This meeting took place in 2017



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Cell Death and Inflammation (K2)


Organizer(s) Seamus J. Martin and John Silke
May 29—June 2, 2017
Royal Dublin Society • Dublin, Ireland
Discounted Abstract Deadline: Jan 31, 2017
Abstract Deadline: Mar 1, 2017
Scholarship Deadline: Jan 31, 2017
Discounted Registration Deadline: Mar 29, 2017

Organized in Collaboration with Science Foundation Ireland
Sponsored by Genentech, Inc. and Novo Nordisk A/S.


Summary of Meeting:
Cell death has long been known to be an important instigator of inflammation in sterile injury, as well as an amplifying factor in infection-associated inflammation, but the specific molecules underpinning this remain obscure. Understanding how dead and dying cells initiate and escalate inflammation has important implications for our understanding and treatment of autoinflammatory and infectious diseases. This meeting will explore current knowledge concerning the cellular constituents that drive inflammation (i.e., damage-associated molecular patterns), as well as how abnormal modes of cell death, such as necrosis, necroptosis and NETosis, can perturb inflammatory outputs and responses to dying cells. In particular, the conference aims to explore gaps in our current understanding of how dead and dying cells influence inflammatory responses in disease settings and will bring together experts in two major research fields, ”cell death” and ”inflammation,” for the purpose of clarifying what the key questions and therapeutic targets are in this rapidly evolving area. Many well-known physiological drivers of cell death (e.g., TNF, TRAIL, CD95/Fas), as well as the molecules that transduce signals from these receptors (e.g., RIPKs, IAPs, TRAFs, IKKs), are also centrally involved in promoting inflammation. However, the tremendous overlap between cell death and inflammatory signaling is only becoming appreciated of late, and although it is also widely accepted that the constituents of healthy cells can drive inflammation upon release into the extracellular space, the identity of these cellular constituents is still a matter of debate. This meeting will focus on teasing out the relationships between cell death and inflammatory signaling to highlight how perturbation of either of these processes invariably impacts upon the other. This meeting will also explore the nature of the molecules that promote and modulate inflammation during cell death. The meeting will bring together scientists from diverse fields (cell death, inflammation, cancer, innate immunity) that would not normally interact, and will identify and explore the key questions and directions that will shape the future of research in this field.

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Scholarships/Awards

National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients

Justin Ingram
Fox Chase Cancer Center, USA

Pratyusha Mandal
Emory University, USA

Susana L. Orozco
University of Washington, USA

Ranja Salvamoser
Walter and Eliza Hall Institute of Medical Research, Australia

Nader Yatim
Institut Pasteur, France