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This meeting took place in 2004
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Frontiers in Structural Biology (Z2)
Organizer(s) Michael F. Summers, John Kuriyan and William I. Weis
April 13—19, 2004
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 15, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 13, 2004
Sponsored by The Director's Sponsor Fund
Joint Meeting:
Structural Genomics (Z1)
Summary of Meeting:
Upon completion of this conference, participants should be able to: - Appreciate and understand the latest methodological breakthroughs that have enabled structural and dynamical studies of ever larger and complex systems at higher resolution and with greater throughput. - Appreciate and understand how the latest methodologies have been applied to current problems in biology, particularly those involving multiple components (i.e., systems that include combinations of proteins, nucleic acids and membranes). - Understand the role of dynamics in biomolecular interactions and function. Rapid technical developments in NMR, X-ray crystallography, atomic force microscopy, cyroelectron microscopy, and computational biology have led to the present explosion of knowledge in structural biology. While structural studies continue to flow into the databases at an ever-accelerating pace, there is an urgent need to couple the flood of structural information with biochemical and biophysical analysis of function. Insights into the structural organization and allosteric mechanisms of complex multidomain macromolecular assemblies, such as transcriptional and signaling complexes, will be important for understanding the malfunction of these systems in human diseases and in the development of therapeutics for cancer and other diseases. The organizers of this symposium find a need to bring together structural biologists working in diverse methodological areas that are interested in these common issues in biology.
View Scholarships/Awards
Upon completion of this conference, participants should be able to: - Appreciate and understand the latest methodological breakthroughs that have enabled structural and dynamical studies of ever larger and complex systems at higher resolution and with greater throughput. - Appreciate and understand how the latest methodologies have been applied to current problems in biology, particularly those involving multiple components (i.e., systems that include combinations of proteins, nucleic acids and membranes). - Understand the role of dynamics in biomolecular interactions and function. Rapid technical developments in NMR, X-ray crystallography, atomic force microscopy, cyroelectron microscopy, and computational biology have led to the present explosion of knowledge in structural biology. While structural studies continue to flow into the databases at an ever-accelerating pace, there is an urgent need to couple the flood of structural information with biochemical and biophysical analysis of function. Insights into the structural organization and allosteric mechanisms of complex multidomain macromolecular assemblies, such as transcriptional and signaling complexes, will be important for understanding the malfunction of these systems in human diseases and in the development of therapeutics for cancer and other diseases. The organizers of this symposium find a need to bring together structural biologists working in diverse methodological areas that are interested in these common issues in biology.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, APRIL 13
WEDNESDAY, APRIL 14
THURSDAY, APRIL 15
FRIDAY, APRIL 16
SATURDAY, APRIL 17
SUNDAY, APRIL 18
MONDAY, APRIL 19
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, APRIL 13
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
Kurt Wüthrich,
ETH Zürich, The Scripps Research Institute, Switzerland
Structural Biology and Proteomics using Solution NMR
Structural Biology and Proteomics using Solution NMR
Stephen C. Harrison,
Harvard Medical School, USA
Assembling Structures
Assembling Structures
08:00—11:00
Membrane Proteins
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*
Patricia A. Jennings,
University of California, San Diego, USA
Donald M. Engelman,
Yale University, USA
Folding and Evolution of Membrane Proteins
Folding and Evolution of Membrane Proteins
Charles R. Sanders,
Vanderbilt University School of Medicine, USA
Membrane Protein Folding, Misfolding, and Disease
Membrane Protein Folding, Misfolding, and Disease
William M. Clemons,
Harvard University Medical School, USA
X-ray Structure of a Protein-Conducting Channel
X-ray Structure of a Protein-Conducting Channel
Werner Kühlbrandt,
Max-Planck-Institute of Biophysics, Germany
