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This meeting took place in 2004



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T Cell Development (B5)


Organizer(s) Frederick W. Alt, Harvey I. Cantor and James P. Allison
February 10—15, 2004
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 9, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 10, 2003

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Upon completion of this conference, participants should: - Gain an updated on exciting research findings on T cell development including new advances in the elucidation of Transcription factors that regulate Th1/Th2 development; Development and selection of NK T cells; Transcriptional control of CD4/CD8 development; and factors that regulate VDJ recombination at the TCR locus - Gain insight into pivotal problems which include: the developmental relationship of suppression to effector CD4 cells and CD8 cells; Relationship of abnormalities in gene recombination to neoplasia; consensus view on development and TCR expression of CD4, CD8 and NK T cells. In the context of our objective, the goal of the meeting is to help generate new approaches to understanding transcriptional control of T cell development and also to help clarify and further develop our understanding of the relationship between dysregulated T cell development and disease mechanisms.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 10

15:00—19:00
Registration

Van Horne Foyer
18:15—19:15
Refreshments

Van Horne Foyer
19:15—19:30
Orientation

Van Horne A
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Van Horne A
Laurie H. Glimcher, Dana-Farber Cancer Institute, USA
Lineage Commitment in Lymphocytes


WEDNESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:15
Early Stem/Progenitor Development
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Irving L. Weissman, Stanford University, USA
Normal and Leukemic Hemotopoiesis: Are Leukemias a Stem Cell Disorder or a Reacquisition of Stem Cell Characteristics

Katia Georgopoulos, Massachusetts General Hospital, USA
Transcription Factors and Early Commitment

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of Lineage Commitment in Early Lymphophoiesis

Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
From Stem Cells to T Cells

Amy J. Wagers, Harvard University, USA
Short Talk: In vivo Dynamics of Hematopoietic Reconstitution following Transplant of Purified Stem and Progenitor Cells

Xiao-Hong Sun, Oklahoma Medical Research Foundation, USA
Short Talk: Notch-Induced E2A Degradation Contributes to the T versus B Lineage Decision

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:00—16:00
Workshop 1: Early Events in Commitment/Receptor Generation

Van Horne A
* Kristin A. Hogquist, University of Minnesota, USA

* Pierre Ferrier, Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France

Cynthia J. Guidos, University of Toronto and Hospital for Sick Children, Canada
Functions of Lunatic Fringe and Notch Signaling in T Cell Commitment and Development

Christine A. Goetz, University of North Carolina at Chapel Hill, USA
STAT5 Signals Regulate B versus T Cell Lineage Commitment

Thomas Serwold, Joslin Diabetes Center, USA
The beta-Catenin Signaling Pathway is Maximally Active in the Earliest Thymocyte Progenitors and is Detectable in All Later T Cell Populations

Adam G. W. Matthews, Massachusetts Institute of Technology, USA
Ordered DNA Release and Target Capture in RAG Transposition

Megan M. Gleason, CBR Institute for Biomedical Research, USA
Dbeta/Jbeta Recombination Substrates can serve as Markers of Vbeta Accessibility and Vbeta to DJbeta Synapsis

Brian B. Haines, Merck, USA
Deletion of a TCRbeta Variable Gene Promoter Results in Aberrant Vbeta Cleavage, Failure to Shut Down Vbeta Access, and Lymphomagenesis Under Conditions of Allelic Exclusion

Timothy P. Bender, University of Virginia Health System, USA
Tissue Specific Inactivation Identifies Critical Roles for c-myb at Three Points during T Cell Development

Verity Erin Mick, University of Minnesota, USA
Transforming Growth Factor beta Superfamily Signaling During T Lymphocyte Development

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:15
Normal and Abnormal TCR Rearrangement and Repertoire Development
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Barry P. Sleckman, Weill Cornell Medical College, USA
Ordered Assembly of T Cell Receptor beta Chain Genes

Craig H. Bassing, Children's Hospital of Philadelphia, USA
Short Talk: Regulated Assembly of T Cell Receptor Beta Variable Region Exons

Jianzhu Chen, Massachusetts Institute of Technology, USA
Short Talk: The TCRbeta Variable Gene Promoter in Vbeta Recombination, Aberrant DNA Cleavages and Tumorigenesis

Jean-Christophe Bories, Inserm, France
Short Talk: The Ets-1 Transcription Factor is Required for Pre-T Cell Receptor Function and Allelic Exclusion at the TCR Beta Locus

Michael S. Krangel, Duke University Medical Center, USA
Promoter-Directed Recombinase Targeting and the Dynamics of TCRalpha Rearrangement

19:15—20:15
Social Hour

Alberta/New Brunswick
19:30—22:00
Poster Session 1: Early Development: Stem Cell to Thymocyte

Alberta/New Brunswick

THURSDAY, FEBRUARY 12

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Intrathymic T Cell Development
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Harald von Boehmer, Harvard Medical School, USA
Surrogate TCRalpha Chain: Fact or Misconception?

