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This meeting took place in 2006



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Nucleic Acid Enzymes (B7)


Organizer(s) Michael M. Cox and Robert C. Landick
February 11—16, 2006
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 11, 2005
Late Abstract Deadline: Nov 3, 2005
Scholarship Deadline: Oct 11, 2005
Early Registration Deadline: Dec 12, 2005

Supported by The Director's Fund

Summary of Meeting:
Enzymes that act on nucleic acids lie at the heart of all processes of information transfer in the biological world. The fields of DNA metabolism and RNA metabolism have often been treated separately, although these two areas of research share many common mechanisms and principles. In addition, many of the relevant processes take place in the context of elaborate molecular machines that share some components. Current research explores the enzymatic mechanisms, and is increasingly focused on the structure and function of the molecular machines of which they are a part. In this meeting, we bring together the fields of RNA and DNA enzymology. The program is uniquely organized to highlight common mechanisms and themes, while at the same time exposing both communities to novel approaches to mechanistic problems. Many sessions are designed to juxtapose prominent individuals working in both areas.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 11

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Thomas A. Steitz, HHMI/Yale University, USA
Motion in RNA and DNA Enzymes


SUNDAY, FEBRUARY 12

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Topology and Polymerases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* James M. Berger, Johns Hopkins University School of Medicine, USA
Structural Mechanisms for Initiating DNA Replication in Bacteria

Smita S. Patel, UMDNJ-RW Johnson Medical School, USA
Dynamics of DNA Replication Catalyzed by Helicase and Polymerase

Eric C. Greene, Columbia University, USA
Short Talk: Visualizing One-Dimensional Diffusion of Proteins on DNA

Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Visualization of Protein-DNA Interactions

Tania A. Baker, Massachusetts Institute of Technology, USA
Controlling Recombination and Repair: Activation, Remodeling and Destruction

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Mechanisms

Chamisa Ballroom 1
* Smita S. Patel, UMDNJ-RW Johnson Medical School, USA

Steven Kazmirski, AstraZeneca, USA
Out-of-Plane Motions in Open Sliding Clamps: Molecular Dynamics Simulations of Eukaryotic and Archaeal PCNA

Kristina M. Herbert, Yale University, USA
Transcriptional Pauses by RNA Polymerase are Mediated by a Common Intermediate

Joshua Lev Adelman, University of California, Berkeley, USA
The Mechanochemistry of Transcription Termination Factor Rho

Colin G. Wu, Washington University School of Medicine, USA
Kinetic Mechanism of DNA Unwinding by E. coli RecBC Helicase

Amy Kathleen McClendon, University of Cincinnati, USA
Recognition of DNA Supercoil Geometry by Human Type II Topoisomerases

Scott W. Nelson, Pennsylvania State University, USA
Uncoupling of the T4 Phage Replisome upon Encountering an Abasic Lesion in the Leading Strand DNA Template

Katharina Schlacher, MD Anderson Cancer Center, USA
DNA Polymerase V and RecA Protein, a Minimal Mutasome

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Polymerases 1
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Stephen J. Benkovic, Pennsylvania State University, USA
Studies on the T4 Replisome

Seth A. Darst, Rockefeller University, USA
Structural Basis for Transcription Repair Coupling in Bacteria

Robert C. Landick, University of Wisconsin-Madison, USA
Regulatory Dynamics in the RNA Polymerase Active Site

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

MONDAY, FEBRUARY 13

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Complex Systems
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Myron F. Goodman, University of Southern California, USA
Roles of DNA Polymerase V and RecA Protein in SOS Damage-Induced Mutation

Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
The Mechanisms of Replication Fork Restart

Stephen C. West, Francis Crick Institute, UK
Short Talk: A Role for Pol eta in Double-Strand Break Repair by Homologous Recombination

Nicholas E. Dixon, University of Wollongong, Australia
A Molecular Mousetrap Determines Polarity of Replication Fork Arrest by Tus-Ter Sites in E. coli

Piero R. Bianco, University at Buffalo, State University of New York, USA
Short Talk: Single Molecule Studies of the Role of Rad54 Protein in the Synapsis Stage of Homologous Recombination

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: Complex Systems

Chamisa Ballroom 1
* Stephen C. West, Francis Crick Institute, UK

Alice P. Telesnitsky, University of Michigan, USA
RT Template Switching is an HIV-1 Fidelity Mechanism

Dieudonne Ndjonka, Ohio State University, USA
Crystal Structure of a Cleavage-Active Conformation of Phage Lambda Repressor

Fred Dyda, NIDDK, National Institutes of Health, USA
Structure, DNA Recognition and Active Site Assembly of a New Class of DNA Transposase

