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This meeting took place in 2004



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Molecular Mechanisms of HIV Pathogenesis (X7)


Organizer(s) Beatrice H. Hahn, Wesley I. Sundquist, Michael H. Malim and Didier Trono
April 12—18, 2004
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Dec 11, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 12, 2004

Supported by Keystone Symposia


Summary of Meeting:
To replicate and cause disease, HIV-1 must overcome cellular and humoral immune responses, defeat innate cellular defense systems, usurp cellular factors, and reprogram the normal biology of the cell. Historically, detailed genetic analyses of viral functions and evolution have identified key viral determinants for the successful completion of each stage in the replication cycle. More recently, studies of innate antiviral and immune responses, host genetics, cell biology, and neuropathogenesis have identified host factors that HIV-1 must overcome in order to replicate. The field is now poised to combine these studies to define the molecular mechanisms that underlie important host/virus interactions, and our meeting therefore focuses on emerging concepts in the molecular mechanisms of HIV pathogenesis. Significant recent advances in this area include: the definition of a variety of envelope/receptor interactions, the development of tools for depleting cellular proteins and visualizing viral trafficking in real time, the discovery of cellular factors and genetic elements that restrict viral replication, an increased understanding of the activities of pathogenesis factors such as nef, the identification of host factors required for viral replication, assembly and budding, the development of non-pathogenic primate lentiviral models, and an increased understanding of the origins and evolution of HIV and primate lentiviruses in general. This recent progress opens the way to answering new questions: - How does the virus penetrate its target cells, once the envelope binds its receptors and undergoes an increasingly well characterized number of structural modifications? - What is the site and mechanism of uncoating, the step through which the inner components of viral cores lose their external layer, the capsid, and organize into an enzymatically active nucleoprotein complex? - How does the virus escape what increasingly appears to be a formidable attempt of the cell to repel this genetic invader? - How does the viral genome find its way to regions of the chromosome in which it is almost always successfully expressed? - How does the combination of host and viral factors modulate viral transcription and cell division, seemingly adapting it to the extracellular environment, and in some rare but critical cells resulting in latent, reactivatable gene expression? - How does the virus hijack intracellular machineries to organize the formation of new particles and promote their release from the infected cell? - What cells host the long-term reservoir of HIV that seems to preclude viral eradication in patients treated with highly active chemotherapy? - How do these cells avoid elimination by the immune system? - Why are naturally occurring SIV infections not causing disease in their natural hosts? - How can we best utilize these SIVs as tools to probe the pathogenic mechanisms of HIV? By bringing together a group of international leaders in HIV/AIDS research, new and exciting information in all of these areas will be presented, new paradigms will be established, and, perhaps, new approaches for anti-HIV therapeutics will be identified.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, APRIL 12

15:00—19:00
Registration

Grand Foyer
18:15—19:15
Refreshments

Grand Foyer
19:15—19:30
Orientation

Ballroom B, C
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom B, C
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA

Gary J. Nabel, Sanofi, USA
The Critical Path to an Effective AIDS Vaccine

Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV-1 Release


TUESDAY, APRIL 13

06:30—08:00
Breakfast

Lower Level
08:00—11:00
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom B, C
* Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Innate Intracellular Immunity to HIV-1 in Old World Monkeys

David C. Montefiori, Duke University Medical Center, USA
Neutralizing Antibodies Induced by Candidate HIV-1 Vaccines

Alexandra Trkola, University of Zürich, Switzerland
Antibodies: Surrogate or Supporter of Protective Immunity?

Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
The V3 Loop: Always Changing, Always the Same

Gregory B. Melikian, Emory University, USA
Short Talk: Dissecting the Steps of HIV ENV-Induced Fusion: Coreceptor Engagement, Fusion Pore Formation, and Pore Enlargement

James Mark Binley, San Diego Biomedical Research Institute, USA
Short Talk: Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-HIV Monoclonal Antibodies and a Clade B HIV+ Plasma

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Ballroom A, Grand Foyer
13:00—22:00
Poster Viewing

Ballroom A, Grand Foyer
14:00—16:00
Workshop 1: HIV Accessory Protein and Assembly
Attendance Limited to 125

