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This meeting took place in 2005



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Mechanisms of DNA Replication and Recombination (A1)


Organizer(s) Stephen P. Bell and Roland Kanaar
January 5—11, 2005
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 15, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 5, 2004

Supported by The Director's Fund

Summary of Meeting:
The Keystone Symposium on DNA Replication and Recombination is the only meeting of its type that draws large numbers of participants from both fields. The meeting has been designed to have a comprehensive coverage of the central aspects of both fields, including the traditional studies of biochemical mechanisms, how structural biology is informing our understanding of molecular function, and how biochemical mechanisms are expanding our understanding of biological function. Recent studies make it clear that the stability of the genome relies upon coordinated function of these two events, particularly at the DNA replication fork. This meeting provides a special opportunity for people working in replication and recombination to benefit from a comprehensive view, spanning complex biological concepts to atomic detail. The fact that the meeting is "open" ensures maximum exposure and accessibility for speakers and participants. The inclusion of workshops provides the opportunity for more junior members of the field (including graduate students and postdocs) to present their work and to explore work being performed in the broader field. Finally, the diversity of topics covered by this meeting exposes the participants to a broader spectrum of ideas, techniques and results than the more focused meetings we normally attend. Past meetings have facilitated important interactions between the replication and recombination fields and we anticipate that this will continue. The last meeting of this type was held in January 2002 and the many significant developments in the intervening time will make this a timely and exciting meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 5

15:00—19:30
Registration

Columbine Foyer
18:30—19:30
Refreshments

Longs Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
James E. Haber, Brandeis University, USA
Multiple Recombination and Replication Mechanisms to Repair a Broken Chromosome


THURSDAY, JANUARY 6

07:00—08:00
Breakfast

Grays
08:00—11:00
Mechanisms of Recombination
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Stephen C. Kowalczykowski, University of California, Davis, USA
Visualization of Recombination at the Single-Molecule Level

Michael M. Cox, University of Wisconsin-Madison, USA
Short Talk: Genome Reconstitution after Extensive DNA Damage in Deinococcus radiodurans

Phoebe A. Rice, University of Chicago, USA
Structure of a Rad51 Filament

Stephen C. West, Francis Crick Institute, UK
Double Strand Break Repair by Homologous Recombination

Roland Kanaar, Erasmus MC, Netherlands
Dynamics of Genome Maintenance Processes

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
14:00—16:00
Workshop 1: Regulation of DNA Replication

Longs
* Oscar Aparicio, University of Southern California, USA
Mrc1 is Required for Normal Progression of Replication Forks throughout Chromatin in Saccharomyces cerevisiae

Chrystelle Maric Antoinat, Institut Andre Lwoff, France
Structure and Distribution of Joint DNA Molecules during the Naturally Synchronous S Phase in Physarum polycephalum

Peter W. Lewis, University of Wisconsin-Madison, USA
Regulation of DNA Replication and Transcription by the Drosophila Myb Complex

Brian R. Calvi, Indiana University, USA
Humpty Dumpty Defines a New Gene Family Required for DNA Amplification and Cell Proliferation

Marie-Francoise Noirot-Gros, Institut National de la Recherche Agronomique, France
YabA, A Novel Initiation Regulator in Gram-Positive Bacteria

Jue D. Wang, Massachusetts Institute of Technology, USA
Nutritional Control of Replication Elongation

Kai Stoeber, University College London, UK
HPV E4 Protein Inhibits DNA Replication by Blocking Pre-RC Assembly

14:00—16:00
Workshop 2: DNA Recombination

Quandary
* Wolf-Dietrich Heyer, University of California, Davis, USA
Activation of Recombinational DNA Repair by DNA Damage Checkpoint-Mediated Phosphorylation of Rad55 Protein

Cindy W. Fung, Columbia University, USA
The Role of the Rad51 ATPase in Homologous Recombination

Alexander V. Mazin, Drexel University College of Medicine, USA
The Role of Ca2+ in Activation of Human Homologous Recombination Proteins

Piero R. Bianco, University at Buffalo, State University of New York, USA
Single Molecule Studies of the Human Rad54 Protein Reveal Insight into the Mechanism of Stimulation of DNA Strand Exchange

Francesca Storici, Georgia Institute of Technology, USA
Mechanism of Double-Strand Break Repair by Single-Strand Oligonucleotides in Yeast

Matthew Porteus, Stanford University School of Medicine, USA
The Use of Zinc Finger Nuclease to Manipulate the Genome of Human Somatic Cells in a Site-Specific Fashion

