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This meeting took place in 2014
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Biology of B Cell Responses (Q4)
Organizer(s) Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweig
February 9—14, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 16, 2013
Abstract Deadline: Nov 14, 2013
Scholarship Deadline: Oct 16, 2013
Discounted Registration Deadline: Dec 10, 2013
Sponsored by BioLegend, Inc. and Celgene Corporation.
Joint Meeting:
Prophylactic and Therapeutic Antibodies (Q3)
Summary of Meeting:
The requirements and processes relevant for the induction of protective B cell responses remain largely unclear, and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of this meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection and B cell tumors. The specific aims are to: 1) Identify factors involved in the developmental programming and function of B cells; 2) Elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance; 3) Define how B cell responses are initiated and regulated; 4) Provide insight into the mechanisms and dynamics underlying germinal center responses; and 5) Establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early-stage and established researchers to engage in interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at an international level. Interactions will be fostered across disciplines. Access to the parallel meeting on “Prophylactic and Therapeutic Antibodies” will provide all attendees with the unique opportunity to engage in expanded interdisciplinary interaction with translational scientists from academia and industry.
View Scholarships/Awards
The requirements and processes relevant for the induction of protective B cell responses remain largely unclear, and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of this meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection and B cell tumors. The specific aims are to: 1) Identify factors involved in the developmental programming and function of B cells; 2) Elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance; 3) Define how B cell responses are initiated and regulated; 4) Provide insight into the mechanisms and dynamics underlying germinal center responses; and 5) Establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early-stage and established researchers to engage in interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at an international level. Interactions will be fostered across disciplines. Access to the parallel meeting on “Prophylactic and Therapeutic Antibodies” will provide all attendees with the unique opportunity to engage in expanded interdisciplinary interaction with translational scientists from academia and industry.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 9
MONDAY, FEBRUARY 10
TUESDAY, FEBRUARY 11
WEDNESDAY, FEBRUARY 12
THURSDAY, FEBRUARY 13
FRIDAY, FEBRUARY 14
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 9
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Deciphering the Guidance Cue Code for B Cell Immunity
Deciphering the Guidance Cue Code for B Cell Immunity
08:00—09:15
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Margaret Karow,
Akriveia Therapeutics, USA
Introductory Remarks
Introductory Remarks
Joseph Miletich,
Merck, USA
Antibody Therapeutic Indications: Expanding Beyond Cancer and Inflammatory Diseases
Antibody Therapeutic Indications: Expanding Beyond Cancer and Inflammatory Diseases
09:00—11:35
Programming B Cell Physiology
Meeting has ended...abstracts no longer viewable online.
Barry P. Sleckman,
Weill Cornell Medical College, USA
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks
Cornelis Murre,
University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate
Hassan Jumaa,
Institute for Immunology, Ulm University Hospital, Germany
Pre B Cell Development
Pre B Cell Development
*
Stephen L. Nutt,
Walter and Eliza Hall Institute, Australia
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation
Amy L. Kenter,
University of Illinois College of Medicine, USA
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo
09:15—11:30
Novel Antibody Therapy for Pain
Meeting has ended...abstracts no longer viewable online.
*
Margaret Karow,
Akriveia Therapeutics, USA
Mark T. Brown,
Pfizer, USA
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain
John A. Latham,
Alder BioPharmaceuticals, USA
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine
Stephen P. Squinto,
OrbiMed Healthcare Fund Management, USA
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases
14:30—16:30
Workshop 1: From B Cell Selection and Homeostasis to Programming and Functions
*
Michael P. Cancro,
University of Pennsylvania, USA
*
Frances E. Lund,
University of Alabama at Birmingham, USA
Jeffrey J. Bednarski,
Washington University School of Medicine, USA
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC
Hannes Bergmann,
John Curtin School of Medical Research, Australian National University, Australia
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival
Barbara Bertocci,
INSERM 783, France
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation
Keith M. Hamel,
Abbvie, Inc., USA
The Epigenetic Reader Cecr2 in B-Lymphopoiesis
The Epigenetic Reader Cecr2 in B-Lymphopoiesis
Yogesh S. Jeelall,
John Curtin School of Medical Research, Australian National University, Australia
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production
Beatriz León,
University of Alabama at Birmingham, USA
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells
Matthew S. Macauley,
The Scripps Research Institute, USA
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens
Trang T.T. Nguyen,
University of California, Davis, USA
Secreted IgM Enforces B Cell Central Tolerance Induction
Secreted IgM Enforces B Cell Central Tolerance Induction
14:00—16:30
Workshop 1: Crossing the Blood-Brain Barrier
Jean E. Lachowicz,
Angiochem, Canada
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors
*
Robert G. Thorne,
Denali Therapeutics, USA
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments to Central Nervous System Target Sites
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments to Central Nervous System Target Sites
Denise D. Karaoglu,
AbbVie Bioresearch Center, USA
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection
Morten Hanefeld Dziegiel,
Copenhagen University Hospital, Denmark
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies
Graham K. Farrington,
Biogen Idec, USA
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity
17:00—19:15
Self-Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.
