Sheraton Steamboat Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2005



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cell Development, Function and Disease (C5)


Organizer(s) Harinder Singh, Mark J. Shlomchik and Riccardo Dalla-Favera
March 28—April 3, 2005
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 29, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 28, 2005

Supported by The Director's Fund

Summary of Meeting:
The defining feature of B lymphocyte development is the combinatorial recombination of antigen receptor gene segments which results in the generation of a vast repertoire of clonogenic B cells. Each naïve B cell expresses a unique antigen receptor comprised of an antibody molecule associated with signal transduction components. Signaling through the B cell receptor is required for B cell survival, activation in response to antigen and the induction of tolerance. B cell activation in germinal centers is accompanied by somatic hypermutation and isotype switch recombination of immunoglobulin (Ig) genes. The former process is used to select for higher affinity antibodies in an immune response and the latter to generate antibodies with different effector functions. Aberrant B cell activation can result in autoimmune disease or lymphomagenesis. Considerable progress has been recently achieved in several areas including (i) regulation of early B cell development from a lymphoid progenitor, (ii) mechanisms underlying somatic hypermutation and class switching of Ig genes, (iii) signalling functions of the B cell receptor, (iv) analysis of B cell subsets, (v) establishment and functioning of germinal centers (vi) control of plasma cell differentiation and (vii) mechanisms underlying autoimmunity. The meeting represents the continuation of a longstanding forum that uniquely focuses on both murine and human B cell biology so as to promote the analysis of B cell diseases and the generation of new therapeutic approaches. It brings together leading as well as young investigators.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 28

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
Max D. Cooper, Emory University, USA
The Origin of B and T Cells


TUESDAY, MARCH 29

06:30—08:00
Breakfast

3 Saddles/Sevens/Bear River
08:00—11:15
B Cell Development
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
Richard (Randy) Hardy, Fox Chase Cancer Center, USA
Short Talk: Delineating and Characterizing the Earliest Stages in B Cell Development

Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany
Regulation of B Lymphopoiesis by EBF Proteins

Cornelis Murre, University of California, San Diego, USA
Regulation and Function of HLH Proteins in B Cell Development

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of B cell Commitment by Pax5

Ana Cumano, Pasteur Institute, France
Role of Flk2R and IL-7R Signaling in B Cell Development

* Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Gene Regulatory Networks in B Cell Development

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Aspen
13:00—22:00
Poster Viewing

Rainbow/Twilight/Aspen
14:30—16:00
Workshop 1: MHC II Signaling and Ag-Presentation

Storm Peak
* Marcus R. Clark, University of Chicago, USA
Phosphorylated B Cell Antigen Receptor Complexes are Retained on the Cell Surface Following Receptor Stimulation

Barbara J. Vilen, University of North Carolina at Chapel Hill, USA
Independent Trafficking of µm and Ig-alpha/beta is Facilitated by Dissociation of the BCR Complex

Pedro Geraldes, Joslin Diabetes Center, USA
Immunoglobulin Heavy Chain and Long Lived B Cells

Pavel Tolar, Francis Crick Institute, UK
Probing B-Cell Receptor Structure and Antigen-Induced Clustering by FRET

* Yair Argon, University of Pennsylvania, USA
Roles of the Chaperones BiP and GRP94 in Ig Secretion

Boaz Tirosh, Hebrew University, Israel
XBP-1 Promotes IgM Synthesis and Secretion, but is Dispensable for Endoplasmic Reticulum Degradation in Primary Plasmablasts

Admar Verschoor, Harvard Medical School, USA
Detection of Antigen Trafficking in vivo by Multi-Photon Microscopy

14:30—16:00
Workshop 2: B Cell Development

Sunshine Peak
* David M. Allman, University of Pennsylvania, USA

* Barbara Lynne Kee, University of Chicago, USA
ID2 is a Major Determinant of Lymphoid Cell Fates

Rachel M. Gerstein, University of Massachusetts Medical School, USA
E47 is Required for the Earliest Steps of B Cell Differentiation

