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This meeting took place in 2005



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Obesity: Molecular Physiology and Genetics of the Control of Body Weight (J4)


Organizer(s) Rudolph L. Leibel and Joel K. Elmquist
January 27—February 2, 2005
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 27, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 29, 2004

Sponsored by Biovitrum AB, Cell Press and Lilly Research Laboratories


Summary of Meeting:
The rapid increase in the prevalence of obesity in developed and developing countries constitutes a major threat to the health of individuals, and the medical economics of their countries. Obesity accounts for major fractions of type 2 diabetes, dyslipidemias, hypertension and stroke, and a growing proportion of certain cancers. The past decade has seen impressive advances in the elucidation of the molecular genetics and molecular physiology of the control of body weight and composition. However, this understanding has not yet been translated into successful preventive or therapeutic approaches to the disease. Likewise, the molecular bases for the relationship of obesity to most of the medical sequelae mentioned above remain unknown. The purpose of this meeting is to bring together scientists working on the molecular genetics and physiology of energy homeostasis with investigators seeking to understand aspects of the systemic physiology and environment that are interacting with clear genetic predisposition to increase the prevalence. Investigators have been selected for their contributions to the understanding of specific aspects of the molecular and systemic control of body weight, and the contributions of developmental and environmental factors, as well as for their interest in the functional mechanisms by which these interact.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 27

15:00—19:30
Registration

Grays Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
* Rudolph L. Leibel, Columbia University, USA

* Morris J. Birnbaum, Pfizer Inc., USA

C. Nick Hales, ,
The Effects of Fetal and Infant Growth on Susceptibility to Obesity, Diabetes and Renal Disease and on Longevity

Donald F. Steiner, University Of Chicago, USA
A Diabetes Research Perspective


FRIDAY, JANUARY 28

07:00—08:00
Breakfast

Grays Peak
08:00—11:15
Central Regulation of Energy Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

Luciano Rossetti, Merck Research Laboratories, USA
Metabolic Sensing in the Brain

Michael W. Schwartz, University of Washington, USA
Hormonal Mediation of Energy Homeostasis

Martin G. Myers, Jr., University of Michigan, USA
Molecular Analysis of Leptin Receptor Function and Energy Homeostasis

Jeffrey M. Friedman, Rockefeller University, USA
To Eat or Not to Eat

Jonathan Dean Hommel, GlaxoSmithKline, USA
Short Talk: Leptin Signals Directly to Dopamine Neurons of the VTA to Regulate Feeding Behavior

Min-Seon Kim, University of Ulsan College of Medicine, South Korea
Short Talk: Role of Forkhead Transcription Factor FOXO1 in the Regulation of Feeding

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Central Actions of Metabolic Signals
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA

Rachel L. Batterham, University College London, UK
The Role of PYY in Regulating Energy Homeostasis in Man

Richard B. Simerly, Vanderbilt University, USA
Leptin and Hypothalamic Neural Development

Harvey J. Grill, University of Pennsylvania, USA
Contributions of Caudal Brainstem and Hypothalamus to The Neurobiology of Energy Balance

Suzanne M. Appleyard, Washington State University, USA
Short Talk: Appetite Regulators Interact at NTS POMC-EGFP Neurons Activated by Visceral Afferent Inputs

17:00—19:00
Insulin-Dependent Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Thomas (Gus) A. Gustafson, Janssen Pharmaceuticals, USA

Michael P. Czech, University of Massachusetts Medical School, USA
Targets of Phosphoinositide Signaling

Alan R. Saltiel, UC, San Diego, USA
Spatial Compartmentalization of Signal Transduction in Insulin Action

Morris J. Birnbaum, Pfizer Inc., USA
Achieving Specificity in Signaling to Growth and Metabolism

Feng Liu, University of Texas Health Science Center, USA
Short Talk: Insulin Stimulates PDK1 Phosphorylation at Ser163: A Mechanism for Activation

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 1

Torreys Peak

SATURDAY, JANUARY 29

07:00—08:00
Breakfast

Grays Peak
08:00—11:15
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
* Marc L. Reitman, NIDDK, National Institutes of Health, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Insights in the Development and Function of Brown Fat and its Role in Metabolic Syndrome Studied by Gene Expressin Analysis

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Resistin as a Regulator of Metabolism

Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Superoxide and Mitochondrial Uncoupling Protein-2: A Pathway Linking Obesity and Hyperglycemia with Beta-Cell Dysfunction

Bruce M. Spiegelman, Harvard Medical School, USA
Role of the PGC Coactivators in Lipid and Energy Metabolism