Electron Microscopy of Membrane Transport Proteins
Electron Microscopy of Membrane Transport Proteins
Yafei Huang,
New York University Medical Center, USA
Short Talk: Structure and Mechanism of the Glycerol-3-Phosphate Transporter
Short Talk: Structure and Mechanism of the Glycerol-3-Phosphate Transporter
08:00—11:00
Bioinformatics/Target Selection
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Andrej Sali,
University of California, San Francisco, USA
Modeling the Structure of Proteins and Macromolecular Assemblies
Modeling the Structure of Proteins and Macromolecular Assemblies
*
Janet M. Thornton,
European Bioinformatics Institute, UK
From Structure to Function
From Structure to Function
Juswinder Singh,
Celgene Corporation, USA
A Classification of Disulfide Space and Its Role in Protein Structure and Function
A Classification of Disulfide Space and Its Role in Protein Structure and Function
Steven E. Brenner,
University of California, Berkeley, USA
The Pfam 5000: Implications of Target Selection for Structural Genomics
The Pfam 5000: Implications of Target Selection for Structural Genomics
17:00—18:50
Pushing the Limits in Structural Biology I (Joint)
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*
David A. Agard,
University of California, San Francisco, USA
Brian T. Chait,
Rockefeller University, USA
New Approaches for the Study of Protein Complexes
New Approaches for the Study of Protein Complexes
Barry Honig,
Columbia University / HHMI, USA
Pushing the Limits of Computational Structural Biology
Pushing the Limits of Computational Structural Biology
Ad Bax,
NIDDK, National Institutes of Health, USA
Weak Alignment NMR: How Detailed a View Can We Get?
Weak Alignment NMR: How Detailed a View Can We Get?
18:50—19:00
NIH Protein Structure Initiative
Meeting has ended...abstracts no longer viewable online.
John C. Norvell,
NIGMS, National Institutes of Health, USA
08:00—11:00
Signaling at the Membrane
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Patricia A. Jennings,
University of California, San Diego, USA
Structure and Mechanism of Kinases and Anchoring Proteins
Structure and Mechanism of Kinases and Anchoring Proteins
Wendell A. Lim,
University of California, San Francisco, USA
The Logic of Signaling Switches and Scaffolds
The Logic of Signaling Switches and Scaffolds
Daniel J. Leahy,
Johns Hopkins School of Medicine, USA
Conformational Change in ErbB Receptor Signaling
Conformational Change in ErbB Receptor Signaling
K. Christopher Garcia,
Stanford University School of Medicine, USA
Unraveling the Mechanisms of Neurotrophin Receptor Signaling
Unraveling the Mechanisms of Neurotrophin Receptor Signaling
Douglas M. Freymann,
Northwestern University, USA
Short Talk: Structure of the Homo-Heterodimeric GTPase Core of the SRP Targeting Complex
Short Talk: Structure of the Homo-Heterodimeric GTPase Core of the SRP Targeting Complex
08:00—11:00
Molecular Biology/ Protein Expression/Purification I
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*
Spencer Emtage,
SGX Pharmaceuticals, Inc., USA
Scott A. Lesley,
Genomics Institute of the Novartis Research Foundation, USA
A Multi-Tiered Approach to Structural Genomics
A Multi-Tiered Approach to Structural Genomics
Kenneth H. Lundstrom,
BioXtal, Inc., Switzerland
Structural Genomics on Membrane Proteins - The MEPNET Approach
Structural Genomics on Membrane Proteins - The MEPNET Approach
Glen A. Evans,
Egea BioSciences, Inc., USA
Application of Gene Synthesis in Pharmacuetical Development
Application of Gene Synthesis in Pharmacuetical Development
Gerald W. Becker,
Roche Diagnostics, USA
Cell Free Protein Expression Systems for Structural Biology
Cell Free Protein Expression Systems for Structural Biology
17:00—19:00
Macromolecular Interactions I
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*
William I. Weis,
Stanford University, USA
G. Marius Clore,
NIDDK, National Institutes of Health, USA
Insights into Recognition in Transient Protein-Protein Complexes
Insights into Recognition in Transient Protein-Protein Complexes
Wei Yang,
NIDDK, National Institutes of Health, USA
Insights into the Mechanism of DNA Polymerase
Insights into the Mechanism of DNA Polymerase
Sepideh Khorasanizadeh,
Sanford Burnham Prebys Medical Discovery Institute, USA
Recognition of Lysine-Methylated Histone Tails by the Chromodomain
Recognition of Lysine-Methylated Histone Tails by the Chromodomain
Josep Rizo,
University of Texas Southwestern Medical Center, USA
Short Talk: Mad Conformational Signaling in the Mitotic Spindle Checkpoint
Short Talk: Mad Conformational Signaling in the Mitotic Spindle Checkpoint
17:00—19:00
Molecular Biology/ Protein Expression/Purification II
Meeting has ended...abstracts no longer viewable online.
