Whistler Conference Centre Floorplan

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This meeting took place in 2005



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Tuberculosis: Integrating Host and Pathogen Biology (D1)


Organizer(s) Gilla Kaplan, Clifton Barry III and Stewart Cole
April 2—7, 2005
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Dec 2, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 2, 2005

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Tuberculosis is the leading infectious cause of mortality in the world today with 4 million deaths predicted for the year 2004. With the completion of the genome sequence of both Mycobacterium tuberculosis and Homo sapiens it is now possible to elucidate the dynamic interaction between the pathogen and its human host. Contemporary tools and novel technologies are currently being used to explore the molecular mechanisms that underlie host resistance and susceptibility, microbial drug resistance, the metabolic adaptations of the organism to latency and reactivation, and mechanisms of microbial pathogenesis. Recent studies have highlighted the importance of microbial regulatory systems and cell wall lipids in determining the ultimate outcome of infection. The development of novel vaccine candidates based on an understanding of the host response to infection has been facilitated by recent scientific advances. The aim of this meeting is to review the latest knowledge in these diverse fields of research and to provide an open forum for discussion and collaboration for scientists from the various disciplines required to control this disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 2

15:00—19:30
Registration

Grand Foyer
18:30—19:30
Refreshments

Grand Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
Paul W. Ewald, University of Louisville, USA
Vaccines and the Evolution of Virulence


SUNDAY, APRIL 3

07:00—08:00
Breakfast

Sea to Sky Ballrm B/C
08:00—11:00
Exploratory Genomics. Plenary Session sponsored by The Ellison Medical Foundation
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Stewart T. Cole, Institut Pasteur, France
Evolutionary and Comparative Genomics of the M. tuberculosis Complex

Gary K. Schoolnik, Stanford University, USA
The Transcriptome of M. tuberculosis: Lessons Learned from a Study of the DosR Regalon

Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Genetic and Proteomic Approaches to Virulence in Tuberculosis

Rajesh S. Gokhale, National Institute of Immunology, India
How Metabolic Diversity may be Generated from Limited Number of Genes: Exploring the Architecture of Mycobacterial Cell Envelope

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky Ballrm B/C
13:00—22:00
Poster Viewing

Sea to Sky Ballrm B/C
16:30—17:00
Coffee & Snacks Available

Grand Foyer
17:00—19:00
Mycobacterial Metabolism
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Douglas B. Young, Imperial College London, UK
and

Brian D. Robertson, Imperial College London, UK
The Role of Trehalose in Mycobacterial Persistence

David R. Sherman, Seattle Biomedical Research Institute, USA
The Hypoxia/NO Stress Regulon

Christophe Guilhot, Centre National de la Recherche Scientifique, France
Phenolic glycolipid biosynthesis

19:00—20:00
Social Hour

Sea to Sky Ballrm B/C
19:30—22:00
Poster Session 1

Sea to Sky Ballrm B/C

MONDAY, APRIL 4

07:00—08:00
Breakfast

Sea to Sky Ballrm B/C
08:00—10:20
Mechanism of Drug Action
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Role of Nitroimidazoles in Understanding Non-Replicating Persistence of MTB

James C. Sacchettini, Texas A & M University, USA
Structural Biology on Drug Targets from M. tuberculosis

Stephen H. Gillespie, Royal Free and University College London, UK
Developing Understanding of Anti-tuberculosis Chemotherapy through Monotherapy Studies

10:20—11:00
Host-Pathogen Interaction 1
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
Alan Aderem, Center for Infectious Disease Research, USA
Systems Biology and Immunity: A Systems Approach to Dissecting Immunity

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky Ballrm B/C
13:00—22:00
Poster Viewing

Sea to Sky Ballrm B/C
16:30—17:00
Coffee & Snacks Available

Grand Foyer
17:00—19:00
Host-Pathogen Interaction 2
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Gilla Kaplan, Bill & Melinda Gates Foundation, USA
Differential Host Response to Clinical Isolates of M. tuberculosis

JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Non-human Primates as a Model for Human Tuberculosis

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Tuberculosis - Immunogenetics and Vaccine Design

19:00—20:00
Social Hour

Sea to Sky Ballrm B/C
19:30—22:00
Poster Session 2

Sea to Sky Ballrm B/C

TUESDAY, APRIL 5

07:00—08:00
Breakfast

Sea to Sky Ballrm B/C
08:00—11:00
Macrophage Biology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* David G. Russell, Cornell University, USA
Mycobacterium and the Macrophage: Who Says What to Whom?

David J. Kusner, University of Iowa, USA
Phagosome Maturation in Response to MTB Infection

Lalita Ramakrishnan, University of Cambridge, UK
Monitoring and modulating Mycobacterium-Macrophage Interactions in Real-Time in Transparent Zebrafish Embryos

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy - Novel Innate Immunity Mechanism

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky Ballrm B/C
13:00—22:00
Poster Viewing

Sea to Sky Ballrm B/C
16:30—17:00
Coffee & Snacks Available

Grand Foyer
17:00—19:00
Genetic Determinants of Host Response
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Host Pathogen Interactions in Tuberculosis: From a Global to a Specific View

Emil Skamene, McGill University Health Centre, Canada
Genetic Determinants of Resistance and Susceptibility

Warwick J. Britton, Centenary Institute, Australia
Manipulating the Cytokine Environment to Enhance Responses to Vaccines against Tuberculosis.

19:00—20:00
Social Hour

Sea to Sky Ballrm B/C
19:30—22:00
Poster Session 3

Sea to Sky Ballrm B/C

WEDNESDAY, APRIL 6

07:00—08:00
Breakfast

Sea to Sky Ballrm B/C
08:00—11:00
Vaccines and Immune Response
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Peter L. Andersen, Statens Serum Institut, Denmark
TB Subunit Vaccines - Recent Developments in the Post Antigen Discovery Era

Robert J. North, Trudeau Institute, USA
Mouse Tuberculous as a Model of Tuberculosis in Susceptible Humans

Mark Raymond Alderson, PATH, USA
Development of a Subunit Vaccine for Tuberculosis: Rational Selection of Antigens and Adjuvants

Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
The Host Immune Response to BCG Vaccination

09:20—09:40
Coffee Break

Grand Foyer
16:30—17:00
Coffee & Snacks Available

Grand Foyer
17:00—19:00
Bacterial Signaling and Defense Mechanisms
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballrm A
* Carl F. Nathan, Weill Cornell Medical College, USA
New Targets In M. Tuberculosis: Stress Resistance and Repair

Valerie Mizrahi, University of Cape Town, South Africa
The Role of Error-Prone DNA Polymerases in Damage Tolerance and Genetic Adaptation in Mycobacteria

William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Mycobacterial Stress Response Systems and Animal Models

19:00—20:00
Social Hour

Sea to Sky Ballrm B/C
20:00—23:00
Entertainment

Sea to Sky Ballrm B/C

THURSDAY, APRIL 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

AstraZeneca R&D Bill & Melinda Gates Foundation
The Ellison Medical Foundation
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Corixa Corporation


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