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This meeting took place in 2019
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Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics (X2)
Organizer(s) Saba Valadkhan and Piero Carninci
February 24—28, 2019
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Oct 25, 2018
Abstract Deadline: Nov 29, 2018
Scholarship Deadline: Oct 25, 2018
Discounted Registration Deadline: Jan 10, 2019
Sponsored by Cell Research and Ionis Pharmaceuticals, Inc.
Joint Meeting:
RNA-Protein Interactions (X1)
Summary of Meeting:
Although emerging evidence points to the critical importance of the long non-coding transcriptome in human physiology and pathology, the clinical potential of long non-coding RNAs (lncRNAs) as therapeutic and prognostic targets remain largely unexplored. The increasing availability of high-throughput technologies and newly developed computational methodologies are rapidly making it possible to address this gap in our knowledge. However, optimal use of these new capabilities and recognition of their power in transforming the field of lncRNA research require the formation of new collaborative and training efforts. This conference specifically aims to: 1) Communicate the latest available technologies and developing methodologies for lncRNA functional genetics to the lncRNA community; 2) Bridge the already thriving lncRNA mechanistic and basic research to the clinical need for novel, effective diagnostic, prognostic and therapeutic targets; 3) Highlight and promote the emerging feasibility of performing lncRNA functional genetics; and 4) Stimulate the formation of new collaborative efforts that will accelerate the integration of the lncRNA research into the existing body of biological knowledge.
View Scholarships/Awards
Although emerging evidence points to the critical importance of the long non-coding transcriptome in human physiology and pathology, the clinical potential of long non-coding RNAs (lncRNAs) as therapeutic and prognostic targets remain largely unexplored. The increasing availability of high-throughput technologies and newly developed computational methodologies are rapidly making it possible to address this gap in our knowledge. However, optimal use of these new capabilities and recognition of their power in transforming the field of lncRNA research require the formation of new collaborative and training efforts. This conference specifically aims to: 1) Communicate the latest available technologies and developing methodologies for lncRNA functional genetics to the lncRNA community; 2) Bridge the already thriving lncRNA mechanistic and basic research to the clinical need for novel, effective diagnostic, prognostic and therapeutic targets; 3) Highlight and promote the emerging feasibility of performing lncRNA functional genetics; and 4) Stimulate the formation of new collaborative efforts that will accelerate the integration of the lncRNA research into the existing body of biological knowledge.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
MONDAY, FEBRUARY 25
TUESDAY, FEBRUARY 26
WEDNESDAY, FEBRUARY 27
THURSDAY, FEBRUARY 28
FRIDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
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Douglas L. Black,
University of California, Los Angeles, USA
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Anne Ephrussi,
European Molecular Biology Laboratory, Germany
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Saba Valadkhan,
Case Western Reserve University, USA
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Piero Carninci,
RIKEN Center for Integrative Medical Sciences, Japan
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
New Genome Editors and Inhibitors from the CRISPR Family Tree
New Genome Editors and Inhibitors from the CRISPR Family Tree
Coffee Break
09:50—12:30
Functional RNA Elements in Mammalian Genomes (Joint)
Meeting has ended...abstracts no longer viewable online.
