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This meeting took place in 2006



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Adipogenesis, Obesity and Inflammation (J4)


Organizer(s) Philipp E. Scherer and Steven E. Shoelson
January 21—26, 2006
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Sep 21, 2005
Late Abstract Deadline: Oct 13, 2005
Scholarship Deadline: Sep 21, 2005
Early Registration Deadline: Nov 21, 2005

Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development


Summary of Meeting:
The worldwide epidemic in obesity has brought with it dramatic increases in the prevalence of co-morbid, chronic conditions including insulin resistance, type 2 diabetes, the metabolic syndrome, and atherosclerosis. The rapid rise in these major public health problems underscores a growing need to understand the physiological and pathological bases of feeding and obesity, and the pathophysiological links between obesity and these associated morbidities. This meeting focuses on recent advances being made in our understanding of the molecular basis of feeding and nutrient storage and on the molecular consequences of obesity in terms of promoting risk of developing diabetes and cardiovascular disease. Specific topics related to potential causes of obesity include: I) Central regulation of feeding and adiposity, II) Genetic defects leading to obesity, and III) Adipogenesis and adipocyte differentiation. Topics related to the consequences of obesity include: I) Adipokines and other products of adipocytes, II) Inflammation in fat and other organs and the recruitment and involvement of macrophages, III) Accumulation of lipids and adipocytes in other organs, IV) Etiology of the metabolic syndrome and association with atherosclerosis. Special attention will be given to translational insights that highlight some of the clinical implications of excess storage of adipose tissue. Some sessions will be held jointly with the “Diabetes Mellitus and the control of Cellular Energy Metabolism” meeting that will effectively complement the obesity meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 21

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Christopher B. Newgard, Duke University Medical Center, USA
Comprehensive Metabolic Profiling for Understanding of Obesity and Diabetes Mechanisms


SUNDAY, JANUARY 22

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Lipid and Carbohydrate Metabolism and Energy Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Bei B. Zhang, Pfizer Inc., USA
Short Talk: Role of DPP-4 Inhibitors in Glycemia Control and Beta-cell Preservation

Bruce M. Spiegelman, Harvard Medical School, USA
The Transcriptional Basis of Energy Homeostasis

Richard N. Bergman, Cedars-Sinai Medical Center, USA
Pathophysiology of the Metabolic Syndrome

Christopher K. Glass, University of California, San Diego, USA
Anti-inflammatory and Antidiabetic Roles of PPARgamma in Macrophages

Domenico Accili, Columbia University, USA
Forkhead Proteins in Diabetes and Obesity

Rudolf Zechner, University of Graz, Austria
Short Talk: ATGL: A Newly Discovered Rate-limiting Enzyme for the Lipolysis of Stored Fat

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Hot Topics I

British Columbia Ballroom
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Philip G. McTernan, University of Warwick, UK
Sub-clinical Inflammation in Type 2 Diabetes: Effect of Endotoxemia on Initiating the Inflammatory Cascade in Human Adipose Tissue

Robert M. O'Doherty, University of Pittsburgh, USA
Toll-like Receptor-4 Mediates Palmitate and Lipopolysaccaride Activation of the IKK/IkappaB/NFkappaB Pathway in Skeletal Muscle

Carl W. Porter, Roswell Park Cancer Institute, USA
Spermidine/spermine N1-Acetyltransferase as a Effector of Fat Homeostasis

Ofer Reizes, Cleveland Clinic Foundation, USA
Weight Reduced Diet Induced Obese Mice Have Small Fat Cells, Improved Glucose Clearance, and are Leptin Sensitive

Ann V. Hertzel, University of Minnesota, USA
Lipid Metabolism and Adipokine Levels in Fatty Acid Binding Protein Null and Transgenic Mice

Joel P. Berger, Takeda Pharmaceuticals International, USA
A Novel Selective Peroxisome Proliferator-Activator Receptor-gamma Modulator is a Robust Insulin Sensitizer with Diminished Adverse Cardiovascular Effects

