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This meeting took place in 2005



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Frontiers of NMR in Molecular Biology IX (A8)


Organizer(s) Brian D. Sykes, Juli Feigon and James H. Prestegard
January 29—February 4, 2005
Banff Centre • Banff, Alberta Canada
Abstract Deadline: Sep 29, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 30, 2004

Supported by The Director's Fund

Summary of Meeting:
Nuclear Magnetic Resonance (NMR) has a long history of evolving to meet new challenges of molecular biology; this evolution will be even more rapid in a genomic and post-genomic era. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches for fast structure determination and the prospect of having more targets for the pharmaceutical industry has spawned new NMR based means of screening for molecular interactions. For the future, NMR is expanding into biologically and medically important areas such as integrated systems biology and metabonomics. There are new demands for working with large complex data sets. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting demands new methods for monitoring macromolecular interaction in large systems as well as motion in these systems. The advances needed often come from discussions among scientists expert in solids NMR, macromolecular solution NMR, molecular biology and drug discovery. The ultimate challenge for the meeting will be to stimulate discussion among scientists representing these diverse fields. The meeting will be largely organized around new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, computational biologists, and drug design specialists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. Scheduled breaks between formal presentation sessions are ideal for simulating discussion among participants. Discussion of more practical aspects will be promoted by the addition of afternoon workshops having a tutorial structure.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 29

15:00—19:30
Registration

Eric Harvie Foyer
18:30—19:30
Refreshments

Eric Harvie Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
NMR as a Tool in Drug Research


SUNDAY, JANUARY 30

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
NMR Studies of Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Robert G. Griffin, Massachusetts Institute of Technology, USA

Stanley J. Opella, University of California, San Diego, USA
New NMR Methods for Membrane Proteins

Lynmarie K. Thompson, University of Massachusetts, USA
Solid-State NMR Studies of Structure and Dynamics in Transmembrane Signaling

Mei Hong, Massachusetts Institute of Technology, USA
Structure and Folding of Membrane Peptides and Proteins

Tomasz Cierpicki, University of Michigan, USA
Short Talk: Measurement of Residual Dipolar Couplings and Refinement of the Structures of Membrane Proteins – Application to 50 kDa Complex of OmpA in DPC Micelles

Jianjun Wang, Wayne State University, USA
Short Talk: NMR Structural Studies of Human Apolipoprotein A-I and High-Density Lipoprotein Particles

09:20—09:40
Coffee Break

Eric Harvie Foyer
11:00—13:00
Poster Setup

122, 124
13:00—22:00
Poster Viewing

122, 124
16:30—17:00
Coffee & Snacks Available

Eric Harvie Foyer
17:00—19:00
NMR in Integrated Systems Biology
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Iain D. Campbell, University of Oxford, UK

Jeremy K. Nicholson, Imperial College London, UK
NMR Spectroscopic Approaches in Metabonomics and Global Systems Biology

Dorothee Kern, Brandeis University, HHMI, USA
Dynamic Personality of an Enzyme Underlies Catalysis

Michael D. Reily, Pfizer Global Research & Development, USA
Metabolic Profiling Using NMR Spectroscopy

Ian A. Lewis, University of Wisconsin-Madison, USA
Short Talk: Automated Filtering of NMR Spectra: A New Tool for the Discovery of Metabolites Associated with Type 2 Diabetes

19:00—20:00
Social Hour

122,124
19:30—22:00
Poster Session 1

122, 124

MONDAY, JANUARY 31

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Large Proteins and Large Protein Assemblies
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* John L. Markley, University of Wisconsin-Madison, USA

Gerhard Wagner, Harvard Medical School, USA
Protein-Protein Interactions and Their Inhibition

Brian D. Sykes, University of Alberta, Canada
Calcium Regulatory Proteins: From Solution to Intact Muscle Fiber

Iain D. Campbell, University of Oxford, UK
Multi-Domain Proteins at the Cell-Surface

Mitsuhiko Ikura, University of Toronto, Canada
Structure and Function of “Large" Transcription and Signaling Complexes

Masatsune Kainosho, Nagoya University, Japan
Short Talk: SAIL Method: An Ultimate Stable-Isotope Assisted NMR Approach

09:20—09:40
Coffee Break

Eric Harvie Foyer
11:00—13:00
Poster Setup

122, 124
13:00—22:00
Poster Viewing

122, 124
15:00—16:30
Workshop A: New Structural Information - RDC's and Paramagnetic Distances

Eric Harvie Theatre
* Ad Bax, NIDDK, National Institutes of Health, USA

Bernd Simon, European Molecular Biology Laboratory, Germany
A New Protocol to Orient Structural Domains Based on RDCs

