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This meeting took place in 2011
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Obesity (J2)
Organizer(s) Steven R. Smith and Jacqueline M. Stephens
January 12—17, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 17, 2010
Late Abstract Deadline: Oct 15, 2010
Scholarship Deadline: Sep 17, 2010
Early Registration Deadline: Nov 12, 2010
Sponsored by Takeda Pharmaceutical Company Limited
Summary of Meeting:
An obesity epidemic is sweeping across the Westernized world. More than ever, there is an acknowledgement that the regulation of body weight regulation is more complicated than ever imagined. The last decade has seen rapid progress in our understanding of how body weight is regulated; multiple organs are involved adding to the complexity. These exciting discoveries are leading us in new directions in therapeutics and helping us to better understand of mechanisms underlying the successes of obesity surgery. The goal of this meeting is to bring to light recent advances in the molecular and cellular aspects of these inter-related systems controlling body weight. It is becoming increasingly clear that there are multiple interlocking and redundant systems controlling energy intake, energy expenditure, substrate selection and ultimately body weight. This meeting will assemble international leaders from each of these thematic areas. The program highlights recent advances in the molecular etiology in the major peripheral organs that orchestrate energy balance: adipose tissue, the brain and the gut. Emphasis will be placed on the role of the gut in the regulation of energy metabolism, how the peripheral tissues signal to the brain, and adipose tissue as an orchestrator of metabolism. A major goal of the meeting is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate new developments and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on “Diabetes”, which will share two Keynote Speakers and three joint plenary sessions with this meeting. The joint sessions will cover mitochondrial energetics, how adipose tissue causes insulin resistance and the epigenetic control of metabolism concluding with a workshop / panel discussion on mechanisms of insulin resistance in obesity.
View Scholarships/Awards
An obesity epidemic is sweeping across the Westernized world. More than ever, there is an acknowledgement that the regulation of body weight regulation is more complicated than ever imagined. The last decade has seen rapid progress in our understanding of how body weight is regulated; multiple organs are involved adding to the complexity. These exciting discoveries are leading us in new directions in therapeutics and helping us to better understand of mechanisms underlying the successes of obesity surgery. The goal of this meeting is to bring to light recent advances in the molecular and cellular aspects of these inter-related systems controlling body weight. It is becoming increasingly clear that there are multiple interlocking and redundant systems controlling energy intake, energy expenditure, substrate selection and ultimately body weight. This meeting will assemble international leaders from each of these thematic areas. The program highlights recent advances in the molecular etiology in the major peripheral organs that orchestrate energy balance: adipose tissue, the brain and the gut. Emphasis will be placed on the role of the gut in the regulation of energy metabolism, how the peripheral tissues signal to the brain, and adipose tissue as an orchestrator of metabolism. A major goal of the meeting is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate new developments and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on “Diabetes”, which will share two Keynote Speakers and three joint plenary sessions with this meeting. The joint sessions will cover mitochondrial energetics, how adipose tissue causes insulin resistance and the epigenetic control of metabolism concluding with a workshop / panel discussion on mechanisms of insulin resistance in obesity.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
WEDNESDAY, JANUARY 12
THURSDAY, JANUARY 13
FRIDAY, JANUARY 14
SATURDAY, JANUARY 15
SUNDAY, JANUARY 16
MONDAY, JANUARY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
WEDNESDAY, JANUARY 12
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
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Deborah M. Muoio,
Duke University Medical Center, USA
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Steven R. Smith,
AdventHealth, USA
Stephen O'Rahilly,
University of Cambridge, UK
Common Metabolic Disorders: Lessons from Human Genetics
Common Metabolic Disorders: Lessons from Human Genetics
David A. Sinclair,
Harvard Medical School, USA
Genetic and Pharmacological Interventions to Treat Age-Related Diseases
Genetic and Pharmacological Interventions to Treat Age-Related Diseases
08:00—11:00
Mitochondrial Bioenergetics in Health and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.