14:30—16:30
Hot Topics I

* Silvia Corvera, University of Massachusetts Medical School, USA

Takehide Ogihara, Fukushima Medical University, Japan
Role of eNOS in Beta Cell Regeneration after Bone Marrow Transplantation in STZ-Diabetic Mouse Models

Su-Jin Kim, University of British Columbia, Canada
Quantitative Post-Transplant Islet Imaging In Vivo Using Micro Positron Emission Tomography (PET) for the Determination of Islet Graft Survival

Haruhisa Iguchi, National Cancer Center Research Institute, Japan
SOX6 Attenuates Glucose Stimulated Insulin Secretion and Acts as a Co-Repressor for PDX1

Dinesh C. Gautam, NIDDK, National Institutes of Health, USA
A Critical Role for Beta-Cell M3 Muscarinic Acetylcholine Receptors in Regulating Insulin Release and Blood Glucose Homeostasis

Mirela Delibegovic, University of Aberdeen, UK
Dessecting the Tissue Specific Roles of Protein-Tyrosine Phosphatase 1B (PTP1B)

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Molecular Mechanism of Adipogenesis and Adipokines
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Domenico Accili, Columbia University, USA

Stephen R. Farmer, Boston University School of Medicine, USA
Transcriptional Control of Adipocyte Formation and Function

M. Daniel Lane, Johns Hopkins University, USA
Role of the C/EBPs in Adipogenesis

Ormond A. MacDougald, University of Michigan, USA
Role of Wnt Signaling in Development of Adipose Tissues and Bone

Shigeki Shimba, Nihon University, Japan
Short Talk: BMAL1, a Master Component of the Molecular Clock, Regulates Adipogenesis and IL6 Expression

17:00—19:00
Mitochondria and Diseases
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Short Talk: Regulation of Myocardial Mitochondrial Oxidative Capacity by PI3-Kinase and Akt

Michael A. Brownlee, Albert Einstein College of Medicine, USA
Mitochondrial Disfunction, Methylhlyoxal Generation and Diabetic Complications: A Novel Mechanism for Regulation of Gene Expression of Hyperglycemra

Nils-Goran Larsson, Max Planck Institute for the Biology of Aging, Germany
The Role of Mitochondrial Dysfunction in Aging and Diabetes

David E. Kelley, Merck & Co., Inc., USA
Mitochondrial Dysfunction in the Pathogenesis of Insulin Resistance

Ingrid A. Dahlman, Karolinska Institutet, Sweden
Short Talk: Downregulation of Electron Transport Genes in Visceral adipose Tissue in Type 2 Diaberes Independantly of Obesity and Possibly Involving Tumor Necrosis Factor alpha

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

MONDAY, JANUARY 23

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Regulators of Obesity and Inflammation
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Mark A. Febbraio, Garvan Institute of Medical Research, Australia
Short Talk: HSP 72 Protects against Diet-Induced Insulin Resistance by Blocking JNK Phosphorylation

Michael Karin, University of California, San Diego, USA
IKK/NF-kappaB Activation Pathway

Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Integration of Stress Signals in the Endoplasmic Reticulum in Obesity and Diabetes

Anthony W. Ferrante, Columbia University, USA
Adipose Tissue Inflammation and Macrophages

Bente Klarlund Pedersen, Rigshospitalet, Denmark
Exercise and IL-6 action

Peter Cornelius, Systamedic, USA
Short Talk: Resistance of CCR2-/- Mice to Diet-Induced Obesity

08:00—11:15
Organelle Biogenesis and Energy Control
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: Signaling Networks Fueling Mitochondrial Metabolism in Fat

Tracey A. Rouault, NICHD, National Institutes of Health, USA
The Role of Iron Regulatory Proteins in Mammalian Iron Metabolism and Neurodegeneration

