Hyatt Regency Monterey Floorplan

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This meeting took place in 2005



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Hormonal Regulation of Tumorigenesis (B6)


Organizer(s) Nancy L. Weigel, Suzanne A. Fuqua and Donald Tindall
February 20—25, 2005
Hyatt Regency Monterey • Monterey, California USA
Abstract Deadline: Oct 20, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 20, 2004

Supported by The Director's Fund

Summary of Meeting:
Steroid hormones are key factors in the development and growth of tumors in hormone dependent tissues including breast and prostate. These cancers are not only two of the most prevalent cancers, but are also second only to lung cancer in deaths from cancer. Thus, there is a great deal of interest in developing methods to block the actions/production of the steroids. The actions of the steroids are mediated by steroid hormone receptors, members of the nuclear receptor family of ligand-activated transcription factors. However, recent and ongoing studies have shown that the type and magnitude of the activities of the receptors is dependent upon the cohort of coactivators, corepressors, and activity of cell signaling pathways in the cell; these factors and their interaction with receptors are potential therapeutic targets. In both breast and prostate cancer, hormone ablation, or anti-hormone therapies are commonly used. However, tumors become resistant to these treatments. Although, it was initially assumed that these tumors had bypassed the requirements for the steroid receptors, there is exciting new data coming from a number of labs indicating that these tumors remain receptor-dependent and that alterations in receptor expression, coregulator expression and/or cell signaling permit the receptors to continue to function. Thus, there is evidence that androgen receptor is activated in tumors that have become resistant to androgen ablation and that some tamoxifen resistant tumors retain estrogen receptor dependence. Consequently, the contribution of steroid receptor action in hormonally regulated tumors is greater than initially realized and raises a new set of questions regarding how to block the receptor activity. The goal of this meeting is to bring together experts in steroid hormone action with experts in hormonal effects in tumorigenesis to address the important questions of the mechanisms by which the hormones and their receptors induce growth of tumors and how these processes can be blocked.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 20

15:00—19:30
Registration

Regency Foyer
18:30—19:30
Refreshments

Regency Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Regency Main
Bert W. O'Malley, Baylor College of Medicine, USA
Coactivators and Tissue Specific Responses to Nuclear Receptors

* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA


MONDAY, FEBRUARY 21

07:00—08:00
Breakfast

Regency 1 - 3
08:00—11:00
Nuclear Receptor Action
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Myles Brown, Dana-Farber Cancer Institute, USA
Chromosome Scall Analysis of ER Action

Keith R. Yamamoto, University of California, San Francisco, USA
The Dissecting of Regulatory Networks in Seeking Ligands

Elizabeth M. Wilson, University of North Carolina at Chapel Hill, USA
A Novel Coregulator of Androgen Receptor Transactivation Binds the AR NH2-Terminal FXXLF Motif

Donald P. McDonnell, Duke University School of Medicine, USA
Orphan Nuclear Receptors as Targets for Drug Discovery in Breast Cancer

Michael J. Garabedian, New York University School of Medicine, USA
Short Talk: Role of the Hsp90 Cochaperone p23 in ER-Dependent Gene Expression, Cell Adhesion and Angiogenesis in Breast Cancer Cells

09:20—09:40
Coffee Break

Regency Foyer
11:00—13:00
Poster Setup

Regency 1-3
13:00—22:00
Poster Viewing

Regency 1-3
14:00—16:00
Workshop 1: Regulation of Tumor Cell Growth

Regency Main
* Daniel Medina, Baylor College of Medicine, USA

Alexander Yemelyanov, Northwestern University, USA
Expression and Function of Glucocorticoid Receptor in Prostate Carcinomas and PC Cells

Zhengying Wang, University of Miami, USA
Vitamin D3 Inhibits Cancer Cell Proliferation through Nuclear Exclusion and Decreased Activity of Cyclin-Dependent Kinase 2

Chao Li, Baylor College of Medicine, USA
Regulation of SRC3/AIB1 by Turnover

Amy H. Bouton, University of Virginia School of Medicine, USA
Src-p130Cas Interactions Regulate Estrogen Dependence and Antiestrogen Resistance of Breast Cancer Cells

Åsa Kronblad, Malmö University Hospital, Sweden
ERK1/2 Inhibition Increases Anti-Estrogen Treatment Efficacy by Prevention of Hypoxia-Induced Down-Regulation of ER-alpha. A Combination Therapy Potentially Targeting Hypoxic and Dormant Tumor Cells

