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This meeting took place in 2004
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Biology of Hypoxia: The Role of Oxygen Sensing in Development, Normal Function and Disease (D3)
Organizer(s) Randall S. Johnson, Amato Giaccia and M. Celeste Simon
March 25—30, 2004
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 24, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 26, 2004
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Upon completion of this conference, participants should be able to: - Understand the most current and important aspects of hypoxia research generally - Appreciate current understanding of relationships between hypoxia and angiogenesis - Understand the relationship between oxygen sensing and metabolic function, particularly as it relates to cell and tissue survival during hypoxic injury - Appreciate current thinking on the role of oxygen sensing and hypoxic response in ischemic injuries, such as stroke and myocardial infarction - Gain an understanding of current ideas about the molecular sensing and signaling mechanisms induced by hypoxia - Understand the developmental roles oxygen sensing fulfill in model organisms, and gain insights into how these are relevant to human biology/pathology. A chief objective will be to bring the very disparate groups that work on hypoxia together. There is currently no other meeting where this occurs, and it will allow, we believe, unprecedented opportunities for cross-fertilization and collaboration to occur. A number of controversies on the mechanisms and effects of oxygen exist in the current literature; this meeting will bring the various points of view into the same setting and will allow a consensus on these issues to be built.
View Scholarships/Awards
Upon completion of this conference, participants should be able to: - Understand the most current and important aspects of hypoxia research generally - Appreciate current understanding of relationships between hypoxia and angiogenesis - Understand the relationship between oxygen sensing and metabolic function, particularly as it relates to cell and tissue survival during hypoxic injury - Appreciate current thinking on the role of oxygen sensing and hypoxic response in ischemic injuries, such as stroke and myocardial infarction - Gain an understanding of current ideas about the molecular sensing and signaling mechanisms induced by hypoxia - Understand the developmental roles oxygen sensing fulfill in model organisms, and gain insights into how these are relevant to human biology/pathology. A chief objective will be to bring the very disparate groups that work on hypoxia together. There is currently no other meeting where this occurs, and it will allow, we believe, unprecedented opportunities for cross-fertilization and collaboration to occur. A number of controversies on the mechanisms and effects of oxygen exist in the current literature; this meeting will bring the various points of view into the same setting and will allow a consensus on these issues to be built.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, MARCH 25
FRIDAY, MARCH 26
SATURDAY, MARCH 27
SUNDAY, MARCH 28
MONDAY, MARCH 29
TUESDAY, MARCH 30
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, MARCH 25
19:30—21:00
Presentations on Hypoxia: Current State of the Field and Future Directions
Meeting has ended...abstracts no longer viewable online.
M. Celeste Simon,
University of Pennsylvania, USA
Oxygen Sensing in Development and Disease
Oxygen Sensing in Development and Disease
Randall S. Johnson,
University of Cambridge, UK
The Physiology of Hypoxia: The Role of Molecular Adaptation
The Physiology of Hypoxia: The Role of Molecular Adaptation
Amato J. Giaccia,
Stanford University, USA
Molecular Therapeutics Based on the Proteomic/Genomic Response in Hypoxia
Molecular Therapeutics Based on the Proteomic/Genomic Response in Hypoxia
08:00—11:00
Function of Hypoxic Response in Development I: Model Organisms and Mammals
Meeting has ended...abstracts no longer viewable online.
Robert O. Poyton,
University of Colorado, Boulder, USA
Mitochondrial-Nuclear Interaction in O2 Sensing
Mitochondrial-Nuclear Interaction in O2 Sensing
Christopher Bradfield,
University of Wisconsin, USA
Understanding Hypoxia Signalling from a Superfamily Perspective
Understanding Hypoxia Signalling from a Superfamily Perspective
*
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Functional Analysis of the Role of the Oxygen Sensors PHD1, PHD2 and PHD3 Using Gene-Inactivation in Mice And Morpholino-Knockdown in Zebrafish
Functional Analysis of the Role of the Oxygen Sensors PHD1, PHD2 and PHD3 Using Gene-Inactivation in Mice And Morpholino-Knockdown in Zebrafish
16:45—19:15
Function of Hypoxic Response in Development II: Mammalian Systems
Meeting has ended...abstracts no longer viewable online.
