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This meeting took place in 2006



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Structural Genomics (J5)


Organizer(s) Cheryl H. Arrowsmith, Christine A. Orengo, and Andrzej Joachimiak
January 29—February 3, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 29, 2005
Late Abstract Deadline: Oct 21, 2005
Scholarship Deadline: Sep 29, 2005
Early Registration Deadline: Nov 29, 2005


Summary of Meeting:
The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 29

15:00—19:30
Registration

Longs Foyer
18:30—19:30
Refreshments

Longs Foyer
19:30—20:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Quandary/Longs
Roger D. Kornberg, Stanford University, USA
RNA Polymerase II Structure and Mechanism


MONDAY, JANUARY 30

07:00—08:00
Breakfast

Grays
08:00—11:00
Protein Expression/Purification
Meeting has ended...abstracts no longer viewable online.

Quandary
* Aled M. Edwards, University of Toronto, Canada
Making Proteins for Structural Biology

Pär L. Nordlund, Karolinska Institute, Sweden
Library Screening Methods for the Production of Human Proteins and Domains

Binesh Shrestha, University of Oxford, UK
Short Talk: High Throughput Expression of Human Proteins in Insect Cells

Ian E. Hunt, Novartis Institutes for Biomedical Research, USA
Short Talk: From Gene to Protein: A Review of New and Enabling Technologies for Multi-Parallel Baculovirus Mediated Protein Expression

Shigeyuki Yokoyama, RIKEN, Japan
Cell Free Protein Expression


Following Session is for Frontiers in Structural Biology (J6)

08:00—11:00
Membranes and Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Longs
* Daniel J. Leahy, Johns Hopkins School of Medicine, USA

H. Ronald Kaback, University of California, Los Angeles, USA
Structure and Mechanism of Lac Permease

Pascal F. Egea, University of California, San Francisco, USA
Targeting Proteins to Membranes: The Signal Recognition Particle

Elizabeth Reisinger Sprague, California Institute of Technology, USA
Short Talk: Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging

Lukas K. Tamm, University of Virginia, USA
Membrane Interactions of Influenza Hemagglutinin Fusion Proteins

Douglas C. Rees, California Institute of Technology, USA
Structural Studies of ABC Transporters

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
16:30—17:00
Coffee Available

Longs Foyer
17:00—19:00
Bioinformatics
Meeting has ended...abstracts no longer viewable online.

Quandary
* Christine A. Orengo, University College London, UK
Target Selection that Samples Structure and Function Space

John Moult, University of Maryland Biotechnology Institute, USA
Structural Bioinformatics for Target Selection, SNPs, and Alternative Splicing

Burkhard Rost, Columbia University, USA
Structural Genomics Changes our Map of Protein Space

Olivier Lichtarge, Baylor College of Medicine, USA
Short Talk: Evolutionary Importance Guides Functional Annotation of Proteins Based on Local Structural Similarity


Following Session is for Frontiers in Structural Biology (J6)

17:00—19:00
Macromolecular Interactions
Meeting has ended...abstracts no longer viewable online.

Longs
* Douglas C. Rees, California Institute of Technology, USA

Stephen C. Blacklow, Harvard Medical School, USA
Structural Basis for Recruitment of Mastermind Co-activators to Notch1 Transcription Complexes

Karin C. Felderer, Max-Planck-Institute of Biochemistry, Germany
Short Talk: The 20s Proteasome: Mechanism of Substrate Translocation

Daniel J. Leahy, Johns Hopkins School of Medicine, USA
Ihog, a New Co-receptor for Hedgehog

Gerhard Wagner, Harvard Medical School, USA
Probing Macromolecular Interactions of Gene Expression with NMR

19:00—20:00
Social Hour with Lite Bites

Grays
19:30—22:00
Poster Session 1: Bioinformatics and Structural Genomics: Project Overviews/Summaries

Grays

TUESDAY, JANUARY 31

07:00—08:00
Breakfast

Grays
08:00—11:15
Pushing Limits of Structural Biology (Joint)
Meeting has ended...abstracts no longer viewable online.

