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This meeting took place in 2006



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Cell Biology of Virus Entry, Replication and Pathogenesis (C4)


Organizer(s) Herbert W. Virgin, Robert A. Lamb, Richard W. Compans, Robert W. Doms and Michael B.A. Oldstone
February 24—March 1, 2006
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Oct 25, 2005
Late Abstract Deadline: Nov 17, 2005
Scholarship Deadline: Oct 25, 2005
Early Registration Deadline: Dec 23, 2005

Supported by The Director's Fund

Summary of Meeting:
The elucidation of the molecular interactions between viral components and cells, and how this determines the outcome of infection is the most exciting area of modern virology. New advances in structural biology, genetics, and molecular virology have speeded the pace of discovery in this area and led to significant insights into virology, immunology and cell biology. The new NIH emphasis on mechanisms of viral infection provides new support and excitement for this already fertile area. The pivotal areas to be covered are (i) the cell biology of virus entry, uncoating, protein traffic, assembly, budding and release, (ii) the defensive mechanisms that cells and organisms use to combat viruses, (iii) strategies of viral immune evasion. These areas impact significantly on fundamental issues in cell biology, cell and species tropism, and pathogenesis of viral diseases. The meeting will once again provide a cross disciplinary forum for discussing novel insights into cell biology of virus infection and the relationship of these findings to pathogenesis and defense. Each session covers a topic rather than a virus family in order to foster discussion across virus family-boundaries. Our topic oriented program has been very successful in the many successful meetings organized since 1988.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 24

15:00—19:30
Registration

Zia Concourse
18:30—19:30
Refreshments

Sunset Room
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Stephen C. Harrison, Harvard Medical School, USA
Viral Membrane Fusion: The Converging Paradigms


SATURDAY, FEBRUARY 25

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Viral Receptor Binding and Entry (a)
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Theodore S. Jardetzky, Stanford University, USA

Terence S. Dermody, Vanderbilt University School of Medicine, USA
Reovirus Cell Entry and Activation of Innate Immune Response Signaling

Yusuke Yanagi, Kyushu University, Japan
Measles Virus Receptors: Their Roles in Tropism and Signal Transduction

John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Early Steps of Retroviral Replication

Susan R. Ross, University of Pennsylvania, USA
MMTV Interaction with Toll-like Receptors and Other Immunological Signaling Pathways

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
14:30—16:30
Workshop 1: Viral Receptors and Entry

* Frederic S. Cohen, Rush Medical College, USA

Christopher Aiken, Vanderbilt University School of Medicine, USA
Inside-Out Regulation of HIV-1 Particle Fusion

Carolyn B. Coyne, University of Pittsburgh, USA
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions

Kimberly A. Bishop-Lilly, Naval Medical Research Center, USA
Characterization of the EphrinB2-Binding Site on the Henipavirus G Glycoprotein

Robert A. Davey, Texas Biomedical Research Institute, USA
siRNA Screening for Cellular Factors Required for Infection by Human Respiratory Syncytial Virus Reveals Important Role for Clathrin-Mediated Endocytosis

Karin Stiasny, Medical University of Vienna, Austria
Structural and Functional Dissection of the Flavivirus Membrane Fusion Pathway

Oscar Negrete, Sandia National Labs, USA
EphrinB3 is an Alternate Receptor for Nipah Virus

Lily Y. Lee, Harvard Medical School, USA
Poliovirus Entry and RNA Release: A Multidisciplinary Study

Roy Duncan, Dalhousie University, Canada
Simplified Fusion Machines: The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins.

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Receptor Binding and Entry (b)
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Robert A. Lamb, Northwestern University, USA

Theodore S. Jardetzky, Stanford University, USA
Structural Insights into Paramyxovirus Fusion Protein Folding and Function

Robert P. Blumenthal, NCI, National Institutes of Health, USA
Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins

Richard W. Compans, Emory University, Rollins Research Center, USA
Specific Inhibition of Paramyxovirus F-Mediated Membrane Fusion

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

SUNDAY, FEBRUARY 26

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Viral Movement and Trafficking
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Ari Helenius, ETH Zurich, Switzerland
How Viruses Enter Animal Cells

Thomas J. Hope, Northwestern University, USA
Virus Interactions with Dendritic Cells: Moving to the Synapse

Geoffrey L. Smith, University of Cambridge, UK
Ligand-Induced and Non-Fusogenic Dissolution of a Virus Membrane

Xiaowei Zhuang, Harvard University, USA
Entry and Trafficking of Influenza Viruses by Single-Virus Tracking

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
14:30—16:30
Workshop 2: Immunity, Antivirals and Vaccines

* Mary K. Estes, Baylor College of Medicine, USA

Sheri L. Hanna, University of Pennsylvania, USA
Contribution of WNV Envelope N-linked Glycosylation to Assembly, Infectivity and Tropism