*
Max Gassmann,
University of Zürich, Switzerland
Hypoxia-Independent Erythropoietin Gene Expression
Hypoxia-Independent Erythropoietin Gene Expression
Jeffrey M. Arbeit,
Washington University School of Medicine, USA
Persistent Neonatal Quiescent Hypervascularity Produced by Chronic Constitutive HIF-1alpha Signaling in Transgenic Mice
Persistent Neonatal Quiescent Hypervascularity Produced by Chronic Constitutive HIF-1alpha Signaling in Transgenic Mice
Roland H. Wenger,
University of Zürich, Switzerland
HIF-1, PASKIN and the Hypoxic Response in Male Germ Cell Differentiation
HIF-1, PASKIN and the Hypoxic Response in Male Germ Cell Differentiation
Ernestina Schipani,
University of Michigan, USA
Chondrogenesis and Hypoxia
Chondrogenesis and Hypoxia
David C. Beebe,
Washington University, USA
Short Talk: Oxygen Regulates Lens Cell Proliferation and Governs Lens Growth in Adult Rats
Short Talk: Oxygen Regulates Lens Cell Proliferation and Governs Lens Growth in Adult Rats
08:00—11:00
Pulmonary Hypoxia
Meeting has ended...abstracts no longer viewable online.
Stella Kourembanas,
Children's Hospital Boston, Harvard Medical School, USA
Molecular and Cellular Responses of the Lung to Hypoxia
Molecular and Cellular Responses of the Lung to Hypoxia
Larrisa A. Shimoda,
Johns Hopkins School of Medicine, USA
Hypoxia-Induced Alterations in Smooth Muscle Cell Ion Homeostasis
Hypoxia-Induced Alterations in Smooth Muscle Cell Ion Homeostasis
Ivan F. McMurtry,
University of Colorado Health Sciences Center, USA
Role of RhoA/Rho Kinase Signaling in Hypoxic Pulmonary Hypertension
Role of RhoA/Rho Kinase Signaling in Hypoxic Pulmonary Hypertension
*
Stephen L. Archer,
Queen's University, Canada
O2 Sensors in the Ductus Arteriosis and the Pulmonary Artery
O2 Sensors in the Ductus Arteriosis and the Pulmonary Artery
14:00—16:00
Workshop: HIF-1 and Drug Development
*
M. Celeste Simon,
University of Pennsylvania, USA
Alexey V. Bazarov,
University of California, San Francisco, USA
Reaching for Fresh Air: Implication of HIF-1a in Astrocytoma Invasion
Reaching for Fresh Air: Implication of HIF-1a in Astrocytoma Invasion
Navdeep S. Chandel,
Northwestern University, USA
Mitochondrial Electron Transport Chain Regulates HIF-1alpha Protein Stabilization Independent of Respiration
Mitochondrial Electron Transport Chain Regulates HIF-1alpha Protein Stabilization Independent of Respiration
Cormac Taylor,
University College Dublin, Ireland
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1alpha
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1alpha
L. Eric Huang,
University of Utah, USA
A Paradoxial Role for Hypoxia in Cell Growth
A Paradoxial Role for Hypoxia in Cell Growth
Till Acker,
University of Giessen, Germany
Regulation of HIF and HPHD Function in Malignant Brain Tumors
Regulation of HIF and HPHD Function in Malignant Brain Tumors
Koh Nakayama,
Sanford-Burnham Medical Research Institute, USA
Regulation of PHD Abundance by SIAH2 E3 Ligase Modulates the Expresession of HIF1alpha Level in Hypoxia
Regulation of PHD Abundance by SIAH2 E3 Ligase Modulates the Expresession of HIF1alpha Level in Hypoxia
16:45—19:00
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiology
Meeting has ended...abstracts no longer viewable online.
Nanduri R. Prabhakar,
University of Chicago, USA
Plasticity in Hypoxic Sensing at the Carotid Body
Plasticity in Hypoxic Sensing at the Carotid Body
José López-Barneo,
Hospital Universitario Virgen del Rocío, Spain
Regulation of O2 Sensing by Ion Channels
Regulation of O2 Sensing by Ion Channels
Frank J. Giordano,
Yale University, USA
HIF-1alpha in the Heart: The Good, the Bad, the Ugly
HIF-1alpha in the Heart: The Good, the Bad, the Ugly
*
Kenneth Walsh,
Boston University School of Medicine, USA
Growth Signals in the Heart and Vasculature
Growth Signals in the Heart and Vasculature
John W. Severinghaus,
University of California, San Francisco, USA
Consensus Proposal for Hypoxic Ventilatory Response
Consensus Proposal for Hypoxic Ventilatory Response
08:00—11:00
Hypoxia-Induced Cell Death and Drug Discovery
Meeting has ended...abstracts no longer viewable online.
