Fairmont Banff Springs Floorplan

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This meeting took place in 2005



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HIV Pathogenesis (X7)


Organizer(s) Michael M. Lederman, Richard A. Koup and Michael H. Malim
April 9—15, 2005
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Dec 9, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 10, 2005


Summary of Meeting:
More than 20 years of basic and applied research have help to dissect the intimate relationship between HIV and its host. Since HIV targets, infects and compromises cells of the immune system, the interactions between this virus and host defenses are both especially complex and also offer key insights into mechanisms of cell biology, immune defenses and evolutionary adaptation. This Keystone symposium will focus on the mechanisms utilized by the virus for establishment of infection and propagation, protective innate and adaptive host defense mechanisms and mechanisms utilized by HIV to elude these defenses. This meeting will bring together scientists representing a number of different disciplines who have addressed these key issues. The goal of this meeting is to facilitate interdisciplinary interactions that will promote better insights into HIV disease pathogenesis.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 9

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
Douglas D. Richman, University of California, San Diego, USA
HIV Pathogenesis: Twenty Years of Successes and Failures

José G. Esparza, Bill & Melinda Gates Foundation, USA
Harnessing Science and Policy to Accelerate HIV Vaccine Development


SUNDAY, APRIL 10

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Transmission
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* John P. Moore, Weill Medical College of Cornell University, USA

Ashley T. Haase, University of Minnesota, USA
The Fast Phase of Slow Lentiviral Infection

Susan A. Allen, Emory University School of Public Health, USA
Couples' HIV Counseling and Testing in basic science research and public health

Yvette van Kooyk, Vrije University Medical Center, Netherlands
Viruses Use Carbohydrates to Escape Immunity Induced by Dendritic Cells

Andrew Blauvelt, Oregon Health & Science University, USA
CCR5-Mediated HIV Infection of Langerhans Cells

Clare Jolly, University College London, UK
Short Talk: Cell to Cell Spread of HIV-1 Across a Virological Synapse

08:00—11:20
Viral Diversity
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Carolyn Williamson, University of Cape Town, South Africa
Genetic Heterogeneity of Subtype C HIV-1 Infection in Africa

Francine McCutchan, PATH, USA
Screening for HIV-1 Dual Infection in Populations Exposed to Multiple Subtypes

Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Understanding and Explaining the Limitations of HIV Evolution

James I. Mullins, University of Washington, USA
HIV Evolution in Forward and Reverse

Chunfu Yang, Centers for Disease Control, USA
Short Talk: Genetic Diversification and Recombination of HIV-1 Group M in Kinshasa, Democratic Republic of Congo

Wendy M. Blay, Seattle Biomedical Research Institute, USA
Short Talk: Convergent Patterns of Change in Potential N-Linked Glycosylation (PNG) Sites of SHIV89.6p

Terri Wrin, Monogram Biosciences, USA
Short Talk: Evolution of HIV-1 Envelope and Antibody Neutralization Activity in Identical Twins and a Sibling Infected with the Same Virus

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Workshop 1: Intracellular Interactions

Van Horne Ballroom AB
* Greg J. Towers, University College London, UK

Vincent Piguet, Cardiff University, UK
Trafficking of HIV-1 to the Dendritic Cell-T cell Infectious Synapse Uses DC-SIGN and the Pathway of Tetraspanin Sorting to the Immunological Synapse

Mark E. Sharkey, Miller School of Medicine, University of Miami, USA
Stable Sequestration and Dissemination in Trans of Intracellular Virions by HIV-1 Infected Macrophages

Mojgan H. Naghavi, Centre for Research in Infectious Diseases, University College Dublin, Ireland
Overexpression of Fasciculation and Elongation Protein zeta-1 (FEZ1) Induces a Postentry Block to Retroviruses in Cultured Cells

Philippe Gallay, The Scripps Research Institute, USA
Interplay Between HIV-1 Capsid, Cyclophilin A and Primate Restriction

