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This meeting took place in 2004



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Immune Evasion (X6)


Organizer(s) Giorgio Trinchieri and Anne O'Garra
March 25—30, 2004
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Nov 24, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 26, 2004

Sponsored by DNAX Research, Inc.


Summary of Meeting:
Infectious pathogens and tumors use many mechanisms to evade an immune response and survive in the organisms. Some of the same mechanisms are of relevance for the regulation of tolerance to self-antigens or its breakdown in autoimmunity. Their modulation may also results in successful graft take or rejection in organ transplantation. In the recent years there has been great progress in the understanding of many of these mechanisms that are very diverse but all result in the escape of the pathogen or tumor from an effective immune response with deleterious effect. Infectious disease immunity has been teaching us much about the mechanisms of immune evasion and what we have learned from these studies has greatly contributed to the understanding of cancer immune evasion and of the immunological mechanisms regulating autoimmunity and graft rejection. Because this meeting is planned to be concurrent with a meeting on Microbial Latency, the presentations on immunity to infections are limited to those fields (e.g. immunodeviation or oncogenic viruses) that provided important information for the understanding of the mechanisms of immune evasion. We have attempted to cover many aspects of immune evasion in cancer as well as to provide examples of the importance of similar mechanisms in autoimmunity, transplantation, and pregnancy. The two concurrent meetings (latency and evasion) should, thus, be very complementary.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 25

15:00—19:00
Registration

Rio Grande D
18:15—19:15
Refreshments

Rio Grande ABC
19:15—19:20
Orientation

Bataan
19:20—19:30
Introductory Remarks
Meeting has ended...abstracts no longer viewable online.

Bataan
JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA

19:30—21:30
Keynote Session (Joint). Keynote Session Sponsored by The Ellison Medical Foundation
Meeting has ended...abstracts no longer viewable online.

Bataan
* Edward S. Mocarski, Emory University, USA

* Anne O'Garra, Francis Crick Institute, UK

Ulrich H. Koszinowski, Max Von Pettenkofer Institut, Germany
Mechanisms of Immunoevasion in Cytomegalovirus

Stanley Falkow, Stanford University, USA
Persistent Bacterial Infection


FRIDAY, MARCH 26

07:00—08:00
Breakfast

Bataan
08:00—11:15
Role of Antigen Presenting Cells in Immunoregulation, Immunodeviation and Tolerance. Session Sponsored in part by Schering-Plough Laboratory for Immunological Research
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Brian L. Kelsall, NIAID, National Institutes of Health, USA
Inhibitory Pathways for Controlling Dendritic Cell Functions

Andrea la Sala, NIAID, National Institutes of Health, USA
Short Talk: Inhibition of Interleukin(IL)-12 Production by Gi-Protein Coupled Receptors is Mediated by Phosphoinositide-3 Kinase (PI3K) Activation, Phosphorylation of Protein Kinase B/ AKT, and Activation of c-Jun N-Terminal Kinase

* Ralph M. Steinman, Rockefeller University, USA
Control of Immunity and Tolerance by Dendritic Cells in vivo

Hyam I. Levitsky, , USA
Reconciling the Tumor Immunosurveillance Hypothesis, Immunoediting, and the Barrier of Tumor-Specific T cell Tolerance

Matthew L. Albert, Genentech, Inc., USA
Molecular and Cellular Requirements for Cross-Priming versus Cross-Tolerance

P'ng Loke, New York University School of Medicine, USA
Short Talk: The Role of Adaptive Immunity in the Recruitment/Differentiation of Alternatively Activated Macrophages

08:00—11:15
Host Control of Persistence. Session Sponsored by The Ellison Medical Foundation
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Rafi Ahmed, Emory University School of Medicine, USA
Memory CD8 T Cell Differentiation

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Role of Regulatory T Cells in Persistnet Infections

Leo Lefrançois, University of Connecticut Health Center, USA
The Control of Memory CD8T Cell Persistence by IL15

* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
TNF and Tuberculosis

J. Scott McClellan, Washington University School of Medicine, USA
Short Talk: A Beta-2-Microglobulin-dependent but MHC Class Ia-Independent Mechanism is Essential for Control of Chronic Gamma-Herpesvirus Infection

Wendy P. Loomis, Harvard Medical School, USA
Short Talk: GILT, A Lysosomal Thiol Reductase, is Required for the Priming of Microbe-Specific CD8+ T Cells

09:20—09:40
Coffee Break

Bataan
11:15—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Immunoprivileged Sites
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Thomas A. Ferguson, Washington University School of Medicine, USA
Termination of Antigen Specific Immunity; What We Have Learned From Immune Privileged Sites

Phillippe Le Bouteiller, INSERM, France
Human Cytomegalovirus-Placental HLA-G Interactions

17:00—19:00
Persistence in the Face of Innate Immunity: The Oldest Profession?
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Lewis L. Lanier, University of California, San Francisco, USA
NK Cell Recognition of Cytomegalovirus

Grant McFadden, University of Florida, USA
Immune Evasion Strategies by Poxviruses

Ann B. Hill, Oregon Health & Science University, USA
MCMV Interference with Antigen Presentation does not Affect Size of CD8 T Cell Responses

Nancy J. Raab-Traub, University of North Carolina at Chapel Hill, USA
Short Talk: Potential Immune Selection of EBV LMP1 in Nasopharyigeal Carcinoma

19:00—20:00
Social Hour

Bataan
19:30—22:00
Poster Session 1

Bataan

SATURDAY, MARCH 27

07:00—08:00
Breakfast

Rio Grande A-C
08:00—11:15
Dysregulation of the Immune Response by Pathogens (Joint). Session Sponsored by the Burroughs Wellcome Fund.
Meeting has ended...abstracts no longer viewable online.

Bataan
* Alan Sher, NIAID, National Institutes of Health, USA
Regulation of Immune Response in Chronic Infectino in Eukariotics

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Chronic Helminth Infections and Immune Evasion: Cellular and Molecular Mechanisms

Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Immune Response Polarization by Dendritic Cells

Gary B. Huffnagle, University of Michigan, USA
Mechanisms Underlying Chronic Fungal Infections and Allergies

Thomas B. Nutman, NIAID, National Institutes of Health, USA
Response of Human Dendritic, Macrophages and Langerhans’ Cells to Filarial Parasites

09:20—09:40
Coffee Break

Rio Grande A-C
13:00—14:00
Poster Setup

Bataan
14:00—22:00
Poster Viewing

Bataan
14:00—16:00
Workshop 1

Rio Grande C-D
Drake M. LaFace, Merck Research Labs - Palo Alto, USA
Recombinant Adenovirus Vectors Moderate Immune Evasion

Philippe Krebs, The Scripps Research Institute, USA
Functional Paralysis of Cytotoxic T Cells Following Immunization with Recombinant Adenovirus

Scott E. Hensley, NIAID, National Institutes of Health, USA
Viral Immune Evasion Genes of Adenoviral Vectors Affect their Efficiency as Vaccine Carriers

Paola Allavena, Instituto Clinico Humanitas, Italy
Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immuno-Suppressive Program

Karen H. Redlitz, University of Virginia, USA
Cytokine Regulation of Indoleamine 2,3-Dioxygenase Activity in Human Melanoma Cell Lines

Wu-Shiun Hou, Massachusetts Institute of Technology, USA
DC Survival and Immunogenicity is Differentially Regulated by Innate and Acquired Immune System Signals

Weiping Zou, University of Michigan, USA
Immune Evasion in Human Ovarian Cancer

Jessica Carolyn Karl, National Cancer Institute, National Institutes of Health, USA
Tolerance in T Cell Depleted Host is Mediated by B Cells and Bone Marrow Stroma in the Presence of Classical Costimulation