Jie Liu, University of California, Davis, USA
Dynamics of T4 Gene 32 Protein-ssDNA Interactions during Presynaptic Filament Assembly

16:30—17:00
Coffee & Snacks Available

Longs Foyer
17:00—19:00
Mechanisms of DNA Replication
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Tom E. Ellenberger, Washington University School of Medicine, USA
The Anatomy of Infidelity: Lesion Bypass By Faithful and Promiscuous Polymerases

Michael E. O'Donnell, Rockefeller University, USA
Clamp Loaders

Anja-Katrin Bielinsky, University of Minnesota, USA
Short Talk: Mcm10 Controls the Stability and Chromatin Association of DNA Polymerase-alpha

Haruhiko Takisawa, Osaka University Graduate School of Science, Japan
Protein Networks in the Assembly of the Eukaryotic Replication Fork in Xenopus Egg Extracts

19:00—20:00
Social Hour

Grays
19:30—22:00
Poster Session 1

Grays

FRIDAY, JANUARY 7

07:00—08:00
Breakfast

Grays
08:00—11:00
Genome Stability I
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Tania A. Baker, Massachusetts Institute of Technology, USA
Transposition by Phage Mu

George Chaconas, University of Calgary, Canada
Short Talk: 3D Reconstruction of the Mu Transposase and the Type 1 Transpososome: A Structural Framework for Mu DNA Transposition

John F.X. Diffley, Francis Crick Institute, UK
DNA Replication Control and Genome Stability in Saccharomyces cerevisiae

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Double-Strand Breaks and the Maintenance of Genomic Integrity

Vicki Lundblad, The Salk Institute for Biological Studies, USA
A Telomere-Specific RPA Mediates Replication and Repair at Chromosome Ends

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
14:00—16:00
Workshop 3: Mechanisms of Site-Specific Recombination and Replication

Longs
Ronald Chalmers, University of Nottingham Medical School, UK
Miniature Inverted-Repeat Transposable Elements (MITES) in Neisseria

Jeanne Marie DiChiara, University of Illinois at Urbana-Champaign, USA
The Integrase of Bacteroides Mobile Element CTnDOT Represents a Divergent Member of the Tyrosine Recombinase Family

Hiroshi Nakai, Georgetown University Medical Center, USA
The Mu Transpososome and Host Factors Promote Assembly of the Restart Primosome by a PriA-PriC-Dependent Pathway during Phage Mu Transposition

Graham F. Hatfull, University of Pittsburgh, USA
Site-Specific Recombination in the Mycobacterium Bxb1

Glenn Sanders, Replidyne, Inc., USA
General Priming in a Gram Positive Organism, B. subtilis

Marc S. Wold, University of Iowa, USA
Phosphorylation and Intersubunit Interactions Regulate Replication Protein A

Chiara Indiani, Rockefeller University, USA
Mechanism of DNA Polymerase Switching on a DNA Sliding Camp.

* Anca M. Segall, San Diego State University, USA
Control of Holliday Junction Resolution and Directionality by lambda Integrase

14:00—16:00
Workshop 4: Topoisomerases and Helicases

Quandary
* Ian D. Hickson, University of Copenhagen, Denmark

Leonard Wu, Weatherall Institute of Molecular Medicine, UK
Resolution of Homologous Recombination Intermediates by the Bloom’s Syndrome Helicase

Marie-Agnès Petit, nstitut National de La Rescherche Agronomique (INRA), France
The UvrD Helicase, and Not the Rep Helicase, Dismantles RecA Nucleoprotein Filaments in Escherichia coli

Rebecca C. Burgess, National Cancer Institute, USA
Visualization of Srs2 Anti-Recombinase Activity in vivo

Steven Brill, Rutgers University, USA
Characterization of Slx5-Slx8, a Potential SUMO E3 Ligase in S. cerevisiae

Zoya Petrushenko, University of Oklahoma, USA
DNA Remodeling by E. coli Condensin MukBEF and its SMC Subunit MukB

Fekret Osman, University of Oxford, UK
Loss of the F-Box DNA Helicase, Fdh1, Promotes Rhp51-Dependent Recombination and Suppression of Genotoxin Sensitivity in Schizosaccharomyces pombe Cells Lacking Rad22

16:30—17:00
Coffee & Snacks Available

Longs Foyer
17:00—19:00
Chromosome Dynamics I
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Virginia A. Zakian, Princeton University, USA
Processivity of Telomerase in Baker's Yeast

