germany
Structural and Functional Studies of She2

Anil K. Padyana, Boehringer Ingelheim Pharmaceuticals, Inc., USA
Crystal Structure of Shikimate 5-Dehydrogenase (SDH) Bound to NADP: Insights into Function and Evolution

Ming-Tao Pai, National Tsing Hua University, Taiwan
Solution Structure of the Hypothetical Protein HP0495 from Helicobacter pylori

Shuh-Chyung Song, University of Rochester, USA
Crystal Structure of NNA7 at 1.75 A Resolution; an Fab Fragment that Recognizes a Human Blood-Group Glycopeptide Antigen on Glycophorin A

Adelinda Yee, Ontario Cancer Institute, University of Toronto, Canada
Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics

DeokCheon Yeh, University of Maryland, NIST, USA
NMR Structure of the Hypothetical Protein HI0004 from Haemophilus Influenzae


FRIDAY, APRIL 16

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby/Eagles Nest
08:00—11:00
Crystallization and Crystal Handling
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* George T. DeTitta, Hauptman-Woodward Medical Research Institute, USA
From Crystallization Screening to Crystals

Rebecca Page, Brown University, USA
High Throughput Protein Crystallography Technologies: Analysis of Large Scale Experiments Using Positive and Negative Data

Reiner Kiefersauer, Max Planck Institute for Biochemistry, Germany
Free Mounting System ™ A Novel Tool to Improve Handling and Quality of Protein Crystals

Zbigniew Dauter, National Cancer Institute and National Synchrotron Light Source, USA
Structure Determination with Halides


Following Session is for Frontiers in Structural Biology (Z2)

08:00—11:00
Macromolecular Machines
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Dorothee Kern, Brandeis University, HHMI, USA

James A. Spudich, Stanford University, USA
Single Molecule Analysis and the Myosin Family of Molecular Motors

Seth A. Darst, Rockefeller University, USA
Structural Studies of Prokaryotic Transcription

Nikola P. Pavletich, Memorial Sloan-Kettering Cancer Center, USA
Structural Biology of Ubiquitin Protein Ligases

Tom E. Ellenberger, Washington University School of Medicine, USA
Visualizing the Beginning and End Game of DNA Replication

Penmetcha K.R. Kumar, National Institute of Advanced Industrial Science & Technology, Japan
Short Talk: Structural Basis of Activation of HutP by L-Histidine: A RNA-Binding Protein that Regulates the Transcription of Hut Operon in Bacillus subtilis

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Wasatch/Superior/Superior Lobby
13:00—22:00
Poster Viewing

Wasatch/Superior/Superior Lobby
16:00—17:00
Plenary
Meeting has ended...abstracts no longer viewable online.

Ronald D. Ruth, , USA
Short Talk: The Compact Light Source for Protein Crystallography


Following Session is for Frontiers in Structural Biology (Z2)

16:00—17:00
Plenary
Meeting has ended...abstracts no longer viewable online.

Ronald D. Ruth, , USA
Short Talk: The Compact Light Source for Protein Crystallography

16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Pushing the Limits in Structural Biology II (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Ad Bax, NIDDK, National Institutes of Health, USA

David A. Agard, University of California, San Francisco, USA
Pushing the Limits of Resolution in Widefield Light Microscopy

Bridget Carragher, New York Structural Biology Center, USA
High Throughput Single Particle Electron Microscopy of Macromolecular Assemblies

Axel T. Brünger, Stanford University, USA
Structure of the ATPase p97/VCP

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
19:30—22:00
Poster Session 2

Wasatch/Superior/Superior Lobby

SATURDAY, APRIL 17

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby/Eagles Nest
08:00—11:15
X-ray and NMR Data Collection. Session Sponsored in part by Bruker AXS and Bruker Biospin Corporation.
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Ian A. Wilson, The Scripps Research Institute, USA

Gaetano Thomas Montelione, Rutgers University, USA
Structural Proteomics of Eukaryotic Protein Domain Families

John L. Markley, University of Wisconsin-Madison, USA
The Center for Eukaryotic Structural Genomics (CESG)

Peter Kuhn, The Scripps Research Institute, USA
Data Centric Experimentation in Structural Proteomics

Thomas Earnest, Lawrence Berkeley National Laboratory, USA
Integrating Intelligence into Beamline Automation

Andrzej Joachimiak, Argonne National Laboratory, USA
High-Throughput Pipeline for Protein Structure Determination Using X-Ray Crystallography and Synchrotron Radiation


Following Session is for Frontiers in Structural Biology (Z2)

08:00—10:45
Protein Stability and Design
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Peter E. Wright, The Scripps Research Institute, USA

Brian W. Matthews, University of Oregon, USA
T4 Lysozyme as a Test Bed for Protein Design Algorithms

A. Joshua Wand, University of Pennsylvania, USA
Protein Cold Denaturation

David M. LeMaster, Wadsworth Center, New York State Department of Health, USA
The Absence of Kinetic Thermal Stabilization in a Hyperthermophile Rubredoxin Indicated by 40 Microsecond Folding in the Presence of Irreversible Denaturation