Garibaldi A/B
* Wesley I. Sundquist, University of Utah School of Medicine, USA
Following the RNA


SIRT1 Deacetylates the HIV Tat Protein and is Required for Tat-Mediated Transactivation of the HIV Promoter

Roger J. Pomerantz, Seres Therapeutics, Inc., USA
A Dead Box Protein is as a Critical Cellular Co-Factor of HIV-1 REV: Effects on Viral Persistence and Reservoirs in Different Cell-Types

Chad M. Swanson, King's College London, UK
A Link between Viral Assembly and Nuclear Export

Andrew J. Mouland, McGill University, Lady Davis Institute, Canada
The Specific Association of hnRNP A2 to its Cognate Response Sequence in HIV-1 RNA Implications in Viral Assembly

Heinrich Göttlinger, Dana Farber Cancer Institute, USA
Roles of AIP1 and ESCRT-III in HIV Budding

Marc C. Johnson, Cornell University, USA
Visual Comparison of Retroviral Late-Domain Phenotypes

Rebecca J. Loomis, University of North Carolina at Chapel Hill, USA
Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Release

Vicente Planelles, University of Utah, USA
The Mechanisms of HIV-1 VPR-Mediated G2 Arrest and Apoptosis: Role of the Host Cell DNA Damage Signaling Pathway

14:00—16:15
Workshop 1: HIV Envelope Structure and Neutralization

Ballroom B, C
* Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA

Barna Dey, NIAID, National Institutes of Health, USA
Characterization of Mutant HIV-1 Envelope Glycoproteins Stabilized in the CD4-Bound Conformation

Kathy P. Fernando, University of Pennsylvania, USA
HIV Env Lacking CD4 Binding as a Vaccine Approach

Marie Pancera, Fred Hutchinson Cancer Research Center, USA
Characterization of Stabilized Trimeric HIV-1 gp120 Envelope Glycoprotein

Suganya Selvarajah, The Scripps Research Institute, USA
Modified gp140 Trimers to Elicit b12-Like Antibodies

Chinglai Yang, Emory University, USA
Characterization of an HA/Gp41 Chimeric Protein: Enhanced Interaction with the Broadly Neutralizing Monoclonal Antibody 2F5 against HIV

Jason E. Hammonds, Emory University, USA
Induction of Antibody Responses to CD4-Induced Epitopes by Induced Pseudovirions and Recombinant Protein Immunogens

Jonathan M. Gershoni, Tel Aviv University, Israel
Backtracking from mAb to Epitope - A Combinatorial Approach

Carolina Herrera, Imperial College, UK
Consequences of HIV-1 Env Cleavage on Antigenicity, Infectivity, and Neutralization

Gerald V. Quinnan, Jr., Uniformed Services University Health Sciences, USA
Protection Against Rhesus Monkey Adapted-SHIV Challenge by Active Induction of HIV-1 Neutralizing Antibodies or SIV gag-Specific Cytotoxic T Cells

16:30—16:45
Coffee & Snacks Available

Grand Foyer
16:45—19:00
Natural SIV Infection: Lessons from the Monkey (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom B, C
* Paul M. Sharp, University of Edinburgh, UK
Evolution from SIV to HIV

Beatrice H. Hahn, University of Pennsylvania, USA
Molecular Epidemiology of Simian Immunodeficiency Virus Infection in Wild Chimpanzees

Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships Underlying Non-Pathogenic SIV Infections

Greg J. Towers, University College London, UK
Short Talk: Species-Specific Infection of Lentiviruses

Nathaniel R. Landau, New York University School of Medicine, USA
Short Talk: Mechanism of APOBEC3G Deamination of HIV Reverse Transcripts

19:00—20:00
Social Hour

Ballroom A, Grand Foyer
19:30—22:00
Poster Session 1

Ballroom A, Grand Foyer

WEDNESDAY, APRIL 14

06:30—08:00
Breakfast

Lower Level
08:00—11:00
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Meeting has ended...abstracts no longer viewable online.

