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This meeting took place in 2005


Here are the related meetings in 2018:
Atherosclerosis: Lessons Learned and Concepts Challenged (B2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Cellular Biology of Atherosclerosis (A7)


Organizer(s) Ira Tabas and Elizabeth Nabel
January 22—27, 2005
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 22, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 22, 2004

Part of the Translational Medicine Series, Supported by Pfizer Global Research and Development

Summary of Meeting:
Atherosclerotic vascular disease, the leading cause of death in the industrialized world, begins when lipoproteins retained in the arterial wall provoke a series of cellular reactions involving macrophages, endothelial cells, smooth muscle cells, and immune cells. The lesion is propagated through a series of complex cell-cell and cell-lipid interactions, leading to inflammation, extracellular matrix alterations, and necrosis. These events, in turn, promote plaque disruption, acute thrombosis, and sudden vascular occlusion. The cellular processes of atherogenesis represent key therapeutic targets, but successful strategies will require a thorough understanding of the cellular and molecular mechanisms involved. In this meeting, leading cellular and molecular biologists will discuss the latest advances in these areas of research. A major goal is to spawn new interactions between researchers focused on atherogenesis per se and those with expert knowledge in cell biological areas that warrant greater representation in atherosclerosis research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 22

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
James E. Rothman, Yale University School of Medicine, USA
Principles of Membrane Fusion


SUNDAY, JANUARY 23

07:00—08:00
Breakfast

Crestone Peak
08:00—11:00
Endothelial Function and Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Bradford C. Berk, University of Rochester Medical Center, USA
Atheroprotective Mechanisms of Steady Laminar Blood Flow

David Harrison, Emory University, USA
Oxidant Stress and Vascular Function

Hanjoong Jo, Emory University, USA
Short Talk: Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production from a nox1-Based NADPH Oxidase

Michael E. Mendelsohn, , USA
Molecular Mechanisms Regulating Vascular Smooth Muscle Cell Tone and Blood Pressure

Philip Marsden, University of Toronto, Canada
Short Talk: The Cell-Specific Expression of Endothelial Nitric Oxide Synthase (eNOS): A Role for Chromatin-Based Mechanisms

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
14:00—16:00
Workshop 1: Novel Molecular Targets in Atherosclerosis and Identification through Genomic and Proteomic Approaches

Red Cloud/Shavano
* Karen K. Hirschi, Yale University, USA

Willmar D. Patino, NHLBI, National Institutes of Health, USA
FOS as a Novel Marker of Atherosclerosis

Paul Kroeger, Abbott Laboratories, USA
Effects of 1alpha,25-dihydroxyvitamin D3 on Gene Expression Profiling in Human Coronary Artery Smooth Muscle Cells

Santhi K. Ganesh, NHLBI, National Institutes of Health, USA
Dissection of a Complex Vascular Disease: The CardioGene Study - Genomics of In-Stent Restenosis

Jan H. N. Lindeman, Leids Universitair Medisch Centre, Netherlands
Cathepsin K and S are the Principal Proteases in Stable (AAA) and Ruptured Aortic Abdominal Aneurysm (AAAAA)

Carlie J. M. de Vries, University of Amsterdam, Netherlands
TR3 Nuclear Receptor is a Novel Target for Intervention in Smooth Muscle Cell Hyperplasia

Daniel Eefting, TNO Prevention and Health, Netherlands
Blocking of the MCP-1/CCR2 Pathway Inhibits Intimal Hyperplasia in Vein Grafts

16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:15
The Entry and Differentiation of Monocytes in Nascent Atherosclerotic Lesions
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Arrest Chemokines and Monocyte Recruitment to Atherosclerosic Lesions

Myron I. Cybulsky, University of Toronto, Canada
Leukocytes, Inflammation and the Initiation of Atherosclerosis

Ralph Gareus, EMBL Program On Mouse Biology, Italy
Short Talk: The Role of Endothelial NF-kappaB in Atherosclerosis

William A. Muller, Northwestern University Feinberg School of Medicine, USA
Cellular and Molecular Control of Transendothelial Migration

Aron Chakera, University of Oxford, UK
Short Talk: Duffy Antigen/Receptor for Chemokines (DARC): A Novel Anti-Inflammatory/Anti-Chemokine Approach to Atherosclerosis

19:15—20:15
Social Hour

Crestone Peak
19:30—22:00
Poster Session 1

Crestone Peak

MONDAY, JANUARY 24

07:00—08:00
Breakfast

Crestone Peak
08:00—11:15
The Role of Macrophages in Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Christopher K. Glass, University of California, San Diego, USA
Regulation of Macrophage Foam Cell Formation and Development of Atherosclerosis by PPARs

Mason W. Freeman, Massachusetts General Hospital, USA
Macrophage Inflammatory Processes and Atherosclerosis

Yury I. Miller, University of California, San Diego, USA
Short Talk: Early Forms of Oxidized LDL Augment Cytokine Responses to LPS via a PI3K/Akt Mechanism

Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptors at the Crossroads of Lipid Metabolism and Inflammation

Robert Clive Landis, University of West Indies, Barbados
Short Talk: Impaired Anti-Inflammatory Signaling following Scavenging of Haptoglobin2-2:Hemoglobin Complexes by CD163

Ira Tabas, Columbia University, USA
Signal Transduction in Cholesterol-Loaded Macrophages

