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This meeting took place in 2018



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Bioenergetics and Metabolic Disease (J4)


Organizer(s) Patrick Seale, Kendra K. Bence and P. Darrell Neufer
January 21—25, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 28, 2017
Abstract Deadline: Oct 26, 2017
Scholarship Deadline: Sep 28, 2017
Discounted Registration Deadline: Nov 29, 2017

Sponsored by MedImmune, Moderna Therapeutics and Novo Nordisk A/S


Summary of Meeting:
Obesity and type 2 diabetes are major drivers of chronic disease and premature death. A promising strategy to reduce obesity and improve metabolic health is through promoting energy expenditure via thermogenesis, including obligatory (accompanies all metabolic processes) and facultative (adaptive) mechanisms. Obesity and insulin resistance also lead to profound metabolic changes in various cells/tissues that contribute to tissue dysfunction. This conference brings together basic and clinical researchers from industry and academia focused on the study of cellular and organismal energy metabolism in the context of metabolic disease. A variety of approaches and topics will be featured, including: basic mechanisms of mitochondrial and cellular energetics; the emerging role of brown and beige fat in adaptive thermogenesis; central regulation of energy expenditure; and the effects of exercise on muscle and whole-body metabolism. In addition to the plenary sessions, the meeting will feature workshops on emerging research areas and novel therapeutic opportunities. Overall, the goals of the conference are to: 1) Provide a cutting-edge understanding of the basic mechanisms that control cellular and whole-body energetics; 2) Discuss the physiological role of brown fat and other energy expenditure pathways in humans; 3) Consider novel strategies for increasing energy expenditure and combating metabolic disease; and 4) Engage attendees in critical discussions about important areas for future research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.

SUNDAY, JANUARY 21

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 22

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
This lecture will provide a broad introduction to the central control of various metabolic parameters.

Columbine Ballroom
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

* Patrick Seale, University of Pennsylvania, USA

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Control of Integrative Physiology by the Melanocortin Circuitry

09:00—11:30
Central Modulation of Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.

Columbine Ballroom
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

* Gregory James Morton, University of Washington, USA

Matthew R. Hayes, University of Pennsylvania, USA
Metabolic Neuropeptides as Modulators of Energy Balance, Motivation and Reward

Coffee Break

Xiaoyong Yang, Yale University School of Medicine, USA
Short Talk: O-GlcNAc Signaling in Central Nutrient Sensing and Brain-Fat-Liver Communication

Christoph Buettner, Mount Sinai School of Medicine, USA
Brain Control of Adipose Tissue Functionality as a Determinant of Hypothalamic and Liver Function

Daniel L. Marks, Oregon Health & Science University, USA
Central Mechanisms in Cancer Cachexia

Bernard B. Allan, NGM Biopharmaceuticals, USA
Short Talk: GDF15 Induces Cancer Anorexia and Cachexia through GFRAL-dependent Activation of Neuronal Circuitry

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
14:30—16:30
Workshop 1: Emerging Therapeutic Targets for Metabolic Disease (Joint)

Columbine Ballroom
* Cecile Vernochet, Pfizer, USA

* Shamina M. Rangwala, Janssen, Johnson & Johnson, USA

Philipa Levesque-Damphousse, Institut de Recherches Cliniques de Montréal, Canada
SerpinA3N, an Early Biomarker of Non-Alcoholic Fatty Liver Disease

Majid Mufaqam Syed-Abdul, University of Missouri, USA
Progressive Reductions in Hepatic DNL with Increasing Doses of TVB-2640, a First-in-Class Pharmacologic Inhibitor of FASN

Senad Divanovic, Cincinnati Children's Hospital Medical Center, USA
Metabolic Reprogramming of Th17 Cells Regulates Inflammatory Vigor and NAFLD Pathogenesis

Joe S. Grimsby, MedImmune, USA
GLP-1R/GCGR Dual Agonist Reduced Obesity by Increasing Energy Expenditure due to its Effects in Brown Adipose Tissue and Browning of White Fat

Hyeonwoo Kim, Dana-Farber Cancer Institute/Harvard Medical School, USA
Identification of the Irisin Receptor and its Role in Exercise

Brian N. Finck, Washington University School of Medicine, USA
Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes and NAFLD

Monica Dentice, Università degli Studi di Napoli Federico II, Italy
Muscle-Specific Action of Deiodinases Induces Metabolic Switches in Muscle thereby Influencing Systemic Energy Metabolism

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Brown and Beige Fat Thermogenesis
Meeting has ended...abstracts no longer viewable online.
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.