Quandary/Longs
* Gerhard Wagner, Harvard Medical School, USA

X. Sunney Xie, Harvard University, USA
Single Molecule Approach to Biochemistry: From in vitro to in vivo Studies

Lewis E. Kay, University of Toronto, Canada
NMR Spectroscopy of Supra- Molecular Machines making the new invisible...visible. NMR Studies of Excited Protein States Seeing the Invisible

Ann E. McDermott, Columbia University, USA
Protein Structure and Dynamics by Solid State NMR

Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK
Crystal structures of functional states of the ribosome

Joachim Frank, Columbia University, USA
Application of Cryo-EM to Image Ribosome Dynamics

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
16:30—17:00
Coffee Available

Longs Foyer
17:00—19:00
Crystallization and NMR Sample Production
Meeting has ended...abstracts no longer viewable online.

Quandary
* Andrzej Joachimiak, Argonne National Laboratory, USA

Naomi Chayen, Imperial College London, UK
Protein Crystallization: The Current Challenge

Gaetano Thomas Montelione, Rutgers University, USA
Protein Sample Production Technologies for Large-Scale Structural Proteomics

Zygmunt S. Derewenda, University of Virginia, USA
Protein crystallization: from art to science

Alexander Shekhtman, University at Albany, State University of New York, USA
Short Talk: Mapping STructural INTeractions in Vivo Using in-cell NMR (STINT-NMR)


Following Session is for Frontiers in Structural Biology (J6)

17:00—19:00
Experiment and Theory in Macromolecular Dynamics
Meeting has ended...abstracts no longer viewable online.

Longs
* Dorothee Kern, Brandeis University, HHMI, USA

Arthur G. Palmer, III, Columbia University, USA
NMR Studies of Protein Dynamics

Mari L. DeMarco, Washington University, USA
Mapping the Early Steps in Conversion of the Prion Protein

Zimei Bu, Fox Chase Cancer Center, USA
Short Talk: Coupled Protein Domain Motion in Taq Polymerase Revealed by Neutron Spin Echo Spectroscopy

Philip Anfinrud, National Institutes of Health, USA
Time-Resolved X-ray Crystallography: Watching Proteins Function in Real Time

19:00—20:00
Social Hour with Lite Bites

Grays
19:30—22:00
Poster Session 2: NMR, Crystallography and Protein Production Methods

Grays

WEDNESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Grays
08:00—11:00
Data Collection and Analysis. Session sponsored by Bruker AXS and Bruker Biospin Corporation
Meeting has ended...abstracts no longer viewable online.

Quandary
* Gaetano Thomas Montelione, Rutgers University, USA

Andrzej Joachimiak, Argonne National Laboratory, USA
Application of Structural Genomics Pipeline to Expand Protein Fold Space and Discover Protein Function

Thomas Szyperski, SUNY at Buffalo, USA
GFT NMR-Based Structural Genomics

Ad Bax, NIDDK, National Institutes of Health, USA
Weak alignment offers shortcuts in NMR structure determination

Thomas C. Terwilliger, Los Alamos National Laboratory, USA
PHENIX: New methods for automated structure solution, model-building, ligand-fitting and refinement

Wladek Minor, University of Virginia, USA
Short Talk: The Integration of Data Reduction and Structure Solution - From Diffraction Images to an Initial Model in Minutes


Following Session is for Frontiers in Structural Biology (J6)

08:00—11:00
Protein-Nucleic Acid Interactions
Meeting has ended...abstracts no longer viewable online.

Longs
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Lorena S. Beese, Duke University Medical Center, USA
Structural Studies of DNA Polymerase

Dale B. Wigley, Institute of Cancer Research, UK
Structure and Mechanism of RecBCD: A Machine for Processing DNA Breaks

Hong Li, Florida State University, USA
Short Talk: Co-Crystal Structure of the Splicing Endonuclease and its RNA Substrate

Karolin Luger, Colorado State University, USA
Nucleosome Structure

Juli Feigon, University of California, Los Angeles, USA
Structural and Functional Studies of Human Telomerase and Yeast RNase III

09:20—09:40
Coffee Break

Longs Foyer
11:00—13:00
Poster Setup

Grays
13:00—22:00
Poster Viewing

Grays
16:30—17:00
Coffee Available

Longs Foyer
17:00—19:00
Late Breaking Developments in Structural Genomics
Meeting has ended...abstracts no longer viewable online.