Spencer Emtage,
SGX Pharmaceuticals, Inc., USA
A Modular Automation Platform for Large-Scale Production of Eukaryotic Proteins
A Modular Automation Platform for Large-Scale Production of Eukaryotic Proteins
*
Cheryl Arrowsmith,
University of Toronto, Canada
Structural Proteomics: Structural Biology on a Genome Wide Scale
Structural Proteomics: Structural Biology on a Genome Wide Scale
Geoffrey Waldo,
Los Alamos National Laboratory, USA
Progress on High Throughput Folding Interference Reporters and Directed Evolution/New Protein tagging an Detection Systems Using GFP Microdomains
Progress on High Throughput Folding Interference Reporters and Directed Evolution/New Protein tagging an Detection Systems Using GFP Microdomains
20:00—22:10
Workshop: Graduate Student/Postdoctoral Presentations
*
Jeffrey B. Bonanno,
Albert Einstein College of Medicine, USA
Mark A. DePristo,
Harvard University, USA
Heterogeneity and Inaccuracy in Protein Structures Solved by X-ray Crystallography
Heterogeneity and Inaccuracy in Protein Structures Solved by X-ray Crystallography
Maria Dolores Díaz,
University of Washington, USA
Cytochrome P450 Homotropic Cooperativity as Probed by Heteronuclear NMR
Cytochrome P450 Homotropic Cooperativity as Probed by Heteronuclear NMR
Celia W. Goulding,
University of California, Irvine, USA
Discovery of Heme Uptake Pathway in M. tuberculosis
Discovery of Heme Uptake Pathway in M. tuberculosis
Marek Grabowski,
University of Virginia, USA
The Structural Genomics Experimental Pipeline: Insights from Global Target Lists
The Structural Genomics Experimental Pipeline: Insights from Global Target Lists
Izabela Katarzyna Janda,
University of Virginia, USA
Protein Crystallization by Surface Entropy Reduction Approach
Protein Crystallization by Surface Entropy Reduction Approach
Piotr Lasota,
University of Virginia, USA
Small Scale Automation on the Bench
Small Scale Automation on the Bench
Lynsey A. Mack,
University of Edinburgh, Scotland
Studies of Extremophilic SSB Proteins
Studies of Extremophilic SSB Proteins
Dierk Niessing,
Ulm University, Germany
Structural and Functional Studies of She2
Structural and Functional Studies of She2
Anil K. Padyana,
Boehringer Ingelheim Pharmaceuticals, Inc., USA
Crystal Structure of Shikimate 5-Dehydrogenase (SDH) Bound to NADP: Insights into Function and Evolution
Crystal Structure of Shikimate 5-Dehydrogenase (SDH) Bound to NADP: Insights into Function and Evolution
Ming-Tao Pai,
National Tsing Hua University, Taiwan
Solution Structure of the Hypothetical Protein HP0495 from Helicobacter pylori
Solution Structure of the Hypothetical Protein HP0495 from Helicobacter pylori
Shuh-Chyung Song,
University of Rochester, USA
Crystal Structure of NNA7 at 1.75 A Resolution; an Fab Fragment that Recognizes a Human Blood-Group Glycopeptide Antigen on Glycophorin A
Crystal Structure of NNA7 at 1.75 A Resolution; an Fab Fragment that Recognizes a Human Blood-Group Glycopeptide Antigen on Glycophorin A
Adelinda Yee,
Ontario Cancer Institute, University of Toronto, Canada
Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics
Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics
DeokCheon Yeh,
University of Maryland, NIST, USA
NMR Structure of the Hypothetical Protein HI0004 from Haemophilus Influenzae
NMR Structure of the Hypothetical Protein HI0004 from Haemophilus Influenzae
08:00—11:00
Macromolecular Machines
Meeting has ended...abstracts no longer viewable online.