Thomas J. Hope, Northwestern University, USA
Cell Biology of TRIM5alpha

Eric Poeschla, University of Colorado School of Medicine, USA
Identification of the LEDGF/p75 HIV-1 Integrase-Interaction Domain and NLS Reveals NLS-Independent Chromatin Tethering

16:30—17:00
Coffee & Snacks Available

Van Horne Ballroom Foyer
17:00—19:15
Virus and Cells: The Way In
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Thomas J. Hope, Northwestern University, USA

Robert W. Doms, University of Pennsylvania School of Medicine, USA
HIV Entry and its Inhibition

Judy Lieberman, Harvard University, USA
Use of Small Interfering RNAs to Block Transmission of HIV and Other Sexually Transmitted Diseases

Stuart F.J. Le Grice, NCI, National Institutes of Health, USA
Reverse Transcription – A New Look at an Old Adversary

Frederic D. Bushman, University of Pennsylvania, USA
Targeting of HIV DNA Integration to Transcription Units: Tethering via a Human Transcription Factor

17:00—19:15
Transmission and Immune Escape
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* David I. Watkins, University of Miami, USA
CD8+ Responses in LTNP and Vaccinated Macaques

Eric Hunter, Emory University, USA
Env Determinants that Influence Neutralization Sensitivity - Lessons from Transmission Pairs

Georgia D. Tomaras, Duke University Medical Center, USA
Immune Escape in HIV-1 Infection

Catherine A. Blish, Stanford University School of Medicine, USA
Short Talk: Susceptibility of Recently Transmitted HIV-1 Variants to Neutralization by Autologous and Heterologous Plasma

Jesus F. Salazar-Gonzalez, University of Alabama at Birmingham, USA
Short Talk: HIV-1 Quasispecies Complexity in Acute and Early Infection

Marcus Altfeld, Heinrich-Pette-Institute, Germany
Short Talk: De-Novo Generation of HIV-1-Specific CD8+ T Cell Responses Directed Against CTL Escape Variants

19:15—20:15
Social Hour

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 1

New Brunswick, Alberta, Cascade

MONDAY, APRIL 11

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Protective Immunity I: Neutralizing Antibodies (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Lynn Morris, National Institute for Communicable Diseases, South Africa
Neutralizing Antibody Responses to Subtype C HIV-1 Infection in Africa

John R. Mascola, NIAID, National Institutes of Health, USA
Evaluating the Neutralizing Antibody Response Elicited by DNA and Recombinant Adenoviral Vaccines

Dennis R. Burton, The Scripps Research Institute, USA
Envelope on the Surface on HIV is Heterogeneous

George M. Shaw, University of Pennsylvania, USA
Antigenic Conservation and Immunogenicity of the Co-Receptor Binding Site and Membrane-Proximal External Region (MPER) of HIV-1 and HIV-2

Bing Chen, Children's Hospital Boston, USA
Short Talk: Structure of an Unliganded Simian Immunodeficiency Virus gp120 Core

Ping Zhu, Florida State University, USA
Short Talk: Cryo-Electron Microscopy of Envelope Spikes on SIV Surfaces

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Workshop 1: Immune Reconstitution and Augmentation

Van Horne Ballroom C
* Genoveffa Franchini, NCI, National Institutes of Health, USA
Testing Rational Approaches for Immune Therapy for HIV-1-Infected Individuals in the SIVmac251 Model

Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
A Novel Therapeutic Immunization Strategy Against HIV

Kevin N. Brown, University of Pittsburgh, USA
Short Talk: Disproportionate Loss of CD11c+ Lymph Node Dendritic Cells in AIDS Associated with Failed Langerhans Cell Migration is Overridden by Injection of Mature Monocyte-Derived Dendritic Cells

Moiz Kitabwalla, Lipid Sciences, Inc., USA
Short Talk: Delipidated Retroviruses as Potential Autologous Therapeutic Vaccines—A Pilot Experiment

Jean D. Boyer, University of Pennsylvania, USA
Short Talk: Dramatic Induction of Antigen Specific Immune Responses and Effects on Viral Rebound Analyzed in a Novel Chronic SIV Infection Treatment Modely by Optimized SIV DNA Antigens + IL-12 Adjuvant Vaccine

