Beaver Run Resort Floorplan

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This meeting took place in 2005



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Tissue-Selective Nuclear Receptors (D4)


Organizer(s) William T. Schrader, John A. Cidlowski, Kenneth S. Korach and Donald P. McDonnell
September 18—22, 2005
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Jun 17, 2005
Late Abstract Deadline: Jul 1, 2005
Scholarship Deadline: Jun 17, 2005
Early Registration Deadline: Jul 18, 2005

Sponsored by the Director's Fund

Summary of Meeting:
The nuclear hormone receptors engender great research interest, and have spawned numerous scientific meetings. The past Keystone Symposia dealt with this topic from the perspective of molecular biology. This meeting will bring together three aspects of research impacting human health via the nuclear receptors. These three groups are (a) basic scientists, (b) pharmaceutical drug discoverers and (c) clinicians. The meeting will unfold a series of questions regarding unmet medical needs for drugs involving nuclear receptor ligands, recent advances towards a molecular understanding of tissue-selectivity as a hallmark for improved safety and efficacy, and a resources workshop to address and fulfill needs for emerging novel research tools. This meeting will differ from other Keystone meetings dealing with the nuclear hormone receptor family by concentrating upon the link of molecular tools to unmet medical needs for improved therapeutics.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, SEPTEMBER 18

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session: What's Wrong with Current NHR Therapies?
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
William T. Schrader, NIEHS, National Institutes of Health, USA
Tissue-Selective Receptor Modulators: What Do We Know and What We Only Think We Know?

J. Larry Jameson, Northwestern University School of Medicine, USA
Unmet Medical Needs of NHR Therapies


MONDAY, SEPTEMBER 19

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Human Disease Targets for Tissue-Selective Modulators
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* William T. Schrader, NIEHS, National Institutes of Health, USA

William W. Chin, Harvard Medical School, USA
Selective NRH as Novel Therapeutics

John D. Baxter, University of California, San Francisco, USA
Selective Modulation of the Thyroid Hormone Receptor

Gerald H. Nabozny, Boehringer Ingelheim Inc., USA
Glucocorticoids and Inflammatory Disease

Heather A. Harris, Wyeth Pharmaceuticals, USA
Characterization and Potential Clinical Applications for Estrogen Receptor-beta Selective Agonists

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Experimental Pharmacophores for Investigational Use
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Richard Hochberg, Yale University School of Medicine, USA

John A. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Critical Structural Features Underlying the Activities of Nuclear Hormone Receptor Ligands

Lawrence G. Hamann, Novartis Institutes for BioMedical Research, USA
Tissue Selective Androgen Receptor Modulators

Richard A. Heyman, ORIC Pharmaceuticals, USA
The Intersection of Nuclear Receptors and Metabolic Syndrome

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

TUESDAY, SEPTEMBER 20

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Mouse Genetic Models
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Günther Schütz, German Cancer Research Center, Germany
Analysis of Glucocorticoid-, Mineralocorticoid- and Estrogen-Receptor Function by Gene Targeting

Adriana Maggi, University of Milan, Italy
A Mouse Reporting on ER Transcriptional Activity to Understand the Complexities of Female Physiology in Mammals

* Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Estrogen Receptor Pharmacology in Mouse Lines

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
The Role of LXRs and FXR in Enterohepatic Lipid Metabolism

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Tissue-Selective Receptor Expression and Function
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA

Keith R. Yamamoto, University of California, San Francisco, USA
Physiological Expression Patterns Reflect Integration of “Sectors” of Multiple Regulatory Networks

John A. Cidlowski, NIEHS, National Institutes of Health, USA
The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications

Richard C. Winneker, Wyeth Pharmaceuticals, USA
Tissue Selective Properties of a Novel, Nonsteroidal Progesterone Receptor Agonist, Tanaproget

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

WEDNESDAY, SEPTEMBER 21

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Coactivator and Corepressor Proteins and the Tissue Selectivity Problem
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* William T. Schrader, NIEHS, National Institutes of Health, USA

Jeffrey N. Miner, Ligand Pharmaceuticals, USA
Steroid Receptor Modulators: Approaches to Selectivity for Androgen Receptor

Bert W. O'Malley, Baylor College of Medicine, USA
Coactivators and Tissue Specific Responses to Nuclear Receptors

Donald P. McDonnell, Duke University School of Medicine, USA
The Biological Consequences of Differential Nuclear Receptor-Cofactor Interactions

09:20—09:40
Coffee Break

Foyer
14:30—16:30
Workshop

Peak 5
* Donald P. McDonnell, Duke University School of Medicine, USA

Anne Minnich, Sanofi Phamaceuticals, USA
Effects of Potent and Bioavailable PPARalpha and gamma Agonists in Inflammatory Disease Models

Thomas Gustafson, Janssen Pharmaceuticals, USA
Metaglidasen (MBX-102), a Non-TZD Selective PPARgamma Modulator (SPPARgammaM) with Potent Anti-Diabetic and Hypo-Lipidemic Activity in the Absence of Significant Body or Heart Weight Increases

Christine Y. Ivashchenko, Sanofi Aventis, Germany
Knockout of PPARgamma in Endothelial Cells Increases the Inflammatory Response to TNF-alpha

Jun Xia, University of Illinois at Urbana-Champaign, USA
Structural Determinants of Constitutive Androstane Receptor (CAR) Required for its Glucocorticoid Receptor Interacting Protein-1 (GRIP1)- Mediated Nuclear Accumulation

Wen Xie, University of Pittsburgh, USA
Pathway- and Gender-Specific Cross-Talk between Xenobiotic Receptors PXR and CAR

Edwin R. Sanchez, University of Toledo College of Medicine, USA
Selective Targeting of Steroid-Regulated Physiologies via TPR Co-Chaperones

Emily J. Faivre, AbbVie, USA
Liganded Human Progesterone Receptor Induces Src-Dependent Oscillations of Erk 1/2 MAPK Activity via Transactivation of the EGFR in a Breast Cancer Cell Model

Jacek Ostrowski, Bristol-Myers Squibb Company, USA
Chromatin Acetylation is a Potential Mechanism for the Differential Effects of Novel Non-Steroidal Ligands on Transactivation Activity of Androgen Receptor in Mouse Myoblast C2C12 Cells

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Receptor Structure and Imaging
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Geoffrey L. Greene, University of Chicago, USA

Timothy M. Willson, GlaxoSmithKline, USA
Characterization of PPAR Modulators Derived from Structure-Guided Synthesis

Dino Moras, Institute of Genetics, Molecular and Cellular Biology, France
Structural basis for ligand (in) dependent activity of RXR

Donald B. Defranco, University of Pittsburgh School of Medicine, USA
Role of Molecular Chaperones in Nuclear Mobility and Hormone Exchange of Glucocorticoid Receptors

19:00—20:00
Social Hour

Peaks 1-3
20:00—23:00
Entertainment

Peak 1-3

THURSDAY, SEPTEMBER 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-DK070484-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Boehringer Ingelheim Pharmaceuticals, Inc.


Bristol-Myers Squibb Company


Educational grant from Lilly USA, LLC


Exelixis, Inc.


GlaxoSmithKline


Ligand Pharmaceuticals


Merck Research Laboratories


Wyeth Research Labs


Merck Research Laboratories


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