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P. Darrell Neufer,
East Carolina University, USA
Mary-Ellen Harper,
University of Ottawa, Canada
Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits
Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits
Xianwen Yi,
University of North Carolina, USA
Short Talk: Does Alpha-Lipoic Acid Retain Body Energy by Regulating Nitric Oxide and Reversing Mitochondrial Dysfunction?
Short Talk: Does Alpha-Lipoic Acid Retain Body Energy by Regulating Nitric Oxide and Reversing Mitochondrial Dysfunction?
Iain Scott,
University of Pittsburgh, USA
Short Talk: A Prokaryote-Derived Mitochondrial Acetyltransferase Counteracts the Respiratory Effects of SIRT3
Short Talk: A Prokaryote-Derived Mitochondrial Acetyltransferase Counteracts the Respiratory Effects of SIRT3
Bruce M. Spiegelman,
Harvard Medical School, USA
Transcriptional Regulation of Adipogenesis and Energy Homeostasis
Transcriptional Regulation of Adipogenesis and Energy Homeostasis
11:15—12:00
NIH Sponsored Workshop: NIH Loan-Repayment Program (Joint)
Milton Hernandez,
NIAID, National Institutes of Health, USA
14:30—16:30
Workshop 1: Hot Topics in Obesity Mechanisms
*
Antonio J. Vidal-Puig,
University of Cambridge, UK
Parth Patwari,
Brigham and Women's Hospital, USA
The Alpha-Arrestin ARRDC3 Regulates Obesity in Mice and Humans
The Alpha-Arrestin ARRDC3 Regulates Obesity in Mice and Humans
Shwetha Ramachandrappa,
Cambridge University, UK
Single Minded 1 (SIM1) in Severe Early Onset Obesity
Single Minded 1 (SIM1) in Severe Early Onset Obesity
Peter K. Jackson,
Stanford University, USA
Ciliopathies and Monogenic Obesity Disorders: Bardet-Biedl Syndrome (BBS) and Tubby Family Proteins Direct GPCR Traffic to the Primary Cilium
Ciliopathies and Monogenic Obesity Disorders: Bardet-Biedl Syndrome (BBS) and Tubby Family Proteins Direct GPCR Traffic to the Primary Cilium
Clemence Blouet,
University of Cambridge, UK
Nutrient Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice
Nutrient Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice
Nicole Ehrhardt,
Cedars-Sinai Medical Center, USA
Lmf1 Deficiency Causes Lipodystrophy
Lmf1 Deficiency Causes Lipodystrophy
Rebecca E. Mercer,
University of Alberta, Canada
Leptin Resistance in the Magel2-null Mouse Model of Prader-Willi Syndrome Precedes the Development of Obesity and is Associated with Increased Melanocortin Responsiveness
Leptin Resistance in the Magel2-null Mouse Model of Prader-Willi Syndrome Precedes the Development of Obesity and is Associated with Increased Melanocortin Responsiveness
17:00—19:00
The Adipose-Brain Axis
Meeting has ended...abstracts no longer viewable online.
*
Karine Clément,
INSERM/Sorbonne Universite, France
Randy J. Seeley,
University of Michigan, USA
A Role for CNS PPARgamma in the Regulation of Energy Balance
A Role for CNS PPARgamma in the Regulation of Energy Balance
Steven R. Smith,
AdventHealth, USA
Adipose Tissue Hypoxia in Obesity
Adipose Tissue Hypoxia in Obesity
17:00—19:00
Sirtuins, NAD Biology and Circadian Control of Metabolism
Meeting has ended...abstracts no longer viewable online.