Barbara K. Felber, NCI, National Institutes of Health, USA
Short Talk: Control of Viremia after Antiretroviral Treatment and Therapeutic Vaccination with Novel forms of DNA Vaccines in Chronically SIVmac251-Infected Macaque

16:30—17:00
Coffee & Snacks Available

Van Horne Ballroom Foyer
17:00—19:00
Virus and Cells: The Way Out
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA

Jaisri R. Lingappa, University of Washington, USA
HIV-1 Capsid Assembly Intermediates: Biochemical Sites for Regulation of Anti-Viral Factors and Virus Production Kinetics

Ben Berkhout, University of Amsterdam, Academic Medical Center, Netherlands
HIV-1 Can Evade RNAi-Mediated Inhibition by Altering the Secondary Structure of its RNA Genome

Wesley I. Sundquist, University of Utah School of Medicine, USA
HIV-1 Budding

Elena Chertova, NCI, National Institutes of Health, USA
Short Talk: Proteomic and Biochemical Analysis of HIV-1 Produced from Human Monocyte-Derived Macrophages

17:00—19:15
Protective Immunity II: Cellular Responses
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Kent J. Weinhold, Duke University Medical Center, USA
Immunologic Hallmarks of Early Acute HIV-1 Infection in a Clade B Heterosexual Transmission Cohort - Insights for Vaccine Development

Clive M. Gray, National Institute for Communicable Diseases, South Africa
CD8+ T Responses Associated with Control of HIV-1 Subtype C Infections

Mark Connors, NIAID, National Institutes of Health, USA
Qualitative Features of an Effective HIV-Specific CD8+ T Cell Response

Bali Pulendran, Stanford University School of Medicine, USA
Modulating Vaccine Responses with Dendritic Cells and Pathogen Recognition Receptors

19:00—20:00
Social Hour

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 2

New Brunswick, Alberta, Cascade

TUESDAY, APRIL 12

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:15
Pathogenesis: Determinants of Disease Progression. Session Sponsored in Part by Gilead Sciences, Inc.
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Michael M. Lederman, Case Western Reserve University, USA

Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA
Studies HIV-1 Acquisition in the Absence and Presence of Existing Infection

Mary Carrington, NCI, National Institutes of Health, USA
The Influence of HLA on HIV: Relating Allelic Effects in Disease Progression to Those in Infection

Steven G. Deeks, University of California, San Francisco, USA
Immune Activation, Viral Fitness and Disease Progression

Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Lessons from Sooty Mangabeys

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immunology and Virology of Controlled HIV Infection

08:00—11:00
Novel Immunogens and Vaccine Concepts I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Stephen A. Udem, Wyeth Pharmaceuticals, USA
Next Generation pDNA and Recombinant VSV Vectored Vaccines for Immunization Against HIV

Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
Analysis of HIV-1 Envelope Glycoproteins for Immunogen Design to Elicit Broadly Neutralizing Antibodies

Feng Gao, Duke University Medical Center, USA
Immunogenicity of Consensus Envelope Immunogens

James E. Robinson, Tulane University Health Sciences Center, USA
Probing the Neutralization Face of HIV-1 Env with Human Monoclonal Antibodies

Robert G. Whalen, Altravax, Inc., USA
Short Talk: Use of Directed Molecular Evolution to Create Novel HIV-1 Envelope Variants Capable of Inducing Broadly Neutralizing Antibody Responses in Rabbits

Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Short Talk: Antigen- and Vector-Specific Immune Responses Elicited by rAd5, rAd35, and Chimeric rAd35k5 Vaccines for HIV/SIV in Rhesus Monkeys

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Workshkop 2: Immune Pathogenesis

Van Horne Ballroom AB
* Irini Sereti, NIAID, National Institutes of Health, USA

Arnaud Moris, INSERM - CNRS - UPMC - Hôpital Pitié-Salpêtrière, France
HIV-1 Antigen Presentation by DCs: Role of DC-SIGN