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Danesh Moazed,
Harvard Medical School, USA
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Howard Y. Chang,
Stanford University, USA
Xiang-Dong Fu,
University of California, San Diego, USA
Broad Roles of RNA-Binding Proteins in Regulated Gene Expression
Broad Roles of RNA-Binding Proteins in Regulated Gene Expression
Thomas R. Cech,
HHMI/University of Colorado, USA
RNA-Protein Interactions Regulate Epigenetic Silencing
RNA-Protein Interactions Regulate Epigenetic Silencing
Chris B. Burge,
Massachusetts Institute of Technology, USA
Patterns in the Recognition of RNAs by RBPs
Patterns in the Recognition of RNAs by RBPs
Maiwen Caudron-Herger,
German Cancer Research Center, Germany
Short Talk: Proteome-Wide and Quantitative Identification of RNA-Dependent Protein Complexes
Short Talk: Proteome-Wide and Quantitative Identification of RNA-Dependent Protein Complexes
Mario A. Flores,
NCBI, National Institutes of Health, USA
Short Talk: Dissecting the Characteristics and Functions of Transcribed Enhancers
Short Talk: Dissecting the Characteristics and Functions of Transcribed Enhancers
Yoav Lubelsky,
Weizmann Institute of Science, Israel
Short Talk: Elucidating the Crosstalk between hnRNPK Binding and Nuclear Retention of Long RNAs
Short Talk: Elucidating the Crosstalk between hnRNPK Binding and Nuclear Retention of Long RNAs
Yoko Matsuno,
Niigata University, Japan
Short Talk: Characteristic Convergent Variation in LINE-1 Nucleotides Can Benefit Redundantly Forming Triplexes with lncRNA in Mammalian X-Chromosome Inactivation
Short Talk: Characteristic Convergent Variation in LINE-1 Nucleotides Can Benefit Redundantly Forming Triplexes with lncRNA in Mammalian X-Chromosome Inactivation
14:30—16:30
Workshop 1: lncRNAs: Diversity of Function
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Lingling Chen,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
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Susan B. Carpenter,
University of California, Santa Cruz, USA
Thomas C. Brodnicki,
St Vincent's Institute, Australia
A Long Noncoding RNA Attenuates Dendritic Cell Function and Decreases Autoimmune Disease Susceptibility
A Long Noncoding RNA Attenuates Dendritic Cell Function and Decreases Autoimmune Disease Susceptibility
Ousman Tamgue,
University of Douala, Cameroon and University of Cape Town, IDM, South Africa
Long Non-Coding RNA-26 Promotes Intracellular Mycobacterium tuberculosis Growth through Inhibition of Pro-Inflammatory Genes Expression and Macrophage Activation
Long Non-Coding RNA-26 Promotes Intracellular Mycobacterium tuberculosis Growth through Inhibition of Pro-Inflammatory Genes Expression and Macrophage Activation
Fabio Desideri,
Sapienza University of Rome, Italy
Charme Long Noncoding RNA Shapes the 3D Nuclear Structure by its Close Cooperation with Chromatin
Charme Long Noncoding RNA Shapes the 3D Nuclear Structure by its Close Cooperation with Chromatin
Marine Gautier,
Centre National de la Recherche Scientifique, France
Functional Characterization of Hypoxia-Regulated lncRNAs in Non-Small Cell Lung Carcinomas
Functional Characterization of Hypoxia-Regulated lncRNAs in Non-Small Cell Lung Carcinomas
Paras Sehgal,
Institute of Genomics and Integrative Biology, India
Regulation of Diacyl Glycerol-Mediated Protein Kinase C-Beta Activation by Vascular Endothelial -Associated Long Noncoding RNA 2 Modulates Endothelial Permeability
Regulation of Diacyl Glycerol-Mediated Protein Kinase C-Beta Activation by Vascular Endothelial -Associated Long Noncoding RNA 2 Modulates Endothelial Permeability
Roberto Vendramin,
VIB-KU Leuven, Belgium
SAMMSON Fosters Cancer Cell Fitness by Concertedly Enhancing Mitochondrial and Cytosolic Translation
SAMMSON Fosters Cancer Cell Fitness by Concertedly Enhancing Mitochondrial and Cytosolic Translation
Tan Phat Pham,
Amsterdam University Medical Center, Netherlands
The Age and Shear Regulated Long Non-Coding RNA Aerrie Controls Endothelial Cell Function
The Age and Shear Regulated Long Non-Coding RNA Aerrie Controls Endothelial Cell Function
Laura Stanicek,
Amsterdam University Medical Center, Netherlands
The Shear Stress-Induced Long Non-Coding RNA LASSIE as a Regulator of Endothelial Cell Junctions
The Shear Stress-Induced Long Non-Coding RNA LASSIE as a Regulator of Endothelial Cell Junctions
14:30—16:30
Workshop 1: New RNA Technologies
Daniel Benhalevy,
NIAMS, National Institutes of Health, USA
Proximity-CLIP Provides a Snapshot of Protein-Occupied RNA Elements in Sub-Cellular Compartments
Proximity-CLIP Provides a Snapshot of Protein-Occupied RNA Elements in Sub-Cellular Compartments
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Kevin Drew,
University of Texas at Austin, USA
Systematic Discovery of Endogenous Human Ribonucleoprotein Complexes
Systematic Discovery of Endogenous Human Ribonucleoprotein Complexes
Hong Han,
University of Toronto, Canada
An Integrated High-Throughput Chemical Screening Platform for RNA Splicing Modulators
An Integrated High-Throughput Chemical Screening Platform for RNA Splicing Modulators
Sudhakar Jha,
National University of Singapore, Singapore
Utilization of a Novel Technique to Identify RNA-Binding Proteins
Utilization of a Novel Technique to Identify RNA-Binding Proteins
Jakob Trendel,
European Molecular Biology Laboratory, Germany
Protein Half-Lives on RNA Reveal Human Ribosome Maintenance Independent of Ribosome Biogenesis
Protein Half-Lives on RNA Reveal Human Ribosome Maintenance Independent of Ribosome Biogenesis
Marta Gabryelska,
University of Edinburgh, UK
Probing Ribosome Assembly Dynamics with CLASH
Probing Ribosome Assembly Dynamics with CLASH
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Alena Shkumatava,
Institut Curie-Centre de Recherche, France
Systematic Identification and Quantitative Measurement of RNA-Protein Interactions by incPRINT
Systematic Identification and Quantitative Measurement of RNA-Protein Interactions by incPRINT
17:00—19:30
lncRNAs, Transposons and Evolution of the Genome
Meeting has ended...abstracts no longer viewable online.
