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This meeting took place in 2005



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Leukocyte Trafficking: Cellular and Molecular Mechanisms (C1)


Organizer(s) Eugene C. Butcher and Ulrich H. von Andrian
March 1—6, 2005
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Nov 1, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 3, 2005

Sponsored by ICOS Corporation and The Director's Fund

Summary of Meeting:
The past several years have seen considerable progress in our understanding of inflammation-, tissue-, and microenvironment-selective leukocyte trafficking and its role in immune responses and inflammation. Many adhesion and chemoattractant receptors and ligands that regulate leukocyte migration have been defined, as well as lipid-based traffic modulators and enzymes and signaling molecules involved. Their combinatorial use establishes trafficking programs that correlate with and help define the functional specialization of leukocyte subsets. Recent studies have demonstrated how tissue-specific antigen-presentation in secondary lymphoid organs induces B and T cells to acquire specialized adhesion and chemoattractant receptors, and how these pathways subsequently target antigen-experienced lymphocytes and their effector cell progeny in vivo. New imaging techniques provide unprecedented glimpses of these migratory dynamics in situ. Clinical trials are testing the efficacy of pharmacologic modulation of leukocyte traffic in autoimmune diseases. This program will bring together experts in the physiology and molecular biology of leukocyte trafficking to discuss the latest developments in the field, and to develop strategies for applying these insights to understanding and manipulating immune responses in vivo.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 1

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Steven D. Rosen, University of California, San Francisco, USA


WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Lymphocyte Migration and Cell-Cell Interactions within Tissues
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Eugene C. Butcher, Stanford University, USA

* Ulrich H. Von Andrian, Harvard Medical School, USA

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Chemokines, S1P and Cell Migration in Lymphoid Tissues

Reina E. Mebius, Vrije Universiteit, Netherlands
Cellular Interactions in Secondary and Tertiary Lymphoid Structure Formation

Gudrun F. Debes, University of Pennsylvania, USA
Short Talk: CCR7 is Required for T Cell Exit from Peripheral Tissues

Michael L. Dustin, University of Oxford, UK
Intravital imaging of immunity in mice: patrolling networks

Thorsten R. Mempel, Massachusetts General Hospital, USA
Intravital Immunology: T cell Activation and Effector Function In Vivo

Marko Salmi, University of Turku, Finland
Short Talk: Adhesion Molecule CLEVER-1 Regulates Leukocyte Traffic both in the Vascular and Lymphatic Vessels

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: In situ Visualization of Lymphocyte Migration and Activation

Chamisa Ballroom 1
* Christopher H. Contag, Institute for Quantitative Health Sciences and Engineering, USA
Whole Body Imaging of Lymphocyte Trafficking

Michael D. Cahalan, University of California, Irvine, USA
Imaging T Cell Interactions with Dendritic Cells and B Cells in Lymph Node

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Dendritic Cell - Lymphocyte Interactions In Vivo

James T. Rosenbaum, Oregon Health & Science University, USA
Using the Eye to Image the Immune Response

Richard S. Lewis, Stanford University School of Medicine, USA
Calcium Oscillations Control Thymocyte Motility during Positive Selection in the Three-Dimensional Thymic Environment

16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Different Perspectives on Cell Migration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Reina E. Mebius, Vrije Universiteit, Netherlands

Philippe Herbomel, Institut Pasteur, France
Macrophage Migration in Zebrafish Embryos

Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Dynamic Mechanisms of Immune-Cell Interactions and Tumor Invasion

* John (Jack) B. Hay, University of Toronto, Canada
Insights from Large Animal Studies of Lymphocyte Recirculation

Adam Lacy-Hulbert, Benaroya Research Institute, USA
Short Talk: Roles for alpha (v) Integrins in Marginal Zone and B1 B Cell Trafficking and Activation Revealed by Conditional Gene Deletion

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, MARCH 3

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Chemokines and Novel Attractants in Leukocyte Trafficking
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jason G. Cyster, HHMI/University of California, San Francisco, USA

Bernhard Moser, Cardiff University School of Medicine, UK
Gamma Delta T Cell Trafficking

* Osamu Yoshie, Kinki University, Japan
Antimicrobial and Related Activities of Chemokines

Gerry J. Graham, University of Glasgow, UK
Regulation of the inflammatory response by the chemokine receptor D6

Brian A. Zabel, Stanford University, USA
CMKLR1, Chemerin, and Plasmacytoid Dendritic Cell Recruitment to Sites of Tissue Damage: Linking Hemostasis, Inflammation, and Immunity

Wolfgang Weninger, Centenary Institute, Australia
A Novel Mouse Model to Study Trafficking of Plasmacytoid Dendritic Cells in vivo

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Adhesion Molecules and Signaling in Leukocyte Arrest and Migration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Michael L. Dustin, University of Oxford, UK

Christopher V. Carman, Harvard Medical School, USA
Molecular and Cellular Regulation of Leukocyte Diapedesis

