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This meeting took place in 2006
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Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3)
Organizer(s) James A. Goodrich, Laszlo Tora and Karolin Luger
April 21—26, 2006
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Dec 21, 2005
Late Abstract Deadline: Jan 13, 2006
Scholarship Deadline: Dec 21, 2005
Early Registration Deadline: Feb 21, 2006
Supported by The Director's Fund
Summary of Meeting:
This meeting will encompass the most exciting current research on eukaryotic mRNA transcription and its regulation. Sessions will address the following pivotal topics in the field: how chromatin and its modification actively sets levels of gene-specific transcription; promoter recognition complexes and their function in directing transcription initiation; the structure and organization of large macromolecular transcription complexes as revealed by X-ray crystallography and electron microscopy; transcriptional coregulatory complexes and their roles as mediators of transcriptional regulation during differentiation and development; the steps in the transcript synthesis reaction; and the application of emerging imaging techniques to the real time analysis of transcription in living cells. The goals of this meeting are to report the most recent progress on these topics, as well as to provide an understanding of both detailed transcriptional regulatory mechanisms and how transcriptional regulation integrates with other cellular and developmental processes.
View Scholarships/Awards
This meeting will encompass the most exciting current research on eukaryotic mRNA transcription and its regulation. Sessions will address the following pivotal topics in the field: how chromatin and its modification actively sets levels of gene-specific transcription; promoter recognition complexes and their function in directing transcription initiation; the structure and organization of large macromolecular transcription complexes as revealed by X-ray crystallography and electron microscopy; transcriptional coregulatory complexes and their roles as mediators of transcriptional regulation during differentiation and development; the steps in the transcript synthesis reaction; and the application of emerging imaging techniques to the real time analysis of transcription in living cells. The goals of this meeting are to report the most recent progress on these topics, as well as to provide an understanding of both detailed transcriptional regulatory mechanisms and how transcriptional regulation integrates with other cellular and developmental processes.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, APRIL 21
SATURDAY, APRIL 22
SUNDAY, APRIL 23
MONDAY, APRIL 24
TUESDAY, APRIL 25
WEDNESDAY, APRIL 26
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, APRIL 21
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Roger D. Kornberg,
Stanford University, USA
RNA Polymerase II Transcription: Structure, Mechanism and Regulation
RNA Polymerase II Transcription: Structure, Mechanism and Regulation
08:00—11:15
Structure of Transcription Complexes
Meeting has ended...abstracts no longer viewable online.
*
Christoph W. Müller,
EMBL / Grenoble Outstation, France
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
From the Complete RNA Polymerase II Structure to Transcription Regulation
From the Complete RNA Polymerase II Structure to Transcription Regulation
Patrick Schultz,
Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
The 3-D structures of yeast TFIID and human TFIIE revealed by cryo EM
The 3-D structures of yeast TFIID and human TFIIE revealed by cryo EM
Eva Nogales,
University of California, Berkeley, USA
Electron Microscopy Studies of Multi-Subunit Transcription Factors
Electron Microscopy Studies of Multi-Subunit Transcription Factors
Eric A. Galburt,
Max Planck Institute of Cellular Biology and Genetics, Germany
Short Talk: Single Molecule Transcription of Eukaryotic RNA Polymerase II
Short Talk: Single Molecule Transcription of Eukaryotic RNA Polymerase II
Raymond C. Trievel,
University of Michigan, USA
Short Talk: Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases
Short Talk: Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases
14:30—16:30
Workshop 1: Mysteries of Intergenic Transcription
Ann Dean,
NIDDK, National Institutes of Health, USA
LCRs, Extragenic Transcription and Histone Modifications
LCRs, Extragenic Transcription and Histone Modifications
David J. McBride,
Medical Research Council Human Genetics Unit, UK
Control of Transcription at the Pax6 Locus
Control of Transcription at the Pax6 Locus
Henrietta Szutorisz,
Mount Sinai School of Medicine, USA
The Proteasome Suppresses Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells
The Proteasome Suppresses Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells
Yugong Ho,
University of Pennsylvania School of Medicine, USA
A Role for Intergenic Transcription in Long-Range Gene Activation
A Role for Intergenic Transcription in Long-Range Gene Activation
Tae Hoon Kim,
University of Texas at Dallas, USA
Identification and Analysis of Boundary Elements in the Human Genome
Identification and Analysis of Boundary Elements in the Human Genome
Catherine M. Farrell,
National Library of Medicine, National Institutes of Health, USA
Long-Range Genetic Interactions in the Human Genome
Long-Range Genetic Interactions in the Human Genome
17:00—19:15
Transcript Synthesis - From Initiation through Elongation
Meeting has ended...abstracts no longer viewable online.
