Granlibakken Tahoe Floorplan

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This meeting took place in 2006



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Cardiac Arrhythmias: Linking Structural Biology to Gene Defects (B3)


Organizer(s) W. Jonathan Lederer and Robert S. Kass
January 29—February 3, 2006
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Sep 28, 2005
Late Abstract Deadline: Oct 20, 2005
Scholarship Deadline: Sep 28, 2005
Early Registration Deadline: Nov 29, 2005

Supported by The Director's Fund

Summary of Meeting:
Cardiac arrhythmias are one of the leading causes of death world-wide. Recent studies of the causes of cardiac arrhythmias provide broad new understanding of the heart, providing novel remedies and new approaches for treatment. The new findings will be presented in a tightly integrated set of talks covering structural and molecular biology, cell biology and physiology and therapeutics and clinical approaches. The symposium will bring together a unique group with expertise in structural biology, molecular and systems physiology, and industrial approaches to target discovery and drug development. Newly identified protein structures provide insight into ion channel behavior and regulation. This work spans the behavior, structure and function of normal and disease-linked gene mutations of K+, Na+, Ca2+ , RyR and IP3R channels. In addition, macromolecular complexes have been identified and characterized and reveal how specific elements provide extraordinary local control of cardiac cellular signaling. The subcellular organization, dependent on cytoskeletal organization, has been shown to significantly contribute to the normal cell function and disease. New molecular and pharmacological approaches to treatment arise from this understanding.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 29

15:00—19:30
Registration

Pre-Function

MONDAY, JANUARY 30

07:00—08:00
Breakfast

Granhall
08:00—11:00
Congenital and Acquired Arrhythmias: Clinical and Theoretical Basis
Meeting has ended...abstracts no longer viewable online.

Mountain
* Silvia G. Priori, Foundation Salvatore Maugeri, Italy
Channel Mutations that Underlie Human Arrhythmogenesis.

Denis Escande, University of Nantes, France
Functional Consequences of Scn5a Invalidation in the Mouse Heart

Dan M. Roden, Vanderbilt University School of Medicine, USA
Pharmacogenomic Basis Of Drug-Induced Arrhythmias

Yoram Rudy, Washington University, USA
Modeling Cardiac Arrhythmias

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Lake
13:00—22:00
Poster Viewing

Lake
16:30—17:00
Coffee Available

Pre-Function
17:00—19:00
Ca2+ Dynamics and Arrhythmogenesis
Meeting has ended...abstracts no longer viewable online.

Mountain
Guy Salama, University of Pittsburgh, School of Medicine, USA
Sodium/Calcium Exchanger as a Molecular Determinant of Arrhythmias in Drug-Induced Long QT 2

* W. Jonathan Lederer, University of Maryland Baltimore, USA
Subcellular Changes that Underlie Ca2+ Signaling Dysfunction

Donald M. Bers, University of California, Davis, USA
Na-Ca Exchange, SR Ca Leak and Arrhythmogenesis

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Lake
20:00—21:00
Social Hour

Lake

TUESDAY, JANUARY 31

07:00—08:00
Breakfast

Granhall
08:00—11:00
K+ and Pacemaker Channels
Meeting has ended...abstracts no longer viewable online.

Mountain
* Robert S. Kass, Columbia University, USA
K-and Na- Channel Dysfunction and Arrhythmogenesis

Barry London, University of Pittsburgh, USA
HERG Arrhythmogenesis

Steven A. Siegelbaum, New York State Psychiatric Institute, USA
Cardiac HCN Channels: Regulatory Mechanisms

Michael C. Sanguinetti, University of Utah, USA
KCNQ1 and hERG Channels

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee Available

Pre-Function
17:00—18:20
Na+ Channels
Meeting has ended...abstracts no longer viewable online.

Mountain
* Alfred L. George, Jr., Vanderbilt University, USA
Sodium Channel Mutations and Inherited Arrhythmias

Gordon Tomaselli, Johns Hopkins School of Medicine, USA
Na Channels, Conduction and Arrhythmias

18:30—19:30
Social Hour

Lake
19:30—20:30
Dinner

Granhall

WEDNESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Granhall
08:00—11:00
Ion Channel Modifiers and Arrhythmogenesis
Meeting has ended...abstracts no longer viewable online.

Mountain
* Paul A. Insel, University of California, San Diego, USA
Caveolin-Enriched Signaling Domains and Cardiac GPCR Signal Transduction

Peter J. Mohler, University of Iowa, USA
Dysfunction in Ankyrin-Based Pathways for Ion Channel/Transporter Targeting and Human Arrhythmia

Walter J. Koch, Temple University School of Medicine, USA
Regulating Adrenergic and Calcium Signaling via Gene Therapy

Short Talks Chosen from Abstracts
Presenters to be Selected from Poster Display Contest

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee Available

Pre-Function
17:00—19:00
Kinases
Meeting has ended...abstracts no longer viewable online.

Mountain
Mark E. Anderson, Johns Hopkins University School of Medicine, USA
The Role of Calmodulin Kinase II in Arrhythmias

* John D. Scott, University of Washington, USA
Molecular Architecture in Signal Transduction Complexes

Geoffrey Pitt, Duke University, USA
Calcium Regulation of Diverse Ion Channels and Functions

19:00—20:00
Social Hour

Lake
20:00—21:00
Dinner

Granhall

THURSDAY, FEBRUARY 2

07:00—08:00
Breakfast

Granhall
08:00—11:00
Subcellular Channels and Arrhythmias
Meeting has ended...abstracts no longer viewable online.

Mountain
Xander H.T. Wehrens, Baylor College of Medicine, USA
RyR Regulation and Arrhythmogenesis

Lothar A. Blatter, Rush University Chicago, USA
IP3 Receptors and Arrhythmogenesis

* Barbara E. Ehrlich, Yale University, USA
InsP3R Dependent Oscillations in Cardiac Cells

Elizabeth A. Woodcock, Baker IDI Heart and Diabetes Institute, Australia
IP3 Signaling in Heart

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee Available

Pre-Function
17:00—19:00
Channels as Molecular Targets: A Pharmaceutical Industry Perspective
Meeting has ended...abstracts no longer viewable online.

Mountain
* Maria L. Garcia, Merck Research Laboratories, USA
Rationale Design of Ion Channel Modulators

Søren Peter Olesen, University of Copenhagen, Denmark
HERG Channel Activators as a New Anti-Arrhythmic Principle

Klaus Steinmeyer, Sanofi-Aventis Deutschland GmbH, Germany
Kv1.5 Channel Blockers for the Treatment of Atrial Fibrillation

19:00—20:00
Social Hour

Lake
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Mountain/Lake Rooms

FRIDAY, FEBRUARY 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 HL083678-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck Research Laboratories


NeuroSearch A/S


Sanofi US


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676