*
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire
Ann Marshak-Rothstein,
University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation
(De-)Regulation of B Cell Activation
Roberta Pelanda,
University of Colorado Denver, USA
Positive and Negative Selection of Primary B Cells
Positive and Negative Selection of Primary B Cells
Robert C. Rickert,
Pfizer Inc., USA
Short Talk: B Cell Tolerance to Gut-Associated Antigens
Short Talk: B Cell Tolerance to Gut-Associated Antigens
Claude-Agnès Reynaud,
Necker-Paris Medical School, France
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans
17:00—19:00
Treating Chronic Diseases of Metabolism with Antibody-Based Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
John A. Latham,
Alder BioPharmaceuticals, USA
Neil Stahl,
Regeneron Pharmaceuticals, USA
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies
Peter Libby,
Brigham and Women's Hospital, USA
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment
Estelle Trifilieff,
Novartis Institutes for Biomedical Research, Switzerland
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases
08:00—11:00
Initiating and Regulating B Cell Responses
Meeting has ended...abstracts no longer viewable online.
*
Hedda Wardemann,
German Cancer Research Center, Germany
Tomohiro Kurosaki,
WPI Immunology Frontier Research Center, Osaka University, Japan
Calcium Signaling in B Lymphocytes
Calcium Signaling in B Lymphocytes
Jeffrey V. Ravetch,
Rockefeller University, USA
Regulating B Cell Activation
Regulating B Cell Activation
Jürgen Wienands,
Georg August University of Goettingen, Germany
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds
Maria A. Curotto de Lafaille,
New York University School of Medicine, USA
Short Talk: Regulation of IgE Cell Differentiation and Memory
Short Talk: Regulation of IgE Cell Differentiation and Memory
Kai-Michael Toellner,
University of Birmingham Medical School, UK
Short Talk: Regulation of B Cell Responses by Antibody
Short Talk: Regulation of B Cell Responses by Antibody
08:00—11:00
Tailoring Therapeutics to Meet the Demands of Prophylactic and Long-Term Therapy
Meeting has ended...abstracts no longer viewable online.
*
Marc Retter,
Amgen Inc., USA
Herren Wu,
MedImmune, USA
Engineering Biosuperiors
Engineering Biosuperiors
Javier Chaparro-Riggers,
Rinat-Pfizer Inc., USA
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody
Tomoyuki Igawa,
Chugai Pharmaceutical, Japan
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A
CM Hsieh,
Merck & Co., USA
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis
14:30—16:30
Workshop 2: B Cell Activation and Control of B Cell Responses
*
Anthony L. DeFranco,
University of California, San Francisco, USA
*
Jürgen Wienands,
Georg August University of Goettingen, Germany
Wenxia Song,
University of Maryland, USA
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance
Alberto Martin,
University of Toronto, Canada
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination
Javier M. Di Noia,
Institut de Recherches Cliniques de Montreal, Canada
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome
Carla R. Nowosad,
Rockefeller University, USA
Determining the Architecture and Function of Immune Synapses within B Cell Populations
Determining the Architecture and Function of Immune Synapses within B Cell Populations
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Signaling Pathways in B Cell Survival and Humoral Memory
Signaling Pathways in B Cell Survival and Humoral Memory
Isabelle Robert,
Institute of Genetics and Molecular and Cellular Biology
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3
Pia Dosenovic,
Rockefeller University, USA
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA
14:30—16:30
Workshop 3: B Cell Responses to Foreign Antigens
*
Nicole Baumgarth,
University of California, Davis, USA
Roberto DiNiro,
University of Pittsburgh, USA
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation
Rebecca A. Elsner,
University of Pittsburgh, USA
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses
Eliver Eid Bou Ghosn,
Stanford University, USA
HSC-Independent Development of Antigen-Specific B-1a Memory
HSC-Independent Development of Antigen-Specific B-1a Memory
E. Ashley Moseman,
NINDS, National Institutes of Health, USA
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection
Noel T. Pauli,
Adimab LLC, USA
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans
Kristin M.S. Schroeder,
National Jewish Health, USA
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells
Cristina Gil-Cruz,
Kantonsspital St.Gallen, Switzerland
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens
Adnan R. Khan,
UCB Celltech, UK
"The Breg Gets the Worm:" How Helminths Can Shed a Light on Regulatory B Cells
"The Breg Gets the Worm:" How Helminths Can Shed a Light on Regulatory B Cells
17:00—19:15
B Cell Responses to Foreign Antigens
Meeting has ended...abstracts no longer viewable online.
