Eldorado Hotel & Spa Floorplan

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This meeting took place in 2005



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Cytokines, Disease and Therapeutic Intervention (B4)


Organizer(s) John J. O'Shea, Robert Kastelein and Mary Collins
February 12—17, 2005
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Oct 12, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 13, 2004

Sponsored by Lilly Research Laboratories and The Director's Fund

Summary of Meeting:
With the completion of the human genome project, we will shortly know all of the cytokines encoded within our genome. Indeed within the last few years, there have been reports of at least ten new cytokines. While this will provide us with our "deck of cards", it is also clear that surprises continue to emerge regarding the function of cytokines we thought we knew well. Therefore, a major remaining problem is the understanding of the in vivo role of all these cytokines. Our comprehension of how cytokines work in concert in the protection against pathogens and in the pathogenesis of immune-mediated disease remains limited. Furthermore, the role of cytokines in immune homeostasis, lymphocyte memory and peripheral tolerance are actively being investigated. Equally exciting is the emergence of new cytokine and anti-cytokine therapies that have been remarkably effective. Our goals in this meeting are to review information on the newest cytokines, to provide new insights on their function in host defense and disease pathogenesis, to discuss new findings related to cytokine signaling and structure and to present the latest information on how manipulation of cytokines can be used therapeutically.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 12

15:00—19:30
Registration

Zia Concourse
18:30—19:30
Refreshments

Sunset Room
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Tim R. Mosmann, University of Rochester Medical Center, USA
T Helper Cell Differentiation Then and Now


SUNDAY, FEBRUARY 13

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Type I Cytokines and Immunoregulation
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Rose Zamoyska, University of Edinburgh, UK
IL-7 and Receptor Signals that Regulate Lymphocyte Homeostasis

Warren J. Leonard, National Institutes of Health, USA
IL-21 and Regulation of B Cell Function

* Christopher A. Hunter, University of Pennsylvania, USA
The Role of IL-27 in the Regulation of Th1 and Th2 Responses during Parasitic Infection

Daniel J. Cua, Merck Research Laboratories, USA
The Role of IL-23 in Chronic Inflammation

Nico Ghilardi, Genentech, Inc., USA
The Role of IL-27 in Autoimmune Disease

09:20—09:40
Coffee Break

South Concourse
11:15—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee & Snacks Available

South Concourse
17:00—19:00
Cytokine Signaling
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
John J. O'Shea, NIAMS, National Institutes of Health, USA
Signaling by Type I/II Cytokines

* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Signaling by IL-1 Receptor / Toll-Like Receptor Superfamily

Daniel Kastner, National Institutes of Health, USA
The Systemic Autoinflammatory Diseases: Inherited Disorders of Cytokine Signaling

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
Short Talk: In Vivo Responses to Thymic Stromal Lymphopoietin (TSLP).

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

MONDAY, FEBRUARY 14

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Cytokines in Inflammation and Development
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Susan L. Kalled, Shire Human Genetic Therapies, USA
BAFF Function in the Immune System: Prospects for the Utility of BAFF Blockade in Treating Autoimmune Disorders

John E. Sims, Amgen Inc., USA
IL-1 and IL-1R Family Members in Inflammatory Skin Disease

* Robert A. Kastelein, Merck Research Labs, USA
The Role of IL-23 in Chronic Inflammation Part II

Lothar Hennighausen, National Institutes of Health, USA
The Physiology and Cell-Specificity of Stat5 Signaling

Chaim Putterman, Albert Einstein College of Medicine, USA
Short Talk: TWEAK, a Novel TNF Ligand Superfamily Member, Induces Pro-Inflammatory Chemokines in Kidney Mesangial Cells

Linda C. Burkly, Biogen, Inc., USA
Short Talk: Anti-TWEAK mAbs Inhibit Mouse and Rat Collagen-Induced Arthritis

09:20—09:40
Coffee Break

South Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
15:00—16:30
Workshop 1: IL-17

Anasazi Ballroom
Florencia M. Mc Allister, , USA
IL-17 Pro-Inflammatory Responses in Human Bronchial Epithelial Cells: Implicationas for Cystic Fibrosis

Steven D. Levin, Alpine Immune Sciences, USA
Human and Mouse IL-17A and IL-17F Differentially Bind IL-17RA and IL-17RC

* Sarah L. Gaffen, University of Pittsburgh, USA
Gene Targets of Interleukin-17 Receptor Signaling: Relationship to Inflammatory Bone Disease

Alex M. Owyang, Rigel Pharmaceuticals Inc, USA
IL-25 is Required for the Regulation of Autoimmunity and Immunity to Parasites

16:30—17:00
Coffee & Snacks Available

South Concourse
17:00—19:00
Type II and Other Cytokines
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Rene de Waal Malefyt, Merck Research Labs, USA
The Role of TSLP in Allergic Inflammation