Desirazu N. Rao, Indian Institute of Science, India
Unidirectional Translocation and Interaction with DNA end for Cleavage by Type III Restriction Enzymes

Julia C. Drees, , USA
Inhibition of RecA Protein Function by the RdgC Protein from Escherichia coli

Aliaa Abdelhakim, Massachusetts Institute of Technology, USA
Auto-Tethering of the AAA+ Unfoldase ClpX to the Mu Transpososome Guides Remodeling of the Stable Protein Complex

Min Li, NIDDK, National Institutes of Health, USA
Reconstitution of Efficient Concerted Integration by HIV Integrase: Reaction Pathway and Critical Intermediates

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Complex RNA Systems in RNA Metabolism
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Rachel Green, Johns Hopkins University School of Medicine, USA
Molecular Dissection of Ribosome Function in Two Active Sites

Anna Marie Pyle, Yale University, USA
The HCV NS3 Helicase/Translocase: Activities and Biophysical Properties of a Tunable Motor

Sidney R. Kushner, University of Georgia, USA
Initiation of mRNA Decay in Escherichia coli Involves at Least Six Distinct Endoribonucleases

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Regulation and More Polymerases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Joan W. Conaway, Stowers Institute for Medical Research, USA
Regulation of RNA Polymerase II Transcription

Irina Artsimovitch, Ohio State University, USA
Short Talk: Regulation of Transcription through the Secondary Channel

Michael M. Cox, University of Wisconsin-Madison, USA
Regulation of Recombinase Function in Bacteria

Carol W. Greider, Johns Hopkins University School of Medicine, USA
Telomeres and Telomerase in Stem Cells and Cancer

Michael E. O'Donnell, Rockefeller University, USA
The Mechanics of Lagging Strand DNA Synthesis

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 3: New Enzymes

Chamisa Ballroom 1
* Sidney R. Kushner, University of Georgia, USA

Allyn J. Schoeffler, Genentech, USA
Structure-Function Relationships in Bacterial Type IIA Topoisomerases

Olga N. Umanskaya, Russian Academy of Sciences, Russia
DNA-Topoisomerase II Can Induce but not Accomplish Illegitimate Recombination

Phuong T. Pham, University of Southern Califonria, USA
Processive Aid-catalyzed Cytosine Deamination on ssDNA Simulates Somatic Hypermutation

Shelley L. Lusetti, New Mexico State University, USA
The RecF Protein Antagonizes RecX Function via Direct Interaction

Katrin Karbstein, University of California, Berkeley, USA
An Essential GTPase Promotes Assembly of Pre-Ribosomal RNA Processing Complexes

Anoop Cheeran, Center for DNA Fingerprinting and Diagnostics, India
E.coli RNA Polymerase Mutations Impaired for H-19B N Specific Transcription Antitermination: Implications for the Mechanism of Transcription Antitermination

Dmitry Temiakov, University of Medicine and Dentistry of New Jersey, USA
Structural Basis of Transcription Inhibition by Antibiotic Streptolydigin

Marcin Nowotny, NIDDK, National Institutes of Health, USA
Crystal Structures of RNase H Complexed with RNA‚ÄĘDNA Hybrid Substrate

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Polymerases II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tom E. Ellenberger, Washington University School of Medicine, USA

Peter M. Burgers, Washington University School of Medicine, USA
The Role of Ubiquitinated PCNA in Coordinating Translesion DNA Synthesis

Richard H. Ebright, Rutgers University, USA
Small-Molecule Inhibitors of Bacterial RNA Polymerase: Tagetitoxin, Lipiarmycin, Myxopyronin

Dmitri G. Vassylyev, University of Alabama at Birmingham, USA
Structural Studies of Prokaryotic RNA Polymerases and Transcription Regulation

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Catalysis and Processing Enzymes
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Daniel Herschlag, Stanford University, USA
Dissecting Ribozyme Mechanisms: Lessons Learned about RNA and Catalysis

Tom E. Ellenberger, Washington University School of Medicine, USA
Short Talk: TelK Puts an End to Chromosomes

Steven M. Block, Stanford University, USA
Breaking the Nanometer Barrier in Single-Molecule Studies

Timothy M. Lohman, Washington University School of Medicine, USA
Mechanisms of DNA Unwinding and Translocation by SF-1 DNA Helicases

Linda B. Bloom, University of Florida, USA
Short Talk: Dynamics of Loading the Escherichia coli Sliding Clamp

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Processing Enzymes
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Structural basis for RNA processing by Dicer

James L. Keck, University of Wisconsin Medical School, USA
Structural and Cellular Mechanisms of Bacterial RecQ DNA Helicases

Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA
Mechanism of DNA Nonhomologous End Joining in Bacteria

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

THURSDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676