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This meeting took place in 2004



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Nuclear Receptors: Orphan Brothers (J7)


Organizer(s) David J. Mangelsdorf, Johan H. Auwerx and Holly A. Ingraham
February 28—March 4, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 28, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 29, 2003

Supported by Keystone Symposia


Summary of Meeting:
Upon completion of this conference, participants should be able to: - Have a general knowledge of the importance of nuclear receptors in health and disease, and as potential targets for drug discovery. - Compare the difference and similarity in the biochemical mechanisms of action used by the classic steroid/endocrine receptors and the orphan receptors. - Identify novel ligands and physiologic pathways for the orphan nuclear receptors. Characterize the latest structural/functional properties of receptors from the 3-D structures of their various domains complexed with ligands, cofactors, and DNA. - Have an understanding of the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research. - Promote a productive interaction between academic labs and industry. - Bring together and foster the interaction between the field's leading experts and younger scientists and trainees, with a particular emphasis on the inclusion of under represented groups.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 28

15:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—19:30
Orientation

Red Cloud/Shavano/Torreys
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano/Torreys
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Reciprocal Coupling of Metabolism and Circadian Rhythm


SUNDAY, FEBRUARY 29

07:00—08:00
Breakfast

Grays/Long/Quandary
08:00—11:00
Neuroendocrine Regulators
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland

Holly A. Ingraham, University of California, San Francisco, USA
Orphan Nuclear Receptors of Subfamily V – Gene Dosage Effects and Ligand Independent Modulation

Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Ligand-Independent Nuclear Receptors in the CNS

Orla M. Conneely, Baylor College of Medicine, USA
Essential and Redundant Roles of Nor-1 and Nur77 in Regulation of Myelopoiesis

Ueli Schibler, University of Geneva, Switzerland
Nuclear Receptors and Circadian Rhythms

Timo Kanzleiter, German Institute of Human Nutrition, Germany
Short Talk: An Orphan in the Cold: A Putative Function of Nur77 for Adaptive Thermogenesis in Brown Adipose Tissue


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

08:00—11:00
General Steroid Hormone Action
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Adriana Maggi, University of Milan, Italy

John W. Funder, Prince Henry's Institute of Medical Research, Australia
Aldosterone, Cardiovascular Damage: The New Biology of Mineralocorticoid Receptors

Donald P. McDonnell, Duke University School of Medicine, USA
The Efficacy of Agonist Activated Nuclear Receptors is Dramatically Enhanced by Exposure to Short Chain Fatty Acids in vitro and in vivo

Shigeaki Kato, University of Tokyo, Japan
Co-Regulator and Chromatin Remodeling Complexes for Nuclear Receptors

Olli A. Jänne, University of Helsinki, Finland
Sumoylation in Androgen Receptor Signaling

Debu Chakravarti, Northwestern University, Feinberg School of Medicine, USA
Short Talk: Translating the Histone Code of Transcription

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays/Longs/Quandary
13:00—22:00
Poster Viewing

Grays/Longs/Quandary
15:00—16:00
Hot Topics 1

Red Cloud
* Holly A. Ingraham, University of California, San Francisco, USA

Kim Jongsook Kemper, University of Illinois at Urbana-Champaign, USA
A Corepressor mSin3A-Swi/Snf Human Chromatin Remodeling Complex Mediates Repressor SHP Action in Cholesterol/Bile Acid Metabolism

Janet M. Allen, University College Dublin, Ireland
Beyond the 48: Identification of Novel Nuclear Receptors

Yuriy Shostak, Acropolis, USA
In vitro Genomic Selection: From the C. elegans Genome, to DAF-12 Binding Sites and Response Elements, to Target Genes

Michael R. Downes, The Salk Institute, USA
A Chemical, Genetic and Structural Analysis of the Nuclear Bile Acid Receptor FXR


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

15:00—16:00
Hot Topics 1

Shavano/Torreys
* Michael J. Garabedian, New York University School of Medicine, USA

István Szatmári, University of Debrecen, Hungary
Retinoids Affect Differentiation and Function of Human Monocyte-Derived Dendritic Cells