Karin Loré, Karolinska Institutet, Sweden
Productively Infected Myeloid and Plasmacytoid Dendritic Cells Transfer of HIV-1 Preferentially to Antigen-Specific CD4+ T-Cells

Jean Philippe Herbeuval, National Cancer Institute, National Institutes of Health, USA
AIDS Pathogenesis: Effect of HAART on TRAIL/DR5 Mediated CD4+ T Cell Apoptosis

Scott F. Sieg, Case Western Reserve University, USA
Circulating S Phase T Cells from HIV-Infected Persons are Prone to Die, Express Low Levels of bcl-2 and are Rescued from Apoptosis by Interleukin-2

Michael R. Betts, University of Pennsylvania, USA
HIV-Infected Long-Term Nonprogressors Maintain Polyfunctional HIV Specific CD8+ T Cell Responses of Diverse Memory Phenotypes

Emma L. Turnbull, Jenner Institute, University of Oxford, UK
Analysis of the Functional Cross-Reactivity and Clonality of HIV-Specific CD8+ T Cells Restricted by HLA Alleles Associated with Differing Rates of Progression to AIDS

16:30—17:00
Coffee & Snacks Available

Van Horne Ballroom Foyer
17:00—19:00
Late Breaking Developments
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Joseph Michael McCune, University of California, San Francisco, USA

* Richard A. Koup, NIAID, National Institutes of Health, USA

Cristian Apetrei, University of Pittsburgh, USA
Short Talk: SIVsm Derived from Naturally Infected Sooty Mangabeys Is Not Intrinsically Highly Pathogenic for Rhesus Macaques

Alfredo Garzino-Demo, University of Maryland School of Medicine, USA
Short Talk: Insights in the Mechanism of HIV Suppression by beta-Defensins

Sara R. Klucking, Emory University, USA
Short Talk: Functional Differences in Dendritic Cell Populations and Divergent Disease Outcomes in Primate Models of HIV Infection

Catherine S. Adamson, National Cancer Institute, National Institutes of Health, USA
Short Talk: Viral Resistance to PA-457, a Novel Inhibitor of HIV-1 Maturation: Insights in to the Drug Target and Mechanisms of Action

Joseph Mattapallil, Uniformed Services University of the Health Sciences, USA
Short Talk: Massive Infection and Loss of Memory CD4 T-cells in peripheral and mucosal Tissues During Acute SIV Infection

Alexandra Trkola, University of Zürich, Switzerland
Short Talk: Delay of HIV-1 Rebound after Cessation of Antiretroviral Therapy through Passive Administration of Human Neutralizing Antibodies

17:00—19:00
Novel Immunogens and Vaccine Concepts II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Peter D. Kwong, NIAID, National Institutes of Health, USA
Crystallographic Approach to Vaccine Design Based on the Antigenic and Atomic Structure of Env

Andrew J. McMichael, Oxford University, UK
A Boost for MVA

* Philip R. Johnson, Children's Hospital of Philadelphia, USA
rAAV Vectors as Novel HIV Vaccines

19:00—20:00
Social Hour

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 3

New Brunswick, Alberta, Cascade

WEDNESDAY, APRIL 13

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
CD8 Cell Function and Dysfunction (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Marcus Altfeld, Heinrich-Pette-Institute, Germany

Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
Functional Signatures of Protective Memory T-Cell Responses

Richard A. Koup, NIAID, National Institutes of Health, USA
CD8 and CD4 Cel Function in Viral Infection and Vaccintations

Joseph Michael McCune, University of California, San Francisco, USA
HIV-Induced Perturbations of CD8+ T Cell Maturation

Annika C. Karlsson, Karolinska Institutet, Sweden
Short Talk: Diversity of Epitope and Cytokine Profiles at Different Stages of HIV-1 Infection

Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Contribution of Antigen Processing to the Immunodominance of an HLA-A3-Restricted HIV Epitope