Daniel P. Kelly, University of Pennsylvania, USA
Mitochondrial Adaptation and Maladaptin in Cardiac and Skeletal Muscle

Janet M. Shaw, University of Utah, USA
Mitochondrial Dynamics and Function in Eukaryotic Cells

Mary-Elizabeth Patti, Joslin Diabetes Center, USA
The Mitochondrial Hypothesis and Diabetes Pathogenesis: A Genomics Perspective

Carles Lerin, Hospital Sant Joan de Déu, Spain
Short Talk: Transcriptional Regulation of Glucose Metabolism through PGC-1alpha Acetylation by the GCN5 Acetyl Transferase Complex

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Cellular Responses to Cytokines (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Randal J. Kaufman, Sanford-Burnham Medical Research Institute, USA
Stress in the Endoplasmic Reticulum Activates an Acute Inflammatory Response

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Tissue-specific Effects of Inflammation in Insulin Resistance, Type II Dianetes, and the metabolic Syndrome

Silvia Corvera, University of Massachusetts Medical School, USA
Cellular Energy Control and Secretion

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Secretory Proteins from Adiose Tissue - Significance for Insulin Resistance

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

TUESDAY, JANUARY 24

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Signal Transduction and Glucose Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Paul F. Pilch, Boston University School of Medicine, USA

Morris J. Birnbaum, Pfizer Inc., USA
The Regulation of Glucose and Lipid Metabolism by Akt/PKB

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Adipocyte-secreted Molecule, Retinol Binding Protein 4, and the Metabolic Syndrome

Markus Stoffel, ETH Zürich, Switzerland
Insulin Regulated Transcription Factors

Luciano Rossetti, Merck Research Laboratories, USA
Insulin Signal Transduction in the Hypothalamus

Jacqueline M. Stephens, Louisiana State University, USA
The Regulation of CT-1 and STAT 5A in Adipocytes

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Theraputic Effects of Metformin

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Hot Topics II

British Columbia Ballroom
* Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA

Lisa A. Lesniewski, University of Colorado, Boulder, USA
Macrophage-Specific CAP Gene Deletion Protects Against High Fat Diet-Induced Insulin Resistance

Carrie E. McCurdy, University of Oregon, USA
Chronic Maternal Overfeeding Leads to Fetal Steatosis and Metabolic Programming in the Non-Human Primate

Susanna Hofmann, Klinikum der Universitaet Muenchen, Germany
Impaired Lipid Delivery Increases Insulin Sensitivity in Apolipoprotein E Deficient Mice

Karen Ruschke, , Germany
Deficiency of the Neuronal Transcription Factor NSCL-2 Results in an Increased Number of Preadipocytes in WAT

Robert E. Lewis, University of Nebraska Medical Center, USA
KSR2-/- Mice are Obese and Energy Efficient

14:30—16:30
Hot Topics II

* Ann Louise Olson†, Oklahoma University Health Sciences Center, USA

Nigel Turner, University of New South Wales, Australia
Role of C-Cbl in the Regulating Fatty Acid Oxidation and Energy Metabolism

Jun Wada, Okayama University Graduate School of Medicine, Japan
Gene Delivery of Tim44 Reduces Mitochondrial Superoxide Production and Ameliorates Neointimal Proliferation

Xiaoyong Yang, Yale University School of Medicine, USA
Phosphatidylinositol Signaling Links Protein O-GlcNAc Modification to Insulin Resistance

Sarah L. Gray, University of Northern British Columbia, Canada
Metabolic Characterization of Mice Heterozygous for a Dominant-Negative PPARgamma Mutation

Katja A. Lamia, The Scripps Research Institute, USA
Circadian Clocks and Mammalian Energy Homeostasis

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Adipose Tissue, Lipids and Diabetes
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Perry E. Bickel, University of Texas Southwestern Medical Center, USA
Short Talk: The Birth of the Lipid Droplet