*
Joan W. Conaway,
Stowers Institute for Medical Research, USA
Donal S. Luse,
Cleveland Clinic Foundation, USA
Promoter Clearance and the Transition from Initiation to Elongation by RNA Polymerase II
Promoter Clearance and the Transition from Initiation to Elongation by RNA Polymerase II
James A. Goodrich,
University of Colorado, USA
The Regulation of the Early Steps of Transcription by Noncoding RNAs
The Regulation of the Early Steps of Transcription by Noncoding RNAs
Katherine A. Jones,
The Salk Institute, USA
Spt6 Binds the Ser2P-RNAPII to Facilitate mRNA Processing and Nuclear Export
Spt6 Binds the Ser2P-RNAPII to Facilitate mRNA Processing and Nuclear Export
Keiko Ozato,
NICHD, National Institutes of Health, USA
Short Talk: The Chromatin Binding Protein Brd4 Interacts with P-TEFb and Stimulates RNA Polymerase II Dependent Transcription in vivo
Short Talk: The Chromatin Binding Protein Brd4 Interacts with P-TEFb and Stimulates RNA Polymerase II Dependent Transcription in vivo
Robert C. Landick,
University of Wisconsin-Madison, USA
Short Talk: Regulation of Transcriptional Pausing by RNA Polymerase II
Short Talk: Regulation of Transcriptional Pausing by RNA Polymerase II
08:00—11:15
General Factors and Transcription Initiation
Meeting has ended...abstracts no longer viewable online.
James T. Kadonaga,
University of California, San Diego, USA
Studies of the RNA Polymerase II Core Promoter
Studies of the RNA Polymerase II Core Promoter
Bing Ren,
Ludwig Institute for Cancer Research, USA
Genome-Wide Location Analysis of the RNA Polymerase II Pre-Initiation Complex in Mouse Embryonic Stem Cells and Adult Tissues
Genome-Wide Location Analysis of the RNA Polymerase II Pre-Initiation Complex in Mouse Embryonic Stem Cells and Adult Tissues
Laszlo Tora,
Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
Regulation of RNA Polymerase II Transcription Initiation at Core Promoters by the Diversity in Initiation Complex Formation and Function
Regulation of RNA Polymerase II Transcription Initiation at Core Promoters by the Diversity in Initiation Complex Formation and Function
Kevin Struhl,
Harvard Medical School, USA
Regulation of Transcription Initiation in Yeast
Regulation of Transcription Initiation in Yeast
Gail Miller,
, USA
Short Talk: A DNA-Tethered Hydroxyl Radical Cleavage Probe Reveals the Path for Promoter DNA in the Yeast Preinitiation Complex
Short Talk: A DNA-Tethered Hydroxyl Radical Cleavage Probe Reveals the Path for Promoter DNA in the Yeast Preinitiation Complex
Mariana Fregoso-Lomas,
Instituto de Biotecnología, Mexico
Short Talk: Characterization of p52 in Drosophila melanogaster
Short Talk: Characterization of p52 in Drosophila melanogaster
14:30—16:30
Workshop 2: New and Noteworthy
Chase T. Archer,
University of Texas Southwestern Medical Center, USA
Understanding how Mono-Ubiquitylation of Transactivators Protects Transactivator-DNA Complexes from Destabilization by 26S Proteasome Subcomplexes
Understanding how Mono-Ubiquitylation of Transactivators Protects Transactivator-DNA Complexes from Destabilization by 26S Proteasome Subcomplexes
Jennifer F. Kugel,
University of Colorado Boulder, USA
An 8 Nucleotide RNA Triggers a Rate-limiting Shift of RNA Polymerase II Complexes into Elongation
