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This meeting took place in 2005
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies (J2)
Organizer(s) Scott R. Barnum, Iain L. Campbell and Pedro R. Lowenstein
January 11—15, 2005
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 17, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 11, 2004
Sponsored by Sanofi-Aventis Pharmaceuticals, Inc. and The Director's Fund
Joint Meeting:
Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
Summary of Meeting:
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.
View Scholarships/Awards
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 11
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
WEDNESDAY, JANUARY 12
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
THURSDAY, JANUARY 13
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
FRIDAY, JANUARY 14
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
SATURDAY, JANUARY 15
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 11
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Scott R. Barnum,
University of Alabama, Birmingham, USA
Jonathon D. Sedgwick,
Eli Lilly and Company, USA
Insights at the Molecular Level of Cell-Cell Interactions Modulating Microglial Cell Activation and Brain Inflammation
Insights at the Molecular Level of Cell-Cell Interactions Modulating Microglial Cell Activation and Brain Inflammation
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Bruce W. Chesebro,
Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Direct and Indirect Mechanisms of Pathogenesis in TSE Diseases
Direct and Indirect Mechanisms of Pathogenesis in TSE Diseases
08:00—11:15
Molecular Effectors of CNS Inflammation
Meeting has ended...abstracts no longer viewable online.
*
Trevor Owens,
University of Southern Denmark, Denmark
Immune-glial interactions in induction and regulation of CNS inflammation
Immune-glial interactions in induction and regulation of CNS inflammation
Iain L. Campbell,
University of Sydney, Australia
Cytokine Signaling in CNS Inflammation and Disease
Cytokine Signaling in CNS Inflammation and Disease
Scott R. Barnum,
University of Alabama, Birmingham, USA
Complement and Demyelinating Disease: Not as Simple as We Thought
Complement and Demyelinating Disease: Not as Simple as We Thought
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
08:00—11:00
TSE in Humans and Animals
Meeting has ended...abstracts no longer viewable online.
*
Jean C. Manson,
Institute for Animal Health, Edinburgh, UK
Gino Miele,
University Hospital of Zürich, Switzerland
Transcription Profiling of Prion Diseases
Transcription Profiling of Prion Diseases
Markus Glatzel,
Hamburg University, Germany
Peripheral Pathogenesis of Human Prion Diseases
Peripheral Pathogenesis of Human Prion Diseases
Suzette A. Priola,
Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Acute versus Persistent PrP-res Formation during Establishment of a TSE Infection
Acute versus Persistent PrP-res Formation during Establishment of a TSE Infection
George A. Carlson,
McLaughlin Research Institute, USA
Short Talk: Dissection of Genetic Susceptibility to Prion Disease In Vivo and In Vitro
Short Talk: Dissection of Genetic Susceptibility to Prion Disease In Vivo and In Vitro
Richard S. Stewart,
Washington University School of Medicine, USA
Short Talk: Neurodegenerative Illness Induced in Transgenic Mice by Transmembrane PrP is Dependent upon Expression of Endogenous PrP
Short Talk: Neurodegenerative Illness Induced in Transgenic Mice by Transmembrane PrP is Dependent upon Expression of Endogenous PrP
17:00—19:15
Brain Entry of Cellular Effectors of CNS Inflammation
Meeting has ended...abstracts no longer viewable online.
Britta Engelhardt,
Theodor Kocher Institute/Universitat Bern, Switzerland
Molecular Steps involved in T lymphocyte migration across the blood-brain barrier
Molecular Steps involved in T lymphocyte migration across the blood-brain barrier
Francesca Aloisi,
Instituto Superior de Sanita, Italy
Lymphod neogenesis in the inflamed CNS
Lymphod neogenesis in the inflamed CNS
Candice C. Clay,
University of California, Davis, USA
Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS
Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS
Dorian B. McGavern,
National Institutes of Health, USA
Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection
Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection
Dyana K. Dalton,
Dartmouth Medical School, USA
Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE
Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
17:00—19:00
Structure and Propagation of Prion Proteins
Meeting has ended...abstracts no longer viewable online.
*
Susan Lindquist,
HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly
Prion Assembly and Disassembly
Byron Caughey,
Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Uptake and Neuritic Transport of PrP-res Coincident with Scrapie Infection of Neuronal Cells
Uptake and Neuritic Transport of PrP-res Coincident with Scrapie Infection of Neuronal Cells
Reed B. Wickner,
National Institutes of Health, USA
The [URE3] Prion: Ure2p Prion Domain and Prion Generation
The [URE3] Prion: Ure2p Prion Domain and Prion Generation
Ilia V. Baskakov,
University of Maryland School of Medicine, USA
Short Talk: The First Synthetic Mammalian Prion
Short Talk: The First Synthetic Mammalian Prion
08:00—11:00
New Perspectives in Neurodegeneration: From Prions to Inflammation (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Pedro R. Lowenstein,
University of Michigan School of Medicine, USA
Adriano M. Aguzzi,
University Hospital of Zürich, Switzerland
Immunology and Immunopathology of Prion Infections
Immunology and Immunopathology of Prion Infections
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
CNS Inflammation: Friend or Foe?
CNS Inflammation: Friend or Foe?
