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This meeting took place in 2006



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Genome Sequence Variation and the Inherited Basis of Common Disease and Complex Traits (A2)


Organizer(s) David M. Altshuler, Peter Donnelly and Trudy F.C. MacKay
January 8—13, 2006
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Oct 4, 2005
Late Abstract Deadline: Oct 4, 2005
Scholarship Deadline: Sep 13, 2005
Early Registration Deadline: Nov 7, 2005

Supported by The Director's Fund

Summary of Meeting:
Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible, for the first time, to conduct well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characters, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 8

15:00—19:30
Registration

Lower Atrium
18:30—19:30
Refreshments

Lower Atrium
19:30—21:30
Overview Session: Progress and Prospects
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Peter Donnelly, University of Oxford, UK

Trudy F.C. Mackay, North Carolina State University, USA
Genetic Analysis of Complex Traits in Drosophila

David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Complex Traits in Humans


MONDAY, JANUARY 9

07:00—08:00
Breakfast

Jefferson/Lake/Canyon
08:00—11:00
Genome Sequence Variation
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Charles H. Langley, University of California, Davis, USA
Genomic Patterns of Polymorphism and Divergence: Models and Observations

Kelly A. Frazer, University of California, San Diego, USA
Human DNA Variation and Complex Traits

Deborah A. Nickerson, University of Washington, USA
SNPs in Candidate Genes

Charles Lee, Brigham and Women's Hospital, USA
Structural Variations in the Human Genome

Penelope E. Bonnen, Rockefeller University, USA
Short Talk: Evaluating Potential for Whole Genome Studies in Kosrae - an Isolated Population in Micronesia

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Determinants of Variation: Recombination, Demography, Selection
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Peter Donnelly, University of Oxford, UK
Recombination in the Human Genome

Molly Przeworski, Columbia University, USA
The Signature of Directional Selection on Standing Genetic Variation

Jonathan K. Pritchard, University Of Chicago, USA
A High-Resolution Survey of Deletion Polymorphism in the Human Genome.

Steven A. McCarroll, Harvard Medical School, USA
Short Talk: A Genome-Wide Map of Common Human Deletion Polymorphisms

19:00—20:00
Social Hour with Lite Bites

Jefferson/Lower Atrium
19:30—22:00
Poster Session 1

Jefferson

TUESDAY, JANUARY 10

07:00—08:00
Breakfast

Jefferson/Lake/Canyon
08:00—11:00
Computational Approaches Linking Genotype and Phenotype
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Heather Cordell, University of Cambridge, UK
Multiple Imputation Methods for Genetic Association Analysis of Complex Traits

Zhao-Bang Zeng, North Carolina State University, USA
QTL Analysis, eQTL Analysis and Genetic Architecture of Complex Traits

Andrew G. Clark, Cornell University, USA
Population Genetic Methods for Genotype-Phenotype Association

Jonathan L. Marchini, University of Oxford, UK
Short Talk: A Novel Bayesian Approach to Localising Disease Genes

Dan Arking, Johns Hopkins School of Medicine, USA
Short Talk

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Short Talks
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Trudy F.C. Mackay, North Carolina State University, USA

Jared Drake, Children's Hospital Boston, USA
Conserved Non-Coding Sequences are Selectively Constrained and not Mutation Cold Spots

Benjamin F. Voight, University of Chicago, USA
A Genome-Wide Scan for Targets of Recent and On-Going Directional Selection in Humans

Melanie Bahlo, Walter and Eliza Hall Institute of Medical Research, Australia
Linkage Disequilibrium Mapping Malaria Susceptibility Loci in Papua New Guinea

Julian T. Forton, University of Oxford, UK
Exploiting Allele-Specific Transcript Quantification and the HAPMAP Resource to Localise Long Range Cis-Regulatory Polymorphism

Keyan Zhao, Cornell University, USA
Genome-Wide Association Mapping in a Structured Population of A. thaliana

Minerva M. Carrasquillo, Mayo Clinic, USA
A Set of Putative Functional IDE Variants Shows Simple, Replicable Association with Alzheimer’s Disease and has an Estimated Population Attributable Risk of 46%

Dana C. Crawford, Case Western Reserve University, USA
Genetic Variation is Associated with C-Reactive Protein Levels in a Survey of 7,000 Americans

19:00—20:00
Social Hour with Lite Bites

Jefferson/Lower Atrium
19:30—22:00
Poster Session 2

Jefferson

WEDNESDAY, JANUARY 11

07:00—08:00
Breakfast

Jefferson/Lake/Canyon
08:00—11:00
Architecture of Complex Trait Variation
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Behavioral Differences Between Sympatric Stickleback Species

Rachel B. Brem, University of California, Berkeley, USA
Transcript Phenotypes and Sequence Variation in Yeast Genomes

Wolfgang Stephan, University of Munich, Germany
The Role of Selection in Shaping Polymorphism

Justin Fay, Washington University, USA
Evolution of Transcriptional Regulation

Justin P. Gerke, Washington University, USA
Short Talk: Analysis of Natural Variation in Yeast Sporulation Efficiency

Chao-Qiang Lai, JM-USDA-HNRCA at Tufts University, USA
Short Talk: Microarray-based Mapping of QTLs Affecting Lifespan in Drosophila melanogaster

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Modeling Human Complex Disease Traits in Other Species
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* Gary A. Churchill, The Jackson Laboratory, USA
Co-Adaptated Alleles and the Evolution of Complex Traits

Joseph H. Nadeau, Pacific Northwest Research Institute, USA

J. Lawrence Marsh, University of California, Irvine, USA
Identification of Genetic Factors that Affect Huntington’s Disease Pathology in Drosophila

Justin O. Borevitz, University of Chicago, USA
Short Talk: Genome Wide Association Mapping in Arabidopsis thaliana

19:00—20:00
Social Hour with Lite Bites

Jefferson/Lower Atrium
19:30—22:00
Poster Session 3

Jefferson

THURSDAY, JANUARY 12

07:00—08:00
Breakfast

Jefferson/Lake/Canyon
08:00—11:00
Genetic Basis of Human Disease
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Genetic Basis of Blood Pressure Variation

Jonathan C. Cohen, University of Texas Southwestern Medical Center, USA
Genetic Determinants of Plasma Lipoprotein Levels

Leena P. Peltonen, University of Helsinki and National Public Health Inst, Finland
From Families to Populations: Example of Finland

Augie Kong, deCODE genetics, Iceland
Complex Diseases and Association Studies

Jenny C. Lee, University of California, Los Angeles, USA
Short Talk: Human Sequence Variation Data Facilitates the Fine Mapping of a Low High-Density Lipoprotein Cholesterol Region on Chromosome 16q23-24

09:20—09:40
Coffee Break

Lower Atrium
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Genetics, Medicine and Society
Meeting has ended...abstracts no longer viewable online.

Gallatin/Madison
* David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA

Joel N. Hirschhorn, Children's Hospital, Boston, USA
New Insights into the Genetics of Obesity and Cardiovascular Traits

Kang Zhang, University of Utah, USA
Short Talk: Genetic Study of Diabetic Complications, Age-Related Macular Degeneration, and Glaucoma Using the Utah Population Database

Nicole M. Walley, Duke University, USA
Short Talk

19:00—20:00
Social Hour with Lite Bites

Jefferson/Lower Atrium
20:00—23:00
Entertainment

Jefferson

FRIDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 HG003937-01




We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies JDRF

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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