Sheraton Steamboat Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2005



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Biology of Cardiac Diseases and Regeneration (D2)


Organizer(s) Elizabeth McNally and Jonathan A. Epstein
April 3—8, 2005
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 2, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 3, 2005

Supported by The Director's Fund

Summary of Meeting:
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Myocardial infarction and congestive heart failure, together, account for the majority of cardiovascular disease. An underlying theme in both myocardial infarction and congestive heart failure is an insufficient number of properly functioning cardiomyocytes. Repairing defective cardiomyocytes and/or regenerating cardiomyocytes are important experimental means to improve heart function. To this end, stem cells from embryonic and adult sources have been increasingly explored as a means of restoring cardiac function. Vascular growth remains a significant concern since vascular supply is essential to the survival of regenerated cardiomyocytes. To establish a fully functioning cardiomyocyte requires a detailed understanding of cardiomyocyte differentiation as well as a pluripotent stem cell capable of achieving the cardiomyocyte developmental pathway. At the cellular level, cardiomyocyte dysfunction arises from ischemic insult, genetic or toxic metabolic defects. The broad etiology responsible for the dysfunctioning cardiomyocyte has not limited the identification of molecular pathways in common to these many different forms of heart failure. Defects of intracellular calcium homeostasis are a frequent issue in failing cardiomyocytes. Perturbations of calcium homeostasis directly affect sarcomere function and simultaneously render an altered signaling cascade. The goal of this meeting is twofold. We will discuss cellular and molecular pathways necessary for cardiac regeneration. This will include a discussion of stem cell choice as well as a full evaluation of current stem cell transplant programs with an emphasis on full integration and differentiation of the transplanted stem cell. The second major emphasis of the meeting will be to discuss the failing cardiomyocyte focused on the common and critical molecular pathways found in the diseased cardiomyocyte. These two broad areas overlap considerably since both approaches will be required to successfully repair a failed cardiomyocyte.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 3

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration


MONDAY, APRIL 4

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:15
Cardiovascular Development I
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
* Jonathan A. Epstein, University of Pennsylvania, USA
Develpment of the Cardiac Outflow Tract

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Zebrafish Models of Heart Development

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Control of Heart Development by Transcriptional Coactivators and Corepressors

Edward E. Morrisey, University of Pennsylvania, USA
Short Talk: A Unique Role for Foxp4 in Late Cardiac Development

Kory Lavine, Washington University School of Medicine, USA
Short Talk: Fibroblast Growth Factor Signals Regulate Myocardial Proliferation and Coronary Vasculogenesis in vivo

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Cardiovascular Development II
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Kenneth R. Chien, Karolinska Institutet, Sweden
The Islet-1+ Progenitor Story: Heart Cell Lineage Diversification in Develpment and Disease

* Peter F. Carmeliet, University of Leuven, VIB, Belgium
Mechanisms of Angiogenesis

David A. Cheresh, University of California, San Diego, USA
Growth Factor Signaling in the Tumor Endothelium, Limiting Ischemic Injury Following Myocardial Infarction

Eric C. Svensson, University of Chicago, USA
Short Talk: Fog Genes are Required for Cardiac Looping in Zebrafish

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak

TUESDAY, APRIL 5

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Mechanisms of Cardiomyocyte Failure
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Jonathan G. Seidman, Harvard Medical School, USA
Cardac Morhology, Fibrosis, and Arrhythmia in Hypertrophic and PRKAG2 Cardiomyopathy

* Elizabeth M. McNally, Northwestern University, USA
Cytoskeletal Defects in Cardiomyopathy

Guido E. Tarone, Universita di Torino, Italy
Short Talk: Melusin, a Muscle Specific Integrin Binding Protein, Protects from Cardiac Dilation in Response to Pressure Overload

Joseph M. Metzger, University of Minnesota Medical School, USA
Short Talk: Rescue of Dystrophic Cardiomyopathy Following Acute Administration of Polaxomer 188 in the mdx Mouse

Jennifer L. Hall, University of Minnesota, USA
Short Talk: Identification and Regulation of Sprouty1, an Intrinsic Negative Inhibitor of the ERK Cascade, in the Human Heart