Derek Leroith, Mount Sinai School of Medicine, USA
IGFs, Obesity, Diabetes and Cancer

Jeffrey Flier, Harvard University, USA
Novel Pathways for Regulating Body Weight and Insulin Resistance

Paul F. Pilch, Boston University School of Medicine, USA
Caveolin-1/Cholesterol Modulates Transmembrane Fatty Acid Movement

17:00—19:00
Molecular Control of Insulin Sensitivity
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Morris F. White†, Boston Children's Hospital, Harvard Medical School, USA

Michael P. Czech, University of Massachusetts Medical School, USA
Pathways Controlling Insulin Sensitivity in Adipose Cells

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
A Genomic Screen for the Cellular Basis of Insulin Resistance

Timothy E. McGraw, Weill Medical College of Cornell University, USA
Molecular Control of Glucose Uptake

Liza Makowski, University of North Carolina at Chapel Hill, USA
Short Talk: A Novel Role for Mitochondrial-derived Fatty Acid Metabolites in Regulating Insulin Signaling

Sarah L. Dunn, Children's Hospital Boston, USA
Short Talk: Serine Phosphorylation of Irs2: Regulation of Irs2(Ser965) Phosphorylation by MAP kinase Pathways

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

WEDNESDAY, JANUARY 25

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Complications
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Michael A. Brownlee, Albert Einstein College of Medicine, USA

John S. Yudkin, University of College London, UK
Adipocytokines, Insulin Resistance and Vascular Disease - Common Pathways?

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Inflammation and the Complications of Diabetes

Mason W. Freeman, Massachusetts General Hospital, USA
Type II Diabetes and Atherosclerosis

Juleen R. Zierath, Karolinska Institutet, Sweden
Insulin and AMPK Signaling in Skeletal Muscle: Validation of Targets to Prevent and Treat Type 2 Diabetes Mellitus

Yaacov Barak, Magee-Womens Research Institute, USA
Short Talk: PPARgamma, Adipose Tissue Inflammation and the Metabolic Syndrome

08:00—11:15
Secretory Pathway and Energy Homeostasis
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Fumihiko Urano, Washington University School of Medicine, USA

Jonathan S. Weissman, University of California, San Francisco, USA
Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER Lumen

Takashi Kadowaki, University of Tokyo, Japan
Adiponenctin,Adiponenctin Receptors, and Metabolic Regulation

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Part I: Resistin and Atherosclerosis Part II: A Post-Translational Nuclear Receptor Switch That Synchronizes Circadian Rhythms

Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
Regulation of Insulin Responsive Vesicle Trafficking in Adipocytes

Hans P.M.M. Lauritzen, , Denmark
Short Talk: Imaging of Insulin Signaling in Skeletal Muscle of Living Mice Shows Major Role of T-Tubules

Sonya G. Fonseca, Novartis, USA
Short Talk: WFS1 is Important in Mitigating Endplasmic Retuculum Stress in Beta Cells through the Unfolded Protein Response

09:20—09:40
Coffee Break

BC Foyer
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Metabolic Crosstalk and Energy Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Silvia Corvera, University of Massachusetts Medical School, USA

* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Tissue Specific PPARgamma Effects, Insulin Responsiveness and Energy Homeostasis

Stephen O'Rahilly, University of Cambridge, UK
Human Obesity and Insulin Resistance: Lessons from Experiments of Nature

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Mitochondrial Dysfunction and Type 2 Diabetes

Silvana Obici, University of Cincinnati, USA
Short Talk: Metabolic Consequences of the Activation of the Hexosamine Biosynthesis Pathway in Skeletal Muscle

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

THURSDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK072700-01




We gratefully acknowledge additional support for this conference from:

ALPCO Diagnostics Cell Signaling Technology, Inc.
Novartis Institutes for BioMedical Research Pfizer Global Research & Development

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