Ballroom C
* Tristram G. Parslow, Emory University, USA
The HIV-1 Genomic Dimer Interface as a Target for Structure-Based Drug Design

Kathleen A. Boris-Lawrie, Ohio State University, USA
The Destiny of Retroviral Unspliced RNA: Ribosome or Virion?

Casey D. Morrow, University of Alabama at Birmingham, USA
Selection of the tRNA Primer required for HIV Replication

Chantal Ehresmann, IBMC du Centre National de la Recherche Scientifique, France
The 5' -Untranslated Region of HIV-1 Genomic RNA: Structure and Functional Implications

James R. Williamson, The Scripps Research Institute, USA
Toward Inhibition of HIV Rev-RRE Interactions: Challenges for Targeting RNA

08:00—09:30
Current Issues in the Clinical Evaluation of Vaccines
Meeting has ended...abstracts no longer viewable online.

Ballroom B
John W. Shiver, Sanofi Pasteur, USA
Development of an HIV-1 Vaccine Based on Replication-Defective Adenovirus

* Barney S. Graham, NIAID, National Institutes of Health, USA
Update of Trials of Multi-Clade DNA and Recombinant Adenovirus Vaccines

Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
Update of HVTN Clinical Trials

09:20—09:40
Coffee Break

Grand Foyer
09:50—11:30
Roundtable Discussion: Immunogenicity Criteria for Advancing Candidate Vaccines into Phase III Trials

Ballroom B
* Gary J. Nabel, Sanofi, USA

Dennis R. Burton, The Scripps Research Institute, USA
Criteria for Neutralizing Antibody Responses

Hana Golding, US Food and Drug Administration, USA
Regulatory Perspective

Emilio A. Emini, Bill and Melinda Gates Foundation, USA
Manufacturer's Perspective

John G. McNeil, Sanofi-Pasteur, USA
Clinical Perspective

Steve G. Self, Fred Hutchinson Cancer Research Center, USA
Statistical Perspective

Andrew J. McMichael, Oxford University, UK
Criteria for T Cell Responses

John P. Moore, Weill Medical College of Cornell University, USA
Criteria for Neutralizing Antibody Responses

11:00—13:00
Poster Setup

Ballroom A, Grand Foyer
13:00—22:00
Poster Viewing

Ballroom A, Grand Foyer
14:00—16:00
Workshop 2: The Viral Synapse

Ballroom C
* Michael H. Malim, King's College London, UK

Vincent Piguet, Cardiff University, UK
DC-SIGN-Mediated Infectious Synapse Formation Enhances Transfer of HIV Infection from Dendritic Cells to T Cells

Clare Jolly, University College London, UK
HIV-1 Exploits an Env-Induced Synapse in CD4+ T Cells

Philippe Gallay, The Scripps Research Institute, USA
A Highly Conserved Arginine in the V3 Loop of Gp120 Governs HIV-1 Binding to Coreceptors and Syndecans

Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Mechanisms of DC-Sign Mediated Function in HIV-1 Infection

Rahm Gummuluru, Boston University School of Medicine, USA
Mechanism of DC-SIGN Mediated HIV-1 Transmission

David McDonald, National Institute of Allergy and Infectious Disease, USA
Enhancement of HIV Infection by Activated Dendritic Cells Occurs via Trafficking through a CD81 Enriched Compartment

Ann-Marie M. Roy, University of California, San Francisco, USA
Impact of Coreceptor Use on HIV-1 Viral Output per Infected Cell

John Wilkinson, Westmead Millennium Institute, Australia
Increased HIV-1 Uptake in Immature Dendritic Cells and Increased Viral Transfer to CD4+ T Cells as a Result of Inhibition of the Endosomal - Lysosomal Degradation Pathway

14:00—16:00
Workshop 2: Immunobiology of HIV Infection

Ballroom B
* Luis J. Montaner, Wistar Institute, USA

David Favre, GlaxoSmithKline, USA
Generation of Dysfunctional CD8+ T Cells in the Setting of HIV Infection

Daniel E. Kaufmann, University of Montreal, Canada
Promiscuous Presentation of the Same Epitopes by Different HLA Class II Alleles and Clustering of Overlapping Epitopes both Contribute to the High Frequency of Recognition by CD4 Cells of a Limited Subset of Gag and Nef HIV-1 Peptides