Bruce W. Stillman, Cold Spring Harbor Laboratory, USA
The Origin Recognition Complex: Involvement in DNA Replication, Chromosome Segregation and Cytokinesis

Frank Uhlmann, Cancer Research UK London Research Institute, UK
The Establishment of Sister Chromatid Cohesion during DNA Replication

19:00—20:00
Social Hour

Grays
19:30—22:00
Poster Session 2

Grays

SATURDAY, JANUARY 8

07:00—08:00
Breakfast

Grays
08:00—11:00
Initiation of DNA Replication
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Anindya Dutta, University of Virginia, USA
Replication Initiation in Mammalian Cells

Stephen P. Bell, Massachusetts Institute of Technology, USA
Origin Selection by ORC/Cdc6/MOM

Nick Rhind, University of Massachusetts Medical School, USA
Short Talk: Origin Firing in S. pombe

Johannes C. Walter, Harvard Medical School, USA
Degradation of Cd+1 in S Phase

Stephen D. Bell, Indiana University, USA
Initiators, Origins and Primase in an Archaeon Sulfolobus solfataricus

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
14:00—16:00
Workshop 5: Structural Studies of Replication and Recombination

Longs
* James M. Berger, Johns Hopkins University School of Medicine, USA

Jacob E. Corn, University of California, Berkeley, USA
Towards a Structural Description of Bacterial Priming

Scott Bailey, Yale University, USA
Structural Studies of the Prokaryotic Primosome

Satwik Kamtekar, Yale University, USA
Structural Studies of Protein Priming by phi 29 DNA Polymerase

Xiangpeng Kong, New York University, USA
Crystal Structure of E. coli RecR Protein and Structural-Functional Implications

Andrei L. Okorokov, University College London, UK
Molecular Structure of Human Geminin

Brian A. Learn, Johns Hopkins University, USA
Crystal Structure and Functional Analysis of the DNA-Binding Domain of the Bacteriophage lambda O Replication Initiator

Stephen G. Anderson, University of Florida, USA
Temporal Correlation of ATP Hydrolysis-Dependent DNA and Sliding Clamp Release from the E. coli gamma Complex Clamp Loader

14:00—16:00
Workshop 6: Meiosis and Chromesome Dynamics

Quandary
Matthew J. Neale, Memorial Sloan-Kettering Cancer Center, USA
A Novel Pathway for Removal of Spo11 from Meiotic DNA Double-strand Break Ends

Hiroyuki Oshiumi, Hokkaido University, Japan
Regulation of Crossover Formation by a Cdk Kinase, Cdc28, During Meiosis

Christina M. Bradley, NIDDK, National Institutes of Health, USA
Structural Basis for DNA Compaction by Barrier to Autointegration Factor (BAF)

* Michael J. Lichten, National Cancer Institute, National Institutes of Health, USA
Responding to DNA Double-Strand Breaks: Interplay with Chromosome Structure

Takehiko Kobayashi, National Institute for Basic Biology, Japan
Mechanisms to Keep the Stability of the Ribosomal RNA Gene Cluster in Yeast

Luis F. Aragón, MRC Clinical Sciences Centre, UK
Structural Maintenance of Chromosomes Genes SMC5 and SMC6 are Required for the Correct Segregation of Repetitive Regions

Alexander V. Strunnikov, Guangzhou Institute of Biomedicine and Health, China
Genome-Wide Analysis of Condensin Targeting to Chromatin during Cell Cycle Progression

16:30—17:00
Coffee & Snacks Available

Longs Foyer
17:00—19:00
Mechanism of Checkpoint Function
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Chromosome Break Metabolism in Eukaryotic Cells

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Remodelling at Double-Strand Breaks and Stalled Fork Collapse

Hitoshi Kurumizaka, Waseda University, Japan
Short Talk: Structural and Functional Analyses of the Human Homologous-Pairing Protein, Dmc1

Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
Replication Fork-Dependent Checkpoint Signaling

19:00—20:00
Social Hour

Grays
19:30—22:00
Poster Session 3

Grays

SUNDAY, JANUARY 9

07:00—08:00
Breakfast

Grays
08:00—11:00
Interplay between Replication and Recombination
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Dale B. Wigley, Institute of Cancer Research, UK
Structure and Mechanism of RecBCD

Susan T. Lovett, Brandeis University, USA
Template Switch Replication Fork Repair

Nancy L. Craig, Johns Hopkins University School of Medicine, USA
The hAT Transposase Hermes is a RAG-Like Transposase