An 8 Nucleotide RNA Triggers a Rate-limiting Shift of RNA Polymerase II Complexes into Elongation
Masami Horikoshi,
University of Tokyo, Japan
Structural and Functional Analyses on Chromatin-Related Transcription Regulated by Histone Chaperones
Structural and Functional Analyses on Chromatin-Related Transcription Regulated by Histone Chaperones
Yamini Dalal,
NCI, National Institutes of Health, USA
Analysis of Centromeric Chromatin Reveals a Highly Unusual Structure in vivo
Analysis of Centromeric Chromatin Reveals a Highly Unusual Structure in vivo
Jing-Yi Huang,
National Taiwan University, USA
The Functional Interaction between FACT and PARP-1
The Functional Interaction between FACT and PARP-1
Christian Muchardt,
Institut Pasteur, France
The SWI/SNF Complex Regulates Alternative Splicing
The SWI/SNF Complex Regulates Alternative Splicing
Alexandre Akoulitchev,
University of Oxford, UK
Regulatory Switch between Distinct Chromosomal Conformations of Active Transcriptional Units
Regulatory Switch between Distinct Chromosomal Conformations of Active Transcriptional Units
17:00—19:00
Imaging of Transcription in Vivo
Meeting has ended...abstracts no longer viewable online.
Gordon L. Hager,
NCI, National Institutes of Health, USA
Transcription Factor Mobility and Promoter Progression
Transcription Factor Mobility and Promoter Progression
John T. Lis,
Cornell University, USA
Dynamics of Transcription Factors at Native Specific Gene Loci Examined by Multiphoton Imaging of Live Drosophila Salivary Glands
Dynamics of Transcription Factors at Native Specific Gene Loci Examined by Multiphoton Imaging of Live Drosophila Salivary Glands
Marc Timmers,
University Medical Centre Utrecht, Netherlands
Mobility of TBP and TBP-Complexes in Human Cells
Mobility of TBP and TBP-Complexes in Human Cells
Marco Emilio Bianchi,
Università Vita-Salute San Raffaele, Italy
Short Talk: GR and HMGB1 Influence Each Other’s Residence Time on Chromatin
Short Talk: GR and HMGB1 Influence Each Other’s Residence Time on Chromatin
08:00—11:15
Chromatin - Structure and Remodeling
Meeting has ended...abstracts no longer viewable online.
*
James T. Kadonaga,
University of California, San Diego, USA
Geeta J. Narlikar,
University of California, San Francisco, USA
Mechanisms of ATP-Dependent Chromatin Remodeling
Mechanisms of ATP-Dependent Chromatin Remodeling
Carl Wu,
National Cancer Institute, NIH, USA
and
and
Ed Luk,
Stony Brook University, USA
Regulating Transcription by ATP-Dependent Chromatin Remodeling Complexes
Regulating Transcription by ATP-Dependent Chromatin Remodeling Complexes
Christoph W. Müller,
EMBL / Grenoble Outstation, France
Structural Insight into Drosophila CHRAC Nucleosome Remodeling
Structural Insight into Drosophila CHRAC Nucleosome Remodeling
Paul J. Laybourn,
Colorado State University, USA
Short Talk: Tax-Dependent Displacement of Nucleosomes during Transcriptional Activation of Human T-Cell Leukemia Virus, Type 1
Short Talk: Tax-Dependent Displacement of Nucleosomes during Transcriptional Activation of Human T-Cell Leukemia Virus, Type 1
17:00—19:15
Histone Modification
Meeting has ended...abstracts no longer viewable online.
