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This meeting took place in 2005



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Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies (J2)


Organizer(s) Scott R. Barnum, Iain L. Campbell and Pedro R. Lowenstein
January 11—15, 2005
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 17, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 11, 2004

Sponsored by Sanofi-Aventis Pharmaceuticals, Inc. and The Director's Fund


Summary of Meeting:
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 11

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Mezzanine & Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Scott R. Barnum, University of Alabama, Birmingham, USA

Jonathon D. Sedgwick, Eli Lilly and Company, USA
Insights at the Molecular Level of Cell-Cell Interactions Modulating Microglial Cell Activation and Brain Inflammation

19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Bruce W. Chesebro, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Direct and Indirect Mechanisms of Pathogenesis in TSE Diseases


WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby
08:00—11:15
Molecular Effectors of CNS Inflammation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Trevor Owens, University of Southern Denmark, Denmark
Immune-glial interactions in induction and regulation of CNS inflammation

Iain L. Campbell, University of Sydney, Australia
Cytokine Signaling in CNS Inflammation and Disease

Scott R. Barnum, University of Alabama, Birmingham, USA
Complement and Demyelinating Disease: Not as Simple as We Thought

V. Wee Yong, University of Calgary, Canada
Matrix Metalloproteinases

08:00—11:00
TSE in Humans and Animals
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Jean C. Manson, Institute for Animal Health, Edinburgh, UK

Gino Miele, University Hospital of Zürich, Switzerland
Transcription Profiling of Prion Diseases

Markus Glatzel, Hamburg University, Germany
Peripheral Pathogenesis of Human Prion Diseases

Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Acute versus Persistent PrP-res Formation during Establishment of a TSE Infection

George A. Carlson, McLaughlin Research Institute, USA
Short Talk: Dissection of Genetic Susceptibility to Prion Disease In Vivo and In Vitro

Richard S. Stewart, Washington University School of Medicine, USA
Short Talk: Neurodegenerative Illness Induced in Transgenic Mice by Transmembrane PrP is Dependent upon Expression of Endogenous PrP

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Wasatch/Superior/Superior Lobby
13:00—22:00
Poster Viewing

Wasatch/Superior/Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:15
Brain Entry of Cellular Effectors of CNS Inflammation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Richard M. Ransohoff, Third Rock Ventures, USA
Chemokines

Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Molecular Steps involved in T lymphocyte migration across the blood-brain barrier

Francesca Aloisi, Instituto Superior de Sanita, Italy
Lymphod neogenesis in the inflamed CNS

Candice C. Clay, University of California, Davis, USA
Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS

Dorian B. McGavern, NINDS, National Institutes of Health, USA
Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection

Dyana K. Dalton, Dartmouth Medical School, USA
Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE

17:00—19:00
Structure and Propagation of Prion Proteins
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly

Byron Caughey, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Uptake and Neuritic Transport of PrP-res Coincident with Scrapie Infection of Neuronal Cells

Reed B. Wickner, National Institutes of Health, USA
The [URE3] Prion: Ure2p Prion Domain and Prion Generation

Ilia V. Baskakov, University of Maryland School of Medicine, USA
Short Talk: The First Synthetic Mammalian Prion

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
19:30—22:00
Poster Session 1

Wasatch/Superior/Superior Lobby

THURSDAY, JANUARY 13

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby
08:00—11:00
New Perspectives in Neurodegeneration: From Prions to Inflammation (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Pedro R. Lowenstein, University of Michigan School of Medicine, USA

Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunology and Immunopathology of Prion Infections

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
CNS Inflammation: Friend or Foe?