Christine A. Goetz, University of North Carolina at Chapel Hill, USA
Restricted STAT5 Activation Dictates B Versus T Cell Lineage Commitment

Alessio Delogu, Research Institute of Molecular Pathology, Austria
Pax5-Dependent Gene Repression at B-Lineage Commitment is Essential for Normal Hematopoietic Development

Brock L. Schweitzer, University of Cincinnati College of Medicine, USA
Ets Transcription Factor Spi-C Interferes with PU.1 Activity in Developing B Cells

Emma M.K. Smith, Lund Stem Cell Center, Sweden
Inhibition of EBF Function by Active Notch Signaling Reveals a Novel Regulatory Pathway in Early B-Cell Development

Benjamin C. Harman, Janssen R&D, USA
Plasmacytoid Dendritic Cells Derive From Myeloid-Committed Progenitors Which Upregulate Lymphoid-Associated Genes

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Signaling and Gene Expression in B Cell Development
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Alexander Tarakhovsky, Rockefeller University, USA
Control of Lymphocyte Function by Histone Modifications

Robert G. Roeder, Rockefeller University, USA
Regulation of B cell Differentiation Events by Transcriptional Coactivators and Corepressors

Ranjan Sen, National Institute of Aging, National Institutes of Health, USA
Short Talk: Immunoglobulin Heavy Chain Gene Locus Activation

Patrick Matthias, Friedrich Miescher Institute for Biomed Research, Switzerland
Short Talk: Aiolos and OBF-1 Act in Concert in Early B Lymphocyte Development

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 1

Rainbow/Twilight/Aspen

WEDNESDAY, MARCH 30

06:30—08:00
Breakfast

3 Saddles/Sevens/Bear River
08:00—11:00
B Cell Activation
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Spatial Organization of B Cell Signaling Receptors

Anthony L. DeFranco, University of California, San Francisco, USA
Proximal Events in B Cell Receptor Signaling

John G. Monroe, Genentech, Inc., USA
Ligand-Independent Signaling Functions of the B Cell Receptor

John C. Cambier, University of Colorado SOM, USA
Anergy: Physiologic Relevance and Underlying Mechanisms

David A. Fruman, University of California, Irvine, USA
Short Talk: Transcription Factors That Oppose B Cell Proliferation

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Aspen
13:00—22:00
Poster Viewing

Rainbow/Twilight/Aspen
14:30—16:00
Workshop 3: B Cell Signaling

Storm Peak
Claudine Schiff, Centre d'Immunologie de Marseille, France
Formation of the Pre-B/Stromal Cell Synapse and its Functional Implication in Pre-B Cell Development

Rudi W. Hendriks, Erasmus MC, Netherlands
A Role for Btk Signaling in the Induction of Immunoglobulin Light Chain Rearrangement

* Ananda L. Roy, Tufts University School of Medicine, USA
Function of TFII-I in B cells

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Participation of BCAP in Maintenance of Mature B Lymphocytes through Functional Coupling with c-Rel

Henry H. Wortis, Tufts University, USA
Regulation of Cytoplasmic Ca2+ Levels by PMCA4b and CD22

* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB Activation

Shiang-Jong Tzeng, National Taiwan University, Taiwan
The Mechanism of FcgammaRIIB1-Mediated Negative Selection of B Lymphocytes: Implications for Autoimmunity

Robert H. Carter, NIAMS, National Institutes of Health, USA
The Role of CD19 Signaling in the Germinal Center

14:30—16:00
Workshop 4: Autoimmunity

Sunshine Peak
* Chandra Mohan, University of Texas Southwestern Medical Center, USA

* Ignacio Sanz, Emory University, School of Medicine, USA
Regulation of Autoreactive B-Cells

Carola G. Vinuesa, Australian National University, Australia
The Novel Ubiquitin Ligase - Roquin - Represses Follicular T Cells and prevents Autoimmunity