James A. Spudich,
Stanford University, USA
Single Molecule Analysis and the Myosin Family of Molecular Motors
Single Molecule Analysis and the Myosin Family of Molecular Motors
Seth A. Darst,
Rockefeller University, USA
Structural Studies of Prokaryotic Transcription
Structural Studies of Prokaryotic Transcription
Nikola P. Pavletich,
Memorial Sloan-Kettering Cancer Center, USA
Structural Biology of Ubiquitin Protein Ligases
Structural Biology of Ubiquitin Protein Ligases
Tom E. Ellenberger,
Washington University School of Medicine, USA
Visualizing the Beginning and End Game of DNA Replication
Visualizing the Beginning and End Game of DNA Replication
Penmetcha K.R. Kumar,
National Institute of Advanced Industrial Science & Technology, Japan
Short Talk: Structural Basis of Activation of HutP by L-Histidine: A RNA-Binding Protein that Regulates the Transcription of Hut Operon in Bacillus subtilis
Short Talk: Structural Basis of Activation of HutP by L-Histidine: A RNA-Binding Protein that Regulates the Transcription of Hut Operon in Bacillus subtilis
08:00—11:00
Crystallization and Crystal Handling
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*
George T. DeTitta,
Hauptman-Woodward Medical Research Institute, USA
From Crystallization Screening to Crystals
From Crystallization Screening to Crystals
Rebecca Page,
Brown University, USA
High Throughput Protein Crystallography Technologies: Analysis of Large Scale Experiments Using Positive and Negative Data
High Throughput Protein Crystallography Technologies: Analysis of Large Scale Experiments Using Positive and Negative Data
Reiner Kiefersauer,
Max Planck Institute for Biochemistry, Germany
Free Mounting System ™ A Novel Tool to Improve Handling and Quality of Protein Crystals
Free Mounting System ™ A Novel Tool to Improve Handling and Quality of Protein Crystals
Zbigniew Dauter,
National Cancer Institute and National Synchrotron Light Source, USA
Structure Determination with Halides
Structure Determination with Halides
16:00—17:00
Plenary
Meeting has ended...abstracts no longer viewable online.
Ronald D. Ruth,
, USA
Short Talk: The Compact Light Source for Protein Crystallography
Short Talk: The Compact Light Source for Protein Crystallography
17:00—19:00
Pushing the Limits in Structural Biology II (Joint)
Meeting has ended...abstracts no longer viewable online.
David A. Agard,
University of California, San Francisco, USA
Pushing the Limits of Resolution in Light Microscopy
Pushing the Limits of Resolution in Light Microscopy
Bridget Carragher,
New York Structural Biology Center, USA
High Throughput Single Particle Electron Microscopy of Macromolecular Assemblies
High Throughput Single Particle Electron Microscopy of Macromolecular Assemblies
08:00—10:45
Protein Stability and Design
Meeting has ended...abstracts no longer viewable online.
*
Peter E. Wright,
The Scripps Research Institute, USA
Brian W. Matthews,
University of Oregon, USA
T4 Lysozyme as a Test Bed for Protein Design Algorithms
T4 Lysozyme as a Test Bed for Protein Design Algorithms
David M. LeMaster,
Wadsworth Center, New York State Department of Health, USA
The Absence of Kinetic Thermal Stabilization in a Hyperthermophile Rubredoxin Indicated by 40 Microsecond Folding in the Presence of Irreversible Denaturation
The Absence of Kinetic Thermal Stabilization in a Hyperthermophile Rubredoxin Indicated by 40 Microsecond Folding in the Presence of Irreversible Denaturation
08:00—11:15
X-ray and NMR Data Collection. Session Sponsored in part by Bruker AXS and Bruker Biospin Corporation.