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby

Following Session is for Frontiers in Structural Biology (Z2)

10:45—11:15
Late Breaking Results
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Kristi Elizabeth Pullen, University of California, Berkeley, USA
Short Talk: An Alternate Conformation Stabilized by a Third Metal in the M. tuberculosis PP2c-Family Ser/Thr Protein Phosphatase

Laura M. Guogas, Harvard University, USA
Short Talk: The Crystal Structure of an N-Terminal Basic Peptide Bound to Viral RNA

16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Automated Structure Determination/Refinement/PDB Deposition
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
Thomas C. Terwilliger, Los Alamos National Laboratory, USA
Automated structure solution, density modification, and model-building

* Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
Protein Data Bank: A Resource for Structural Genomics

Wladek Minor, University of Virginia, USA
Rapid Generation of the Initial Model from Diffraction Data


Following Session is for Frontiers in Structural Biology (Z2)

17:00—19:00
Protein and Small Molecule Design
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* A. Joshua Wand, University of Pennsylvania, USA

Susan Marqusee, University of California, Berkeley, USA
Engineering the Energy Landscape of Proteins

Homme Hellinga, Duke University Medical Center, USA
Computational Design of Biologically Active Proteins

John R. Desjarlais, Xencor, USA
Short Talk: From Structural to Biological Specificity: Improving Antibody Efficacy

Qiaojuan Jane Su, Abgenix, Inc., USA
Short Talk: Modeling of an EGFRvIII Antibody Combining Site and Simulation of Epitope-Paratope Interaction Energetics

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
20:00—22:00
NIH Workshop

* John C. Norvell, NIGMS, National Institutes of Health, USA
Production Phase of the Protein Structure Initiative

Arnold Revzin, National Institutes of Health, USA
Review of Grant Applications by the Center for Scientific Review


SUNDAY, APRIL 18

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby/Eagles Nest
08:00—11:00
Functional Annotation
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Wim G.J. Hol, University of Washington, USA
Structural Genomics of Pathogenic Protozoa (SGPP)

Dong Hae Shin, University of California, Berkeley, USA
Structure-Based Annotation of Molecular Function

Christine A. Orengo, University College London, UK
Selecting Targets which Probe Family and Functional Space

Mirek Cygler, Biotechnology Research Institute, Canada
Short Talk: The Structure of the Mitogen-Activated Protein Kinase Scaffold Protein MP1 in Complex with the Adaptor Protein p14

Dominika M. Borek, University of Texas Southwestern Medical Center, USA
Short Talk: Discovery through Crystallography - Structural Studies of Escherichia coli ycfC Gene Product


Following Session is for Frontiers in Structural Biology (Z2)

08:00—11:15
Macromolecular Interactions II
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Gregory D. Bowman, Johns Hopkins University, USA
Mechanism of DNA Polymerase Clamp-Loaders

Dorothee Kern, Brandeis University, HHMI, USA
Rigidity and Catalysis in Thermophilic Enzymes

Peter E. Wright, The Scripps Research Institute, USA
RNA Recognition by Zinc Fingers

Thomas J. Hope, Northwestern University, USA
Fluorescent Visualization of HIV Entry and Trafficking in Living Cells

Peter E. Prevelige, University of Alabama, Birmingham, USA
Short Talk: Identification of the Maturation Induced Changes in Intersubunit Interfaces within Intact HIV-1 Virions by Hydrogen/Deuterium Exchange Mass Spectrometry

J.N. Mark Glover, University of Alberta, Canada
Short Talk: The Structural Consequences of Mutations on the BRCA1 BRCT Domain

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:15
High-Throughput Structure-Based Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
Tom L. Blundell, University of Cambridge, UK
Crystallography, Structural Bioinformatics and Drug Discovery

Stephen W. Kaldor, Quanticel Pharmaceuticals, USA

Aled M. Edwards, University of Toronto, Canada
Structural Proteomics

* Stephen K. Burley, Rutgers University, USA
Structure-Guided Drug Discovery Using Fragment-Based Lead Identification/Lead Optimization


Following Session is for Frontiers in Structural Biology (Z2)

17:00—19:15
The RNA World
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Sarah A. Woodson, Johns Hopkins University, USA
Insights on RNA Folding Mechanisms from Group I Ribozymes

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
A Conformational Switch Controls Hepatitis Delta Virus Ribozyme Catalysis

Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
How the CCA-Adding Enzyme Adds CCA to tRNA without Using an Oligonucleotide Template

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway

Jeffrey M. Vargason, NIEHS, National Institutes of Health, USA
Short Talk: Size Selective Recognition of siRNA by an RNA Silencing Suppressor

19:15—20:15
Social Hour

Ballroom Mezzanine
20:00—23:00
Entertainment

Ballroom

MONDAY, APRIL 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA106226-01




We gratefully acknowledge additional support for this conference from:

Pioneer Hi-Bred a DuPont business
Agouron Pharmaceuticals, Inc.

Bruker BioSpin Corp.

Carl Zeiss MicroImaging, Inc.


Sigma Life Science
 

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