Sean Christensen, Yale University School of Medicine, USA
Toll-like Receptor 9 Controls Anti-DNA Autoantibody Production in Murine Lupus

Barbara J. Vilen, University of North Carolina at Chapel Hill, USA
B Cell Tolerance to Sm is Mediated by Myeloid Dendritic Cells and Macrophages

Sucai Liu, , USA
Receptor Editing Can Lead to Allelic Inclusion and Positive Selection of B Cells Reactive with High Avidity Autoantigens

Laura Mandik-Nayak, Washington University, USA
Characterization of Autoreactive B Cell Response in Healthy vs. Arthritic Mice

Eric Meffre, Yale University School of Medicine, USA
Impaired Early B Cell Tolerance in Patients with Rheumatoid Arthritis

Sooghee Chang, University of Texas Southwestern Medical Center, USA
Origins of Antinuclear Antibodies – Genetically Programmed Selection of Antibodies with Peculiar CDR Charge Motifs into the Primary Immunoglobulin Repertoire

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
B Cell Subsets and Geminal Centers
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* John F. Kearney, University of Alabama, Birmingham, USA
Marginal Zone B-lymphocytes: Development and Function.

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
V Region Repertoires Generated by VH to JH Joining and VH Replacement

Jeffrey L. Browning, Boston University School of Medicine, USA
Short Talk: Effects of FDC Dissolution on Ig Responses in Normal Mice

Frederick W. Alt, Boston Children's Hospital, USA
AID and DNA Deamination in Antibody Gene Diversification.

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 2

Rainbow/Twilight/Aspen

THURSDAY, MARCH 31

06:30—08:00
Breakfast

3 Saddles/Sevens/Bear River
08:00—11:00
Somatic Hypermutation, Class Switching and VDJ Recombination
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
AID: How Does it Aid Antibody Diversity?

Michael S. Neuberger, Medical Research Council, UK
Antibody Somatic Hypermutation and DNA Deamination

Janet M. Stavnezer, University of Massachusetts Medical School, USA
Short Talk: AID-Dependent DNA Breaks during Antibody Class Switching

Michael R. Lieber, University of Southern California, USA
Non-B DNA Structures and NHEJ in Physiologic and Pathologic Gene Rearrangements

David B. Roth, New York University School of Medicine, USA
Short Talk: The Recombinase as Gatekeeper Linking V(D)J REcombination to DNA Repair

Jane A. Skok, New York University School of Medicine, USA
Short Talk: Allelic Exclusion: The Contribution of Locus Decontraction and Centromeric Recruitment

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Aspen
13:00—22:00
Poster Viewing

Rainbow/Twilight/Aspen
14:30—16:00
Workshop 5: VDJ Recombination, Somatic Hypermutation, and Isotype Switching

Sunshine Peak
* Eugene M. Oltz, Vanderbilt University School of Medicine, USA
Accessibility Control of V(D)J Recombination by Promoter/Enhancer Crosstalk

Ann J. Feeney, The Scripps Research Institute, USA
Correlation between the Level of Histone Acetylation and VH Gene Rearrangement Frequency

Anne E. Corcoran, Babraham Institute, UK
Antisense Intergenic Transcription: A General Role in Ordered V(D)J Recombination

Eric Bertolino, University of Chicago, USA
Regulation of IL-7 Dependent Immunoglobulin VH Gene Rearrangements by Stat5

Lisa Borghesi, University of Pittsburgh, USA
Distinct Effects of E47 on Development and Differentiation of Common Lymphoid Progenitors

Katheryn D. Meek, Michigan State University, USA
Separate Clusters of Autophosphorylation Sites in DNA-PKcs Regulate Distinct Steps in DNA End Processing

* Amy L. Kenter, University of Illinois College of Medicine, USA
Chromatin Modification in S Regions is Dependent on AID

Ursula Storb, University of Chicago, USA
Mechanism of Somatic Hypermutation of Immunoglobulin Genes

