Sagebrush Inn & Suites Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2004



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Mast Cells in Physiology, Host Defense and Disease: Beyond IgE (C5)


Organizer(s) Melissa A. Brown, K. Frank Austen and Stephen J. Galli
February 28—March 4, 2004
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 28, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 29, 2003

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Mast cells are critical effector cells in acute allergic reactions. In this setting, mast cell activation by antigen-dependent cross-linking of high affinity receptors for IgE (FcepsilonRI) induces the release of preformed molecules (such as histamine), as well as the synthesis and release of cytokines, chemokines, growth factors, leukotrienes and prostaglandins. However, mast cell functions can also be elicited by immune complexes, complement products, neuropeptides, cytokines and ligands of toll-like receptors. Accordingly, the proven or potential functions of mast cells include diverse, IgE-independent roles in host defense and disease (including autoimmune or cardiovascular disorders) as well as in physiological processes, such as regulation of epithelial barrier function and modulation of nerve function. This conference will assess what is currently known about the roles of mast cells and will consider how our understanding can be advanced by the application of new technologies and approaches to analyze and manipulate mast cell function.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 28

15:00—19:00
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Lobby
19:15—19:30
Orientation

Chamisa Ballroom 1

SUNDAY, FEBRUARY 29

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Mast Cell Development/Migration and in vivo Models I. Session Sponsored in part by GlaxoSmithKline Research & Development Ltd.
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Dean D. Metcalfe, NIAID, National Institutes of Health, USA
Regulation of Normal and Neoplastic Human Mast Cell Development

Cheryl A. London, Ohio State University, USA
Canine Mast Cell Tumors: Role of C-Kit Mutations and Treatment with Kit Inhibitors

* Stephen J. Galli, Stanford University, USA
Mast Cell Reconstitution of Genetically Mast-Cell-Deficient c-kit Mutant Mice as a Model for Investigating Mast Cell Biology in vivo: Insights into the Roles of Mast Cells in Health and Disease

Yukihiko Kitamura, Osaka University Medical School, Japan
Regulation of Mouse Mast Cell Development by MITF

Jakub Abramson, Weizmann Institute of Science, Israel
Short Talk: Dok-1 – A Novel Control Element of the Late Mast Cell Secretory Response

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:15
Mast Cell Development/Migration and in vivo Models II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Shigeo Koyasu, Keio University School of Medicine, Japan
Role of Phosphoinositide 3-Kinase in Differentiation and Function of Mast Cells

Richard L. Stevens, Brigham and Women's Hospital, USA
Regulation of Mast Cell Maturation by RasGRP4

Michael F. Gurish, Brigham and Women's Hospital, Harvard Medical School, USA
Mast Cell Progenitor Trafficking and Expansion

* Hugh R.P. Miller, University of Edinburgh, UK
Role of TGF-b1 in the Regulation of Mast Cell Development, Phenotype and Integrin Expression

19:15—20:15
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 1: Mast Cell Development/Migration and in vivo Models

Chamisa Ballroom 2

MONDAY, MARCH 1

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Positive and Negative Regulation of Mast Cell Function
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Regulation of Mast Cell Activation via FcepsilonRI

Howard R. Katz, Brigham and Women's Hospital, Harvard Medical School, USA
Regulation of Adaptive and Innate Inflammation by the gp49B1 Inhibitory Receptor

Beverly Koller, University of North Carolina at Chapel Hill, USA
Role of G Protein-Coupled Receptors in Regulation of Mast Cell Function

Frank A. Redegeld, University of Utrecht, Netherlands
Mast Cell Sensitizing Immunoglobulin Light Chains in Immediate and Delayed Hypersensitivity Reactions

Ehud Razin, Hebrew University, Hadassah Medical School, Israel
Short Talk: A Novel Function of Lysyl-tRNA Synthetase, Diadenosine Tetraphospate (Ap4A) and STAT3 as Regulators of the Activity of Microphthalmia Transcription Factor in Activated Mast Cells

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:00—16:00
Workshop 1: Identification and Characterization of Mast Cell Products

Chamisa Ballroom 1
Hirohisa Saito, National Research Institute for Child Health and Development, Japan
Transcriptome Profiling of Various Mast Cell Types

* Karl H. Nocka, Pfizer, USA
Searching for Therapeutic Targets in Human Mast Cells

Sue M. Liu, Garvan Institute of Medical Research, Australia
Discovery of Novel Inflammatory Mast Cell Genes

Amos Baruch, Genentech, Inc., USA
Identification and Characterization of Mast Cell Membrane and Secreted Hydrolases Using a Novel Functional Proteomics Approach

Anna Di Nardo, University of California, San Diego, USA
Expression and Function of Cathelicidin Antimicrobial Peptide in Mast Cells

Christine Möller, Uppsala University, Sweden
Stem Cell Factor Regulates Mast Cell Survival via Forkhead and MEK Regulated Expression and Phosphorylation of the BH3-only Pro-apoptotic Protein Bim

16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:15
Mast Cells in Inflammation and Host Defense
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* K. Frank Austen, Harvard Medical School, USA
Generation of cysLTs by Mast Cells in situ - The Receptor-Mediated Action of cysLTs in situ - And the Receptors-Mediated Action of cysLTs on Human Mast Cells in vitro