Kalle Gehring, McGill University, Canada
Measurement of Residual Dipolar Couplings in Spinning Oriented Media

Paul B. Card, University of Texas Southwestern Medical Center, USA
Structural Insights of PAS Domain Dimerization Using Paramagnetic Spin Labeling

Amanda S. Altieri, National Cancer Institute, Frederick, USA
New Insights into STAT Tetramerization Derived from the Solution Structure of the N-Terminal Domain of STAT4

Andrew J. Benie, Novo Nordisk A/S, Denmark
Assigning an Isoform of the Hepatitis 3c Protease, Using a Novel Combination of Triple Resonance Experiments and Residual Dipolar Coupling Constants

16:30—17:00
Coffee & Snacks Available

Eric Harvie Foyer
17:00—19:00
Structural Genomics - New Experimental Approaches
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Peter E. Wright, The Scripps Research Institute, USA

Gaetano Thomas Montelione, Rutgers University, USA
Structural Proteomics of Eukaryotic Protein Domain Families

John L. Markley, University of Wisconsin-Madison, USA
Eukaryotic Structural Proteomics: The NMR Side of the Pipeline

James H. Prestegard, University of Georgia, USA
Residual Dipolar Couplings: A Basis for Protein Structure Determination of Novel Proteins and Protein Complexes

Keith L. Constantine, Bristol Myers Squibb Company, USA
Short Talk: Protein-Ligand NOE Matching: An Approach for High-Throughput Structure Determination of Protein-Ligand Complexes

19:00—20:00
Social Hour

122,124
19:30—22:00
Poster Session 2

122, 124

TUESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:15
New Methods in NMR
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Lewis E. Kay, University of Toronto, Canada

Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
Biomolecular Dynamics Studied by Dipolar Couplings

Ad Bax, NIDDK, National Institutes of Health, USA
Weak Alignment Provides Unique Opportunities in NMR Studies of Biomolecules

Thomas Szyperski, SUNY at Buffalo, USA
GFT NMR Based Protein Structure Determination in High-Throughput

Lucio Frydman, Weizmann Institute of Science, Israel
Principles and Perspectives of sub-Second Multidimensional NMR Spectroscopy

Gerhard Wider, ETH Zurich, Switzerland
Solution NMR Studies of Membrane Protein Structure and Folding

09:20—09:40
Coffee Break

Eric Harvie Foyer
11:15—13:00
Poster Setup

122, 124
13:00—22:00
Poster Viewing

122, 124
15:00—16:45
Workshop B: New Methods for Metabonomics and Drug Discovery

Eric Harvie Theatre
* Gerhard Wagner, Harvard Medical School, USA

Bernhard H. Geierstanger, Genomics Institute of the Novartis Research Foundation, USA
High-throughput Chemical Analysis, Compound Screening and Metabolite Measurements Using An Automated Micro-Coil Flow NMR System and Only Five Microliter of Sample

Gregg Siegal, ZoBio, Netherlands
Target Immobilized NMR Screening – An Efficient and Sensitive New Method for Ligand Discovery

Gordon S. Rule, Carnegie Mellon University, USA
PEPMORPH: Drug Discovery and Homology Detection Using Sparse NMR Data

Daniel F. Wyss, Merck Research Laboratories, USA
NMR-Based Screening Applied to Drug Discovery Targets

Maurizio Pellecchia, University of California, Riverside, USA
Targeting Apoptosis via Chemical Design: A NMR- and Structure-Based Approach

Eric C. Johnson, Bruker Biospin Corporation, USA
NMR Screening Efforts to Identify Inhibitors of the HIV Rev-RRE Interaction

Carolyn M. Slupsky, ,
Metabolomic NMR Data Analysis in Human Disease

16:45—17:00
Coffee & Snacks Available

Eric Harvie Foyer
17:00—19:00
Small Molecule-Macromolecule Interactions and Drug Design
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Michael D. Reily, Pfizer Global Research & Development, USA

Bernd Meyer, University of Hamburg, Germany
STD-NMR: Binding of Ligands to Live Cells and GPCRs and as an Effective Tool to Design New Ligands

Mark McCoy, Merck & Co., Inc., USA
Short Talk: NMR Methods in Drug Discovery

Till Maurer, Boehringer Ingelheim Pharma, Germany
Short Talk: Towards Structural Information from STD NMR Spectroscopy

19:00—20:00
Social Hour

122,124
19:30—22:00
Poster Session 3

122, 124

WEDNESDAY, FEBRUARY 2

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Nucleic Acids and Protein-Nucleic Acid Complexes
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Juli Feigon, University of California, Los Angeles, USA

Joseph D. Puglisi, Stanford University, USA
NMR Investigations of Large RNAs

Gabriele L. Varani, University of Washington, USA
Telomerase RNP: Processivity Determinants and Assembly