Patricia J. Gearhart, NIA, National Institutes of Health, USA
MSH2-MSH6 Stimulates DNA Polymerase Eta, Suggesting a Role for A:T Mutations in Antibody Genes

Andrea Bottaro, University of Rochester School of Medicine and Dentistry, USA
Functional Phylogenetics of Activation-Induced Deaminase

14:30—16:00
Workshop 6: B Cell Subsets and Homeostasis

Storm Peak
* Stephen H. Clarke, University of North Carolina at Chapel Hill, USA
Pre-Plasma Cells Define a Checkpoint for Autoreactive B Cells in Normal Mice

* Shiv Pillai, Massachusetts General Hospital, USA
The BCR Drives Lineage Commitment during B Lymphocyte Development

Rachel A. Liberatore, Columbia University, USA
c-Abl Signaling Contributes to the Generation of Peritoneal B-1 Cells

Robert Berland, Tufts University, USA
Targeted Deletion of the CD5 Enhancer

Ramon Roozendaal, Crucell, Netherlands
Identification of a Novel C4 Receptor Expressed on Subsets of Mouse B-Cells

David Mark Mills, Arena Pharmaceuticals, USA
Regulation of ICOSL Expression/Signaling by BAFF

Sarah F. Andrews, National Institutes of Health, USA
BAFF Promotes Formation of a Functionally Mature B-Cell Receptor

Bhaskar Srivastava, University of Pennsylvania, USA
Lymphopenia Induces Development of Marginal Zone B Cells from Follicular B Cells

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
B Cell Transformation Mechanisms
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
André Nussenzweig, NCI, National Institutes of Health, USA
Chromatin Dynamics at DNA Double Strand Breaks

Louis M. Staudt, NCI, National Institutes of Health, USA
Molecular Profiling of Human Lymphomas and Myelomas

* Riccardo Dalla-Favera, Columbia University, USA
Molecular Pathogenesis of B Cell Lymphomas

David G. Schatz, Yale University School of Medicine, USA
Short Talk: Histone Modification in Somatic Hypermutation and Class Switching

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 3

Rainbow/Twilight/Aspen

FRIDAY, APRIL 1

06:30—08:00
Breakfast

3 Saddles/Sevens/Bear River
08:00—11:15
Affinity Maturation and Memory B Cells
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Garnett H. Kelsoe, Duke University and Medical Center, USA
Inflammation, Affinity Maturation, and Extramedullary Lymphopoiesis

Thomas J. Waldschmidt, University of Iowa, USA
Regulation of the Germinal Center Response in Normal and Autoimmune Mice

Takaharu Okada, RIKEN, Japan
Short Talk: Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Antigen-Specific Memory B Cell Subsets

David M. Tarlinton, Monash University, Australia
Short Talk: The Germinal Center to Plasma Cell Transition

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Exploring and Exploiting Human B Cell Memory

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Aspen
13:00—22:00
Poster Viewing

Rainbow/Twilight/Aspen
14:30—16:00
Workshop 7: B Cell Malignancy

Storm Peak
* Nicholas Chiorazzi, Feinstein Institute for Medical Research, USA

Maxime Hervé, Novartis Institute for Tropical Disease, Singapore
Unmutated and Mutated Chronic Lymphocytic Leukemia B Cells Derive from Common Self-Reactive B Cell Precursors Despite Expressing Different Antibody Reactivity

Carel J. M. van Noesel, Academic Medical Center, Netherlands
Antigen Receptors of Mature B-cell non Hodgkin’s Lymphomas: MALT Lymphomas Express a Distinctive Antibody Repertoire with Frequent Autoreactivity

Wendy F. Davidson, NIAID-National Institutes of Health, USA
Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl

* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Aberrant Expression and Activation of Multiple Receptor Tyrosine Kinases in Classical Hodgkin Lymphoma

Demin Wang, Blood Research Institute, Milwaukee, WI, USA
Phospholipase Cgamma2 Deficiency Accelerates Myc-Mediated Proliferation and Lymphomagenesis