Christian Brander, Institut de Recerca de la Sida, IrsiCaixa, Spain
HLA-B63 (B*1516/B*1517) Presents HLA-B57 Restricted CTL Epitopes and is Associated with Slow HIV Disease Progression

Marie-Claire E. Gauduin, Texas Biomedical Research Institute, USA
Depletion of CD8+ Lymphocytes Results in Rebound Viremia in SIV-Infected Macaques with Undetectable Viral Replication following Early Antiretroviral Therapy

David A. Garber, Emory University, USA
Enhancing the Immunogenicity of MVA-based AIDS Vaccines

Shan Lu, University of Massachusetts Medical Center, USA
Immunogenicity of Monovalent and Polyvalent DNA Prime/Protein Boost Formulations Encoding Primary HIV-1 Env Antigens as Tested in Rabbits and Non-Human Primate Models

16:30—16:45
Coffee & Snacks Available

Grand Foyer
16:45—19:15
Immediate Early Steps in Viral Entry and Uncoating
Meeting has ended...abstracts no longer viewable online.

Ballroom C
* John P. Moore, Weill Medical College of Cornell University, USA
Effect of a Small Molecule CCR5 Inhibitor on Virus Infection in the Rhesus Macaque

John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Cellular Factor Requirement in HIV-1 Uncoating Revealed by a Cell-Free System

Christopher Aiken, Vanderbilt University School of Medicine, USA
Capsid Disassembly and HIV-1 Infection

Thomas J. Hope, Northwestern University, USA
HIV Entry and Early Events (Cytoplasmic Trafficking)

Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Cell and Molecular Requirements for DC-SIGN-Mediated HIV Transmission

16:45—19:00
Advances in Immunobiology
Meeting has ended...abstracts no longer viewable online.

Ballroom B
Arlene H. Sharpe, Harvard Medical School, USA
Current Understanding of Immune Co-Stimulation

* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Induction and Maintenance of Serological Memory

Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Induction of TCD8+ Responses by Viruses

Eli Gilboa, University of Miami, Miller School of Medicine, USA
Therapeutic Vaccination with mRNA Transfected Dendritic Cells for Cancer and Infectious Diseases

19:00—20:00
Social Hour

Ballroom A, Grand Foyer
19:30—22:00
Poster Session 2

Ballroom A, Grand Foyer

THURSDAY, APRIL 15

06:30—08:00
Breakfast

Lower Level
08:00—11:30
Innate Intracellular Antiviral Responses (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom B, C
Michael H. Malim, King's College London, UK
VIF and the Evasion of Host-Mediated Viral cDNA Deamination

Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
HIV Vif versus the Antiviral APOBEC3G Enzyme: New Insights into the Mechanism of Vif Action

Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Intracellular defenses Against Retroelements

* Stephen P. Goff, Columbia University, USA
Cellular Blocks to HIV and MuLV Infection

Jonathan P. Stoye, Francis Crick Institute, UK
Fv1 and Related Retrovirus Restriction Genes

Jaisri R. Lingappa, University of Washington, USA
HP68/RNase L Inhibitor: A Host Factor Critical for Virion Assembly

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Ballroom A, Grand Foyer
13:00—22:00
Poster Viewing

Ballroom A, Grand Foyer
14:00—16:00
Workshop 3: Neuro AIDS and Latency
Attendance Limited to 125

Garibaldi A/B
* Janice E. Clements, Johns Hopkins University, USA

Paul R. Gorry, RMIT University, Australia
Longitudinal Analysis of nef/LTR-Deleted HIV-1 in Blood and CSF of a Long-Term Survivor who Developed HIV-Associated Dementia

Evelyne E. Schaeffer, Centre de Neurochimie, France
Role of the Envelope in HIV-1 Induced Direct Neuronal Cell Damage

Paul R. Clapham, University of Massachusetts Medical School, USA
Biological Analysis of HIV-1 R5 Envelopes Amplified by PCR from Brain and Lymph Node Tissue of AIDS Patients with Neuropathology

Justyna M. Dudaronek, Johns Hopkins School of Medicine, USA
Regulation of Viral Gene Expression in the CNS by Innate Immune Responses during Acute SIV Infection

