Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2005



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Ubiquitin and Signaling (B7)


Organizer(s) Tony Hunter, Claudio Joazeiro and Mark Hochstrasser
February 22—27, 2005
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 21, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 22, 2004

Supported by The Director's Fund

Summary of Meeting:
Our understanding of how ubiquitin regulates cellular function has greatly expanded recently, spurred by discoveries of protein families involved in ubiquitin conjugation and de-conjugation and of non-proteasomal signaling functions for ubiquitin. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in various diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins; the challenge is to determine their functions and mechanistic links to the ubiquitin system. The goal of the meeting is to bring together experts from different areas of ubiquitin research, as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 22

15:00—19:30
Registration

Rio Grande D
18:30—19:30
Refreshments

Rio Grande A-C
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bataan
Cecile M. Pickart, Johns Hopkins University, USA
Assembly and Recognition of Polyubiquitin Signals


WEDNESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Meeting has ended...abstracts no longer viewable online.

Bataan
* Daniel J. Finley, Harvard University, USA

Alexander Varshavsky, California Institute of Technology, USA
The Functions of the N-End Rule Pathway

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Two SCF-Like Ubiquitin Ligases Linked to Cancer

Gina D. Visser, University of Iowa, Carver College of Medicine, USA
Short Talk: c-Cbl RING Finger Tail Sequences are Critical Determinants of EGF Receptor and Sprouty2 Fate

Cam Patterson, University of North Carolina at Chapel Hill, USA
CHIP and Degradation of Unfolded Proteins

Kathleen L. Gould, Vanderbilt University, USA
Structure of APC and U box E3s

Peter S. Brzovic, University of Washington, USA
Short Talk: NMR Investigations of BRCA1-Directed Ubiquitination: Assembly and Structure of a Multi-Protein Ubiquitin Ligase Complex

09:20—09:40
Coffee Break

Rio Grande C/D
11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Meeting has ended...abstracts no longer viewable online.

Bataan
* Dong-Er Zhang, Regents of the University of California, San Diego, USA

Claudio A. P. Joazeiro, The Scripps Research Institute, USA
Functional Genomics of Ubiquitin Ligases

Kim D. Finley, San Diego State University, USA
Short Talk: Defects in Autophagy and Clearance of Ubiquitinated-Proteins are Associated with Progressive Neural Degeneration in Drosophila

Keiji Tanaka, Tokyo Metropolitan Institute of Medical Science, Japan
Recognition of Glycosylated Substrates by SCF(Fbs) Ubiquitin Ligases

Raymond J. Deshaies, Amgen, Inc., USA
Quantitative Mass Spectrometry for Identification of Targets in the Proteasome Ubiquitin System

Jian Hu, University of North Carolina at Chapel Hill, USA
Short Talk: Targeted Ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 Ligase in Response to DNA Damage

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 1

Rio Grande

THURSDAY, FEBRUARY 24

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:00
Deubiquitinating Enzymes
Meeting has ended...abstracts no longer viewable online.

Bataan
* Raymond J. Deshaies, Amgen, Inc., USA

Keith D. Wilkinson, Emory University, USA
Tools for Analyses of Deubiquitinating Enzymes

Kim Orth, University of Texas Southwestern Medical Center, USA
Short Talk: Biochemical and Structural Characterization of the Effector Protein XopD

Robert E. Cohen, University of Iowa, USA
Proteasome-Associated Deubiquitination

Sebastian M. B. Nijman, CeMM, Austrian Academy of Sciences, Austria
Functional Annotation of Deubiquitinating Enzymes Using RNA Interference

Greg Odorizzi, University of Colorado, USA
Short Talk: The Ubiquitin Thiolesterase Doa4 Controls Vesicle Size in Multivesicular Bodies in Yeast

Christopher P. Hill, University of Utah, USA
Proteasome Activation

09:20—09:40
Coffee Break

Rio Grande C/D
11:00—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
Ubiquitin-Like Proteins
Meeting has ended...abstracts no longer viewable online.

Bataan
* Keith D. Wilkinson, Emory University, USA

Dong-Er Zhang, Regents of the University of California, San Diego, USA
ISG15-Specific Isopeptidase UBP43 and Protein ISGylation

Chen Zhao, University of Texas at Austin, USA
Short Talk: The Human ISD15 Conjugation System Targets both Interferon Induced and Constitutive Espressed Proteins in Diverse Cellular Pathways

Frauke Melchior, Universität Heidelberg, Germany
Postranslational Modification with Ubiquitin Related Proteins of the SUMO Family

David Reverter, Sloan-Kettering Institute, USA
Short Talk: Structure and Analysis of an Ubl-Substrate-E2-E3 Complex between SUMO, RanGAP1, Ubc9, and Nup358/RanBP2

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural and Mechanistic Insights into the Nedd8 Conjugation Cascade

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 2

Rio Grande

FRIDAY, FEBRUARY 25

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficking
Meeting has ended...abstracts no longer viewable online.