Shin-ichiro Imai,
Washington University School of Medicine, USA
SIRT1 and NAMPT-Mediated NAD Biosynthesis: Systemic Control of Metabolism and Aging in Mammals
SIRT1 and NAMPT-Mediated NAD Biosynthesis: Systemic Control of Metabolism and Aging in Mammals
Matthew D. Hirschey,
Duke University, USA
Short Talk: SIRT3 Deficiency Accelerates the Development of the Metabolic Syndrome
Short Talk: SIRT3 Deficiency Accelerates the Development of the Metabolic Syndrome
Mitchell A. Lazar,
Perelman School of Medicine, University of Pennsylvania, USA
Epigenomic Regulation of Circadian Rhythm and Metabolism by Nuclear Receptors
Epigenomic Regulation of Circadian Rhythm and Metabolism by Nuclear Receptors
08:00—11:00
Gut Nutrient Sensing in the Regulation of Body Weight
Meeting has ended...abstracts no longer viewable online.
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Randy J. Seeley,
University of Michigan, USA
Elaine Holmes,
Imperial College London, UK
The Gut Microbiome in Obesity
The Gut Microbiome in Obesity
Robert F. Margolskee,
Monell Chemical Senses Center, USA
Taste Receptors in Gut Regulate Endocrine Function
Taste Receptors in Gut Regulate Endocrine Function
Vincent Aguirre,
University of Texas, Southwestern Medical Center, USA
Short Talk: MC4Rs in Autonomic Neurons of the Brainstem Mediate Effects of Gastric Bypass on Diabetes but not Energy Expenditure or Body Weight
Short Talk: MC4Rs in Autonomic Neurons of the Brainstem Mediate Effects of Gastric Bypass on Diabetes but not Energy Expenditure or Body Weight
Hua V. Lin,
Eli Lilly & Co., USA
Short Talk: Short-Chain Fatty Acids Regulate Incretin Secretion & Energy Metabolism and Protect Against Diet Induced Obesity
Short Talk: Short-Chain Fatty Acids Regulate Incretin Secretion & Energy Metabolism and Protect Against Diet Induced Obesity
08:00—11:15
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxicity in Humans
Meeting has ended...abstracts no longer viewable online.
Christoph Handschin,
University of Basel, Switzerland
Coordination of Anabolic and Catabolic Pathways in Skeletal Muscle by PGC1Ą
Coordination of Anabolic and Catabolic Pathways in Skeletal Muscle by PGC1Ą
K. Sreekumaran Nair,
Mayo Clinic, USA
Muscle Mitochondrial Dysfunction and Muscle Insulin Resistance in Diabetes
Muscle Mitochondrial Dysfunction and Muscle Insulin Resistance in Diabetes
P. Darrell Neufer,
East Carolina University, USA
Mitochondrial Bioenergetics, Redox Imbalance and Insulin Resistance
Mitochondrial Bioenergetics, Redox Imbalance and Insulin Resistance
Elizabeth J. Parks,
University of Missouri, USA
Alterations in Fatty Acid Partitioning during Feeding
Alterations in Fatty Acid Partitioning during Feeding
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Novel Actions of Insulin in Control of Brain and Body Metabolism
Novel Actions of Insulin in Control of Brain and Body Metabolism
17:00—19:00
How Adipose Tissue Causes Insulin Resistance (Joint)
Meeting has ended...abstracts no longer viewable online.
Karine Clément,
INSERM/Sorbonne Universite, France
Human Adipose Tissue Remodelling and Metabolic Complications
Human Adipose Tissue Remodelling and Metabolic Complications
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Adipose Tissue Factors: Modulators of Insulin Sensitivity, Inflammation and Apoptosis
Adipose Tissue Factors: Modulators of Insulin Sensitivity, Inflammation and Apoptosis
Timo D. Müller,
Institute for Diabetes and Obesity, Germany
Short Talk: Sequestosome 1 (P62) Deficiency in Adipose Tissue Leads to Obesity and Glucose Intolerance by Impairing BAT Function in Mice
Short Talk: Sequestosome 1 (P62) Deficiency in Adipose Tissue Leads to Obesity and Glucose Intolerance by Impairing BAT Function in Mice
08:00—11:15
Adipose Tissue Architecture
Meeting has ended...abstracts no longer viewable online.
