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This meeting took place in 2007
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Ubiquitin and Signaling (B4)
Organizer(s) Brenda A. Schulman, Tony Hunter, Mark W. Hochstrasser and Claudio A.P. Joazeiro
February 4—9, 2007
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Oct 4, 2006
Late Abstract Deadline: Nov 2, 2006
Scholarship Deadline: Oct 4, 2006
Early Registration Deadline: Dec 4, 2006
Supported by the Director's Fund
Summary of Meeting:
Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and deconjugation, and of nonproteasomal signaling functions for ubiquitin and ubiquitin-related proteins. The first Keystone meeting on Ubiquitin and Signaling, in February 2005, was highly successful, based on both strong attendance and feedback from the participants. The significance and timely nature of the ubiquitination problem is highlighted by the 2004 Nobel Prize in Chemistry honoring pioneers in the field. We anticipate a further explosion in our understanding of ubiquitination over the next few years, and propose a meeting that captures this momentum. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in numerous diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins, presenting the challenge to determine their functions and mechanistic links to the ubiquitin system. In addition, the ubiquitin system is now widely recognized as a target for pharmacological intervention in various diseases. The goal of the meeting is to bring together experts from different areas of ubiquitin research as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
View Scholarships/Awards
Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and deconjugation, and of nonproteasomal signaling functions for ubiquitin and ubiquitin-related proteins. The first Keystone meeting on Ubiquitin and Signaling, in February 2005, was highly successful, based on both strong attendance and feedback from the participants. The significance and timely nature of the ubiquitination problem is highlighted by the 2004 Nobel Prize in Chemistry honoring pioneers in the field. We anticipate a further explosion in our understanding of ubiquitination over the next few years, and propose a meeting that captures this momentum. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in numerous diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins, presenting the challenge to determine their functions and mechanistic links to the ubiquitin system. In addition, the ubiquitin system is now widely recognized as a target for pharmacological intervention in various diseases. The goal of the meeting is to bring together experts from different areas of ubiquitin research as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 4
MONDAY, FEBRUARY 5
TUESDAY, FEBRUARY 6
WEDNESDAY, FEBRUARY 7
THURSDAY, FEBRUARY 8
FRIDAY, FEBRUARY 9
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 4
20:00—21:00
Keynote Address: The Cecile Pickart Memorial Lecture
Meeting has ended...abstracts no longer viewable online.
Alfred L. Goldberg,
Harvard Medical School, USA
What We've Learned and What We Haven't Learned About Protein Degradation
What We've Learned and What We Haven't Learned About Protein Degradation
08:00—11:15
Regulation by E3 Ubiquitin Ligases
Meeting has ended...abstracts no longer viewable online.
Michael Karin,
University of California, San Diego, USA
Crosstalk Between Inflammation Cells and Carcinomas
Crosstalk Between Inflammation Cells and Carcinomas
J. Wade Harper,
Harvard Medical School, USA
Genetic Discovery in the Ubiquitin Proteasome Pathway
Genetic Discovery in the Ubiquitin Proteasome Pathway
Claudio A. P. Joazeiro,
The Scripps Research Institute, USA
Functional Genomic Analyses of Ubiquitin Ligases
Functional Genomic Analyses of Ubiquitin Ligases
Mark A. Estelle,
University of California, San Diego, USA
The F-box Protein TIR1 is a Receptor for the Plant Hormone Auxin
The F-box Protein TIR1 is a Receptor for the Plant Hormone Auxin
Bruce E. Clurman,
Fred Hutchinson Cancer Research Center, USA
Fbw7 at the Crossroads of Cell Division, Growth, and Differentiation
Fbw7 at the Crossroads of Cell Division, Growth, and Differentiation
17:00—19:00
Signal Transduction by Ubiquitin Conjugation and Deconjugation
Meeting has ended...abstracts no longer viewable online.
*
J. Wade Harper,
Harvard Medical School, USA
Vishva M. Dixit,
Genentech, Inc., USA
ATM Mediated Auto-Degradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
ATM Mediated Auto-Degradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
Christian D. Schlieker,
Whitehead Institute for Biomedical Research, USA
Short Talk: Structure of a Herpesvirus-Encoded Deubiquitinating Enzyme Reveals a New Class of Ubiquitin-Specific Proteases
Short Talk: Structure of a Herpesvirus-Encoded Deubiquitinating Enzyme Reveals a New Class of Ubiquitin-Specific Proteases
Paul J. Lehner,
Cambridge Institute for Medical Research, UK
Short Talk: Lysine-63 Linked Ubiquitination is Required for Efficient Internalization and Endolysosomal Degradation of Critical Immunoreceptors
Short Talk: Lysine-63 Linked Ubiquitination is Required for Efficient Internalization and Endolysosomal Degradation of Critical Immunoreceptors
08:00—11:00
Ubiquitin-Like Protein Pathways
Meeting has ended...abstracts no longer viewable online.
*
Daniel J. Finley,
Harvard University, USA
Christopher D. Lima,
Memorial Sloan Kettering Cancer Center, USA
SUMO: Insights into Ubiquitin and Ubiquitin-Like Protein Conjugation
SUMO: Insights into Ubiquitin and Ubiquitin-Like Protein Conjugation
Jorge A. Iñiguez-Lluhi,
University of Michigan, USA
Short Talk: SUMO Modification Regulates Inactivation of the voltage-Gated Potassium Channel KV1.5
Short Talk: SUMO Modification Regulates Inactivation of the voltage-Gated Potassium Channel KV1.5
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Structural Insights into Ubiquitin-like Protein Activation
Structural Insights into Ubiquitin-like Protein Activation
17:00—19:00
Regulation of and by the Proteasome and Signalosome
Meeting has ended...abstracts no longer viewable online.