Jean S. Marshall, Dalhousie University, Canada
Selective Mediator Production by Mast Cells in Response to Pathogens and their Products

Soman N. Abraham, Duke University Medical Center, USA
Mast Cells in Host Defense Against Bacteria

Massimo Triggiani, University of Naples Federico II, Italy
Activation of Human Basophils and Mast Cells by Viral and Bacterial Products

19:15—20:15
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 2: Mast Cell Products and Regulation of Mast Cell Activation

Chamisa Ballroom 2

TUESDAY, MARCH 2

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Roles of Mast Cells in Non-Allergic Disorders I
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Melissa A. Brown, Northwestern University, USA
The Role of Mast Cells in EAE, a Rodent Model of Multiple Sclerosis

Diane Mathis, Harvard Medical School, USA
A Mast Cell-Dependent Model of Autoimmune Arthritis

J. Bruce Sundstrom, NIAID, National Institutes of Health, USA
Short Talk: Human Mast Cells as Potential Reservoirs for Persistent HIV-1 Infection

Zhi Liu, University of North Carolina at Chapel Hill, USA
Role of Mast Cells in Experimental Autoimmune Bullous Pemphigoid

Philip W. Askenase, Yale University School of Medicine, USA
How Mast Cells are Activated in T Cell Immunity: Invariant Valpha14+ Jalpha18+ NKT Cells and B-1 Cells begin the Initiating Cascade

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:00—16:00
Workshop 2: Approaches for the Analysis of Mast Cell Function in vivo

Chamisa Ballroom 1
* Stephen J. Galli, Stanford University, USA

Peter Bradding, University of Leicester Medical School, UK
The Anatomical Distribution of Mast Cells in the Airway of Asthmatics: Functional Implications

Michele Grimbaldeston, Centre for Cancer Biology, Australia
Mast-Cell-Deficient W-sash c-kit Mutant KitW-sh/KitW-sh Mice as a Model for Investigating Mast Cell Biology In Vivo

John M. Hwang, University of Calgary, Canada
Mast Cells Modulate the TH-Cell Inflammatory Response in Cutaneous Contact Sensitivity

Anneke Rijnierse, Utrecht University, Netherlands
The Regulatory Role of Mast Cells in a Murine Model for Inflammatory Bowel Disease

Kelly Monk, Oregon Health & Science University, USA
Role of Mast Cells in Neurofibromatosis Type I

Feng-Chun Yang, Indiana University School of Medicine, USA
Loss of the Nf1 Tumor Suppressor Gene in Schwann Cells Provides a Potent Stimulus for Mast Cell Migration Via Secretion of Soluble Kit Ligand

Maike K. Knackstedt, Charité, Germany
Key Role of Mast Cells in Stress-Mediated Hair Loss

16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Roles of Mast Cells in Non-Allergic Disorders II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Vanessa Ott, Promega, USA
Role of LTB4 in Mast Cell-Induced T Cell Recruitment

* Petri T. Kovanen, Wihuri Research Institute, Finland
Mast Cells in Atherogenesis and its Implications

Akira Matsumori, Kyoto University, Japan
Contribution of Mast Cells in the Development of Congestive Heart Failure

Karin E. de Visser, Netherlands Cancer Institute, Netherlands
Short Talk: The Role of the Adaptive Immune System in Mast Cell Potentiation of Cancer Development

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 3: Roles of Mast Cells in Health and Disease

Chamisa Ballroom 2

WEDNESDAY, MARCH 3

07:00—08:00
Breakfast

Los Vaqueros
08:00—09:20
Role of Mast Cells in Non-Allergic Disorders III
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Barry K. Wershil, Albert Einstein College of Medicine, USA
Role of Neuropeptides and Mast Cells in a Mouse Model of Interstitial Cystitis

Juan Pablo Abonia, Brigham and Women's Hospital, USA
Short Talk: Mast Cell Activation Releases Mouse Mast Cell Protease-5 during Ischemia-Reperfusion which Mediates Cytotoxic Injury of Skeletal Muscle

09:40—11:00
Role of Mast Cells in Physiology and Homeostasis I
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* George H. Caughey, University of California, San Francisco, USA
Structure and Function of Mast Cell Serine Proteases

Magnus Åbrink, Uppsala University, Sweden
Short Talk: Insights Into Mast Cell Function Based on Analyses of mMCP-4 -/- and NDST-2 -/- Mice

Bradley J. Undem, Johns Hopkins University, USA
Mast Cell-Sensory Nerve Interactions

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:15
Roles of Mast Cells in Physiology and Homeostasis II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Mary H. Perdue, McMaster University, Canada
Regulation of Mucosal Barrier Function by Mast Cells

Itsuro Matsumoto, Nagasaki University School of Medicine, Japan
Hypothesis Regarding the Physiological Role of Mast Cells Located in the Median Eminence in the Regulation of the Hypothalamic-Pituitary-Adrenal Response

Rae Silver, Columbia University, USA
Mast Cells in the Brain

Marcus Maurer, Charité - Universitätsmedizin Berlin, Germany
IL-15 Inhibits Mast Cell-Dependent Innate Immune Defense Against Bacteria

19:15—20:15
Social Hour

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

THURSDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI058260-01




We gratefully acknowledge additional support for this conference from:

GlaxoSmithKline Research & Development, Ltd.
UCB Reseach/ UCB Pharma

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676