Meeting has ended...abstracts no longer viewable online.
Gaetano Thomas Montelione,
Rutgers University, USA
Structural Proteomics of Eukaryotic Protein Domain Families
Structural Proteomics of Eukaryotic Protein Domain Families
John L. Markley,
University of Wisconsin-Madison, USA
The Center for Eukaryotic Structural Genomics (CESG)
The Center for Eukaryotic Structural Genomics (CESG)
Peter Kuhn,
The Scripps Research Institute, USA
Data Centric Experimentation in Structural Proteomics
Data Centric Experimentation in Structural Proteomics
Thomas Earnest,
Lawrence Berkeley National Laboratory, USA
Integrating Intelligence into Beamline Automation
Integrating Intelligence into Beamline Automation
Andrzej Joachimiak,
Argonne National Laboratory, USA
High-Throughput Pipeline for Protein Structure Determination Using X-Ray Crystallography and Synchrotron Radiation
High-Throughput Pipeline for Protein Structure Determination Using X-Ray Crystallography and Synchrotron Radiation
10:45—11:15
Late Breaking Results
Meeting has ended...abstracts no longer viewable online.
Kristi Elizabeth Pullen,
University of California, Berkeley, USA
Short Talk: An Alternate Conformation Stabilized by a Third Metal in the M. tuberculosis PP2c-Family Ser/Thr Protein Phosphatase
Short Talk: An Alternate Conformation Stabilized by a Third Metal in the M. tuberculosis PP2c-Family Ser/Thr Protein Phosphatase
Laura M. Guogas,
Harvard University, USA
Short Talk: The Crystal Structure of an N-Terminal Basic Peptide Bound to Viral RNA
Short Talk: The Crystal Structure of an N-Terminal Basic Peptide Bound to Viral RNA
17:00—19:00
Protein and Small Molecule Design
Meeting has ended...abstracts no longer viewable online.
Susan Marqusee,
University of California, Berkeley, USA
Engineering the Energy Landscape of Proteins
Engineering the Energy Landscape of Proteins
Homme Hellinga,
Duke University Medical Center, USA
Computational Design of Biologically Active Proteins
Computational Design of Biologically Active Proteins
John R. Desjarlais,
Xencor, USA
Short Talk: From Structural to Biological Specificity: Improving Antibody Efficacy
Short Talk: From Structural to Biological Specificity: Improving Antibody Efficacy
Qiaojuan Jane Su,
Abgenix, Inc., USA
Short Talk: Modeling of an EGFRvIII Antibody Combining Site and Simulation of Epitope-Paratope Interaction Energetics
Short Talk: Modeling of an EGFRvIII Antibody Combining Site and Simulation of Epitope-Paratope Interaction Energetics
17:00—19:00
Automated Structure Determination/Refinement/PDB Deposition
Meeting has ended...abstracts no longer viewable online.
Thomas C. Terwilliger,
Los Alamos National Laboratory, USA
Automated structure solution, density modification, and model-building
Automated structure solution, density modification, and model-building
*
Helen M. Berman,
Rutgers University, Center for Proteomics Research, USA
Protein Data Bank: A Resource for Structural Genomics
Protein Data Bank: A Resource for Structural Genomics
Wladek Minor,
University of Virginia, USA
Rapid Generation of the Initial Model from Diffraction Data
Rapid Generation of the Initial Model from Diffraction Data
08:00—11:15
Macromolecular Interactions II
Meeting has ended...abstracts no longer viewable online.