*
Alfred L. Goldberg,
Harvard Medical School, USA
Xing Wang Deng,
Yale University, USA
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3-based E3 ligases
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3-based E3 ligases
Ning Zheng,
University of Washington, USA
Mechanism of Auxin Perception by the TIR1 F-box Protein
Mechanism of Auxin Perception by the TIR1 F-box Protein
Daniel J. Finley,
Harvard University, USA
Regulation of Proteasome Function
Regulation of Proteasome Function
Rina Rosenzweig,
Weizmann Institute of Science, Israel
Short Talk: A Mason's Approach to the 19S Proteasome Regulator
Short Talk: A Mason's Approach to the 19S Proteasome Regulator
08:00—11:00
Ubiquitin and Subcellular Compartments
Meeting has ended...abstracts no longer viewable online.
Simona Polo,
FIRC Institute of Molecular Oncology, Italy
Molecular Mechanisms of Coupled Monoubiquitination
Molecular Mechanisms of Coupled Monoubiquitination
Thomas Sommer,
Max Delbrück Center for Molecular Medicine, Germany
Protein Quality Control by the HRD-Ligase Complex
Protein Quality Control by the HRD-Ligase Complex
Mary Ann Osley,
University of New Mexico School of Medicine, USA
Interplay between H2B Ubiquitylation and Histone Chaperones during Transcription Elongation
Interplay between H2B Ubiquitylation and Histone Chaperones during Transcription Elongation
Sylvie Urbé,
University of Liverpool, UK
Control of Growth Factor Receptor Dynamics by Reversible Ubiquitination
Control of Growth Factor Receptor Dynamics by Reversible Ubiquitination
Vincent Chau,
Pennsylvania State University College of Medicine, USA
Short Talk: The Crystal Structure of a RING-Ubc7 Fusion Reveals a Mechanism for the Activation of a Ubiquitin-Conjugating Enzyme
Short Talk: The Crystal Structure of a RING-Ubc7 Fusion Reveals a Mechanism for the Activation of a Ubiquitin-Conjugating Enzyme
17:00—19:00
Novel Functions of Ubiquitin
Meeting has ended...abstracts no longer viewable online.
Russell A. DeBose-Boyd,
University of Texas Southwestern Medical Center, USA
Ubiquitination and Degradation of the Cholesterol Biosynthetic Enzyme, HMG CoA Reductase
Ubiquitination and Degradation of the Cholesterol Biosynthetic Enzyme, HMG CoA Reductase
Mark W. Hochstrasser,
Yale University, USA
Regulation of Ubiquitin Enzymes at the Endoplasmic Reticulum and Nuclear Envelope
Regulation of Ubiquitin Enzymes at the Endoplasmic Reticulum and Nuclear Envelope
Yinon M. Ben-Neriah,
Hebrew University, Hadassah Medical School, Israel
Cell-Polarity Control of Protein Degradation in Intestinal Epithelial Cells
Cell-Polarity Control of Protein Degradation in Intestinal Epithelial Cells
Peter Kaiser,
University of California, Irvine, USA
Short Talk: Proteolysis-Independent Regulation by Poly-Ubiquitination
Short Talk: Proteolysis-Independent Regulation by Poly-Ubiquitination
08:00—11:15
The Ubiquitin System: Disease and Drug Targets
Meeting has ended...abstracts no longer viewable online.
*
Thomas Sommer,
Max Delbrück Center for Molecular Medicine, Germany
Tony Hunter,
The Salk Institute for Biological Sciences, USA
Crosstalk Between Phosphorylation and Sumoylation Pathways and Ubiquitination
Crosstalk Between Phosphorylation and Sumoylation Pathways and Ubiquitination
Gentry N. Patrick,
University of California, San Diego, USA
UPS and Mammalian CNS Synapses
UPS and Mammalian CNS Synapses
Ron R. Kopito,
Stanford University, USA
Protein Aggregation and Neurodegeneration
Protein Aggregation and Neurodegeneration
Laurent Coscoy,
University of California, Berkeley, USA
Ubiquitination on Non-lysine Residues
Ubiquitination on Non-lysine Residues
Agata Smogorzewska,
Rockefeller University, USA
Short Talk: Cloning and Characterization of FANCI, a Novel Component of the Fanconi Anemia Pathway
Short Talk: Cloning and Characterization of FANCI, a Novel Component of the Fanconi Anemia Pathway
Frédéric Colland,
Hybrigenics, France
Short Talk: Identification and Characterization of Small Molecule Inhibitors of Ubiquitin-Specific Protease 8, a Newly Validated Cancer Target
Short Talk: Identification and Characterization of Small Molecule Inhibitors of Ubiquitin-Specific Protease 8, a Newly Validated Cancer Target
17:00—19:00
Proteomics and Other Technology Trends
Meeting has ended...abstracts no longer viewable online.
*
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Pharmacodynamic Imaging with Degron-Containing Luciferase Fusion Proteins
Pharmacodynamic Imaging with Degron-Containing Luciferase Fusion Proteins
Steven P. Gygi,
Harvard Medical School, USA
Mass Spectrometry Based Methods for Analysis of Site Specific Ubiquitination
Mass Spectrometry Based Methods for Analysis of Site Specific Ubiquitination
Dieter A. Wolf,
Harvard School of Public Health, USA
Systematic Screening for Ubiquitylation Substrates
Systematic Screening for Ubiquitylation Substrates
Benjamin Nicholson,
Merck Research Laboratories, USA
Short Talk: Mining the Deubiquitinase Space with a Novel Reporter Assay
Short Talk: Mining the Deubiquitinase Space with a Novel Reporter Assay
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support for this conference from:
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