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This meeting took place in 2004



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siRNAs and miRNAs (E1)


Organizer(s) Thomas Tuschl and Victor Ambros
April 14—19, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Dec 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 17, 2004

Sponsored by Alnylam Pharmaceuticals, Inc. and Merck Research Laboratories

Summary of Meeting:
Short double-stranded RNA molecules are important sequence-specific posttranscriptional regulators of gene expression. Two classes of such RNA molecules have been identified: small interfering RNAs (siRNAs) and microRNAs (miRNAs). While siRNAs are generally complementary to mRNAs and mediate mRNA degradation, most miRNAs are only partially complementary and are believed to act predominantly as translational regulators. siRNAs and microRNA-like siRNA precursors have become important tools for studying gene function in mammalian cells and organisms. miRNAs represent an extensive class of evolutionary conserved noncoding RNAs of about 22 nucleotide in length that are thought to regulate gene expression in metazoans. The first miRNAs to be identified were the products of the lin-4 and let-7 genes of Caenorhabditis elegans. The miRNA and RNAi pathways are fundamentally related as members of the Dicer and the Argonaute protein families are involved in both of these RNA-mediated silencing processes. The aim of this meeting is to report on progress in understanding the molecular mechanisms underlying siRNA/miRNA function, as well as the technological adaptation of these cellular mechanisms to genome-wide analysis of gene function in mammalian systems and as therapeutic agents.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 14

15:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—19:30
Orientation

Grays/Longs
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* David C. Baulcombe, University of Cambridge, UK

Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
RNAi as the Immune System of the C. elegans Genome

Andrew Fire, Stanford University, USA
RNA-Based Immunity


THURSDAY, APRIL 15

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
RNomics of miRNAs and Other Non-Coding RNAs. Session Sponsored in part by ISIS Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Brenda L. Bass, University of Utah, USA

Alexander Hüttenhofer, Universität Innsbruck, Austria
Experimental RNomics: Identification of Small Non-Messenger RNAs in Model Organisms

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNAs in Animals and Plants

Mark A. Kay, Stanford University, USA
RNAi Therapeutics in Animal Models of Human Hepatitis Infection

Oliver Hobert, Columbia University, USA
Short Talk: Two Asymmetrically Distributed and Sequentially Acting microRNAs Control Chemosensory Laterality in C.elegans

James C. Carrington, Donald Danforth Plant Science Center, USA
Small RNAs, Development and Viruses in Plants

André Verdel, Harvard Medical School, USA
Short Talk: RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
miRNAs in Development and Disease, microRNA Targets
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* David P. Bartel, HHMI, MIT and Whitehead Institute, USA

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Enhanced RNAi Mutants of C. elegans

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Temporally Expressed miRNAs and the Control of Developmental Timing

Ann Rougvie, , USA
MicroRNAs and the Control of Developmental Time

Javier F. Palatnik, Institute of Molecular and Cell Biology of Rosario, Argentina
Short Talk: Control of Leaf Morphogenesis by microRNAs

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 1: miRNAs and Other Non-Coding RNAs

Shavano/Torreys

FRIDAY, APRIL 16

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Molecular Mechanisms of RNAi and miRNA Biogenesis and Function - 1. Session Sponsored by Dharmacon, Inc.
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA

Craig C. Mello, University of Massachusetts Medical School, USA
RNAi and Development in C. elegans

Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Biochemical Analysis of Dicer in Mammalian Cells

Thomas Tuschl, HHMI/Rockefeller University, USA
Transcriptional and Posttranscriptional Gene Regulation by dsRNA-Derived Small RNAs

Brenda L. Bass, University of Utah, USA
The Intersection of RNA Editing and RNA Interference

Young Sik Lee, Northwestern University, USA
Short Talk: Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

Qinghua Liu, University of Texas Southwestern Medical Center, USA
Short Talk: R2D2 Bridges the Initiation and Effector Steps of the Drosophila RNAi Pathway

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Molecular Mechanisms of RNAi and miRNA Biogenesis and Function - 2. Session Sponsored in part by Promega Corporation.
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland

Phillip D. Zamore, University of Massachusetts Medical School, USA
RNA Interference: Combining Genetics and Biochemistry to Understand Biology and Mechanism

V. Narry Kim, Institute for Basic Science, South Korea
microRNA Biogenesis

Anastasia Khvorova, University of Massachusetts Medical School, USA
Mechanistic Aspects of Rational siRNA Design

Keqiong Ye, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 2: Molecular Mechanisms of siRNA and miRNA Biogenesis and Function

Shavano/Torreys

SATURDAY, APRIL 17

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Large-Scale RNAi Screens in Cultured Mammalian Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA

Gregory J. Hannon, University of Cambridge, UK
RNAi Mechanism and Application

René Bernards, Netherlands Cancer Institute, Netherlands
High-Throughput Loss-of-Function Genetic Screens in Mammalian Cells Using RNA Interference

Peter S. Linsley, AVI BioPharma, USA
What Expression Profiles Tell Us About siRNAs

Iwao Nozawa, TagCyx Biotechnologies, Japan
Enzymatic Production of siRNA Expression Library

Mark R. Edbrooke, GlaxoSmithKline, UK
Short Talk: The Use of RNAi in the Drug Discovery Process

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Large-Scale RNAi Screens in Non-Mammalian Organisms Session Sponsored in part by Cenix BioScience and Mirus Corporation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* James C. Carrington, Donald Danforth Plant Science Center, USA

Christophe J. Echeverri, Cenix BioScience GmbH, Germany
Genome-Wide RNAi Screens from C. elegans and Drosophila to Human Cells and Back

David C. Baulcombe, University of Cambridge, UK
Mechanisms and Applications of RNA Silencing in Plants

Michael Metzlaff, Bayer BioScience N.V., Belgium
Satellite RNA Virus-Based Gene Silencing Screens in Plants

19:00—20:00
Social Hour

Shavano/Torreys
19:30—22:00
Poster Session 3: Phenotypic Analysis and Screening Using dsRNA and RNA-Based Therapeutics

Shavano/Torreys

SUNDAY, APRIL 18

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Development of Gene-Specific Double-Stranded RNA Drugs. Session Sponsored by Sirna Therapeutics, Inc.
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Peter S. Linsley, AVI BioPharma, USA

Sailen Barik, University of South Alabama, USA
RNA Interference Analysis of Host-Pathogen Signaling

Victor R. Ambros, University of Massachusetts, USA
Classes of Small RNAs Associated with Widespread Gene Silencing in C. elegans

Markus Stoffel, ETH Zürich, Switzerland
Pancreatic Islet-Specific miRNAs and Insulin Secretion

Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA
Short Talk: Chemically Modified Short Interfering RNAs: in vivo Systemic Delivery, Pharmacokinetics and Pharmacodynamics in Mouse

David V. Morrissey, Intellia Therapeutics, Inc., USA
Short Talk: Progress in the Development of Therapeutic siRNAs Against Viral Hepatitis

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Characterization of Small-RNA-Regulated Networks and Escape from Regulation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Craig C. Mello, University of Massachusetts Medical School, USA

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Specificity of microRNAs and ES Cell-Specific Expression

Debora Marks, Columbia University, USA
Computational Biology of miRNA Regulation

Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
Short Talk: Identification of miRNA Targets in Drosophila

Erik Sontheimer, University of Massachusetts Medical School, USA
Short Talk: A Dicer-2-Dependent Assembly Pathway Generates an 80S Silencing Complex in Drosophila

Ulrike Gaul, Rockefeller University, USA
Short Talk: miRNA Function in Drosophila Development

19:00—20:00
Social Hour

Quandary
20:00—23:00
Entertainment

Quandary

MONDAY, APRIL 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA105911-01




We gratefully acknowledge additional support for this conference from:

Alnylam Pharmaceuticals, Inc. Ambion, Inc.

Cell Signaling Technology, Inc.

GenoFunction, Inc.
Isis Pharmaceuticals, Inc. Merck Research Laboratories
Promega Corporation
SIRNA Therapeutics

Thermo Fisher Scientific, Inc.
Cell Signaling Technology, Inc.

Cenix BioScience GmbH


Mirus Bio LLC


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