Michael R. Nonnemacher, Drexel University College of Medicine, USA
An Enhanced Preference for a High Affinity Interaction between HIV-1 Vpr and Sequences within C/EBP Site I Correlates with HIV-1 Associated Dementia

Yefei Han, Johns Hopkins School of Medicine, USA
Latent HIV-1 Genomes Reside in Actively Transcribed Genes in Resting CD4+ T Cells in vivo

Samuel Ambler Williams, Gladstone Institute, USA
NF-kappaB/Rel Transcription Factors and the Regulation of HIV Postintegration Latency

Leor S. Weinberger, University of California, San Francisco, USA
Stochastic Switching in HIV-1 Tat Transactivation as a Possible Mechanism Leading to HIV-1 Proviral Latency

14:00—16:00
Workshop 3: Mechanisms of Antibody-Mediated Neutralization and Escape

Ballroom B, C
* John R. Mascola, NIAID, National Institutes of Health, USA

Ruth A. McCaffrey, Seattle Biomedical Research Institute, USA
The Immunologically ‘Silent’ Face of gp120 Protects HIV-1 SF162 from Neutralization by Anti-gp120 and Anti-gp41 Antibodies

Carol D. Weiss, US Food and Drug Administration, USA
Escaping Fusion Inhibition: Elusive Tactics of the HIV Envelope Glycoprotein

Robert G. Whalen, Altravax, Inc., USA
Creating Improved Viral Immunogens by Directed Molecular Evolution

Kelly A. Stefano Cole, University of Pittsburgh School of Medicine, USA
Characterization of Antibody Binding Properties Associated with Neutralization of SIV

Ralph A. Pantophlet, Simon Fraser University, Canada
Immunofocusing: Re-Engineering Monomeric gp120 to Promote the Induction of HIV-Neutralizing Antibodies

Cheryl A. Pikora, New England Regional Primate Research Center, USA
Persistence of Neutralization Resistance Despite Removal of gp120, Core, N-linked Glycosylation Sites in SIV239

Miroslaw K. Gorny, New York University School of Medicine, USA
Identification of a New Neutralizing Epitope in gp120

16:30—16:45
Coffee & Snacks Available

Grand Foyer
16:45—19:00
HIV Genetic Variation (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom B, C
Francine McCutchan, PATH, USA
Screening for HIV-1 Dual Infection in Populations Exposed to Multiple Subtypes

* Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Neutralization Antibody Signature Patterns in HIV Sequences

Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Stereotypic Escape from CD8T Cell Responses as a Major Driving Force of HIV-1 Sequence Evolution

Dean H. Hamer, National Institutes of Health, USA
Short Talk: HIV-Specific CD4 T Cells are a Hot Spot for Viral Evolution

19:00—20:00
Social Hour

Ballroom A, Grand Foyer
19:30—22:00
Poster Session 3

Ballroom A, Grand Foyer

FRIDAY, APRIL 16

06:30—08:00
Breakfast

Lower Level
08:00—11:00
Nef Function
Meeting has ended...abstracts no longer viewable online.

Ballroom C
John C. Guatelli, University of California, San Diego, USA
Nef, Intracellular Protein Trafficking, and Viral Infectivity

* Kathleen L. Collins, University of Michigan Medical Center, USA
Nef-Mediated MHC-1 Downmodulation in T Cells

Kalle Saksela, University of Helsinki, Finland
Cellular Activation by HIV-1 Accessory Proteins

Andreas Stephan Baur, , Germany
Nef Signaling in T Cells and HIV Replication: New Insights into the Molecular Mechanism

Olivier Schwartz, Institut Pasteur, France
Role of HIV-1 Nef during Viral Replication in Primary Cells

08:00—11:20
Novel Approaches to HIV Vaccination
Meeting has ended...abstracts no longer viewable online.