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Jacqueline M. Stephens,
Louisiana State University, USA
James G. Granneman,
Wayne State University School of Medicine, USA
Imaging the Organization and Trafficking of Lipolytic Proteins
Imaging the Organization and Trafficking of Lipolytic Proteins
David E. James,
University of Sydney, Australia
Mapping the Insulin Signalling Network in Adipocytes
Mapping the Insulin Signalling Network in Adipocytes
Matthew J. Brady,
University of Chicago, USA
Stranger in a Strange Land: Glycogen Metabolism in Adipose Tissue
Stranger in a Strange Land: Glycogen Metabolism in Adipose Tissue
Justin J. Rochford,
University of Aberdeen, UK
Short Talk: The Human Lipodystrophy Protein BSCL2/Seipin Binds the Key Lipogenic Enzyme Lipin 1
Short Talk: The Human Lipodystrophy Protein BSCL2/Seipin Binds the Key Lipogenic Enzyme Lipin 1
Xunshan Ding,
University of Texas Southwestern Medical Center, USA
Short Talk: beta-Klotho in Adipose Tissue Is Required for the Anti-Obesity Effect of Fibroblast Growth Factor 21 in Mice
Short Talk: beta-Klotho in Adipose Tissue Is Required for the Anti-Obesity Effect of Fibroblast Growth Factor 21 in Mice
08:00—11:00
Mechanisms of Metabolic Failure
Meeting has ended...abstracts no longer viewable online.
David A. Bernlohr,
University of Minnesota, USA
Oxidative Stress and Adipocyte Mitochondrial Dysfunction
Oxidative Stress and Adipocyte Mitochondrial Dysfunction
Seung-Hoi Koo,
Korea University, South Korea
Regulation of Hepatic Glucose Output by TORC2/CRTC2
Regulation of Hepatic Glucose Output by TORC2/CRTC2
Roberta Leonardi,
West Virginia University, USA
Short Talk: Gluconeogenesis is Controlled by CoA Levels and PanK1
Short Talk: Gluconeogenesis is Controlled by CoA Levels and PanK1
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
Class IIa Histone Deacetylases are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
Class IIa Histone Deacetylases are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
Deborah M. Muoio,
Duke University Medical Center, USA
Mitochondrial Stress and Metabolic Dysfunction in Skeletal Muscle
Mitochondrial Stress and Metabolic Dysfunction in Skeletal Muscle
Romain Barres,
NNF Center for Basic Metabolic Research, Denmark
Short Talk: Exercise Induces Transient DNA Hypomethylation in Human Skeletal Muscle
Short Talk: Exercise Induces Transient DNA Hypomethylation in Human Skeletal Muscle
14:30—16:30
Workshop 2: Hot Topics in Obesity Therapy
Chenguang Ouyang,
Indiana University, USA
Discovery of Peptides Balanced In Glucagon Receptor Antagonism and GLP-1 Agonism. A Search for the Molecular Basis in the Inversion of Activity at Homologous Receptors
Discovery of Peptides Balanced In Glucagon Receptor Antagonism and GLP-1 Agonism. A Search for the Molecular Basis in the Inversion of Activity at Homologous Receptors
*
Thomas E. Hughes,
Zafgen, Inc, USA
Methionine Aminopeptidase 2 (MetAP2) Inhibition Improves Metabolic Control and Causes Loss of Excess Body Weight in Mice, Dogs, and Humans
Methionine Aminopeptidase 2 (MetAP2) Inhibition Improves Metabolic Control and Causes Loss of Excess Body Weight in Mice, Dogs, and Humans
Shirly Pinto,
Kallyope, USA
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Leads to Weight Loss and Prolongation of GLP-1 Release