Quandary Peak
* Jan Nedergaard, Stockholm University, Sweden

* Kristy L. Townsend, University of Maine, USA

Patrick Seale, University of Pennsylvania, USA
Molecular Regulation of Brown and Beige Adipogenesis

Sheila Collins, Vanderbilt University Medical Center, USA
Receptor Systems and Signaling Mechanisms in White and Brown Adipocytes

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Epigenomic Characterization of Beige Adipocyte Plasticity

Zach Gerhart-Hines, University of Copenhagen, Denmark
Short Talk: Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria

17:00—19:00
Sweet Spots in the Brain: Central Glucose Sensing and Peripheral Glucose Homeostasis
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Christoph Buettner, Mount Sinai School of Medicine, USA

* Zachary Knight, University of California, San Francisco, USA

Sarah Stanley, Icahn School of Medicine at Mount Sinai, USA
New Tools to Study the Role of Glucose-Sensing Neurons

Gregory James Morton, University of Washington, USA
CNS Mechanisms Governing Diabetic Hyperglycemia

Greg S. B. Suh, New York University School of Medicine, USA
Feeding and Nutrient Sensing in Flies and Mice

Eleni Rebelos, Turku University, Finland
Short Talk: Brain-Liver-Pancreas Axis Revised with FDG-PET Imaging

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—09:00
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Patrick Seale, University of Pennsylvania, USA

Bruce M. Spiegelman, Harvard Medical School, USA
Pathways that Control Cellular and Organismal Energy Metabolism

09:00—11:30
Adipose Plasticity and Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.

Columbine Ballroom
* Barbara Cannon, Stockholm University, Sweden

* Li Qiang, Columbia University Medical Center, USA

Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Sex- and Depot- Dependent Mechanisms Shaping Fat Distribution and Metabolic Health

Coffee Break

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Fibrosis in Metabolic Regulation

Su Myung Jung, University of Massachusetts Medical School, USA
Short Talk: A Non-Canonical mTORC2 Signaling Pathway that Regulates Thermogenesis

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Control of Systemic Metabolism by de novo Lipogenesis in Adipose

Paul Cohen, Rockefeller University, USA
Short Talk: Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

11:30—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mitochondria: Form and Function
Meeting has ended...abstracts no longer viewable online.
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.

Quandary Peak
* P. Darrell Neufer, East Carolina University, USA

* Zhidan Wu, Pfizer, USA

Jodi Nunnari, University of California, Davis, USA
Mitochondrial Behavior

Mary-Ellen Harper, University of Ottawa, Canada
Acute Control of the Uncoupling Proteins: Redox, ROS Feedback Loops and Post-Translational Modifications

Erin Leah Seifert, Thomas Jefferson University, USA
Short Talk: Loss of Mitochondrial Phosphate Carrier in Skeletal Muscle: Dissociation of Muscle Dysfunction from Lower ADP Phosphorylating Potential

Daniel P. Kelly, University of Pennsylvania, USA
Transcriptional Control of Mitochondrial Fuel Metabolism

17:00—19:00
Hepatic Metabolism in Obesity
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Bei B. Zhang, Pfizer Inc., USA

* Rebecca A. Haeusler, Columbia University, USA

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Compartmentalization of Hepatic Lipid Metabolism

Morris J. Birnbaum, Pfizer Inc., USA
Regulation of Hepatic Lipid Accumulation

Baoliang Song, Wuhan University, China
New Explorations on the Ancient Cholesterol Molecule

Chaofeng Yang, University of Texas Southwestern Medical Center, USA
Short Talk: Plin5 Is a Key Regulator of Lipid and Glucose Metabolism in the Liver

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Energy Expenditure and Body Weight Regulation in Humans
Meeting has ended...abstracts no longer viewable online.
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.