Astrid K.N. Iversen, Weatherall Institute of Molecular Medicine, UK
Short Talk: The Effect of Common Amino Acid Mutations in Overlapping HIV-1 p17 Gag CTL Epitopes on HLA Binding and Cytotoxic T-Cell Responses

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Workshop 2: Mucosal Immunity

Van Horne Ballroom C
* Jiri Mestecky, University of Alabama at Birmingham, USA
Mucosal Immune Responses to HIV in the Genital Tract of Infected, Highly Exposed Sero-negative, or Immunized Individuals

Robert W. Coombs, University of Washington, USA
Mucosal Shedding of HIV-1: Potential for Interference by Immune Responses

Ronald S. Veazey, Tulane National Primate Research Center, USA
Mucosal Cellular Responses in Nonhuman Primate Models of SIV

Igor M. Belyakov, National Cancer Institute, National Institutes of Health, USA
Short Talk: Mucosal Prime-Boost AIDS Vaccine Induces High Avidity CD8+ CTL Response and Delays Viremia After Intrarectal Infection of Macaques

Shehzad Iqbal, University of Toronto, Canada
Short Talk: Characterization of the Genital Mucosa of HIV Resistant Sex Workers Reveal Increased CD4+ T Cells, RANTES Levels and a Number of Potential Biomarkers by Proteomics Analysis

16:30—17:00
Coffee & Snacks Available

Van Horne Ballroom Foyer
17:00—19:30
Innate Host Defenses
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Donald E. Mosier, The Scripps Research Institute, USA

Robert H. Silverman, Cleveland Clinic Foundation, USA
Interferon Antiviral Defenses Mediated by the 2-5A/RNase L Pathway

Aaron Weinberg, Case Western Reserve University, USA
Mucosal Antiviral beta Defensins

Greg J. Towers, University College London, UK
Restriction of Retroviral Infection by TRIM5

Michael H. Malim, King's College London, UK
APOBEC Proteins, Cytidine Deamination and Innate Resistance to HIV Infection

Olivier Schwartz, Institut Pasteur, France
Short Talk: APOBEC3G: An Ancestral Wide Cellular Defence Against Endogenous and Exogenous Retroviruses

17:00—19:15
Animal Models I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
Nonhuman Primate HIV Vaccine Studies: Will They be Predictive?

Marjorie Robert-Guroff, NCI, National Institutes of Health, USA
A Role for Replication-Competent Adenovirus Recombinants in Vaccine Design

Mauro Bendinelli, Universita di Pisa, Italy
Are there lessons that can be learned from the FIV model?

Cristian Apetrei, University of Pittsburgh, USA
Short Talk: Molecular Epidemiology of SIVsm in Primate Centers in the United States over a 30 Year Period. Consequences for Diagnostic and Monitoring of SIVsm Infection

Salvatore T. Butera, Centers for Disease Control and Prevention, USA
Short Talk: Application of Repeated Mucosal Virus Exposures in Non-Human Primates to Evaluate Strategies to Prevent HIV-1 Transmission

19:15—20:15
Social Hour

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 4

New Brunswick, Alberta, Cascade

THURSDAY, APRIL 14

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:15
Latency and Activation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Frederic D. Bushman, University of Pennsylvania, USA

Jerome A. Zack, University of California, Los Angeles, USA
Modeling HIV Latency

Gary J. Nabel, Sanofi, USA
The Gene Product Murr1 Restricts HIV-1 Replication in Resting CD4+ Lymphocytes

Jonathan Karn, Case Western Reserve University, USA
NF-kappaB and CBF-1: Specific Activators and Repressors of HIV Transcription

Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA
Cellular Factors that Influence Virus-Host Cell Interplay

Roger J. Pomerantz, Seres Therapeutics, Inc., USA
Short Talk: IL-7 Potently and Strain-Specifically Induces the Latent HIV-1 Reservoirs

Nancie M. Archin, University of North Carolina, Chapel Hill, USA
Short Talk: Chromatin Deacetylation does not Precede Waning of HIV Expression