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Leads to Weight Loss and Prolongation of GLP-1 Release
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Claire M. Steppan,
Pfizer, USA
Pharmacological Inhibition to Examine the Role of DGAT1 in Dietary Lipid Absorption in Mice and Man
Pharmacological Inhibition to Examine the Role of DGAT1 in Dietary Lipid Absorption in Mice and Man
Jennifer L. Lachey,
Ember Therapeutics, USA
Characterization of the Thermogenic Program Induced in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
Characterization of the Thermogenic Program Induced in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
Yong Qi,
Sirtris, A GlaxoSmithKline Company, USA
Activation of Sirtuin1 (SIRT1) by the Novel Small Molecule SRT2104 Protects against Diet-Induced Obesity and Improves Glucose Homeostasis by Increasing Fatty Acid and Carbohydrate Oxidation in Mice
Activation of Sirtuin1 (SIRT1) by the Novel Small Molecule SRT2104 Protects against Diet-Induced Obesity and Improves Glucose Homeostasis by Increasing Fatty Acid and Carbohydrate Oxidation in Mice
Andrea R. Nawrocki,
Janssen Pharmaceutical, USA
The Metabotropic Glutamate Receptor mGluR8 Modulates Energy Metabolism and Amphetamine Induced Hyperactivity in Mice
The Metabotropic Glutamate Receptor mGluR8 Modulates Energy Metabolism and Amphetamine Induced Hyperactivity in Mice
Matthias H. Tschöp,
Helmholtz Zentrum München and Technische Universität München, Germany
Enhanced Metabolic Benefits of Single Peptides with Nuclear Hormone Pharmacology
Enhanced Metabolic Benefits of Single Peptides with Nuclear Hormone Pharmacology
17:00—19:00
JAK-STAT Signaling in Obesity
Meeting has ended...abstracts no longer viewable online.
*
Stephen R. Farmer,
Boston University School of Medicine, USA
Jacqueline M. Stephens,
Louisiana State University, USA
STATs in Adipocyte Development and Function
STATs in Adipocyte Development and Function
Martin G. Myers, Jr.,
University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action
Molecular and Neural Mechanisms of Leptin Action
Allison W. Xu,
University of California, San Francisco, USA
Regulation of Energy Balance and Hepatic Lipid Metabolism by Central Stat3 and PI3K Signaling
Regulation of Energy Balance and Hepatic Lipid Metabolism by Central Stat3 and PI3K Signaling
Tamara L. Allen,
Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Modified IC7, a Designer gp130 Receptor Ligand that improves obesity, Improves High Fat Diet-Induced Insulin Resistance
Short Talk: Modified IC7, a Designer gp130 Receptor Ligand that improves obesity, Improves High Fat Diet-Induced Insulin Resistance
17:00—19:00
Lipid Trafficking and Signaling
Meeting has ended...abstracts no longer viewable online.
*
David A. Bernlohr,
University of Minnesota, USA
Rudolf Zechner,
University of Graz, Austria
Lipolysis and the Lipid Droplet Signaling to the PPARs/PGC1á
Lipolysis and the Lipid Droplet Signaling to the PPARs/PGC1á
Saswata Talukdar,
Merck Research Laboratories, USA
Short Talk: GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects
Short Talk: GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects
08:00—11:15
New Players in the Old Game - Adipogenesis
Meeting has ended...abstracts no longer viewable online.
