Beaver Run Resort Floorplan

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This meeting took place in 2006



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Hypoxia and Development, Physiology and Disease (A5)


Organizer(s) M. Celeste Simon, Randall S. Johnson, Amato Giaccia and Max Gassmann
January 16—21, 2006
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 15, 2005
Late Abstract Deadline: Oct 10, 2005
Scholarship Deadline: Sep 15, 2005
Early Registration Deadline: Nov 16, 2005

Supported by The Director's Fund

Summary of Meeting:
Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 16

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* M. Celeste Simon, University of Pennsylvania, USA
Welcoming Remarks

Napoleone Ferrara, University of California, San Diego, USA
VEGF, Hypoxia and Tumor Angiogenesis

Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Schizophrenia, Stem Cells and Sprouty Signaling


TUESDAY, JANUARY 17

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:20
Hypoxia and Model Organisms
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Richard K. Bruick, University of Texas Southwestern Medical Center, USA
Studies on the Structure, Function, Regulation and Therapeutic Targeting of HIF

Pablo Wappner, Fundacion Instituto Leloir, Argentina
Role of the Drosophila HIF-a Homologue, Sima, in Cell Size Determination and Growth Control

* Peter J. Ratcliffe, University of Oxford, UK
HIF Hydroxylases and Oxygen Signaling

Peter F. Carmeliet, University of Leuven, VIB, Belgium
PHDs in Mice and Zebrafish

Peter J. Espenshade, Johns Hopkins University School of Medicine, USA
Short Talk: SREBP Regulates Anaerobic Gene Expression in Fission Yeast

Eelke Gort, University Medical Center Utrecht, Netherlands
Short Talk: A Whole Genome RNAi Screen in C. elegans Allows Identification of Novel Hypoxia Inducible Factor-1 alpha Regulators in Human Cells

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
14:00—16:30
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

* Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA
Novel Small Molecule Inhibitors of HIF-1

Adam V. Patterson, University of Auckland, New Zealand
PR-104: Development of a New Hypoxic Cytotoxin

Erwin G. Van Meir, Emory University School of Medicine, USA
Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1alpha

Patricia A. Burke, CASI Pharmaceuticals, USA
ENMD-1198 Shows Antitumor Activity, Increased Survival, and HIF-1á, NFkappaB and Stat3 Inhibition in vivo

Todd W. Seeley, FibroGen, Inc., USA
FG-2216: Tumor Progression Studies and Correction of Anemia of Cancer in Xenograft Models

David J. Lomb, University of Rochester, USA
HIF Prolyl Hydroxylase Inhibitors Protect Sympathetic Neurons from NGF Deprivation-Induced Death

Andrea L. Bacon, Cancer Research UK, UK
Hypoxia Induced Autophagy and the Role of BNIP3

Nicholas Denko, Ohio State University, USA
HIF1 Reduces Mitochondrial Oxygen Consumption through PDK1 Induction and Protects Tumors from Killing by Hypoxic Cytotoxins

Frank S. Lee, University of Pennsylvania School of Medicine, USA
Familial Erythrocytosis Associated with a Mutation in an Isoform of the HIF prolyl hydroxylase, PHD

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Hypoxic Response in Mammals
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Max Gassmann, University of Zürich, Switzerland
Hypoxia and Erythropoietin Gene Expression

Volker H. Haase, Vanderbilt University, USA
Differential HIF Signaling in Tissues with VHL Gene Deletion

* Randall S. Johnson, University of Cambridge, UK
The Physiologic Response to Hypoxia

Patrick H. Maxwell, Rayne Institute, UK
Short Talk: Regulation of E-Cadherin by VHL and HIF

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 1

Peaks 14-17

WEDNESDAY, JANUARY 18

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
High Altitude Pathophysiology and Pulmonary Responses to Hypoxia
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Max Gassmann, University of Zürich, Switzerland

Benjamin D. Levine, Institute for Exercise and Environmental Medicine, USA
Cardiovascular Adaptation to Chronic High Altitudes

Damian M. Bailey, University of Glamorgan, UK
Free Radicals and Blood-Brain Barrier Function in Acute Mountain Sickness

Sarah Anne Gebb, University of Colorado Health Sciences Center, USA
Fetal Oxygen Tension Drives Lung Branching Morphogenesis

Lorna G. Moore, University of Colorado, Denver, USA
Hypoxia and the Uteroplacental Circulation

Wanja M. Bernhardt, University Hospital Erlangen-Nuremberg, Germany
Short Talk: Preconditional Activation of HIF Ameliorates Ischemic Acute Renal Failure

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Hypoxia and Translation Control
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* M. Celeste Simon, University of Pennsylvania, USA
Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth

Bradly G. Wouters, University Health Network, Canada
Hypoxic Regulation of Translation Initiation and its Impact on Gene Expression

Stephen Lee, University of Ottawa, Canada
Regulation of the HIF/VHL System by Hydrogen Ions