Ballroom B
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Whole Inactivated AIDS Virus Virions with Functional Envelope Glycoproteins

Richard W. Compans, Emory University, Rollins Research Center, USA
Virus-like Particles as HIV Immunogens

* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
A Multi-Clade Envelope-Based Vaccine Strategy for HIV

Stephen A. Udem, Wyeth Pharmaceuticals, USA
VSV as an HIV Vaccine Vector

Hildegund C.J. Ertl, Wistar Institute, USA
Simian-Derived E1-Deleted Adenovirus Vectors for HIV Vaccination

Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Short Talk: Low Seroprevalence of Adenovirus Serotype 35 and Immunogenicity of rAd35-Gag Vaccine in Mice with Pre-Existing Anti-Ad5 Immunity

Adam C. Soloff, University of Pittsburgh, USA
Short Talk: Dual Adenoviral-Based Vaccination Using Serotypes 5 and 35 Induces Broad T Cell Responses to SIV which are Recalled with Heterologous Challenge

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Ballroom A, Grand Foyer
13:00—22:00
Poster Viewing

Ballroom A, Grand Foyer
14:00—16:15
Workshop 4: HIV Entry, Early Events

Ballroom C
* Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Sophie Holuigue, Windeyer Institute of Medical Sciences, University College London, UK
Antibodies Capable of Inactivating HIV-1 Arise Coincidentally with the Initial Decline in Viral Load during acute Infection

Severine Bär, Deutsches Krebsforschungszentrum, germany
Dissecting Steps of gp41-Mediated Membrane Fusion by Quantitative Assays Based on Flow Cytometry: Involvement of the Loop Region in Post Lipid Mixing Events

Ariberto Fassati, University College London, UK
Importin 7 Mediates Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes

Eric Poeschla, University of Colorado School of Medicine, USA
LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but not Oncoretroviral Integrase Proteins and is a Component of Functional HIV-1 Pre-Integration Complexes

Robert J. Gorelick, National Cancer Institute at Frederick, USA
Involvement of the HIV-1 Nucleocapsid Protein in the Synthesis and Integration of the Viral DNA during Infection

Malini Mansharamani, Johns Hopkins School of Medicine, USA
Barrier-to-Autointegration Factor (BAF) Binds HIV-1 Gag and MA Proteins

Kelly M. Champagne, Thomas Jefferson University, USA
The Structure and Folding of a Designed HIV-1 Entry Inhibitor

Hugues J.P. Ryser, Boston University School of Medicine, USA
PDI-Mediated Reduction of Disulfide Bonds in Envelope Glycoprotein gp120 is Required for HIV-1 Entry

Alexa Raney, University of Texas Southwestern Medical Center, USA
In vitro Reconstitution of an Active Pak2/Nef Complex

14:00—16:00
Workshop 4: HIV-Immune Evasion

Ballroom B
Marcus Altfeld, Heinrich-Pette-Institute, Germany
Selection, Transmission, and Reversion of an Antigen Processing CTL Escape Mutation in HIV-1

Annika C. Karlsson, Karolinska Institutet, Sweden
Cellular Immune Responses and Viral Escape in HLA-A2-Positive Patients Following Primary HIV-1 Infection

Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
An HLA B57-Specific Mutation Outside an Immunodominant Epitope Alters Antigen Processing and Leads to CTL Escape

Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
CD8 T Cell Responses and Viral Escape in HIV-Infected Monozygotic Twins Infected with the Same Virus

Astrid K.N. Iversen, Weatherall Institute of Molecular Medicine, UK
Functional and Structural Basis for HIV Escape from T Cell Recognition

Wendy M. Blay, Seattle Biomedical Research Institute, USA
Potential N-Linked Glycosylation Sites Undergo Predictable Patterns of Variation within Constrained Regions of HIV-1 Envelope

16:30—16:45
Coffee & Snacks Available

Grand Foyer
16:45—19:00
NeuroAIDS
Meeting has ended...abstracts no longer viewable online.

Ballroom C
* Dana H. Gabuzda, Dana Farber Cancer Institute, USA
Mechanisms of Neuropathogenesis

Francisco González-Scarano, University of Texas Health Science Center at San Antonio, USA
Determinants of Microglial/Macrophage Tropism and Replication

Karl-Heinz Krause, University of Geneva Faculty of Medicine, Switzerland
HIV, CCR5, and Neurodegeneration

Andrew A. Lackner, Tulane National Primate Research Center, USA
Early Events in the Neuropathogenesis of AIDS

16:45—19:00
Therapeutic Vaccination of HIV-Infected Individuals
Meeting has ended...abstracts no longer viewable online.