Yun Zhu, Emory University School of Medicine, USA
The SDF1/CXCR4 Axis Mediates Estrogen Independence and Tumor Progression in Breast and Ovarian Cancer

Deborah A. Lannigan, University of Virginia, USA
Identification of the First RSK-Specific Inhibitor Reveals an Unexpected Role for RSK in Breast Cancer Cell Proliferation

Glendon M. Zinser, University of Notre Dame, USA
Vitamin D3 and Wnt/Beta-Catenin Crosstalk during Mammary Gland Transformation

16:30—17:00
Coffee & Snacks Available

Regency Foyer
17:00—19:00
Inhibitors of Steroid Metabolism and Steroid Hormone Action in Hormone Dependent Cancer
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Shuk-Mei Ho, University of Massachusetts Medical Center, USA

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in the Regulation of Aromatase Expression in Breast Cancer

Mitchell Dowsett, Royal Marsden, UK
Clinical Use of Aromatase Inhibitors

Craig J. Burd, Ohio State University, USA
Short Talk: Cyclin D1 Blocks Androgen Receptor Activity in Prostatic Adenocarcinoma

Martin P. Tenniswood, University at Albany, USA
Short Talk: Differential Acetylation of Androgen Receptor (AR) and p53 by HDAC Inhibitors and Downstream Target Activation in LNCaP Prostate Cancer Cells

19:00—20:00
Social Hour

Regency 1-3
19:30—22:00
Poster Session 1: Coregulators and Nuclear Receptors 1; Markers; Clinical Studies; Steroid Metabolism

Regency 1-3

TUESDAY, FEBRUARY 22

07:00—08:00
Breakfast

Regency 1 - 3
08:00—11:00
Hormonal Carcinogenesis
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Powel H. Brown, Baylor College of Medicine, USA

Shuk-Mei Ho, University of Massachusetts Medical Center, USA
Epigenetic Regulation of Estrogen Receptor-beta Expression and Prostate Carcinogenesis

Daniel Medina, Baylor College of Medicine, USA
Protective Effects of Steroids in Breast Cancer

Ercole L. Cavalieri, University of Nebraska, USA
Catechol Quinones in the Initiation of Cancer and Other Diseases: A Target for Prevention

John A. McLachlan, Tulane University, USA
Endocrine Disrupters: A Case of Environmental Epigenetics

09:20—09:40
Coffee Break

Regency Foyer
11:00—13:00
Poster Setup

Regency 1-3
13:00—22:00
Poster Viewing

Regency 1-3
16:30—17:00
Coffee & Snacks Available

Regency Foyer
17:00—19:00
Nuclear Receptors and Inhibition of Tumor Growth
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Leonard P. Freedman, Global Biological Standards Institute, USA

Nancy Lynn Weigel, Baylor College of Medicine, USA
Regulation of Prostate Tumor Growth by Vitamin D

JoEllen Welsh, University of New York, Albany, USA
VDR Signaling in Mammary Gland Development and Carcinogenesis in VDR Knockout Mice

Powel H. Brown, Baylor College of Medicine, USA
Chemoprevention in Breast Cancer: Targeting Retinoid Receptors

Anna Abella, INSERM, France
Short Talk: PPARgamma Agonists and HDAC Inhibitors Synergistically Inhibit Prostate Tumor Cell Growth

19:00—20:00
Social Hour

Regency 1-3
19:30—22:00
Poster Session 2: Signaling and Growth Factors; Hormone Independence and Metastasis; Gene Regulation/Expression

Regency 1-3

WEDNESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Regency 1 - 3
08:00—11:00
Estrogen Receptors and Cross-Talk with Cell Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Breast Cancer Regulation by Estrogen Receptors Alpha and Beta and Coregulators

Carlos L. Arteaga, Vanderbilt University School of Medicine, USA
HER2/neu (erbB2) Signaling and Antiestrogen Resistance in Human Breast Cancer

Suzanne AW Fuqua, Baylor College of Medicine, USA
Crosstalk between Estrogen Receptor alpha and Signal Transduction Networks

Ellis R. Levin, University of California, Irvine, USA
Extranuclear Action of ER in Breast Cancer