Quandary Peak
* Alexander S. Banks, Harvard Medical School, USA

* Anna Krook, Karolinska Institutet, Sweden

Herman Pontzer, Hunter College, USA
Evolutionary Origins of Obesity

Michael Rosenbaum, Columbia University Medical College, USA
Regulation of Energy Balance following Weight Reduction

Coffee Break

Wouter D. van Marken Lichtenbelt, Maastricht University, Netherlands
Cold Exposure and Metabolic Health: Role Brown Adipose Tissue and Skeletal Muscle

Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: White Adipose Tissue Lipolysis Not Just a Fuel Supply: Re-Visiting the Significant Thermogenic Contribution of the Triglyceride-Fatty Acid Cycle in Humans Exposed to the Cold or Stimulated with a β3-Adrenergic Receptor Agonist (Mirabegron

Steven R. Smith, Florida Hospital, USA
Metabolic Flexibility and Energy Utilization

08:00—11:00
Hepatic Dysfunction in NASH and NAFLD
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

* Utpal B. Pajvani, Columbia University Medical Center, USA

Gyongyi Szabo, University of Massachusetts Medical School, USA
Inflammasome Activation Pathways in NAFLD and NASH

Samuel Klein, Washington University School of Medicine, USA
Biochemical, Metabolic and Clinical Implications in Obesity and NASH

Coffee Break

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Targeting Mitochondria to Treat NAFLD, NASH and Type 2 Diabetes

Elizabeth J. Parks, University of Missouri, USA
Drug Development in NAFLD: From Lipogenesis to Fibrosis

Anna Laitakari, University of Oulu, Finland
Short Talk: Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects against Fatty Liver Disease and Metabolic Dysfunction in Mice

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Cellular Regulators of Bioenergetics
Meeting has ended...abstracts no longer viewable online.
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.

Quandary Peak
* Deborah M. Muoio, Duke University Medical Center, USA

* Jorge L. Ruas, Karolinska Institutet, Sweden

P. Darrell Neufer, East Carolina University, USA
Redox Circuit Flux and Energy Expenditure

Muthu Periasamy, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, USA
Skeletal Muscle-Based Thermogenic Mechanisms

Edward T. Chouchani, Dana-Farber Cancer Institute, USA
Short Talk: A Novel Molecular Pathway Controls Acute Activation of Adipose Tissue Thermogenesis

Daniel Garcia, The Salk Institute for Biological Studies, USA
AMPK Control of Cellular Energetics

17:00—19:00
The Many Scars of Obesity: Systemic Fibrosis and Hypothalamic Gliosis
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Kendra K. Bence, Pfizer Inc., USA

* Suneil K. Koliwad, University of California, San Francisco, USA

Bart Staels, Institut Pasteur de Lille, Université Lille, France
Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

Joshua Thaler, University of Washington, USA
Hypothalamic Gliosis

Ana Domingos, IRS-Fundação Calouste Gulbenkian, University of Oxford, Portugal
Sympathetic Neuroimmunity for Obesity

Utpal B. Pajvani, Columbia University Medical Center, USA
Short Talk: Notch Mediates Hepatocyte-HSC Crosstalk to Induce Fibrosis in NASH

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, JANUARY 25

07:00—08:00
Breakfast

Colorado Rockies Ballroom
07:30—08:00
Poster Setup

Colorado Rockies Ballroom
08:00—17:00
Poster Viewing

Colorado Rockies Ballroom
08:00—11:00
Skeletal Muscle: Use and Disuse
Meeting has ended...abstracts no longer viewable online.
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.