Ballroom B
Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Therapeutic Immunization against HIV

Richard A. Koup, NIAID, National Institutes of Health, USA
Therapeutic Vaccines: Hypothesis Testing in vivo

* Nina Bhardwaj, Icahn School of Medicine at Mt Sinai, USA
Stimulating Cellular Immunity with Dendritic Cell Based Vaccines

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immunology and virology of controlled HIV infection

19:00—20:00
Social Hour

Ballroom A, Grand Foyer
19:30—22:00
Poster Session 4

Ballroom A, Grand Foyer

SATURDAY, APRIL 17

06:30—08:00
Breakfast

Lower Level
08:00—11:00
HIV-1 in the Nucleus
Meeting has ended...abstracts no longer viewable online.

Ballroom C
Frederic D. Bushman, University of Pennsylvania, USA
DNA Integration by Retroviruses in the Human Genome

* Michael Emerman, Fred Hutchinson Cancer Research Center, USA
HIV Infection of Non-Dividing Cells

Katherine A. Jones, The Salk Institute, USA
The c-Ski-Interacting Protein (SKIP) Facilitates Transcription Elongation by HIV-1 Tat

Barbara K. Felber, NCI, National Institutes of Health, USA
HIV Posttranscriptional Regulation and Viral Latency

Eric M. Verdin, Buck Institute For Research On Aging, USA
Molecular Mechanisms of HIV Latency

08:00—11:00
Lessons for HIV Vaccine Development from other Vaccines
Meeting has ended...abstracts no longer viewable online.

Ballroom B
William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Novel Strategies for Vaccine Protection Against M. tuberculosis

* Kanta Subbarao, NIAID, National Institutes of Health, USA
Preventing Pandemics and Newly Emerging Respiratory Viral Threats through Vaccine Development

Kathrin U. Jansen, Pfizer, USA
Status of Prophylatic Vaccines Against Cervical Cancer

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Novel Vaccine Strategies for the Treatment of Cancer

Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Immunotherapy of Cancer: Lessons Learned from Melanoma

09:20—09:40
Coffee Break

Grand Foyer
16:30—16:45
Coffee & Snacks Available

Grand Foyer
16:45—19:15
HIV-1 and Protein Trafficking in the Cytoplasm
Meeting has ended...abstracts no longer viewable online.

Ballroom C
* Beatrice H. Hahn, University of Pennsylvania, USA

Mark Marsh, University College London, UK
HIV Assembly in the Endocytic Pathway

Markus Thali, University of Vermont, USA
HIV-1 Egress is Gated Through Late Endosomal Membranes

Ganjam V. Kalpana, Albert Einstein College of Medicine, USA
A Novel INI1/hSNF5 Associated HDAC1 Complex is Specifically Incorporated into HIV-1 Virions and is Required for Viral Early Events

Benjamin K. Chen, Mount Sinai School of Medicine, USA
Chimeric Virus Models to Understand HIV-1 Assembly

Paul D. Bieniasz, Rockefeller University, USA
GAG Localization and Interaction with Host Factors during Retrovirus Assembly and Budding

16:45—19:00
Mechanisms of HIV Immune Evasion
Meeting has ended...abstracts no longer viewable online.

Ballroom B
* George M. Shaw, University of Pennsylvania, USA
Immune Control and Escape by HIV-1: Neutralizing Antibodies

Persephone Borrow, University of Oxford, UK
Escape of HIV-1 from the Primary CTL Response

David I. Watkins, University of Miami, USA
SIV Escape from CTL

Philip J. Goulder, University of Oxford, UK
HIV Evolution: CTL Escape Mutation and Reversion following Transmission

20:00—21:00
Social Hour

Ballroom A
21:00—00:00
Entertainment

Ballroom A

SUNDAY, APRIL 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI058790-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Office of AIDS Research, NIH

Bentham Science Publishers Ltd.

Boehringer Ingelheim (Canada) Ltd.


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