Grant E. Nybakken, Washington University, USA
Mechanistic Correlates of Antibody-Mediated Protection against West Nile Virus Infection

Christian D.S. Nelson, Cornell University, USA
Antibody Neutralization Mechanisms: Different Responses to Antibody Binding at the Same Site in a Virus Capsid

Rebecca K. Holmes, King's College London, UK
Unravelling the Importance of Cytidine Deamination for the Anti-Viral Activity of APOBEC3G and APOBEC3F

Dapeng Zhou, MD Anderson Cancer Center, USA
A Natural Glycolipid Ligand of NKT Cells: Implications for Anti-Viral Immunity

Byeongwoon Song, Emory University, USA
TRIM5alpha: Retroviral Restriction and Subcellular Localization

Xiuyan Wang, Yale University School of Medicine, USA
A Novel Antiviral Mechanism Mediated by the Interferon-Inducible Protein Viperin

Michael S. Kay, University of Utah School of Medicine, USA
Steric Accessibility of the HIV-1 gp41 N-Trimer Region

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Virus Assembly and Release
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Richard W. Compans, Emory University, Rollins Research Center, USA

Eric Hunter, Emory University, USA
Cell Biology of Retroviral Assembly and Release

Robert A. Lamb, Northwestern University, USA
Influenza Virus Assembly at the Viral Budozone

Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV Release

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

MONDAY, FEBRUARY 27

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Cellular Genes and Virus Infection
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Otto Haller, University of Freiburg, Germany

Jeff Bergelson, University of Pennsylvania, USA
Kinase Signals Permit Coxsackievirus Entry through Epithelial Type Junction

Stephen P. Goff, Columbia University, USA
Host Factors Involved in Retroviral Replication

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy in Innate Antiviral Immunity

Daved Fremont, Washington University School of Medicine, USA
Structural Mechanisms of Viral Immune Evasion

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
14:30—16:30
Workshop 3: Intracellular Movement, Trafficking and Assembly of Viruses

* Jeff Bergelson, University of Pennsylvania, USA

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication

Susana Guix, Baylor College of Medicine, USA
Studies of Norwalk Virus RNA Encapsidation

Christopher T. Cornell, The Scripps Research Institute, USA
Inhibition of Host Protein Secretion by Coxsackievirus b3 (CVB3): Multiple Gene Products Target a Common Organelle

Benjamin J. Chen, Northwestern University, USA
Influenza Virus Hemagglutinin (H3) Requires Palmitoylation of its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in their Ability to Support Assembly

Markus Thali, University of Vermont, USA
Tetraspanin-Enriched Microdomains (TEMs) Function as Gateways for HIV-1

Glenn F. Rall, Fox Chase Cancer Center, USA
Neurokinin-1 Interacts with the Measles Virus Fusion Protein to Facilitate Trans-Synaptic Spread in Neurons

David C. Johnson, Oregon Health & Science University, USA
Spread of Herpes Simplex Virus in Epithelial and Neuronal Tissues is Promoted by Membrane Proteins gE/gI and US9 which Sort Virions to Cell Junctions

Laura Burleigh, Institut Pasteur, France
Long–Term Transfer of HIV from Immature Dendritic Cells to T Cells Occurs Exclusively through DC-SIGN-Mediated Cis Infection and not Intracellular Storage of Incoming Virus

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Viruses and Immunity
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Elina I. Zuniga, University of California, San Diego, USA
Viral Deregulation of Innate Immunity

Ira Mellman, Genentech, Inc., USA
Dendritic Cells and Virus Infection

Raymond M. Welsh, University of Massachusetts Medical School, USA
Privacy of T Cell-Dependent Heterologous Antiviral Immunity

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room

TUESDAY, FEBRUARY 28

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Control of Infection and Viral Vaccines
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Ann M. Arvin, Stanford University, USA

Rafi Ahmed, Emory University School of Medicine, USA
Mechanisms of T Cell Memory in Antiviral Immunity

Robert W. Doms, University of Pennsylvania School of Medicine, USA

Nancy J. Sullivan, Vaccine Research Center, National Institutes of Health, USA
Ebola Virus Immunity

Curt M. Horvath, Northwestern University, USA
Activation and Inhibition of Cellular Interferon Responses and Innate Antiviral Immunity

09:20—09:40
Coffee Break

Zia Concourse
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Viral Disease and Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Rafi Ahmed, Emory University School of Medicine, USA

Francis V. Chisari, The Scripps Research Institute, USA
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Replication of, and Resistance to, a Novel Norovirus

Ann M. Arvin, Stanford University, USA
New Insights into Varicella-Zoster Virus Pathogenesis

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

WEDNESDAY, MARCH 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI066899-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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