Iichiro Shimomura, Osaka University Graduate School of Medicine, Japan
Short Talk: Visfatin; A New Adipocytokine Secreted from Accumulated Visceral Fat

Yuka Toyoshima, Nippon Medical School, Japan
Short Talk: Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Other Molecular Pathways Related to Energy Homeostasis
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany

Gregory S. Barsh, Stanford University Medical Center, USA
Melanocortin Pathway in Energy Homeostasis

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
The Multiple Roles of Melanin-Concentrating Hormone in Regulating Energy Balance

Michael A. Cowley, Monash University, Australia
Hypothalamic Arcuate Melanocortin Neurons Integrate Signals of Energy State

William F. Colmers, University of Alberta, Canada
Short Talk: Cannabinoid Antagonist Acts like Melanocortin Agonist in MpPVN

17:00—19:00
Cell Biology of the Beta Cell and Adipocyte
Meeting has ended...abstracts no longer viewable online.

Longs Peak
David E. James, University of Sydney, Australia
Insulin Regulation of Glucose Transport in Adipocytes

Michele Solimena, Dresden University of Technology, Germany
Secretory Granules: Biogenesis and Signaling

Per-Olof Berggren, Karolinska Institutet, Sweden
Voltage-Gated L-Type Ca2+ Channels in beta-Cell Physiology and Pathophysiology

Toshio Hosaka, Boston University, USA
Short Talk: p115 Interacts with the GLUT4 Vesicle Protein, IRAP, and Plays a Critical Role in Insulin-Stimulated GLUT4 Translocation

* Timothy E. McGraw, Weill Medical College of Cornell University, USA

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 2

Torreys Peak

SUNDAY, JANUARY 30

07:00—08:00
Breakfast

Grays Peak
08:00—11:15
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
* Helena Edlund, Umeå University, Sweden

Eric Rulifson, University of California, San Francisco, USA
Development of Insulin-Producing and Glucose-Regulating Cells in Drosophila

Ernst Hafen, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Insulin Signaling and Growth Caontrol in D. melanogaster

Wolfgang Driever, University of Freiburg, Germany
Genetic Analysis of Pancreas Development in Zebrafish

Supriya Srinivasan, The Scripps Research Institute, USA
Short Talk: Defining the Serotonergic Circuit that Maintains Energy Homeostasis in C. elegans

Lutz R. Kockel, Harvard Medical School, USA
Short Talk: Genome Wide Analysis of Akt Signaling by dsRNAi in Drosophila

Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
Short Talk: Regulation fo Insulin Producing Midgut Cells by P13K and Tor Signaling in Drosophila

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Intersections of Central Pathways Controlling Food Intake
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Malcolm J. Low, University of Michigan, USA

Laurence H. Tecott, University of California, San Francisco, USA
Quantitative Behavioral Genetic Approaches to the Serotonergic Regulation of Energy Balance in the Mouse

Randy J. Seeley, University of Michigan, USA
A Novel Role for the Cytokine GM-CSF in CNS Energy Balance Regulation

Daniel L. Marks, Oregon Health & Science University, USA
Short Talk: Central Mechanisms in Cachexia

Nina Balthasar, University of Bristol, UK
Short Talk: Melanocortin Action in the Paraventricular Hypothalamus

17:00—19:15
Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Silvia Corvera, University of Massachusetts Medical School, USA

Stevan R. Hubbard, New York University School of Medicine, USA
Structural Basis for Recruitment of Adapter Proteins to the Activated Insulin Receptor

Marc R. Montminy, The Salk Institute for Biological Studies, USA
Regulation of Gluconeogenesis

George Thomas, University of Cincinnati, USA
The Role of S6K1 in the Pathogenesis of Obesity and the Development of Insulin Resistance

Gökhan S. Hotamisligil, Harvard University, USA
Integration of Stress Signals in the Endoplasmic Reticulum in Obesity and Diabetes

Ji Yeon Lee, NIDDK, National Institutes of Health, USA
Short Talk: Talk: Deletion of the Transcription Factor Stat5 in Pancreatic ß-cell Disturbs Normal Glucose Homeostasis

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 3

Torreys Peak

MONDAY, JANUARY 31

07:00—08:00
Breakfast

Grays Peak
08:00—11:15
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
* Yoshihiro Ogawa, Kyushu University, Japan

Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Maturity Onset Diabetes of the Young (MODY): Human Monogenic Diabetes and Unraveling Genetic Transcriptional Networks of the ß Cell

I. Sadaf Farooqi, University of Cambridge, UK
Insights from Monogenic Obesity Syndromes

Gary A. Peltz, Standford University Medical Center, USA
From Mouse to Man: Understanding Disease