08:00—11:00
Animal Models II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
Control of SHIV Viremia and Disease Progression after DNA-MVA Mucosal Immunization in Macaques

James A. Hoxie, University of Pennsylvania, USA
Modulation of SIVmac Pathogenicity and Host Immune Responses by Mutations in the Envelope Transmembrane Cytoplasmic Tail

Ruth M. Ruprecht, Texas Biomedical Research Institute, USA
Harnessing the Power of Monoclonal Antibody Combinations

Vanessa M. Hirsch, NIAID, National Institutes of Health, USA
Virologic Features of Pathogenic and Natural Infection with Simian Immunodeficiency Viruses

John K. Rose, Yale University School of Medicine, USA
Short Talk: Protection Against SIVmac251 Challenge in Rhesus Macaques Vaccinated with VSV and MVA Vectors Expressing Seven SIV Genes

Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Short Talk: Working Backwards to a Vaccine for Control of AIDS Virus Infection

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
14:30—16:30
Workshop 3: Novel Adjuvants

Van Horne Ballroom C
* Jorge E. Flores, PATH, USA

Qigui Yu, , Canada
Expansion of HIV-1-Specific Memory CTL Responses by Dendritic Cells Infected with Human CD154 (CD40L)-Expressing ALVAC Virus: Towards the Development of Molecular Adjuvants for HIV-1 Vaccines

Richard S. Kornbluth, Multimeric Biotherapeutics, Inc., USA
Multimeric Soluble CD40 Ligand and GITR Ligand as DNA Vaccine Adjuvants

John P. Moore, Weill Medical College of Cornell University, USA
The Use of Topically Applied Imiquimod to Induce T-Helper Responses to HIV-1 Env Glycoproteins

Abdul M. Jabbar, Emory University, USA
Augmenting Immunogenicity of DNA Vaccines: Role of Plasmid-Encoded Flt-3 Ligand, as a Molecular Adjuvant in Genetic Vaccination

John R. Greenland, Harvard Medical School, USA
Beta-Amino Ester Polymers Facilitate in vivo DNA Transfection and Adjuvant Plasmid DNA Immunization

Andreas Bråve, Karolinska Institute, Sweden
Needle Free Intradermal Delivery of a Multi-Gene/Multi-Subtype HIV-1 Vaccine with Recombinant GM-CSF

16:30—17:00
Coffee & Snacks Available

Van Horne Ballroom Foyer
17:00—18:45
Immune Defense and Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Gene M. Shearer, National Cancer Institute, National Institutes of Health, USA

Rafick-Pierre Sekaly, Case Western Reserve University, USA
Genomic Profiling of Memory T Cell Population in Healthy and HIV Patients

Daniel C. Douek, NIAID, National Institutes of Health, USA
T-Cell Receptor Recognition Motifs and Immune Escape in Acute SIV Infection

Fatema A. Legrand, University of California, San Francisco, USA
Short Talk: Divergent Immune Responses in HIV-1 Vertically Infected Monozygotic Twins

Guillaume B.E. Stewart-Jones, National Institutes of Health, USA
Short Talk: Crystal Structures of HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLA Motifs

17:00—19:00
Clinical HIV Vaccine Trials
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Barney S. Graham, NIAID, National Institutes of Health, USA
Update on VRC Clinical Trials of Multi-Clade DNA and rAd5 Vaccines

John W. Shiver, Sanofi Pasteur, USA
Development of an HIV-1 Vaccine Based on Replication-Defective Adenovirus Vectors

Jorge E. Flores, PATH, USA
The HIV-1 Vaccine Pipeline and Global Expansion of Clinical Trials

18:45—19:00
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Michael M. Lederman, Case Western Reserve University, USA

19:00—20:00
Social Hour

New Brunswick, Alberta, Riverview
20:00—23:00
Entertainment

New Brunswick, Alberta, Riverview

FRIDAY, APRIL 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-AI064224-01




We gratefully acknowledge additional support for this conference from:

Gilead Sciences, Inc. Office of AIDS Research, NIH

Boehringer Ingelheim (Canada) Ltd.

 

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