Carlo Laudanna, , Italy
Chemokine Signaling to Integrin Activation: Requirements for Lymphocyte/HEV Interactions in vivo

Ronen Alon, Weizmann Institute of Science, Israel
Short Talk: Rolling Lymphocytes Abruptly Arrest on Endothelial ICAM-1 through a Subsecond Bi-Directional LFA-1 Activation by Surface-Bound Chemokine and Juxtaposed Ligand

Alexandre Chigaev, University of New Mexico Health, USA
Short Talk: Real-Time Regulation of VLA-4 Affinity and Conformation under Shear: A Mechanism for Capture of Leukocytes by Endothelium

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, MARCH 4

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
In vivo Insights into Effector and Memory Cell Trafficking
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Alf Hamann, Charité University Medicine Berlin, Germany
Migration of Regulatory T cells

* Sirpa T. Jalkanen, University of Turku, Finland
Entrance and Exit Mechanisms in Leukocyte Trafficking: Role of VAP-1 and CLEVER-1

* Charles R. Mackay, Monash University, Australia
Gene Microarrays Reveal Migration Mechanisms for Different Types of Immune Responses

Chang Hwan Kim, Purdue University, USA
Short Talk: Regulatory T Cells Programmed to Home to Follicles Suppress T Helper Activity and Humoral Immune Responses

Jorge Rodrigo Mora, Takeda Pharmaceuticals, USA
Short Talk: Reciprocal and Dynamic Control of T Cell Homing by Gut and Peripheral Dendritic Cells

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Dendritic Cells and Trafficking
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Regulation of dendritic cell and lymphocyte migration to lymph nodes

* Michael D. Gunn, Duke University Medical Center, USA
Antigen Presenting Cell Types Recruited to the Lung by MCP-1

Gwendalyn J. Randolph, Washington University, USA
Dendritic cell migration from the periphery to lymph nodes

Raymond A. Daynes, University of Utah School of Medicine, USA
Short Talk: Vaccine Adjuvants that Promote the Migration of Antigen Presenting Dendritic Cells from the Skin to Peyer’s Patches are Capable of Inducing both Systemic and Mucosal Immune Responses

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, MARCH 5

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Leukocyte Trafficking in Inflammation and Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Steven D. Rosen, University of California, San Francisco, USA

Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Chemokine- and E-Selectin-Dependent Neutrophil and Monocyte Arrest Under Flow

Antal Rot, University of York, UK
To Serve or Protect: The Biology of Chemokine Interceptors

* Sara Michie, Stanford University, USA
Short Talk: Lymphocyte Migration to Bronchus Associated Lymphoid Tissue

John B. Lowe, Genentech, Inc., USA
Glycan-Dependent Control of Leukocyte Biology

Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Roles of Glycosyltransferases and Sulfotransferases in the Synthesis of L-Selectin Ligands

P. Sriramarao, La Jolla Institute for Molecular Medicine, USA
Short Talk: Serotonin is a Potent Chemoattractant for Eosinophils and Functions Additively with Eotaxin

09:20—09:40
Coffee Break

Chamisa Lobby
14:30—16:30
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy for Autoimmune Diseases

Chamisa Ballroom 1
* Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
T Cell Traffic into the CNS

Michael Briskin, CSO Xios Pharmaceuticals, USA
Integrins as Therapeutic Targets for Inflammatory Bowel Disease

Jesús Rivera-Nieves, Inflammatory Bowel Disease Center, USA
Short Talk: P-Selectin Glycoprotein Ligand-1 (PSGL-1) is Expressed on Intestinal Microvascular Endothelium and its Blockade Attenuates Chronic Ileitis in SAMP1/YitFc Mice

Antje Margret Wengner, Imperial College London, UK
Short Talk: Critical Role of the Chemokine Receptors CXCR5 and CCR7 in the Initiation and Progression of Antigen-Induced Arthritis (AIA)

Robert Weissert, Merck Serono Intl. SA, Geneva Research Center, Switzerland
Short Talk: Targeting Cellular Trafficking in Experimental Autoimmune Encephalomyelitis

Katalin Mikecz, Rush University Medical Center, USA
Short Talk: Intravital Microscopy of Joints

16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Lipid Modulators of Leukocyte Traffic
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gwendalyn J. Randolph, Washington University, USA

Andrew D. Luster, Massachusetts General Hospital, USA
Leukotienes and Leukocyte Trafficking

Makoto Iwata, Tokushima Bunri University, Japan
Retinoic Acid Imprints Gut-Homing Specificity on T Cells

* Hugh Rosen, ActivX Biosciences, USA
Curious Evolution: S1P and the control of lymphocyte recirculation

Markus H. Gräler, Hannover Medical School, Germany
Short Talk: Influence of Sphingosine 1-Phosphate and Its Receptor S1P1 on Lymphocyte Migration and Immunity

19:00—20:00
Social Hour

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, MARCH 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-AI063841-01




We gratefully acknowledge additional support for this conference from:

Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company
EMD Serono, Inc.

ICOS Corporation Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676