Leonard P. Guarente, Massachusetts Institute of Technology, USA
SIRT1 Coordinates Fat Storage with Food Intake: Implications for Aging

Chiao-Chien Connie Hung, Cambridge Institute for Medical Research, UK
Short Talk: A de novo Mutation in TrkB Associated with Severe Human Obesity and Developmental Delay

Douglas R. Cavener, Pennsylvania State University, USA
Short Talk: Neonatal Proliferation of beta-cells is Critically Regulated by PERK (EIF2AK3)

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak
13:00—22:00
Poster Viewing

Torreys Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:30
Measures of Phenotypes Related to Energy Homeostasis in Animals and Humans
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Robert G. MacKenzie, Wayne State University, USA

Roger D. Cone, University of Michigan, USA
Actions of Gut Peptides on the Central Melanocortin System

Tamas L. Horvath, Yale School of Medicine, USA
Synaptic Plasticity in the Hypothalamus and Hippocampus: A Link Between Energy Balance and Cognition

Isabelle Bady, University of Lausanne, Switzerland
Short Talk: Central Glut2-Dependent Glucose Sensors Control Feeding and Energy Expenditure

Anand Mehta, KineMed, Inc., USA
Short Talk: Analysis of the Transcriptional Modulation of Metabolic Networks using GFP Reporters

Adam R. Kennedy, Cytokinetics Inc., USA
Short Talk: Decreased Body Weight and Increased Metabolism on a Very Low Carbohydrate Ketogenic Diet: The Effect of Diet Composition on Gene Expression and Cellular Metabolism

17:00—19:00
Beta Cell Growth and Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Yoshitomo Oka, Tohoku University Graduate School of Medicine, Japan

Helena Edlund, Umeå University, Sweden
Molecular Mechanisms Controlling Generation and Maintenance of beta Cell Function

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Foxa Transcription Factors and the Beta Cell

Seung K. Kim, Stanford University, USA
Development of the Beta Cell

Beatriz Sosa-Pineda, Northwestern University Feinberg School of Medicine, USA
Short Talk: Pax4 is an Essential Regulator of Pancreatic beta-cell Development

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 4

Torreys Peak

TUESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Grays Peak
08:00—11:15
Nutrient Effects on Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peak
* Juleen R. Zierath, Karolinska Institutet, Sweden

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Adipocyte-Secreted Protein Plays a Role in Insulin Resistance

Nahum Sonenberg, McGill University, Canada
4E-BP Mediate Starvation and Oxidative Stress in Drosophilia and Effects on Obesity in Mice

Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors and Metabolic Fuel Selection

Domenico Accili, Columbia University, USA
Metabolic Regulation by Forkhead Proteins

Nils Halberg, Rockefeller University, USA
Short Talk: The Effect of Intermittent Fasting on Insulin Sensitivity

Bai Luo, University of Utah, USA
Short Talk: Cross-Talk Between Hexosamine Biosynthesis Pathway and AMP-Activated Protein Kinase in Adipocytes

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Adipose Tissue Biology
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA

Jeffrey Flier, Harvard University, USA
SOCS3 and teh Genesis of Leptin and Insulin Resistance

Anthony W. Ferrante, Columbia University, USA
Obesity and Adipose Tissue Macrophages

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adiponectin and Resistin - Adipokines Modulating Insulin Signaling

Anthony N. Hollenberg, Beth Israel Deaconess Medical Center, USA
Short Talk: The Role of Leptin and Melanocortin 4 - Receptor (MC4-R) Signaling in the Regulation of Thyrotropin-Releasing Hormone (TRH) Gene Expression

17:00—19:00
Liver Development and Metabolism
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Rebecca A. Taub, VIA Pharmaceuticals, Inc, USA

Christopher B. Newgard, Duke University Medical Center, USA
Metabolic Profiling Applied to Hepatic Regulatory Mechanisms

Bernard Thorens, University of Lausanne, Switzerland
Multiple GLUT2-dependent Glucose Sensors

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Insulin Resistance and Dysregulated Nutrient Homeostasis

Nancy A. Thornberry, Kallyope, Inc., USA
Short Talk: Dipeptidyl Peptidase IV (DPP-IV) Inhibition for Treatment of Type 2 DM: Potential Importance of Selective Inhibition and Discovery of MK-0431

19:00—20:00
Social Hour

Longs Peak Foyer
20:00—23:00
Entertainment

Grays Peak

WEDNESDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-DK070429-01




We gratefully acknowledge additional support for this conference from:

Biovitrum AB Cell Press
Lilly Research Laboratories
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Roche Palo Alto


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