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Role of the LAT Adaptor in T Cell Development and Th1/Th2 Development

Gerald R. Crabtree, Stanford University, USA
Calcineurin/NFAT Signaling in Lymphocyte Development

Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of Runx Transcription Factors in T Cell Development

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Short Talk: A cis Element in the Recombinase Activating Gene Locus Regulates Gene Expression by Counteracting a Distant Silencer

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:00—16:00
Workshop 2: Checkpoint in T Cell Maturation

Van Horne A
* B. J. Fowlkes, NIAID, National Institutes of Health, USA

* Craig H. Bassing, Children's Hospital of Philadelphia, USA

Vernon McNeil Coffield, University of North Carolina at Chapel Hill, USA
Inhibition of Galpha12/13 Signaling Blocks Thymopoiesis at the DN3 Stage of Development

Jennifer O. Manilay, University of California, Merced, USA
The Role of Kuzbanian in Notch Signaling and T Cell Development

Sung-Yun Pai, Dana Farber Cancer Institute, USA
GATA-3 has Multiple Roles in Thymocyte Development

Maria Ciofani, Skirball Institute of Biomolecular Medicine, USA
Requirement for Notch Signaling during TCR beta-Selection

Christine Borowski, Apple Tree Partners, USA
pTalpha and TCRalpha are not Functionally Interchangeable as Partners of TCRbeta during T Cell cevelopment

Ian M. Catlett, University of California, San Diego, USA
Suppressor of Cytokine Signaling 1 Positively Regulates T Cell Receptor Signaling

Tetsuya Yamagata, Tempero Pharmaceuticals, USA
Down-Regulation of the CD8beta Gene by “Self" Peptide is Coupled with the Acquisition of “Innate” Properties by Differentiating Thymocytes

Herbert Kasler, University of California, San Francisco, USA
Short Talk: HDAC7 Regulates Apoptosis in Developing Thymocytes

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:15
Clonal Expansion, Stimuli and Checkpoints
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* James P. Allison, University of Texas MD Anderson Cancer Center, USA
Negative Regulation of T Cell Expansion

Arlene H. Sharpe, Harvard Medical School, USA
Molecular Interaction Underlying Co-Stimulation

Leo Lefrançois, University of Connecticut Health Center, USA
Regulation of T Cell Development and Homeostasis by IL-15

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Cytokine Dependent Regulation of T Cell Suppression

19:15—20:15
Social Hour

Alberta/New Brunswick
19:30—22:00
Poster Session 2: T Cell Subset Development and Function 1

Alberta/New Brunswick

FRIDAY, FEBRUARY 13

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Thymic and Post-Thymic Differentiation of Effector and Memory T Cells
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
Development, Specificity and Function of NKT Cells

Pamela J. Fink, University of Washington, USA
Continued Maturation of Thymic Emigrants in the Lymphoid Periphery

Rose Zamoyska, University of Edinburgh, UK
Receptor Signals that Maintain Naïve and Memory Peripheral T Cells

Susan M. Kaech, Yale University School of Medicine, USA
Short Talk: Selective Expression of IL-7 Receptor Identifies Effector CD8 T Cells that Give Rise to Long Lived Memory Cells

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
CD8alphaalpha has an Unexpected Role in Natural and Aquired Memory of CD8 T Cells

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:00—16:00
Workshop 3: T Cell Lineage Commitment

Van Horne A
* Kim Bottomly, Yale University School of Medicine, USA

Jose Alberola-Ila, California Institute of Technology, USA
GATA-3 Expression is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

Rafal Pacholczyk, Georgia Regents University, USA
The Kinetics of TCR and MHC/Peptide Ligand Interaction is a Crucial Determinant of Thymocyte Lineage Commitment in Addition to the Specificity of the alphabeta TCR

Rémy Bosselut, National Cancer Institute, National Institutes of Health, USA
Analyzing CD4/CD8 Lineage Differentiation in vivo by Stage-Specific Disruption of Intrathymic TCR Signaling

Marc Ehlers, Rockefeller University, USA
Runx3/AML2 Regulates CD4 and Additional Gene Expression during CD4/CD8 Lineage Commitment