Bénédicte Michel, Institut National de la Recherche Agronomique, France
Replication Fork Reversal at Stalled Forks

Richard D. Kolodner, Ludwig Institute for Cancer Research, USA
Identification of Pathways that Prevent Genome Instability

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
14:00—16:00
Workshop 7: Telomeres and Checkpoints

Longs
* Kathleen Collins, University of California, Berkeley, USA
Assembly and Activity of Telomerase Holoenzyme

Tara J. Moriarty, Lady Davis Institute for Medical Research, Canada
The Human Telomerase Accessory Domain Prevents Incorporation of Non-telomeric DNA Sequences and Regulates DNA Elongation in a Substrate Length- and Sequence-dependent Fashion

Eric A. Hendrickson, University of Minnesota Medical School, USA
DNA-PK Regulates Telomere Length and Genomic Stability in Human Somatic Cells

Mark Meuth, University of Sheffield, UK
A Mutant Allele of MRE11 that Suppresses ATM-mediated Signaling and Homologous Recombination Repair Induced by Thymidine

Serge Gangloff, CEA de Fontenay-aux-Roses, France
Spontaneous Mitotic Crossovers are Negatively Controlled by DNA Damage Checkpoint Proteins

Robert A. Sclafani, University of Colorado Denver, USA
Cdc7/Dbf4 and Rad53 Kinases Regulate DNA Replication

14:00—16:00
Workshop 8: DNA Repair

Quandary
* Tanya T. Paull, University of Texas at Austin, USA
Mre11/Rad50/Nbs1 (M/R/N) Interactions with DNA Initiate the ATM Kinase Signaling Response

Bernard S. Lopez, Institut Gustave Roussy, France
Genome Rearrangements Induced by Double Strand Breaks and NHEJ In Mammalian Cells

Sang Eun Lee, University of Texas Health Science Center, USA
Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Break

Beth A. Tamburini, University of Colorado Denver Anchutz Medical Campus, USA
Histone Acetylation and Deacetylation during Double-Strand DNA Repair

Stephane Marcand, Centre des Etudes Atomique, France
Mismatched Priming by DNA Polymerase Pol4 during Non-Homologous End-Joining

Peter McGlynn, University of Aberdeen, UK
Replication in a Protein Rich Environment

16:30—17:00
Coffee & Snacks Available

Longs Foyer
17:00—19:00
Genome Stability II
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
* Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA

Ryan C. Heller, Sloan-Kettering Institute, USA
and

* Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Multiple Pathways of Replisome Loading During Replication Fork Restart

Thomas A. Kunkel, NIEHS, National Institutes of Health, USA
Enzymatic Switching for Efficient and Accurate Translesion DNA Replication

Kiyoshi Mizuuchi, NIDDK, National Institutes of Health, USA
Short Talk: Control of Transposase Activity within a Transpososome by the Configuration of the Flanking DNA Segment of the Transposon

19:00—20:00
Social Hour

Grays
19:30—22:00
Poster Session 4

Grays

MONDAY, JANUARY 10

07:00—08:00
Breakfast

Grays
08:00—11:00
Chromosome Dynamics II
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
Oren Levy, University of California, Berkeley, USA
Giant Proteins that Bully DNA

Douglas E. Koshland, Carnegie Institution of Washington, USA
Cohesins and Condensins: Lord of the Rings or Not?

David J. Sherratt, University of Oxford, UK
Short Talk: E. coli Chromosome Replication and Segregation

Galina V. Petukhova, National Institutes of Health, USA
Short Talk: The Interplay Between Hop2/Mnd1 and Rad51/Dmc1 Proteins in Meiotic Recombination

09:20—09:40
Coffee Break

Longs Foyer
16:30—17:00
Coffee & Snacks Available

Longs Foyer
17:00—19:30
Recombination and DNA Repair
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary
Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Regulation of Initiation of DNA Replication

Wei Yang, NIDDK, National Institutes of Health, USA
Portraints of a Y-Family DNA Polymerase

Jac A. Nickoloff, Colorado State University, USA
Short Talk: Sgs1 Regulation of Gene Conversion Tract Lengths and Crossovers is Independent of ATP Hydrolysis

Matthew D. Weitzman, Children's Hospital of Philadelphia, USA
Interactions of Viruses with the Cellular Replication and Repair Machinery

* Rodney J. Rothstein, Columbia University Medical Center, USA
Choreography of the DNA Damage Response in Budding Yeast

19:30—20:30
Social Hour

Grays
20:30—23:30
Entertainment

Grays

TUESDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676