Wilson H. Miller, Jr., McGill University, Canada
Expression of SMRTbeta Promotes Ligand-Induced Activation of Mutated and Wild-Type Retinoid Receptors

Martin L. Privalsky, University of California, Davis, USA
Isotype-Specificity in the Nuclear Receptor/Corepressor Interaction and in Transcriptional Repression

Rob Jam Michalides, Netherlands Cancer Institute, Netherlands
Tamoxifen Resistance by a Conformational Arrest of the Estrogen Receptor-alpha after PKA Activation in Breast Cancer: Mechanism of Anti-Estrogen Resistance in Breast Cancer

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Transcription and Chromatin (Joint)
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano/Torreys
* Ronald M. Evans, HHMI/The Salk Institute, USA

Beverly M. Emerson, The Salk Institute, USA
Specificity of Gene Regulation through Chromatin

Gordon L. Hager, NCI, National Institutes of Health, USA
Dynamic Interaction of Steroid Receptors with Gene Targets

Robert G. Roeder, Rockefeller University, USA
Integrated Functions of Diverse Coactivators in Transcriptional Activation by Nuclear Receptors.

19:00—20:00
Social Hour

Grays/Longs/Quandary
19:30—22:00
Poster Session 1

Grays/Longs/Quandary

MONDAY, MARCH 1

07:00—08:00
Breakfast

Grays/Long/Quandary
08:00—11:00
Enterohepatic Metabolism
Meeting has ended...abstracts no longer viewable online.

Red Cloud
David D. Moore, Baylor College of Medicine, USA
Mechanisms of Action of Nongenotoxic CARcinogens

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulatory Actions of Enterohepatic Nuclear Receptors

Brandee Wagner, Metacrine, USA
Metabolic Regulation by Orphan Nuclear Receptors

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Entero Hepatic Receptors and Homeostatic Control

* Frank J. Gonzalez, National Institutes of Health, USA
Short Talk: Exploring PPAR Function


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

08:00—11:00
Progesterone and Estrogen Action
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Dean P. Edwards, Baylor College of Medicine, USA
Extranuclear Signaling Mechanisms and Functions of the Progesterone Receptor

Adriana Maggi, University of Milan, Italy
Mechanisms of Estrogen Receptor Activation in vivo

Benita S. Katzenellenbogen, University of Illinois, USA
Estrogen Receptors: Structure-Activity Relationships and Regulation of Gene Expression

Phyllis M. Wise, University of California, Davis, USA
Novel Actions of Estrogens: Protective or Risk Factors in Brain Function

Evan Simpson, Prince Henry's Institute, Australia
Short Talk: LRH-1 and SHP Roles in Estrogen Regulation and the Metabolic Syndrome

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays/Longs/Quandary
13:00—22:00
Poster Viewing

Grays/Longs/Quandary
15:00—16:00
Hot Topics 2

Red Cloud
Toshiya Tanaka, University of Tokyo, Japan
Activation of Peroxisome Proliferator-Activated Receptor delta Induces Fatty Acid beta-oxidation in Skeletal Muscle and Attenuates Diet-Induced Obesity and Insulin Resistance

Bernard R. Pipy, , France
Role of PPARgamma in Induction of Macrophage Mannose Receptor Gene Expression: Implication in the Control of Gastrointestinal Candidosis in Normal and Immunodeficient RAG-2-/- Mice

* George E.O. Muscat, University of Queensland, Australia
RORalpha (NR1F1) Regulates the Expression of Genes Involved in Lipid Catabolism, Cholesterol and Energy Homeostasis in Skeletal Muscle Cells


A Novel CAR-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

15:00—16:00
Hot Topics 2

Shavano/Torreys
* Carol A. Lange, University of Minnesota, USA
Progestin and Mitogen Activated Protein Kinase (MAPK) Dependent Changes in Cell Cycle Regulation in Human Breast Cancer Cells

Cem Elbi, Merrimack Pharmaceuticals, USA
Molecular Chaperones Function as Steroid Receptor Nuclear Mobility Factors

Raymond Blind, Vanderbilt University School of Medicine, USA
Regulation of Glucocorticoid Receptor-Mediated Transcriptional activation: The Role of Receptor Phosphorylation and Cofactor Recruitment