Batu Erman, National Institutes of Health, USA
The Cytoplasmic Tails of the CD4 and CD8 Co-Receptors Determine the CD4:CD8 Ratio

Takashi Usui, Kyoto University, Japan
GATA-3 Suppresses Th1 Development by Down-Regulation of Stat4, Not Through Effects on IL-12R Beta2 Chain or T-bet

Osamu Kaminuma, Tokyo Metropolitan Institute of Medical Science, Japan
GATA-3 Suppresses IFN-gamma Gene Transcription Independently of Binding to the cis-Regulatory Elements

Tatyana Chtanova, University of California, Berkeley, USA
T Follicular Helper Cells Distinguished from Th1 and Th2 Subsets by their Expression of Certain Cytokines, Cell Surface Molecules and the Transcription Factor BCL-6

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:15
Development of Th1/ Th2 Cells
Meeting has ended...abstracts no longer viewable online.

Van Horne A
Anne O'Garra, Francis Crick Institute, UK
IL-10 and TH1/TH2 Development

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Activation of Cytokine Expression in Naïve Helper T Cells

Steven L. Reiner, Columbia University, USA
Transcriptional Control of Effector T Cell Fate

* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
BTLA, an Inhibitory Receptor in Lymphocytes with Similarities to CTLA-4 and PD-1

19:15—20:15
Social Hour

Alberta/New Brunswick
19:30—22:00
Poster Session 3: T Cell Subset Development and Function 2

Alberta/New Brunswick

SATURDAY, FEBRUARY 14

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Regulatory T Cells: Development and Function
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Harvey Cantor, Dana Farber Cancer Institute, USA
Deletional and Suppressive Mechanisms that Maintain Self-Tolerance

Hong Jiang, Columbia University, USA
Short Talk: Regulatory CD8+ T Cells Function to Maintain Peripheral Self-Tolerance and Facilitate Affinity Maturation of T Cells to Foreign Antigens

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Mechanisms of Development and Function of Regulatory CD4 T Cells

Juan J. Lafaille, New York University School of Medicine, USA
Regulatory T Cells in Autoimmunity and Allergy

09:20—09:40
Coffee Break

Van Horne Foyer
14:00—16:00
Workshop 4: Regulatory Defects and Disease

Van Horne A
* Nora E. Sarvetnick, University of Nebraska Medical Center, USA

* C. Garrison Fathman, Stanford University, USA

Roland Grenningloh, Merck Serono, Germany
Ets-1: A Key Factor for the Development of Th1 Effector Functions

Emily S. Venanzi, Joslin Diabetes Center, USA
Aire Influences Negative Selection and the Development of Autoimmunity

Maureen McGargill, St Jude Children's Research Hospital, USA
Drak2, a Negative Regulator of Lymphocyte Signaling

Noriyuki Kuroda, Institute for Enzyme Research, University of Tokushima, Japan
A Novel Enzymatic Function of AIRE

Matthew A. Burchill, University of Minnesota, USA
STAT5 Activation Governs the IL-2-Dependant Development of CD4+CD25+ regulatory T cells

Jianwei Li, Memorial Sloan-Kettering Cancer Center, USA
The Analysis of Low-Affinity T Cells Specific for MBP Peptide in the Development of EAE

Emma E. Hamilton-Williams, University of Queensland, Australia
Toll-Like Receptor Ligands Lower the Precursor Frequency of Autoreactive CD8 T Cells Required for Autoimmunity, but do Not Break Cross-Tolerance

Renu G. Jain, Grifols S.A., USA
IL-10 Nullifies CTLA-4 Inhibitory Function to Sustain Activation of Islet-Resident Diabetogenic CD4 T Cells and Development of Diabetes

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:15
Dysregulated T Cell Development: Autoimmunity and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Diane Mathis, Harvard Medical School, USA
Aire

C. Garrison Fathman, Stanford University, USA
Short Talk: GRAIL, an E3 Ubiquitin Ligase, is Necessary for Anergy Induction in CD4+ T Cells

A. Thomas Look, Dana-Farber Cancer Institute, USA
The Emerging Genetics of T-Cell Acute Lymphoblastic Leukemia: A Fish Tale

André Nussenzweig, NCI, National Institutes of Health, USA
Checkpoint and Repair Pathways Monitoring Normal and Abnormal TCR Rearrangements

Frederick W. Alt, Boston Children's Hospital, USA
Linking Histones to Cancer

20:00—21:00
Social Hour

Cascade/Conservatory
21:00—00:00
Entertainment

Cascade/Conservatory

SUNDAY, FEBRUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI058531-01




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