Dietmar W. Siemann,
University of Florida, USA
Vascular Targeting: Induction of Ischemic Cell Death in Cancer Therapy
Vascular Targeting: Induction of Ischemic Cell Death in Cancer Therapy
Martin Brown,
Stanford University, USA
Exploiting Tumor Hypoxia in Cancer Therapy
Exploiting Tumor Hypoxia in Cancer Therapy
Giovanni Melillo,
Immuno-Oncology at AstraZeneca, USA
Targeting HIF-1 for Development of Cancer Therapeutics
Targeting HIF-1 for Development of Cancer Therapeutics
Mark W. Dewhirst,
Duke University Medical Center, USA
Paradoxical HIF-1alpha Signaling during Tumor Reoxygenation: The Role of Free Radicals and Stress Granules
Paradoxical HIF-1alpha Signaling during Tumor Reoxygenation: The Role of Free Radicals and Stress Granules
16:45—19:00
Hypoxia and Tumorigenesis
Meeting has ended...abstracts no longer viewable online.
*
Adrian L. Harris,
University of Oxford, Weatherall Institute of Molecular Medicine, UK
Hypoxia and Tumorigenesis
Hypoxia and Tumorigenesis
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Molecular Pathogenesis of the von Hippel-Lindau Hereditary Cancer Syndrome
Molecular Pathogenesis of the von Hippel-Lindau Hereditary Cancer Syndrome
Volker H. Haase,
Vanderbilt University, USA
Functional Consequences of Conditional Inactivation of Vhl: The Role of Hif
Functional Consequences of Conditional Inactivation of Vhl: The Role of Hif
Peter Vaupel,
University of Mainz, Germany
Tumors: Out of Oxygen, but Still Alive and Kicking
Tumors: Out of Oxygen, but Still Alive and Kicking
Short Talk(s) Chosen from Abstracts
08:00—11:00
Signaling of Hypoxia
Meeting has ended...abstracts no longer viewable online.
Paul T. Schumacker,
Northwestern University, USA
Reactive Oxygen Species and Signaling of Hypoxia
Reactive Oxygen Species and Signaling of Hypoxia
*
Peter J. Ratcliffe,
University of Oxford, UK
The Role of VHL and Protein Hydroxylation in Hypoxia Signaling
The Role of VHL and Protein Hydroxylation in Hypoxia Signaling
Frank S. Lee,
University of Pennsylvania School of Medicine, USA
Short Talk: A P582S Polymorphism of Hypoxia Inducible Factor-1alpha (HIF-1a) Does Not Impair Pro-564 Hydroxylation
Short Talk: A P582S Polymorphism of Hypoxia Inducible Factor-1alpha (HIF-1a) Does Not Impair Pro-564 Hydroxylation
Wayne S. Zundel,
University of Colorado Health Sciences Center, USA
Short Talk: Distinct Aerobic and Hypoxic Mechanisms of HIF-1 Regulation by CSN5
Short Talk: Distinct Aerobic and Hypoxic Mechanisms of HIF-1 Regulation by CSN5
16:45—19:15
Signaling of Hypoxia II
Meeting has ended...abstracts no longer viewable online.
Lorenz Poellinger,
Karolinska Institutet, Sweden
Structure of HIF-1 and Relationship to Hypoxia Signaling
Structure of HIF-1 and Relationship to Hypoxia Signaling
*
H. Franklin Bunn,
Brigham and Women's Hospital, USA
HIF Activation and Oxygen-Dependent Gene Expression in Invertebrates
HIF Activation and Oxygen-Dependent Gene Expression in Invertebrates
Daniel J. Peet,
University of Adelaide, Australia
Normoxic Activation of HIF2 alpha by NEMO
Normoxic Activation of HIF2 alpha by NEMO
Joseph A. Garcia,
University of Texas Southwestern Medical Center, USA
Insights from EPAS1/HIF-2a Null Mice: The Role of HIF-2 in ROS & Mitochondrial Homeostasis
Insights from EPAS1/HIF-2a Null Mice: The Role of HIF-2 in ROS & Mitochondrial Homeostasis
Mark A. Krasnow,
Stanford University School of Medicine, USA
Genetic Dissection of Hypoxia Response Pathways in Drosophila
Genetic Dissection of Hypoxia Response Pathways in Drosophila
*Session Chair †Invited, not yet responded.
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