Kevin P. Claffey, University of Connecticut Health Center, USA
Short Talk: AMP-dependent Protein Kinase alpha1 and alpha2 are Key Regulators of VEGF Expression and Repression of MAPK Pathways in Cellular Adaptation to Hypoxia

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 2

Peaks 14-17

THURSDAY, JANUARY 19

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:20
Physiological and Pathophysiologic Responses to Hypoxia
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Joachim Fandrey, University Duisburg-Essen, Germany
Regulation of HIF-1 by Mediators of Inflammation

Nanduri R. Prabhakar, University of Chicago, USA
O2 Sensing in Intermittent Hypoxia: Role of Reactive Species and HIF-Transcription Factor(s)

Agnes Görlach, German Heart Center Munich, Germany
Short Talk: NFkappaB is Required for HIF-1alpha Transcription in Response to Thrombin and Oxidative Stress

L. Eric Huang, University of Utah, USA
Hypoxia and Genetic Instability

Eileen P. White, Rutgers University, USA
Hypoxia, Apoptosis, and Genome Instability

Claire E. Lewis, University of Sheffield Medical School, UK
Short Talk: Inflammation and tumor progression: the role of the hypoxic macrophage

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
14:00—16:30
Workshop 2: Cellular Responses to Hypoxia

* Masi M. Yamamoto, Tohoku University, Japan
Regulation of Erythropoietin Gene Expression

Constantinos Koumenis, University of Pennsylvania, USA
The Role of the Unfolded Protein Response in Tumor Cell Resistance to Hypoxia/Anoxia

Lawrence B. Gardner, New York University School of Medicine, USA
Hypoxic Suppression of Id-1 via Activation of the Unfolded Protein Response is Aberrant in Neuroblastoma

Vibha Chauhan, Stanford University, USA
Zhangfei is a Novel Gene that is Induced by both Hypoxia and ER Stress and Regulates XBP1 Function.

Bing-Hua Jiang, Thomas Jefferson University, USA
AKT 1 Regulates VEGF and HIF-1alpha Expression through HDM2, TSC1/2, and p70S6K1 Pathways

Robert D. Guzy, University of Chicago, USA
Disruption of Mitochondrial Complex II Leads to Increased ROS, Normoxic HIF-1alpha Stabilization, and Enhanced Tumor Formation

Cormac Taylor, University College Dublin, Ireland
Hypoxia Increases the Pool of IKKbeta Leading to NFkappaB Activation: a Possible Role for PHD-1

Koh Nakayama, Sanford-Burnham Medical Research Institute, USA
Multimerization of PHDs Alters Prolyl-Hydroxylase Activity and Susceptibility to Siah2-Dependent Degradation during Hypoxia

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Hypoxia, Disease and Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Mark W. Dewhirst, Duke University Medical Center, USA
Pleiotropic Effects of HIF-1 Blockade on Tumor Radiosensitivity

Martin Brown, Stanford University, USA
Exploiting Tumor Hypoxia in Cancer Therapy

Till Acker, University of Giessen, Germany
Short Talk: Regulation of HIF Function in Malignant Brain Tumors by Metabolic Parameters (PO2, pH, glucose, ROS)

Ralph A. Kelly, Genzyme Corporation, USA
Harnessing the Tissue Response to Hypoxia: Pre-Clinical and Human Experience with a Constitutively Active Hypoxia-Inducible Factor 1 Alpha Transgene in Advanced Vascular Ischemic Disease

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 3

Peaks 14-17

FRIDAY, JANUARY 20

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Signaling of Hypoxia
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Lorenz Poellinger, Karolinska Institutet, Sweden
Structure/Function Analysis of HIF

Margaret Ashcroft, University of Cambridge, UK
HDM2 Positively Regulates HIF Expression

Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Electron Transport and Oxygen Sensing

Eli Keshet, Hebrew University, Israel
Hypoxia and the Hibernating Heart

Maria F. Czyzyk-Krzeska, University of Cincinnati, USA
Short Talk: Hydroxylation of Proline 1465 and VHL-Ubiquitylation of Rpb1 is Induced by Oxidative Stress and Controls Oncogenic Process in Renal Cancer Cells in the Absence of HIF

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Hypoxia and Tumorigenesis
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Amato J. Giaccia, Stanford University, USA
Exploiting HIF Gene Expression in Cancer Therapy

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The von Hippel Lindau Cancer Syndrome

Gabriele A.I. Bergers, University of California, San Francisco, USA
HIF-1 and Astrocytoma Invasion

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
HIF-1 Overexpression in Human Cancer: Mechanisms and Consequences

19:15—20:15
Social Hour with Lite Bites

Peaks 14-17
20:00—23:00
Entertainment

Peaks 14-17

SATURDAY, JANUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA117421-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research
Ruskinn Technology Ltd, a division of the Baker Company, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genzyme Corporation


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676