Davide F. Robbiani, Rockefeller University, USA
Somatic Activation of MYC and BCL6 Induces Multiple Myeloma and Diffuse Lymphoma in Mice

Rhine R. Shen, Dana-Farber Cancer Institute, USA
TCL1 Augments Activation Induced Cytidine Deaminase (AID) Expression in Support of Germinal Center B Cell Transformation

Laura Pasqualucci, Columbia University, USA
Extent and Mechanism of Aberrant Somatic Hypermutation in Diffuse Large B-Cell Lymphoma

14:30—16:00
Workshop 8: B Cell Immune Responses

Sunshine Peak
* Lynn M. Corcoran, Walter and Eliza Hall Institute of Medical Research, Australia
Differential Requirement for OBF-1 during Antibody Secreting Cell Differentiation

* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Competition and Compartmentalization of Plasmablasts and Plasma Cells

Nicholas D. Huntington, Walter and Eliza Hall Institute, WEHI, Australia
Dissecting the Requirement for BCR Signals in T-D Immune Responses

Falk Hiepe, Charité - Universitätsmedizin Berlin, Germany
Long-Lived Plasma Cells Contribute Significantly to Autoantibody Production in Systemic Lupus Erythematosus (SLE) and Represent a Novel and Essential Target for Cellular Therapies

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Long Term B Cell Memory in Humans After Smallpox Vaccination

Thierry C. Defrance, INSERM, France
The Endoplasmic Reticulum is the Central Executioner of Plasma Cell Death

Rachel Ettinger, MedImmune, USA
IL-21 Drives Terminal Differentiation of Human Naïve B Cells into Antibody Secreting Plasma Cells

Anatoly V. Rubtsov, University of Colorado Health Sciences Center, USA
Lsc Regulates Marginal Zone B Cell Migration and Adhesion and is Necessary for the IgM T-Dependent Primary Antibody Response

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Plasma Cells
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
Hergen Spits, University of Amsterdam, Netherlands
Short Talk: Role of Stat5 in Human Memory B Cell Development

* Kathryn L. Calame, Columbia College of Physicians and Surgeons, USA
The Roles of B Lymphocyte Induced Maturation Protein in Lymphocyte Differentiation

Linda M. Hendershot, St. Jude Children's Research Hospital, USA
Plasma Cell Differentiation and the Unfolded Protein Response

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: Plasma Cell Differentiation in Humans

Paul A. Wade, NIEHS, National Institutes of Health, USA
Short Talk: MTA3 in GC and B Cell Differentiation

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 4

Rainbow/Twilight/Aspen

SATURDAY, APRIL 2

06:30—08:00
Breakfast

3 Saddles/Sevens/Bear River
08:00—11:00
B Cells, Autoimmunity, and Immunodeficiency
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Toll-like Receptor Signaling in Systemic Autoimune Disease

Jan S. Erikson, Wistar Institute, USA
The Regulation and Activation of Lupus-Associated B Cells

Martin G. Weigert, University of Chicago, USA
Anti-DNA Antibodies and Autoimmunity

* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Activation and Regulation of Autoreactive B Cells in vivo

Timothy W. Behrens, Genentech, Inc., USA
Short Talk: Signaling through the BCR Shuts Off Receptor Editing

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
B Cell Tolerance
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
Carola G. Vinuesa, Australian National University, Australia
Tolerogenic Signaling in B Cells

Kyoko Hayakawa, Fox Chase Cancer Center, USA
Selection of B-1 B Cells Producing Natural Autoantibody

* Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Development of Autoantibodies in Normal Humans and in Patients with SLE

Gregg J. Silverman, New York University Langone Medical Center, USA
Short Talk: Peripheral B Cell Tolerance

20:00—21:00
Social Hour

Foyer/Grand Ballroom
20:00—23:00
Entertainment

Grand Ballroom

SUNDAY, APRIL 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research
GlaxoSmithKline Research & Development, Ltd.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676