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:15
Immunoregulatory T Cells
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Anne O'Garra, Francis Crick Institute, UK
Il-10-Sacreting Regulatory T Cells

Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Role of IL-10-Producing T Cells in the Pathogenesis of Tuberculosis

Fiona M. Powrie, University of Oxford, UK
Immunoregulatory T Cells in Autoimmunity

Dominique Kaiserlian, INSERM-U851, France
Regulatory CD4+ T cells in Oral Tolerance

17:00—19:15
Persistence in the Face of Adaptive Immunity: A Mammalian Theme?
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Philip D. Greenberg, University of Washington, USA
Mysteries of Cellular Immune Control of Viruses

* Robert L. Hendricks, University of Pittsburgh, USA
Retention of Memory CD8+ T Cells in Latent HSV-1 Infected Sensory Ganglia

Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
Impact of Viral Sequence Evolution on Immune Control of HIV-1 and HCV

Rama Rao Amara, Emory University, USA
Short Talk: Immune Control of HIV Persistence and Latency

Kim J. Hasenkrug, NIAID, National Institutes of Health, USA
Short Talk: Regulatory T Cells Suppress Anti-Viral CD8+ T Cell Functions and Contribute to Retroviral Persistence

19:15—20:15
Social Hour

Bataan
19:30—22:00
Poster Session 2

Bataan

SUNDAY, MARCH 28

07:00—08:00
Breakfast

Bataan
08:00—11:00
Unresponsiveness and Immunosuppression in Cancer
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Hans Schreiber, University of Chicago, USA
Solid Tumors: Overcoming Stromal Barriers and Immune Escape

Dmitry I. Gabrilovich, Wistar Institute, USA
Defective Dendritic Cell Differentiation and Function in Cancer

Alexander H. Enk, Universitäts-Hautklinik Heidelberg, Germany
DC, Tumors and Regulatory T Cells

08:00—11:15
Pathogen Escape from Control
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
John M. Leong, University of Massachusetts Medical School, USA
Platelet Activation and High-Level Bacteremia by a Relapsing Fever Spirochete, Borrelia hermsii

Cliona M. Rooney, Baylor College of Medicine, USA
Overcoming Tumor Immune Evasion Strategies to Improve CTLs for the Adoptive Immunotherapy of EBV-Related Tumors

Kenneth L. Tyler, University of Colorado School of Medicine, USA
Reovirus Control of Intracellular Signaling and Apoptosis

* Edward S. Mocarski, Emory University, USA
Cytomegalovirus Control of Dissemination and Latency

Maaike E. Ressing, Leiden University Medical Center, Netherlands
Short Talk: Evasion from HLA Class II-Restricted T Cell Immunity during Lytic EBV Infection

Padraic Fallon, Trinity College Dublin, Ireland
Short Talk: Parasitic Helminth Subversion of Inflammation by a Chemokine-Binding Protein

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:00—16:00
Workshop 2

Rio Grande C-D
Niamh E. Mangan, Trinity College, Ireland
Novel Immune Modulation by Helminths Protects Mice from Allergic Diseases

Michael J. Brumlik, University of Texas Health Science Center, USA
Identification of a Gene Encoding a Novel Mitogen-Activated Protein Kinase in Toxoplasma gondii

Mark T. Orr, Infectious Disease Research Institute, USA
Restoring an Immune Evasion Strategy to Herpes Simplex Virus

David McKechnie Haig, Moredun Research Institute, Scotland
Immunomodulation by a gamma-Herpesvirus and a Parapoxvirus: A Tale of Two Interleukin-10s

W. L. William Chang, University of California, Davis, USA
Cytomegalovirus-Encoded IL-10: A Potential Immune Evasion Mechanism that Affects Immature and Mature Dendritic Cells

Elke Scandella, Kantonsspital St. Gallen, Switzerland
Impact of CCR7 on Function and Distribution of Antiviral Effector and Memory Cytotoxic T Lymphocytes