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
The Immune System in Atheroslcerosis
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Göran K. Hansson, Karolinska University Hospital, Sweden
Role of Adaptive Immunity in Atherosclerosis

Joseph L. Witztum, University of California, San Diego, USA
The Role of Innate Immunity in Atherosclerosis

Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: Constitutive Trafficking of Lymphocytes into the Murine Aorta

Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis

19:00—20:00
Social Hour

Crestone Peak
19:30—22:00
Poster Session 2

Crestone Peak

TUESDAY, JANUARY 25

07:00—08:00
Breakfast

Crestone Peak
08:00—11:15
Smooth Muscle Cell Proliferation, Differentiation, and Phenotypic Modulation
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Brant M. Weinstein, NICHD, National Institutes of Health, USA
Building Vascular Networks during Development

Karen K. Hirschi, Yale University, USA
Role of Gap Junction Communication in Mural Cell Differentiation

Nicola Ferri, University of Milan, Italy
Short Talk: Pericellular Regulation of Vascular Smooth Muscle Remodeling: MMP2-Mediated Cleavage of the Novel MMP Inhibitor RECK

Gary K. Owens, University of Virginia, USA
Molecular Regulation of Smooth Differentiation in Development and Disease

* Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Cell Cycle, Vascular Proliferation, and Inflammation

Debbie Beasley, Tufts New England Medical Center, USA
Short Talk: Toll-like Receptor 2 is Expressed in Vascular Smooth Muscle Cells and Mediates C. pneumoniae-Induced Chemokine Release

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
14:00—16:00
Workshop 2: New Insights into the Pathobiology of the Macrophage Foam Cell

Red Cloud/Shavano
* Mason W. Freeman, Massachusetts General Hospital, USA

Howard S. Kruth, NHLBI, National Institutes of Health, USA
Macrophage Foam Cell Formation without LDL Modification or Receptors

Valerie Sier-Ferreira, Academic Medical Center, Netherlands
Prevention of NF-kappaB Activation in Macrophages Impairs Foam Cells Formation

Marta Scatena, University of Washington, USA
Osteopontin as a Survival Factor for Macrophages

Tracie A. Seimon, Columbia University, USA
Two-Step Mechanism of Cholesterol-Induced Macrophage Apoptosis: Apoptosis Requires a Priming Step Mediated by p38 MAPK induced UPR activation, and a Trigger Step Mediated by the Engagement of Type A Scavenger Receptor

Richard C. Austin, McMaster University, Canada
Activation of the Unfolded Protein Response (UPR) During Atherosclerotic Lesion Growth in ApoE-Deficient Mice

Lianne S.M. Boesten, TNO-PG, Leiden University Medical Center, Netherlands
Retinoblastoma Deficiency in Macrophages Increases Atherosclerosis in ApoE-Deficient Mice

Elaine W. Raines, University of Washington, USA
Macrophage Expression of Active MMP-9 is Sufficient to Induce Plaque Rupture in APOE-/- Mice

16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Cellular Calcium Metabolism in Atherosclerotic Lesions
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Linda L. Demer, University of California, Los Angeles, USA
The Role of Vascular Stem Cells in Arterial Calcification

Catherine M. Shanahan, University of Cambridge, UK
Initiators, Inhibitors and Vesicles in Arterial Calcification

Cecilia M. Giachelli, University of Washington, USA
Osteopontin and Atherosclerosis: Linking Inflammation and Matrix Mineralization

19:00—20:00
Social Hour

Crestone Peak
19:30—22:00
Poster Session 3

Crestone Peak

WEDNESDAY, JANUARY 26

07:00—08:00
Breakfast

Crestone Peak
08:00—11:15
Cholesterol Efflux and Nuclear Receptors
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Richard A. Heyman, ORIC Pharmaceuticals, USA
Orphan Nuclear Receptors as Targets for Cardiovascular Disease

* Alan R. Tall, Columbia University, USA
Role of ABCG1 and ABCG4 in Cellular Cholesterol Efflux to HDL

Xiaohui Zha, Ottawa Hospital Research Institute, Canada
Intracellular Vesicular Trafficking in Cholesterol Efflux Pathways

Omar L. Francone, Pfizer Inc., USA
The Role of ABCA1 in Cholesterol Trafficking

Theo J. C. Van Berkel, University of Leiden, Netherlands
Short Talk: Role of ABCA1 and SR-BI in Cholesterol Transport and Atherosclerosis

Edward A. Fisher, New York University School of Medicine, USA
Short Talk: Molecular Regulation of Foam Cell Gene Expression After Reversal of Dyslipidemia in a Mouse Atherosclerosis Regression Model

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Arterial Wall-Based Therapy of Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Peter Libby, Brigham and Women's Hospital, USA
Diabetes, Metabolic Syndrome and Vessel Wall Therapies

Stefano Martinotti, Clinical Pathology University of Chieti, Italy
Short Talk: A Variant in the COX-2 Promoter Decreases Protein Expression and Influences Plaque Stability

Stefanie Dimmeler, University of Frankfurt, Germany
Progenitor Cells for Vascular Repair

19:00—20:00
Social Hour

Crestone Peak
20:00—23:00
Entertainment

Crestone Peak

THURSDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-HL079776-01




We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Basic Cardiovascular Sciences

Novartis Institutes for BioMedical Research
Pfizer Global Research & Development
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Exelixis, Inc.


Pfizer Inc.


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