Neil Mabbott,
Institute for Animal Health, UK
Prions and the Immune System: Identifying Targets for Intervention
Prions and the Immune System: Identifying Targets for Intervention
Monica J. Carson,
University of California, Riverside, USA
Microglia and the Regulation of Autoreactive Immune Responses
Microglia and the Regulation of Autoreactive Immune Responses
17:00—19:15
Inflammation: Good or Bad in Neurodegeneration?
Meeting has ended...abstracts no longer viewable online.
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Genetic Dissection of Inflammation in Neurodegenerative Diseases
Genetic Dissection of Inflammation in Neurodegenerative Diseases
Vitaly Vasilevko,
University of California, Irvine, USA
Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease
Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease
John M. Hallenbeck,
National Institutes of Health, USA
Cytokines in the Initiation and Immunomodulation of Stroke
Cytokines in the Initiation and Immunomodulation of Stroke
Stanley H. Appel,
Methodist Neurological Institute, USA
Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease
Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease
Ikuo Tsunoda,
Louisiana State University, USA
Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?
Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?
Palwinder K. Mander,
GlaxoSmithkline, UK
Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration
Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
17:00—19:00
Modeling Prion Diseases
Meeting has ended...abstracts no longer viewable online.
*
Charles Weissmann,
Scripps Institute, USA
Stanley B. Prusiner,
University of California, San Francisco, USA
Mad Cows and Synthetic Prions
Mad Cows and Synthetic Prions
Jean C. Manson,
Institute for Animal Health, Edinburgh, UK
Host PrP in the Control of TSE Disease
Host PrP in the Control of TSE Disease
Giovanna R. Mallucci,
University of Leicester, UK
Targeting Cellular Prion Protein: A New Therapeutic Goal in Prion Disease
Targeting Cellular Prion Protein: A New Therapeutic Goal in Prion Disease
John Collinge,
Institute of Neurology, University College London, UK
Title to be Determined
Title to be Determined
08:00—11:15
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Meeting has ended...abstracts no longer viewable online.
*
Iain L. Campbell,
University of Sydney, Australia
Kenneth C. Williams,
Boston College, USA
Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression
Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression
John K. Fazakerley,
University of Edinburgh, UK
Innate and Adaptive Immune Responses in Viral Encephalitis
Innate and Adaptive Immune Responses in Viral Encephalitis
Jay A. Nelson,
University of Nebraska Medical Center, USA
Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis
Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis
Martina Deckert,
University of Cologne, Germany
Immune Reactions in Bacterial and Parasitic Infections of the CNS
Immune Reactions in Bacterial and Parasitic Infections of the CNS
Robyn S. Klein,
Washington University School of Medicine, USA
Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis
Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis
Pedro R. Lowenstein,
University of Michigan School of Medicine, USA
Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences
Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
08:00—11:00
Workshop: Hot Topics
Meeting has ended...abstracts no longer viewable online.
*
Surachai Supattapone,
Dartmouth Medical School, USA
Biochemical Studies of Prion Protein Conformation and Conversion
Biochemical Studies of Prion Protein Conformation and Conversion
Gianluigi Zanusso,
University of Verona, Italy
Biochemical Fingerprints of Human and Bovine Prions
Biochemical Fingerprints of Human and Bovine Prions
Jiyan Ma,
Ohio State University, USA
Retro-Translocation of PrP to the Cytosol and its Potential Roles in Prion Disease
Retro-Translocation of PrP to the Cytosol and its Potential Roles in Prion Disease
Sami J. Barmada,
Washington University School of Medicine, USA
Short Talk: Visualization of Prion Infection in Transgenic Mice Expressing GFP-Tagged Prion Protein
Short Talk: Visualization of Prion Infection in Transgenic Mice Expressing GFP-Tagged Prion Protein
Per Hammarström,
Linkoping University, Sweden
Short Talk: Novel Conformational Probes for Protein Misfolding Diseases
Short Talk: Novel Conformational Probes for Protein Misfolding Diseases
17:00—19:00
Inflammation, Stem Cells and Neurogenesis
Meeting has ended...abstracts no longer viewable online.
*
Francesca Aloisi,
Instituto Superior de Sanita, Italy
Theo D. Palmer,
Stanford University Medical Center, USA
Inflammatory Modulation of Adult Hippocampal Neurogenesis
Inflammatory Modulation of Adult Hippocampal Neurogenesis
Larisa Poluektova,
University of Nebraska Medical Center, USA
Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis
Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis
Evan Snyder,
Sanford-Burnham Medical Research Institute, USA
Inflammation, Stem Cells and Neurogenesis
Inflammation, Stem Cells and Neurogenesis
Gianvito Martino,
San Raffaele Scientific Institute, Italy
Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders
Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders
Following Session is for Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
17:00—19:00
Diagnostics and Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
R. Anthony Williamson,
The Scripps Research Institute, USA
Antibodies and Prion Biology
Antibodies and Prion Biology
Qingzhong Kong,
Case Western Reserve University, USA
Human Prion Disease
Human Prion Disease
Herbert Budka,
Medical University of Vienna, Austria
David Peretz,
Novartis, USA
Short Talk
Short Talk
*Session Chair †Invited, not yet responded.
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