Dennis H. Dowhan, Baylor College of Medicine, USA
Regulation of Steroid Hormone Receptor Mediated Alternative Splicing by U2AF-Related Proteins CAPER & CAPERb

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Nuclear Receptor Coregulators (Joint)
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano/Torreys
* Bert W. O'Malley, Baylor College of Medicine, USA

Keith R. Yamamoto, University of California, San Francisco, USA
Hormones and Response Elements: Two Receptor Ligands that Together Specify Functional Surfaces and Trascriptional Regulatory Networks

Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptors and Inflammation

Bruce M. Spiegelman, Harvard Medical School, USA
OXPHOS Pathway Dysregulated in Human Diabetes is Controlled by PGC-1 Coactivation

19:00—20:00
Social Hour

Grays/Longs/Quandary
19:30—22:00
Poster Session 2

Grays/Longs/Quandary

TUESDAY, MARCH 2

07:00—08:00
Breakfast

Grays/Long/Quandary
08:00—11:00
Developmental Regulators
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Carl S. Thummel, University of Utah School of Medicine, USA
Molecular Mechanisms of Hormone Signaling and Nuclear Receptor Function in Drosophila

Ann E. Sluder, Cambria Biosciences LLC, USA
Nematode Nuclear Receptors: Conservation, Variation and Function

Vincent Giguère, McGill University, Canada
Molecular Mechanisms and Functional Genomics of ERR/PGC-1 Interaction in Metabolic Control

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Regulation of Mammalian Parturition by Nuclear Receptors and Coactivators

* Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Reciprocal Regulation of Oct4 Expression by the Orphan Receptors LRH-1 and GCNF


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

08:00—11:00
Vitamin D and T3 Receptors
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Jacques Samarut, Centre National de la Recherche Scientifique, France
Roles of Thyroid Hormone Receptor Isoforms in Mouse Development

* Leonard P. Freedman, Global Biological Standards Institute, USA
Nuclear Receptor Coactivators: It's Hip to be DRIP

Catherine C. Thompson, Pfizer, USA
Multiple Roles of the Corepressor Hairless in Nuclear Receptor Signaling

Judah S. Denburg, McMaster University, Canada
Selective Thyroid Hormone Analogs

Myles Brown, Dana-Farber Cancer Institute, USA
Short Talk: Coactivator as Oncogene

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays/Longs/Quandary
13:00—22:00
Poster Viewing

Grays/Longs/Quandary
15:00—16:00
Hot Topics 3

Red Cloud
Lena Jendeberg, Biovitrum, Sweden
Structural Insights into the Heterodimeric Complex of LXRa and RXRb Ligand-Binding Domains in a Fully Agonistic Conformation

Andrew I. Shulman, University of Texas Southwestern Medical Center, USA
Molecular Basis of Allosteric Ligand Activation in RXR Heterodimers

* Frances M. Sladek, University of California, Riverside, USA
Comparison of HNF4 Binding Sites in the Human and Mouse Genomes

Souphatta Sasorith, Institut de Genetique et de Biologie Moleculaire et Cellulaire(IGBMC), France
3D Nuclear Receptors Thematic Database

Yanhong Shi, Beckman Research Institute of City of Hope, USA
The Expression and Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

15:00—16:00
Hot Topics 3

Shavano/Torreys
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA

Kevin Link, Cincinnati Children's Hospital Medical Center, USA
SWI/SNF is Required for Co-Activator Stimulated Androgen Receptor Activation

Catherine F. Teyssier, INSERM EMI 0229, France
Regulation of PGC-1 Coactivator Activity by Arginine Methylation

Paul M. Yen, Johns Hopkins University, USA
Cyclical Recruitment of TFIIH Subunits and other Co-Activators to Thyroid Hormone Response Elements (TREs): Evidence for "Signature" Coactivator Profiles in Target Gene Regulation

Michael A. Mancini, Baylor College of Medicine, USA
Transcription Factor Dynamics on Integrated Prolactin Promoter-Enhancer Arrays

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
3-D Structure (Joint)
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano/Torreys
* Donald P. McDonnell, Duke University School of Medicine, USA

Timothy M. Willson, GlaxoSmithKline, USA
Are All Orphan Nuclear Receptors Good Drug Targets?