Bataan
* Wesley I. Sundquist, University of Utah School of Medicine, USA

Linda Hicke, Northwestern University, USA
Regulation of Receptor Endocytosis by Monoubiquitin Signals

Simona Polo, FIRC Institute of Molecular Oncology, Italy
Ubiquitination Directs Clathrin-Independent Internalization

James H. Hurley, University of California, Berkeley, USA
Structural Mechanisms for Intracellular Sorting of Monoubiquitinated Membrane Proteins

Ivan Dikic, Goethe University Medical School, Germany
Regulation of Ub-Binding Proteins by Monoubiquitination

Hsiangling Teo, Nanyang Technological University, Singapore
Short Talk: ESCRT-I and ESCRT-II: Crystal Structures and Interactions

Hemmo Meyer, University Duisburg-Essen, Germany
Short Talk: p97/Cdc48 and its Adapters: a Multifunctional Ubiquitin-Dependent Chaperone System

09:20—09:40
Coffee Break

Rio Grande C/D
11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Meeting has ended...abstracts no longer viewable online.

Bataan
* Frauke Melchior, Universität Heidelberg, Germany

Mary Ann Osley, University of New Mexico School of Medicine, USA
Histone Ubiquitylation: Roles in Transcription Initiation and Elongation

Peter Kaiser, University of California, Irvine, USA
Short Talk: Ubiquitination Regulates Several Components of the Met4 Transcription Complex

Lijun Sun, University of Texas Southwestern Medical Center, USA
Short Talk: Ubiquitin Signaling in the NF-kappaB Pathway

Jonathon Pines, University of Cambridge, UK
Mitosis - What's Ubiquitin Got To Do With It?

19:00—20:00
Social Hour

Rio Grande
19:30—22:00
Poster Session 3

Rio Grande

SATURDAY, FEBRUARY 26

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:00
New Trends
Meeting has ended...abstracts no longer viewable online.

Bataan
* Ivan Dikic, Goethe University Medical School, Germany

Daniel J. Finley, Harvard University, USA
Elongation and Disassembly of Multiubiquitin Chains Bound to the Proteasome: Opposing Roles of Ubiquitin-Ligase Hul5 and Deubiquitinating Enzyme Ubp6

Wei Gu, Columbia University, USA
Dissecting the Complexity in the p53-Ubiquitination Pathway

Sudha K. Shenoy, Duke University Medical Center, USA
Regulation of ERK Scaffolding and Signaling by Beta-Arrestin Ubiquitination

Leonard Girnita, Karolinska Institute, Sweden
Short Talk: Insulin-like Growth Factor-1 (IGF-1R) Ubiquitination: Functional Impact on IGF-1R Signaling Pathways

Chris Stefan, University of California, San Diego, USA
Short Talk: Genome-Wide Screening for Membrane Protein Quality

Tom K. Kerppola, University of Michigan, USA
Short Talk: Visualization of Ubiquitination in Living Cells by Ubiquitin-Mediated Fluoresence Complementation

09:20—09:40
Coffee Break

Rio Grande C/D
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
The Ubiquitin System: Disease and Drug Targets
Meeting has ended...abstracts no longer viewable online.

Bataan
* Christopher P. Hill, University of Utah, USA

David J. Glass, Novartis Institutes for Biomedical Research, USA
Signaling Pathways Mediating Skeletal Muscle Hypertrophy and Atrophy

Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV-1 Release

James Gavin, Takeda Boston, USA
Short Talk: Drug Discovery in the Pathways for Ubiquitin and Ubiquitin-like Protein Conjugation

Steven P. Gygi, Harvard Medical School, USA
Quantitative Proteomics Strategies for the Study of Protein Ubiquitination

19:00—20:00
Social Hour

Rio Grande
20:00—23:00
Entertainment

Rio Grande

SUNDAY, FEBRUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Celgene Corporation Cell Signaling Technology, Inc.
Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company Novartis Institutes for BioMedical Research

Global Peptide Services


Proteome Resources LLC

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Regeneron Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676