Quandary Peak
* Bruce M. Spiegelman, Harvard Medical School, USA

* Erin Leah Seifert, Thomas Jefferson University, USA

Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Control and the Circadian Clock: Turning Back Time on Diabetes Pathogenesis

David E. James, University of Sydney, Australia
Probing the Exercise Regulated Phosphoproteome in Skeletal Muscle

Coffee Break

Deborah M. Muoio, Duke University Medical Center, USA
Adaptive Responses to Exercise Controlling Metabolism

Kelsey H. Fisher-Wellman, Duke Molecular Physiology Institute, USA
Short Talk: Organic Cations as a Class Lower the Efficiency of Mitochondria Energy Transduction and Protect against Nutrient-Induced Metabolic Disease

David J. Glass, Novartis Institutes for Biomedical Research, USA
Molecular Mechanisms Regulating Muscle Mass and Mitochondria

08:00—11:00
Feel Your Gut: The Gut-Brain-Food Connection
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Elizabeth J. Parks, University of Missouri, USA

* Thomas Alexander Lutz, University of Zürich, Switzerland

Zachary Knight, University of California, San Francisco, USA
Nutritional Regulation of Hunger Circuits

Kendra K. Bence, Pfizer Inc., USA
Targeting Fructose Metabolism for the Treatment of NAFLD/NASH

Coffee Break

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
Gut Peptides Drive Metabolic Organs: Direct vs. Indirect Mechanisms

Mark D. Erion, Janssen Pharmaceutical, USA
Approaches Targeting Metabolic Control and Weight Management – From Mice to Man

Nicholas Vincent DiPatrizio, University of California, Riverside, School of Medicine, USA
Short Talk: Endocannabinoids Inhibit Gut-Brain Satiation Signaling in Obesity

11:00—12:00
Lunch

Colorado Rockies Ballroom
12:00—14:30
Poster Session 4

Colorado Rockies Ballroom
14:30—16:30
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)

Grays/Longs Peak
* Jacqueline M. Stephens, Louisiana State University, USA

* Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA

Anna Worthmann, University Medical Center Hamburg-Eppendorf, Germany
Increased Hepatic Bile Acid Production Shapes the Gut Microbiome after Cold Induced Brown Adipose Tissue Activation

Raul C. Camacho, Janssen, USA
Amino Acids as Glucagon Receptor Specific Biomarkers for Glucagon Receptor/Glucagon-Like Peptide 1 Receptor Dual Agonists

Katrin J. Svensson, Stanford University, USA
Isthmin Is a Secreted Protein that Prevents Hepatic Steatosis and Regulates Glucose Homeostasis

Anthony Scime, York University, Canada
A Novel Energy Sensing Mechanism that Synchronizes Progenitor Cell Metabolism

Chelsea Hepler, University of Texas Southwestern Medical Center, USA
Directing Visceral White Adipocyte Precursors to a Thermogenic Adipocyte Fate

Alexander Bartelt, Ludwig-Maximilians-University, Germany
Brown Fat Thermogenic Adaptation Requires Nfe2l1-Induced Proteasomal Activity

Michael D. Neinast, University of Pennsylvania, USA
Whole-Body Metabolic Fate of Branched Chain Amino Acids in Health and Insulin Resistance

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Novel Effectors of Energy Metabolism
Meeting has ended...abstracts no longer viewable online.
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.

Quandary Peak
* Sheila Collins, Vanderbilt University Medical Center, USA

* Claudio Villanueva, University of Utah School of Medicine, USA

Shingo Kajimura, University of California, San Francisco, USA
BAT-Secreted Adipokines Regulate Energy Expenditure

Jiandie Lin, University of Michigan Medical School, USA
Endocrine Checkpoint for NASH Progression

Ajay Chawla, University of California, San Francisco, USA
Host Immunity and Energetics

17:00—18:45
Fat on the Brain: Adipose-Brain Crosstalk
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Gary J. Schwartz, Albert Einstein College of Medicine, USA
Metabolic Sensing in Adipose Tissue Nerves

Pierre Léopold, University of Nice, France
Humoral Communication between Fat and Brain in Drosophila

Suneil K. Koliwad, University of California, San Francisco, USA
Hypothalamic Microglia as Fat Sensors: Physiology vs. Pathology

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Colorado Rockies Ballroom

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

MedImmune Moderna Therapeutics
Novo Nordisk A/S
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK116303-01

Funding for this conference was made possible (in part) by 1 R13 DK116303-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676