Jean-Paul Renaud, NovAliX, France
Orphan nuclear receptor characterization through structural studies

Geoffrey L. Greene, University of Chicago, USA
Short Talk: ERalpha/ERbeta Ligand Discrimination and Allosteric Communication between Ligand, Receptor and Co-Regulators

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: The Nuclear Receptor Signaling Atlas: Building a Comprehensive Atlas of Orphan and Nuclear Receptor Function

19:00—20:00
Social Hour

Grays/Longs/Quandary
19:30—22:00
Poster Session 3

Grays/Longs/Quandary

WEDNESDAY, MARCH 3

07:00—08:00
Breakfast

Grays/Long/Quandary
08:00—11:00
Intermediary Metabolism
Meeting has ended...abstracts no longer viewable online.

Red Cloud
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Orphan Brother, Where Art Thou?

Daniel Metzger, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Functional Role of RXRs and PPARgamma in Adipocytes

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuts and Bolts of Repression

Peter Tontonoz, University of California, Los Angeles, USA
Orphan Nuclear Receptors in Atherosclerosis

* Malcolm G. Parker, Imperial College London, UK
Short Talk: Role of RIP140 Corepressor in Adipose Biology


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

08:00—11:00
Steroid Receptors and Disease
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Estrogen Receptor-a Directs Cyclical Epigenetic Processes on a Natural Promoter through the Ordered, Combinatorial Recruitment of Cofactors

J. Wesley Pike, University of Wisconsin-Madison, USA
Molecular Actions of Vitamin D and Its Analogs in Transcriptional Regulation

Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Physiological Disruption Due to Loss of Functional Estrogen Receptors

Jan-Åke Gustafsson, University of Houston, USA
New Roles of Estrogen Receptor Beta

* Heather A. Harris, Wyeth Pharmaceuticals, USA
Short Talk: Selective Estrogen Receptor-Beta Agonists are Potent Anti-Inflammatory Agents

09:20—09:40
Coffee Break

Longs Peak Foyer
15:30—16:30
Hot Topics 4

Red Cloud
* Bruce Blumberg, University of California, Irvine, USA
Vitamin K2 Regulation of Bone Homeostasis is Mediated by the Steroid and Xenobiotic Receptor, SXR

David Hervé Volle, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
Testicular Function in LXR-Deficient Mice

Jae In Lee, Amgen Inc., USA
ASC-2, as an Essential Transcriptional Coactivator of the Liver X Receptors in vivo

Hilde Irene Nebb, University of Oslo, Norway
Liver X Receptor Signaling Pathways in Adipose Tissue


Following Session is for Nuclear Receptors: Steroid Sisters (J8)

15:30—16:30
Hot Topics 4

Shavano/Torreys
* E. Brad Thompson, University of Texas Medical Branch, USA

Raj Kumar, Commonwealth Medical College, USA
Induced alpha-Helix Structure in the AF1 of the Steroid Receptors Upon Direct Binding to Cofactor Protein

Eugene Hur, University of California, San Francisco, USA
Accommodation and Discrimination of Hydrophobic Motifs in the Androgen Receptor

Fraydoon Rastinejad, University of Oxford, UK
Structural Basis for Bile Acid Binding and Activation of FXR

Timothy R. Geistlinger, Amyris, USA
Specific Proteomimetic Inhibitors of NR:SCR

17:00—17:30
Coffee & Snacks Available

Longs Peak Foyer
17:30—19:30
Nuclear Receptor Round-Up (Joint). Session Sponsored in part by X-Ceptor Therapeutics, Inc.
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano/Torreys
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Bert W. O'Malley, Baylor College of Medicine, USA
Searching for Novel and Diverse Functions of Steroid Hormone Receptor Coactivators

Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors: The Final Word

19:30—20:00
Social Hour

Grays/Longs/Quandary
20:00—23:00
Entertainment

Grays/Longs/Quandary

THURSDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK066661-01




We gratefully acknowledge additional support for this conference from:


X-Ceptor Therapeutics, Inc.

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