Neil Mabbott, Institute for Animal Health, UK
Prions and the Immune System: Identifying Targets for Intervention

Monica J. Carson, University of California, Riverside, USA
Microglia and the Regulation of Autoreactive Immune Responses

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Wasatch/Superior/Superior Lobby
13:00—22:00
Poster Viewing

Wasatch/Superior/Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:15
Inflammation: Good or Bad in Neurodegeneration?
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* V. Wee Yong, University of Calgary, Canada

Tony Wyss-Coray, Stanford University School of Medicine, USA
Genetic Dissection of Inflammation in Neurodegenerative Diseases

Vitaly Vasilevko, University of California, Irvine, USA
Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease

John M. Hallenbeck, National Institutes of Health, USA
Cytokines in the Initiation and Immunomodulation of Stroke

Stanley H. Appel, Methodist Neurological Institute, USA
Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease

Ikuo Tsunoda, Louisiana State University, USA
Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?

Palwinder K. Mander, GlaxoSmithkline, UK
Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration

17:00—19:00
Modeling Prion Diseases
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Charles Weissmann, Scripps Institute, USA

Stanley B. Prusiner, University of California, San Francisco, USA
Mad Cows and Synthetic Prions

Jean C. Manson, Institute for Animal Health, Edinburgh, UK
Host PrP in the Control of TSE Disease

Giovanna R. Mallucci, University of Leicester, UK
Targeting Cellular Prion Protein: A New Therapeutic Goal in Prion Disease

John Collinge, Institute of Neurology, University College London, UK
Title to be Determined

19:00—20:00
Social Hour

Wasatch/Superior/Superior Lobby
19:30—22:00
Poster Session 2

Wasatch/Superior/Superior Lobby

FRIDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliff/Superior Lobby
08:00—11:15
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Iain L. Campbell, University of Sydney, Australia

Kenneth C. Williams, Boston College, USA
Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression

John K. Fazakerley, University of Edinburgh, UK
Innate and Adaptive Immune Responses in Viral Encephalitis

Jay A. Nelson, University of Nebraska Medical Center, USA
Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis

Martina Deckert, University of Cologne, Germany
Immune Reactions in Bacterial and Parasitic Infections of the CNS

Robyn S. Klein, Washington University School of Medicine, USA
Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis

Pedro R. Lowenstein, University of Michigan School of Medicine, USA
Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences

08:00—11:00
Workshop: Hot Topics
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Surachai Supattapone, Dartmouth Medical School, USA
Biochemical Studies of Prion Protein Conformation and Conversion

Gianluigi Zanusso, University of Verona, Italy
Biochemical Fingerprints of Human and Bovine Prions

Jiyan Ma, Ohio State University, USA
Retro-Translocation of PrP to the Cytosol and its Potential Roles in Prion Disease

Sami J. Barmada, Washington University School of Medicine, USA
Short Talk: Visualization of Prion Infection in Transgenic Mice Expressing GFP-Tagged Prion Protein

Per Hammarström, Linkoping University, Sweden
Short Talk: Novel Conformational Probes for Protein Misfolding Diseases

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Inflammation, Stem Cells and Neurogenesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Francesca Aloisi, Instituto Superior de Sanita, Italy

Theo D. Palmer, Stanford University Medical Center, USA
Inflammatory Modulation of Adult Hippocampal Neurogenesis

Larisa Poluektova, University of Nebraska Medical Center, USA
Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis

Evan Snyder, Sanford-Burnham Medical Research Institute, USA
Inflammation, Stem Cells and Neurogenesis

Gianvito Martino, San Raffaele Scientific Institute, Italy
Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders

17:00—19:00
Diagnostics and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* R. Anthony Williamson, The Scripps Research Institute, USA
Antibodies and Prion Biology

Qingzhong Kong, Case Western Reserve University, USA
Human Prion Disease

Herbert Budka, Medical University of Vienna, Austria

David Peretz, Novartis, USA
Short Talk

20:00—21:00
Social Hour

Ballroom 1-3
20:00—23:00
Entertainment

Ballroom 1-3

SATURDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-NS050910-01




We gratefully acknowledge additional support for this conference from:

Sanofi US
Alzheimer's Association


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational grant from Lilly USA, LLC


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676