*
Carl Wu,
National Cancer Institute, NIH, USA
Jerry L. Workman,
Stowers Institute for Medical Research, USA
Macromolecular Complexes that Modify Histones
Macromolecular Complexes that Modify Histones
Michael Grunstein,
University of California, Los Angeles, USA
Acetylation of H2AZ Lysine 14 is Associated with Genome-Wide Gene Activity in Yeast
Acetylation of H2AZ Lysine 14 is Associated with Genome-Wide Gene Activity in Yeast
Ronen Marmorstein,
Wistar Institute, USA
Chromatin Recognition by Enzymes that Regulate Gene Expression
Chromatin Recognition by Enzymes that Regulate Gene Expression
Jane Mellor,
University of Oxford, UK
Short Talk: The Spt6 Transcription Elongation Factor Maintains Co-Transcriptional Methylation of Lysine 36 on Histone H3 to Repress Transcription Initiation within Genes
Short Talk: The Spt6 Transcription Elongation Factor Maintains Co-Transcriptional Methylation of Lysine 36 on Histone H3 to Repress Transcription Initiation within Genes
Judd C. Rice,
University of Southern California, Norris Cancer Center, USA
Short Talk: A Novel Methyl-Specific Trans-Tail Histone Code Defines Distinct Regions of Silent Chromatin
Short Talk: A Novel Methyl-Specific Trans-Tail Histone Code Defines Distinct Regions of Silent Chromatin
08:00—11:15
Coregulatory Complexes
Meeting has ended...abstracts no longer viewable online.
*
Beverly M. Emerson,
CEDAR, OHSU Knight Cancer Institute, USA
Joan W. Conaway,
Stowers Institute for Medical Research, USA
Transcriptional Regulatory Complexes
Transcriptional Regulatory Complexes
Michael T. Marr,
University of California, Berkeley, USA
Dynamic Interaction and Differential Requirement for Transcriptional Coactivator Complexes
Dynamic Interaction and Differential Requirement for Transcriptional Coactivator Complexes
Danny F. Reinberg,
HHMI/New York University, USA
Transcriptional Coregulators in Gene Expression
Transcriptional Coregulators in Gene Expression
Sohail Malik,
Rockefeller University, USA
Short Talk: Identification of an Accessory Factor for Human Mediator Function Delineates a Novel Aspect of its Mode of Action in RNA Polymerase II Transcription
Short Talk: Identification of an Accessory Factor for Human Mediator Function Delineates a Novel Aspect of its Mode of Action in RNA Polymerase II Transcription
Shigeaki Kato,
University of Tokyo, Japan
Short Talk: Function of Co-Regulator Complexes for Nuclear Receptors
Short Talk: Function of Co-Regulator Complexes for Nuclear Receptors
Michel Werner,
Institut Jacques Monod, France
Short Talk: TFIIS RNA Polymerase II-Binding Domain and Med31 Subunit of Mediator Play a Redundant Role in Transcription Initiation
Short Talk: TFIIS RNA Polymerase II-Binding Domain and Med31 Subunit of Mediator Play a Redundant Role in Transcription Initiation
17:00—19:15
Transcriptional Regulation during Differentiation and Development
Meeting has ended...abstracts no longer viewable online.
*
Katherine A. Jones,
The Salk Institute, USA
Beverly M. Emerson,
CEDAR, OHSU Knight Cancer Institute, USA
Transcriptional Regulation by p53
Transcriptional Regulation by p53
Margaret T. Fuller,
Stanford University, USA
Tissue Specific TAF Homologs Relieve Repression by Polycomb to Allow Differentiation
Tissue Specific TAF Homologs Relieve Repression by Polycomb to Allow Differentiation
Sharon Y.R. Dent,
University of Texas MD Anderson Cancer Center, USA
In Vivo Functions of Histone Modifying Enzymes
In Vivo Functions of Histone Modifying Enzymes
Ferenc Müller,
Forschungszentrum Karlsruhe, Germany
Short Talk: TBP is Required for Zygotic Activation of Develomentally Regulated Genes Rather than Constitutively Expressed Genes in the Zebrafish Embryo
Short Talk: TBP is Required for Zygotic Activation of Develomentally Regulated Genes Rather than Constitutively Expressed Genes in the Zebrafish Embryo
Didier Devys,
Institute of Genetics and Molecular and Cellular Biology, France
Short Talk: Abnormal Function of TFTC-Type Complexes and Chromatin Decondensation Induced by Polyglutamine-Expanded Ataxin-7
Short Talk: Abnormal Function of TFTC-Type Complexes and Chromatin Decondensation Induced by Polyglutamine-Expanded Ataxin-7
*Session Chair †Invited, not yet responded.
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