Sergei V. Kotenko, New Jersey Medical School, USA
Class II Cytokine Receptors and Their Ligands: Diversities and Similarities

Kevin Klucher, ZymoGenetics, Inc., USA
Short Talk: IL 28/29

Tomohiro Yoshimoto, Hyogo College of Medicine, Japan
Short Talk: IL-18-Stimulated Th1 Cells Induce Allergic Asthma

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

TUESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Cytokines and Disease Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Thomas A. Wynn, Pfizer, USA
Opposing Roles for IL-13 and its Decoy Receptor in Health and Disease

* Christine A. Biron, Brown University, USA
Cytokines and Viral Immunity

Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans

Robert D. Schreiber, Washington University School of Medicine, USA
The Molecular and Cellular Basis of Cancer Immunosurveillance and Immunoediting

Mette Ejrnaes, La Jolla Institute for Allergy and Immunology, USA
Short Talk: IL-21 in Models of Acute and Chronic LCMV Infection

09:20—09:40
Coffee Break

South Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
15:00—16:45
Workshop 2: Targeting Cytokines

Anasazi Ballroom
Norihiro Nishimoto, Wakayama Medical University, Japan
Anti-IL-6 Receptor Antibody Therapy for Immunological Diseases

* Foo Y. Liew, University of Glasgow, UK
Innate Mediators in Autoimmune Disease

Andrea Keane-Myers, National Institutes of Health, USA
Short Talk: Opposing Roles for IL-21 in Mouse Models of Asthma

Heni Rachmawati, University of Groningen, Netherlands
Short Talk: Chemically Modified Interleukin-10 (IL-10) with a Liver-Specific Ligand: A New Strategy for the Treatment of Liver Fibrosis with a Therapeutic Cytokine

Eugene A. Zhukovsky, Boehringer Ingelheim Pharmaceuticals, Inc., USA
Short Talk: Development of Dominant Negative Antagonists of BAFF for the Treatment of Autoimmune Diseases

Kyle I. Happel, Louisiana State University Health Sciences Center, USA
Short Talk: IL-23 is Critical to Survival during Pulmonary Infection with Klebsiella pneumoniae

16:30—17:00
Coffee & Snacks Available

South Concourse
17:00—19:00
Cytokines in Autoimmunity and Inflammation
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Padraic Fallon, Trinity College Dublin, Ireland
Helminth Modulation of Cytokines: Therapeutic Exploitation

* Mary Collins, Wyeth Research, USA
IL-21 in Inflammation and Autoimmunity

Christoph Binder, University of California, San Diego, USA
Cytokines and Cardiovascular Disease

Jean-Christophe Renauld, Ludwig Institute for Cancer Research, Belgium
Short Talk: Role of IL-13 in the Asthma-Like Phenotype Induced by IL-9 in vivo

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room

WEDNESDAY, FEBRUARY 16

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Targeting Cytokines II
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Trudi M. Veldman, AbbVie, USA
Anti-IL12 Antibody Development and Clinical Trial Data

Ivan J. Fuss, National Institutes of Health, USA
Anti-Interleukin-12 Antibody Treats Active Crohn’s Disease

Fabio Martinon, Harvard School of Public Health, USA
Short Talk: NALP3/Cryopyrin Forms an IL-1beta-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

* Marc Feldmann, University of Oxford, UK
TNF Antagonism and the Treatment of Autoimmune Disease

Gabor G. Illei, National Institutes of Health, USA
Short Talk: In vivo Blockade of the IL-6 Receptor Interferes with T and B Cell Differentiation and Activation in Patients with Systemic Lupus Erythematosus

Jonathan Zalevsky, Takeda San Diego, Inc., USA
Short Talk: Towards a Ligand-Selective TNF Antagonist: Optimization of Dominant-Negative TNF Proteins as Selective Inhibitors of Soluble TNF That Spare Transmembrane TNF in Animal Models of Inflammation and Infection

09:20—09:40
Coffee Break

South Concourse
16:30—17:00
Coffee & Snacks Available

South Concourse
17:00—19:00
Regulation of Cytokine Gene Expression
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Transcriptional Regulation of Cytokines

Stephen T. Smale, University of California, Los Angeles, USA
Nucleosome Remodeling and the Regulation of the Immune Response

* William E. Paul, NIAID, National Institutes of Health, USA
GATA3 and the Regulation of Th2 Function

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

THURSDAY, FEBRUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-AI063645-01




We gratefully acknowledge additional support for this conference from:

Lilly Research Laboratories Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Abbott Bioresearch Center


DNAX Research Institute


Educational donation provided by Amgen


Genentech, Inc.


Wyeth Research Labs


Biogen Idec


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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