Quandary
* Cheryl Arrowsmith, University of Toronto, Canada

William C. Nierman, Institute for Genomic Research, USA
Genomic Sequencing: What Can We Expect in the Next Five Years

John C. Norvell, NIGMS, National Institutes of Health, USA
Protein Structure Imitative: Progress and Plans

James E. Bradner, Novartis Institutes for BioMedical Research, USA
Chemical Biology Tools to Complement Structural Genomics


Following Session is for Frontiers in Structural Biology (J6)

17:00—19:00
Enzyme Mechanism
Meeting has ended...abstracts no longer viewable online.

Longs
* Arthur G. Palmer, III, Columbia University, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Structural Biology of Dicer

Dorothee Kern, Brandeis University, HHMI, USA
Short Talk: Intrinsic Motions along the Enzymatic Reaction Trajectory Observed by Crystallography, NMR and Computation

Peter E. Wright, The Scripps Research Institute, USA
Protein Dynamics and Enzyme Function: An NMR View of Dihydrofolate Reductase

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Structural Insights into the Unusual Chemistry of Sir2 Deacetylases

19:00—20:00
Social Hour with Lite Bites

Grays
19:30—22:00
Poster Session 3: Structures, Structural and Functional Analysis and Applications of Structural Genomics

Grays

THURSDAY, FEBRUARY 2

07:00—08:00
Breakfast

Grays
08:00—11:00
Biological/Biochemical Insights from Structural Genomics
Meeting has ended...abstracts no longer viewable online.

Quandary
Cheryl Arrowsmith, University of Toronto, Canada
Structural Proteomics as a Tool for Genome Annotation

Udo Oppermann, University of Oxford, UK
An Integrated Structural and Functional Genomics Approach towards the Human SDR Family

Susan S. Taylor, University of California, San Diego, USA
Evolution and Diversity of the Protein Kinase Superfamily

* Ian A. Wilson, The Scripps Research Institute, USA
Structural proteomics of Thermotoga maritima

Andrew Robinson, University of Groningen, Netherlands
Short Talk: Structural Genomics of the Mobile Metagenome


Following Session is for Frontiers in Structural Biology (J6)

08:00—11:00
Protein Folding and Design
Meeting has ended...abstracts no longer viewable online.

Longs
* Lorena S. Beese, Duke University Medical Center, USA

Kevin W. Plaxco, University of California, Santa Barbara, USA
From Playing with Toys to Predicting Protein Folding Fates

Stephen L. Mayo, California Institute of Technology, USA
Modulation and De Novo Design of Protein-Protein Interactions

Maxim S. Pometun, University of Pennsylvania, USA
Short Talk: Cold-Induced Unfolding of Encapsulated Proteins

Jonathan S. Weissman, University of California, San Francisco, USA
Structural Biology of Protein Aggrogation Diseases

David Eisenberg, University of California, Los Angeles, USA
Structural Studies of Amyloid

09:20—09:40
Coffee Break

Longs Foyer
16:30—17:00
Coffee Available

Longs Foyer
17:00—19:00
Applications of Structural Genomics to Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Quandary
Stephen K. Burley, Rutgers University, USA
Fragment Based Drug Discovery for Oncology Targets

Tom L. Blundell, University of Cambridge, UK
High-Throughput Crystallography, Structural Bioinformatics and Fragment-Based Drug Discovery

* Michael Sundström, Karolinska University Hospital and Karolinska Institutet, Sweden
Structural Chemistry of Human Protein Families


Following Session is for Frontiers in Structural Biology (J6)

17:00—19:00
Macromolecular Interactions
Meeting has ended...abstracts no longer viewable online.

Longs
* Peter E. Wright, The Scripps Research Institute, USA

Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland
NMR Experiments for Large and Small Protein Complexes

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Specificity in a Multi-enzyme Signaling Cascade

Ethan C. Settembre, Novartis Vaccines, USA
Short Talk: Assembly of the Rotavirus Internal Core Particle

Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Signaling by Receptors with Two Transmembrane Domains

19:00—20:00
Social Hour with Lite Bites

Grays
20:00—23:00
Entertainment

Grays

FRIDAY, FEBRUARY 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 GM075727-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research Varian, Inc.

Bruker BioSpin Corp.

Spectra Gases, Inc. Stable Isotopes Group


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



SGX Pharmaceuticals


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