Antonio Lanzavecchia,
Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection
B Cell Memory to Infection
*
Patrick C. Wilson,
University of Chicago, USA
B Cell Immunity to Influenza in Humans
B Cell Immunity to Influenza in Humans
Hedda Wardemann,
German Cancer Research Center, Germany
B Cell Clonal Selection
B Cell Clonal Selection
Scott D. Boyd,
Stanford University, USA
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion
Stuart G. Tangye,
Garvan Institute of Medical Research, Australia
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans
17:00—19:00
Overcoming Challenging Indications for Antibody Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
Margaret Karow,
Akriveia Therapeutics, USA
Bruce L. Roberts,
Vedanta Biosciences, USA
New Insights into the Mechanism of Action of Alemtuzumab
New Insights into the Mechanism of Action of Alemtuzumab
Ronald A. Ignotz,
University of Massachusetts Medical School, USA
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice
Andreas Grauer,
Amgen, USA
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L and Sclerostin
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L and Sclerostin
Ronald B. DeMattos,
Lilly Research Laboratories, USA
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies
08:00—11:30
Regulating B Cell Immunity
Meeting has ended...abstracts no longer viewable online.
Marc K. Jenkins,
University of Minnesota Medical School, USA
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection
Michael G. McHeyzer-Williams,
The Scripps Research Institute, USA
Intra-Clonal Analysis of B Cell Memory
Intra-Clonal Analysis of B Cell Memory
Carola G. Vinuesa,
Australian National University, Australia
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis
Shane Crotty,
La Jolla Institute for Allergy and Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)
*
Hai Qi,
Tsinghua University, China
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells
Hui Hu,
University of Alabama at Birmingham, USA
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation
Andre Ballesteros-Tato,
University of Alabama at Birmingham, USA
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2
08:00—11:00
Prophylaxis versus Therapeutic Treatment of Infectious Disease
Meeting has ended...abstracts no longer viewable online.
*
Michael A. Barry,
Mayo Clinic, USA
Arturo Casadevall,
Albert Einstein College of Medicine, USA
A New Synthesis for Antibody-Mediated Immunity
A New Synthesis for Antibody-Mediated Immunity
Deborah C. Molrine,
University of Massachusetts Medical School, USA
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination
Charles Ken Stover,
MedImmune, LLC, USA
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections
Gene Tan,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus
14:30—16:45
Workshop 4: Follicular Helpers and Germinal Center Biology
*
Ann M. Haberman,
Yale University School of Medicine, USA
*
Takaharu Okada,
RIKEN, Japan
Simon N. Willis,
Walter and Eliza Hall Institute, Australia
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism
Peter Sage,
Harvard Medical School, USA
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells
Michela Locci,
University of Pennsylvania, USA
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells
Tharu M. Fernando,
Genentech, Inc., USA
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance
Seung Goo Kang,
Kangwon National University, South Korea
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs
Florian Weisel,
University of Pittsburgh, USA
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
Alexander D. Gitlin,
Rockefeller University, USA
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center
Roy Ramiscal,
John Curtin School of Medical Research, Australian National University, Australia
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells
Ziv Shulman,
Weizmann Institute, Israel
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers
14:00—16:30
Workshop 2: When an Antibody Isn’t Enough
*
Hilde Revets,
Ablynx, Belgium
Barbara S. Fox,
Tilos Therapeutics, Inc., USA
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract
Anthony B. Cooper,
Adimab, LLC, USA
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics
Rastislav Tamaskovic,
University of Zürich, Switzerland
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors
Kipp Weiskopf,
Stanford University, USA
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer
Nicholas J. Veomett,
Weill Cornell Medical College, USA
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities
14:30—16:30
Workshop 5: B Cell Memory
*
Andreas Radbruch,
Deutsches Rheuma-Forschungszentrum, Germany
*
Stuart G. Tangye,
Garvan Institute of Medical Research, Australia
Jean-Nicolas Schickel,
Adimab, LLC, USA
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria
Alexander Frühwirth,
Institute for Research in Biomedicine, Switzerland
Identification of a Marker for Recently Activated Memory B Cells
Identification of a Marker for Recently Activated Memory B Cells
Pierre J. Milpied,
The Scripps Research Institute, USA
Intraclonal Analysis of Memory B Cell Functional Plasticity
Intraclonal Analysis of Memory B Cell Functional Plasticity
Justin J. Taylor,
Fred Hutchinson Cancer Research Center, USA
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response
Niklas Engels,
Georg August University Goettingen, Germany
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells
Tyani D. Chan,
Garvan Institute of Medical Research, Australia
Novel Regulatory Control of IgE Antibody Responses
Novel Regulatory Control of IgE Antibody Responses
Kathryn A. Pape,
University of Minnesota, USA
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells
Kaval Kaur,
Agency for Science, Technology and Research, Singapore
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination
17:00—19:15
Germinal Center Biology
Meeting has ended...abstracts no longer viewable online.