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Cardiac Development and Aging in Drosophila

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:15
Stem Cells in Cardiac Regeneration
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
* Charles E. Murry, University of Washington, USA
Stem Cell Transplantation for Cardiac Repair

Michael D. Schneider, Imperial College London, UK
Stem Cells in Cardiomyocyte Regeneration

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA
The Homeodomain Transcription Factor Irx5 Establishes the Mouse Cardiac Ventricular Repolarization Gradient

Nadia A. Rosenthal, The Jackson Laboratory, USA
Enhancing Cardiac Regeneration with Growth Factors

19:15—20:15
Social Hour

Foyer
19:30—22:00
Poster Session 2

Sunshine Peak

WEDNESDAY, APRIL 6

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:15
Molecular Pathogenesis of Heart Failure
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Andre Terzic, Mayo Clinic College of Medicine, USA
KATP Channels in Stress Response

Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Molecular Basis of Heart Failure and Cardiac Arrhythmias and Novel Therapy

* R. John Solaro, University of Illinois at Chicago, USA
Thin Filament Defects in the Failing Heart.

Anthony J. Muslin, Sanofi Global Research & Development, USA
Short Talk: Akt1 Promotes Physiologic, but Antagonizes Pathologic, Cardiac Growth

Kenneth Walsh, University of Virginia School of Medicine, USA
Short Talk: Disruption of Coordinated Tissue Growth and Angiogenesis in the Heart Mediates Progression from Adaptive Cardiac Hypertrophy to Heart Failure

Pilar Ruiz-Lozano, Stanford University, USA
Short Talk: Migratory Precursors and Myocyte Function

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Signaling Defects in Cardiomyocyte Failure
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
* Jean E. Schaffer, Washington University School of Medicine, USA
Lipid Metabolic Defects as a Cause of Cardiomyopathy

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Analysis of Cyclophilin D Function Reveals a Necessary Role for Mitochondrial Pore Permeability

Howard A. Rockman, Duke University Medical Center, USA
New Concepts in Heptahelical Receptor Signaling in Heart Failure

Richard T. Lee, Harvard University, USA
Short Talk: Injectable Self-Assembling Nanofibers for Targeted Myocardial Delivery

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak

THURSDAY, APRIL 7

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:15
Cell Death and Mitochondrial Function
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
* Michael T. Crow, Johns Hopkins School of Medicine, USA
Control of Mitochaondrial Death Signaling in the Heart by ARC

* Eduardo Marban, Cedars-Sinai Medical Center, USA
Cardiac Stem Cells

Peter J. Gruber, University of Iowa, USA
Short Talk: Epigenetic Modifications Reduce the Severity of Ischemia-Reperfusion Injury in the Murine Heart

Michael Seth Kapiloff, Oregon Health & Science University, USA
Short Talk: The mAKAP Signaling Complex and the Induction of Cardiac Myocyte Hypertrophy

April Stempien-Otero, University of Washington, USA
Short Talk: Plasminogen Dependent Cardiac Fibrosis

Sameer S. Chopra, Vanderbilt University School of Medicine, USA
Short Talk: The Voltage-Gated Sodium Channel SCN5A is Required for Embryonic Heart Development and Function in Zebrafish

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Stem Cell Diversity
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Mark F. Pittenger, University of Maryland Medical Center, USA
Allogenetic Mesemchymal Stem Cells in Cardiac Therapeutics

* Doris A. Taylor, Texas Heart Institute, USA
Short Talk: Putting Vascular Back into Stem Cell based Cardiovascular Repair

Cindy M. Martin, University of Minnesota, USA
Short Talk: Progenitor Cell Populations and their Participation in Myocardial Regeneration

Michel Pucéat, INSERM, France
Short Talk: Stem Cells Improves Left Ventricular Function in Infarcted Sheep Myocardium

19:00—20:00
Social Hour

Foyer
20:00—23:00
Entertainment

Storm Peak/Mt Werner

FRIDAY, APRIL 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-HL079688-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Osiris Therapeutics, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676