*
Matthew J. Brady,
University of Chicago, USA
Antonio J. Vidal-Puig,
University of Cambridge, UK
Allostatic Load and Over-Load in the Context of PPARgamma Ablation
Allostatic Load and Over-Load in the Context of PPARgamma Ablation
Evan D. Rosen,
Harvard University, USA
Comparative Epigenomic Analysis of Human and Murine Adipogenesis
Comparative Epigenomic Analysis of Human and Murine Adipogenesis
Stephen R. Farmer,
Boston University School of Medicine, USA
Repression of Gene Programs during the Conversion of Mesenchymal Stem Cells to Adipocytes
Repression of Gene Programs during the Conversion of Mesenchymal Stem Cells to Adipocytes
Merlin Crossley,
University of New South Wales, Australia
The Transcriptional Regulators: KLF3, C-Terminal Binding Protein Co-Repressor (Ctbp), and Friend of Gata in the Regulation of Adipogenesis
The Transcriptional Regulators: KLF3, C-Terminal Binding Protein Co-Repressor (Ctbp), and Friend of Gata in the Regulation of Adipogenesis
Kai Ge,
NIDDK, National Institutes of Health, USA
Short Talk: Epigenetic Regulation of Adipogenesis by Histone Methylation
Short Talk: Epigenetic Regulation of Adipogenesis by Histone Methylation
Juliane G. Bogner-Strauss,
Graz University of Technology, Austria
Short Talk: Adipocyte Plasma Membrane-Associated Protein (APMAP): A Transmembrane Protein Required for Adipogenesis and Targeted by PPARgamma
Short Talk: Adipocyte Plasma Membrane-Associated Protein (APMAP): A Transmembrane Protein Required for Adipogenesis and Targeted by PPARgamma
08:00—11:15
Insulin Signaling, Action and Secretion
Meeting has ended...abstracts no longer viewable online.
Laurie J. Goodyear,
Joslin Diabetes Center, Harvard Medical School, USA
Exercise-Induced Enhancement of Insulin Action
Exercise-Induced Enhancement of Insulin Action
Jorge L. Ruas,
Karolinska Institutet, Sweden
Short Talk: Hypertrophic Effects of the PGC1a4 Isoform on Skeletal Muscle
Short Talk: Hypertrophic Effects of the PGC1a4 Isoform on Skeletal Muscle
*
Christopher B. Newgard,
Duke University Medical Center, USA
In Search of Targets for Restoring beta-Cell Function in Diabetes
In Search of Targets for Restoring beta-Cell Function in Diabetes
Angela M. Hall,
Washington University School of Medicine, USA
Short Talk: Suppression of Monoacylglycerol Acyltransferase-1 (Mogat1) Improves Glucose Tolerance in Diet-Induced Obese Mice
Short Talk: Suppression of Monoacylglycerol Acyltransferase-1 (Mogat1) Improves Glucose Tolerance in Diet-Induced Obese Mice
Andrew Butler,
St. Louis University, USA
Short Talk: Adropin-Deficient Mice Exhibit a Pre-Diabetic Condition and Increased Metabolic Distress with Diet-Induced Obesity
Short Talk: Adropin-Deficient Mice Exhibit a Pre-Diabetic Condition and Increased Metabolic Distress with Diet-Induced Obesity
Vijay K. Yechoor,
University of Pittsburgh, USA
Short Talk: Bmal1 and beta-Cell Clock are Required for Mitochondrial Function and GSIS
Short Talk: Bmal1 and beta-Cell Clock are Required for Mitochondrial Function and GSIS
14:30—16:30
Workshop: Mechanisms of Insulin Resistance: Recent Advances and Current Controversies (Joint)
Deborah M. Muoio,
Duke University Medical Center, USA
Laurie J. Goodyear,
Joslin Diabetes Center, Harvard Medical School, USA
P. Darrell Neufer,
East Carolina University, USA
17:00—19:00
Epigenetic Control of Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Steven R. Smith,
AdventHealth, USA
Mary-Elizabeth Patti,
Joslin Diabetes Center, USA
Developmental Origins of Obesity and Type 2 Diabetes
Developmental Origins of Obesity and Type 2 Diabetes
Kevin L. Grove,
Novo Nordisk, USA
Programming Metabolic Disease: Effects of Maternal Obesity and Diet
Programming Metabolic Disease: Effects of Maternal Obesity and Diet
Andrew P. Feinberg,
Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease
The Epigenetic Basis of Common Human Disease
*Session Chair †Invited, not yet responded.
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