Juli Feigon, University of California, Los Angeles, USA
Structural and Functional Studies of Human Telomerase and Yeast RNase III

Nancy L. Greenbaum, Hunter college of CUNY, USA
Structural Biology of Pre-mRNA Splicing

Teresa Carlomagno, Universität Hannover, Germany
Short Talk: The Conformation of the 2-OH Group of RNA in Solution: Implications for RNA Structure Stabilization

09:20—09:40
Coffee Break

Eric Harvie Foyer
11:00—13:00
Poster Setup

122,124
13:00—22:00
Poster Viewing

122,124
15:00—16:30
Workshop C: NMR Approaches and Applications for Membrane Proteins

Eric Harvie Theatre
* Stanley J. Opella, University of California, San Diego, USA

Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA
Ion Transport and Apoptosis Regulatory Proteins in Lipid Environments.

Anna A. De Angelis, University of California, San Diego, USA
High-Resolution NMR Spectroscopy of Membrane Proteins in Bicelles

Charles R. Sanders, Vanderbilt University School of Medicine, USA
Assessing the General Feasibility of Solution NMR-Based Structural Determination for Polytopic Membrane Proteins

Cheryl A. Hawkins, National Institutes of Health, USA
Structure of Saposin C in a Membrane-Mimicking Environment

Philip L. Yeagle, University of Connecticut, USA
Membrane Protein Domain Behavior Suggests Folding Paradigms

Jin-Hong Chen, Memorial Sloan-Kettering Cancer Center, USA
Direct Observation of Membrane Lipid Hydration

16:30—17:00
Coffee & Snacks Available

Eric Harvie Foyer
17:00—19:00
Solid-State NMR
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Lynmarie K. Thompson, University of Massachusetts, USA

Robert G. Griffin, Massachusetts Institute of Technology, USA
Amyloid and Membrane Protein Structure Determination with Dipolar Recoupling and Dynamic Nuclear Polarization

Hartmut Oschkinat, FMP Berlin, Germany
Structure Determination of Proteins by Magic-Angle Spinning Solid-State NMR

Robert Tycko, NIDDK, National Institutes of Health, USA
Amyloid Fibrils and Protein Folding Intermediates: Solid State NMR Methods and Results

Klaus Gawrisch, NIAAA, National Institutes of Health, USA
Short Talk: NMR Studies on Single Lipid Bilayers Supported in Cylindrical Aluminum Oxide Nanopores – Reconstitution of GPCR

19:00—20:00
Social Hour

122,124
19:30—22:00
Poster Session 4

122, 124

THURSDAY, FEBRUARY 3

07:00—08:30
Breakfast

Donald Cameron Hall
08:00—11:00
Motions in Proteins and Nucleic Acids
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany

Erik R. P. Zuiderweg, University of Michigan, USA
The Allostery of Hsp70 Chaperones Sstudied by NMR

A. Joshua Wand, University of Pennsylvania, USA
Protein Dynamics and Thermodynamics: A View Emerging from NMR Relaxation

Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
New Methods and Applications of NMR in Drug Discovery

Lewis E. Kay, University of Toronto, Canada
Solution NMR of High Molecular Weight Proteins

Arthur G. Palmer, III, Columbia University, USA
Protein Motions in Catalysis, Binding, and Folding

09:20—09:40
Coffee Break

Eric Harvie Foyer
16:30—17:00
Coffee & Snacks Available

Eric Harvie Foyer
17:00—19:00
Protein Folding and Disease
Meeting has ended...abstracts no longer viewable online.

Eric Harvie Theatre
* James H. Prestegard, University of Georgia, USA

Peter E. Wright, The Scripps Research Institute, USA
Functionally Disordered Proteins: A New Challenge in Structural Biology

Christopher M. Dobson, University of Cambridge, UK
NMR Spectroscopy in Studies of Protein Folding and Misfolding

Richard Dixon, University of North Carolina, Chapel Hill, USA
Short Talk: New Insights into FAK Signaling Based on Detection of a FAT Domain Folding Intermediate

Markus Zweckstetter, Max-Planck Institute for Biophysical Chemistry / DZNE, Germany
Short Talk: Staying Dr. Jeckle: Residual Structure and Slow Dynamics in alpha-Synuclein

20:00—21:00
Social Hour

Donald Cameron Hall
20:00—23:00
Entertainment

Donald Cameron Hall

FRIDAY, FEBRUARY 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-GM073374-01




We gratefully acknowledge additional support for this conference from:

Chenomx Varian, Inc.

Bruker BioSpin Corp.

Cambridge Isotope Laboratories

ISOTEC, a member of the Sigma-Aldrich Group

Spectra Gases, Inc. Stable Isotopes Group


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


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