Jean-Luc Davignon, INSERM, France
Impairment of IFN-gamma-Induced Tyrosine Phosphorylation of STAT1 by HCMV through a New Mechanism

Ramsey H. McIntire, University of Kansas Medical Center, USA
Recombinant Soluble HLA-G1 and -G2 Regulate Production of Anti-Inflammatory Cytokines by U937 Cells

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Cancer Immunoevasion
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Peter Hersey, University of Newcastle, Australia
How Human Melanoma Cells Evade TRAIL Induced Apoptosis

Federico Garrido, Hospital Universitario Virgen de las Nieves, Spain
MHC Antigens and Tumor Immune Escape

Soldano Ferrone, University of Pittsburgh, USA
HLA Antigens and Tumor Cell Immunoescape

17:00—19:00
Challenges of the Intracellular Lifestyle
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Bernard Roizman, University of Chicago, USA
The Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1(HSV-1)

Nancy C. Reich, Stony Brook University, USA
Interferon and Apoptosis in Host Defense

* John C. Boothroyd, Stanford University School of Medicine, USA
Toxoplasma Gondii Persistence

Kathy DeRiemer, University of California, Davis, USA
Short Talk: Latency in Mycobacterium tuberculosis: Epidemiological Evidence for the Role of a Specific Regulon

19:00—20:00
Social Hour

Bataan
19:30—22:00
Poster Session 3

Bataan

MONDAY, MARCH 29

07:00—08:00
Breakfast

Rio Grande A-C
08:00—11:00
Cancer Due to Persistent Infections (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Robert W. Tindle, Royal Children's Hospital, Australia
Immune Evasion in Human Papillomavirus-Associated Cervical Carcinoma

Timothy L. Cover, Vanderbilt University School of Medicine, USA
Helicobacter pylori: Virulence Factors and Cancer

Laimonis A. Laimins, Northwestern University, USA
The Differentiation-Dependent Life Cycle of Human Papillomaviruses

* Yuan Chang, University of Pittsburgh Cancer Institute, USA
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?

Rosemary Rochford, Upstate Medical University, State University of New York, USA
Short Talk: Holoendemic Malaria Alters Epstein-Barr Virus Persistence in Children

Sonja M. Best, NIAID, National Institutes of Health, USA
Short Talk: A Role for Caspases in Mediating Persistent Viral Infections?

09:20—09:40
Coffee Break

Rio Grande A-C
16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Alternative Mechanisms of Immunoevasion
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Vincenzo Bronte, University of Verona, Italy
L-Arginine Catabolism in Myeloid Suppressor Cells as a Tool to Restrain T Cell Response

Andrew L. Mellor, Georgia Regents University, USA
Tolerance by Tryptophan Catabolism

* Jay A. Berzofsky, NCI, NIH, USA
NKT Cell Mediated Suppression of Immunosurveillance through IL-13, Myeloid Cells, and TGF-beta

Paulo C. Rodriguez, Louisiana State University Health Sciences Center, USA
Short Talk: Arginase I Production by Tumor Associated Myeloid Cells Down-Regulates CD3z Chain and Block Specific T Cell Responses

17:00—19:00
Quiescence and Latency
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Jerome A. Zack, University of California, Los Angeles, USA
Characterization and Elimination of Latent HIV

Clifton E. Barry III, NIAID, National Institutes of Health, USA
The role of latent organisms in active TB: targeting cellular energy metabolism in the absence of replication with nitroimidazoles

* Samuel H. Speck, Emory University, USA
Murine gammaherpesvirus 68 Persistence via Manipulation of B Cell Development

19:00—20:00
Social Hour

Bataan
20:00—23:00
Entertainment

Bataan

TUESDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 U13 AI60000-01




National Institutes of Health

Grant No. 1R13AI058934-01




We gratefully acknowledge additional support for this conference from:


DNAX Research Institute

Schering-Plough Research Institute

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