Leslie C. Hodges, University of California, San Francisco, USA
Short Talk: Estrogen Receptor Pathways to Proliferation in the Mammary Gland

09:20—09:40
Coffee Break

Regency Foyer
11:00—13:00
Poster Setup

Regency 1-3
13:00—22:00
Poster Viewing

Regency 1-3
14:00—16:00
Workshop 2: Nuclear Receptors and their Coregulators

Regency Main
* Wayne D. Tilley, University of Adelaide, Australia

ZhaoYi Wang, Creighton University, USA
A Novel Variant of Estrogen Receptor-Alpha is Expressed in ER-Negative Breast Cancer and Mediates Membrane-Initiated Estrogen Signaling

Virgilio A. Salvo, Tulane University, USA
MEK5-Erk5 Signaling Promotes Estrogen-Independent Tumorigenesis of Breast Carcinoma Cells

Fuzhong Zheng, Baylor College of Medicine, USA
Estrogen Receptor Mediates the Estradiol-Induced Phosphorylation of SRC-3

Irina Agoulnik, Florida International University College of Medicine, USA
Short Talk: A Role for Tif2 in Emergence of Aggressive Prostate Cancers after Androgen Ablation

Catherine K. Yang, University of Southern California, USA
Synergistic Effects of Beta-Catenin and Nuclear Receptor Coactivator CoCoA

Hong-Wu Chen, University of California, Davis, USA
Androgen Receptor and the p160/SRC Coactivators Control Prostate Cancer Cell Proliferation via Distinct Mechanisms

Sung Hee Baek, Seoul National University, South Korea
Roles of Nuclear Receptor Coregulators to Regulate Metastasis Suppressor Genes in Prostate Cancer

16:30—17:00
Coffee & Snacks Available

Regency Foyer
17:00—19:00
Androgen Action in Prostate Cancer
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA

Donald J. Tindall, Mayo Clinic and Foundation, USA
Androgen Regulation of the Growth and Survival of Prostate Cancer Cells

Johannes V. Swinnen, KU Leuven, Belgium
Androgenic Regulation of Lipogenic Gene Expression in Prostate Cancer

Michael B. Cohen, University of Iowa, USA
Short Talk: Androgen Regulation of TNFR Family-Induced Apoptosis

19:00—20:00
Social Hour

Regency 1-3
19:30—22:00
Poster Session 3: Coregulators and Nuclear Receptors 2; Cell/Tumor Growth/Apoptosis

Regency 1-3

THURSDAY, FEBRUARY 24

07:00—08:00
Breakfast

Regency 1 - 3
08:00—11:15
Androgen Receptors and Cross-Talk with Cell Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Donald J. Tindall, Mayo Clinic and Foundation, USA

Wayne D. Tilley, University of Adelaide, Australia
Androgen Receptor in Prostate Cancer Development and Progression

Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of Hormone Refractory Prostate Cancer

Duane D. Miller, University of Tennessee Health Science Center, USA
SARMS- Biology and Chemistry

Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
MAPK Signaling in Cancer

Gerhard A. Coetzee, University of Southern California, USA
Short Talk: AR-Mediated Conversion of Androgen Ablation Sensitive to –Insensitive Cells

Shan Lu, University of Cincinnati School of Medicine, USA
Short Talk: PI3K-Akt Signaling Pathway is Critical for Androgen-Independent Growth in Prostate Cancer Cells

09:20—09:40
Coffee Break

Regency Foyer
16:30—17:00
Coffee & Snacks Available

Regency Foyer
17:00—19:00
Steroids and Cancer
Meeting has ended...abstracts no longer viewable online.

Regency Main
* Suzanne AW Fuqua, Baylor College of Medicine, USA

Jan-Åke Gustafsson, University of Houston, USA
Antiproliferative Actions of ERbeta

Leonard P. Freedman, Global Biological Standards Institute, USA
Mechanisms of Action of ERalpha - Selective Agents

Patricia V. Elizalde, Instituto de Biología y Medicina Experimental, Argentina
Progesterone Action in Breast Cancer Cells

Jianming Xu, Baylor College of Medicine, USA
Short Talk: Dual Role of the Cancer-Amplified Coactivator AIB3 in Mammary Gland Development and Tumorigenesis

19:00—20:00
Social Hour

Regency Foyer
20:00—23:00
Entertainment

Regency Main

FRIDAY, FEBRUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-CA112924-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Wyeth Research Labs


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