David M. Tarlinton,
Monash University, Australia
The Impact of Arginine Methylation on B-Cell Responsiveness
The Impact of Arginine Methylation on B-Cell Responsiveness
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
The Ins and Outs of Germinal Centers: Selection, Generation and Identity
The Ins and Outs of Germinal Centers: Selection, Generation and Identity
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Germinal Center Biology
Germinal Center Biology
*
Gabriel D. Victora,
Rockefeller University, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers
Roger Sciammas,
University of California, Davis, USA
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4
17:00—19:15
In vivo Induction of Therapeutic Antibodies for Prophylactic Treatment of Disease
Meeting has ended...abstracts no longer viewable online.
*
Peter M. Palese,
Icahn School of Medicine at Mount Sinai, USA
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase
Ronald G. Crystal,
Weill Medical College of Cornell University, USA
Viral Vectors as Platforms for Anti-Addiction Vaccines
Viral Vectors as Platforms for Anti-Addiction Vaccines
Lélia Delamarre,
Genentech, Inc., USA
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells
Seleeke F. Flingai,
University of Pennsylvania, USA
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo
Erin Crossey,
University of New Mexico, USA
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9
08:00—11:30
Generation of Diversity (Joint)
Meeting has ended...abstracts no longer viewable online.
Max D. Cooper,
Emory University, USA
Immune System Ontogeny and Phylogeny
Immune System Ontogeny and Phylogeny
David G. Schatz,
Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation
Targeting of V(D)J Recombination and Somatic Hypermutation
Frederick W. Alt,
Boston Children's Hospital, USA
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events
*
F. Nina Papavasiliou,
Rockefeller University, USA
Short Talk: Generation of Diversity: Beyond Genomic Changes
Short Talk: Generation of Diversity: Beyond Genomic Changes
Changchun Xiao,
The Scripps Research Institute, USA
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways
Carol E. Schrader,
University of Massachusetts, USA
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes
14:30—16:30
Workshop 6: Ig Diversity and Biology of B Cell Tumors
*
Eric Meffre,
Yale University School of Medicine, USA
Nobuo Sakaguchi,
Kumamoto University, Japan
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification
Wai Yen Alfred Lim,
MRC Laboratory of Molecular Biology, UK
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line
Xiaohua Wang,
Berkeley Lights Inc, USA
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation
Amanda C. Drennan,
University of Wisconsin, Madison, USA
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma
Virginia G. de Yébenes,
Centro Nacional de Investigaciones Cardiovasculares, Spain
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction
Daniel Gadala-Maria,
Yale University, USA
Genotyping Methods for Improving Detection of Immunoglobulin Mutations
Genotyping Methods for Improving Detection of Immunoglobulin Mutations
Adrienne Greenough,
Duke University, USA
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome
Sébastien Storck,
Institut Necker-Enfants Malades, France
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes
14:00—16:30
Workshop 3: What We Are Learning about Antibody Therapeutics
*
Peter Brams,
Bristol-Myers Squibb, USA
Fabricio Montalvao,
Institut Pasteur, France
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging
Karin A. van Schie,
Sanquin Research, University of Amsterdam, Netherlands
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing
Nancy E. Everds,
Amgen, Inc, USA
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells
Stefan Barghorn,
AbbVie, Germany
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy
Mark J. Kwakkenbos,
AIMM Therapeutics, Netherlands
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability
Nathan J. Alves,
Indiana University, USA
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)
17:00—19:15
B Cell Cancer Biology
Meeting has ended...abstracts no longer viewable online.
Klaus Rajewsky,
Max Delbrück Center for Molecular Medicine, Germany
Modeling B Cell Lymphomagenesis in Mice
Modeling B Cell Lymphomagenesis in Mice
Louis M. Staudt,
NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas
Therapies Targeting Pathological Signaling in B Cell Lymphomas
Riccardo Dalla-Favera,
Columbia University, USA
Molecular Genetics of Diffuse Large B Cell Lymphoma
Molecular Genetics of Diffuse Large B Cell Lymphoma
*
Ralf Küppers,
University of Duisburg-Essen, Medical School, Germany
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma
Uttiya Basu,
Columbia University, USA
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome
17:00—19:00
What We've Learned from Antibody Treatment of Inflammation
Meeting has ended...abstracts no longer viewable online.
*
Neil Graham,
Regeneron Pharmaceuticals, USA
Meena Subramanyam,
Biogen Idec, USA
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned
Neil Graham,
Regeneron Pharmaceuticals, USA
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor
Thomas A. Waldmann,
National Institutes of Health, USA
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab
*Session Chair †Invited, not yet responded.
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