Peter E. Wright,
The Scripps Research Institute, USA
RNA Recognition by Zinc Fingers
RNA Recognition by Zinc Fingers
Thomas J. Hope,
Northwestern University, USA
Fluorescent Visualization of HIV Entry and Trafficking in Living Cells
Fluorescent Visualization of HIV Entry and Trafficking in Living Cells
Peter E. Prevelige,
University of Alabama, Birmingham, USA
Short Talk: Identification of the Maturation Induced Changes in Intersubunit Interfaces within Intact HIV-1 Virions by Hydrogen/Deuterium Exchange Mass Spectrometry
Short Talk: Identification of the Maturation Induced Changes in Intersubunit Interfaces within Intact HIV-1 Virions by Hydrogen/Deuterium Exchange Mass Spectrometry
J.N. Mark Glover,
University of Alberta, Canada
Short Talk: The Structural Consequences of Mutations on the BRCA1 BRCT Domain
Short Talk: The Structural Consequences of Mutations on the BRCA1 BRCT Domain
08:00—11:00
Functional Annotation
Meeting has ended...abstracts no longer viewable online.
*
Wim G.J. Hol,
University of Washington, USA
Structural Genomics of Pathogenic Protozoa (SGPP)
Structural Genomics of Pathogenic Protozoa (SGPP)
Dong Hae Shin,
University of California, Berkeley, USA
Structure-Based Annotation of Molecular Function
Structure-Based Annotation of Molecular Function
Christine A. Orengo,
University College London, UK
Selecting Targets which Probe Family and Functional Space
Selecting Targets which Probe Family and Functional Space
Mirek Cygler,
Biotechnology Research Institute, Canada
Short Talk: The Structure of the Mitogen-Activated Protein Kinase Scaffold Protein MP1 in Complex with the Adaptor Protein p14
Short Talk: The Structure of the Mitogen-Activated Protein Kinase Scaffold Protein MP1 in Complex with the Adaptor Protein p14
Dominika M. Borek,
University of Texas Southwestern Medical Center, USA
Short Talk: Discovery through Crystallography - Structural Studies of Escherichia coli ycfC Gene Product
Short Talk: Discovery through Crystallography - Structural Studies of Escherichia coli ycfC Gene Product
17:00—19:15
The RNA World
Meeting has ended...abstracts no longer viewable online.
Sarah A. Woodson,
Johns Hopkins University, USA
Insights on RNA Folding Mechanisms from Group I Ribozymes
Insights on RNA Folding Mechanisms from Group I Ribozymes
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
A Conformational Switch Controls Hepatitis Delta Virus Ribozyme Catalysis
A Conformational Switch Controls Hepatitis Delta Virus Ribozyme Catalysis
Thomas A. Steitz,
HHMI/Yale University, USA
How the CCA-Adding Enzyme Adds CCA to tRNA without Using an Oligonucleotide Template
How the CCA-Adding Enzyme Adds CCA to tRNA without Using an Oligonucleotide Template
Dinshaw J. Patel,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway
Jeffrey M. Vargason,
NIEHS, National Institutes of Health, USA
Short Talk: Size Selective Recognition of siRNA by an RNA Silencing Suppressor
Short Talk: Size Selective Recognition of siRNA by an RNA Silencing Suppressor
17:00—19:15
High-Throughput Structure-Based Drug Discovery
Meeting has ended...abstracts no longer viewable online.
Tom L. Blundell,
University of Cambridge, UK
Crystallography, Structural Bioinformatics and Drug Discovery
Crystallography, Structural Bioinformatics and Drug Discovery
Stephen W. Kaldor,
Quanticel Pharmaceuticals, USA
*
Stephen K. Burley,
Rutgers University, USA
Structure-Guided Drug Discovery Using Fragment-Based Lead Identification/Lead Optimization
Structure-Guided Drug Discovery Using Fragment-Based Lead Identification/Lead Optimization
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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Agouron Pharmaceuticals, Inc. |
Carl Zeiss MicroImaging, Inc. |
|
Sigma Life Science |
Spectra Gases, Inc. Stable Isotopes Group |
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Sunesis Pharmaceuticals, Inc. |
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