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John L. Rinn,
, USA
Igor Ulitsky,
Weizmann Institute of Science, Israel
Functions, Modes of Action and Localization of Long Noncoding RNAs in Mammalian Cells
Functions, Modes of Action and Localization of Long Noncoding RNAs in Mammalian Cells
Lynne E. Maquat,
University of Rochester Medical Center, USA
Role of Retrotransposon Elements within Cellular RNAs
Role of Retrotransposon Elements within Cellular RNAs
Paulo P. Amaral,
University of Cambridge, UK
Defining the Landscape of Covalent Modifications in Conserved Noncoding RNAs using Direct-RNA Sequencing
Defining the Landscape of Covalent Modifications in Conserved Noncoding RNAs using Direct-RNA Sequencing
Paolo Gandellini,
Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
Short Talk: LEADeR Role of miR-205 Host Gene as Long Non-Coding RNA in Prostate Basal Cell Differentiation
Short Talk: LEADeR Role of miR-205 Host Gene as Long Non-Coding RNA in Prostate Basal Cell Differentiation
Giovanni Pascarella,
RIKEN CLST Yokohama Institute, Japan
Short Talk: Somatic Retrotransoposons-Associated Structural Variants in Health and Neurodegeneration
Short Talk: Somatic Retrotransoposons-Associated Structural Variants in Health and Neurodegeneration
17:00—19:00
RNP in Phase Transition
Meeting has ended...abstracts no longer viewable online.
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Kristen W. Lynch,
University of Pennsylvania, USA
Kathrin Plath,
University of California, Los Angeles, USA
A New Mode of Xist Action
A New Mode of Xist Action
Roy R. Parker,
HHMI/University of Colorado, USA
RNP Granules in Health and Disease
RNP Granules in Health and Disease
Kimberly L. Mowry,
Brown University, USA
Large RNP Transport Granules Drive mRNA Localization
Large RNP Transport Granules Drive mRNA Localization
Joseph Lobel,
University of California, San Francisco, USA
Short Talk: Pat1 Activates Late Steps in mRNA Decay by Multiple Mechanisms
Short Talk: Pat1 Activates Late Steps in mRNA Decay by Multiple Mechanisms
Xiong Ji,
Peking University, China
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
Coding and Noncoding RNAs on Chromatin (Joint)
Meeting has ended...abstracts no longer viewable online.
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Kathrin Plath,
University of California, Los Angeles, USA
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Igor Ulitsky,
Weizmann Institute of Science, Israel
Danesh Moazed,
Harvard Medical School, USA
RNAi in Chromatin Remodeling
RNAi in Chromatin Remodeling
Yijun Ruan,
The Jackson Laboratory for Genomic Medicine, USA
Protein-RNA-Chromatin Interactions
Protein-RNA-Chromatin Interactions
Coffee Break
Jeannie T. Lee,
Massachusetts General Hospital, USA
Xist RNA Antagonizes the Chromatin Remodeler, BRG1, on the Inactive X Chromosome
Xist RNA Antagonizes the Chromatin Remodeler, BRG1, on the Inactive X Chromosome
Valerio Orlando,
King Abdullah University of Science and Technology, Saudi Arabia
RNAi Component Ago1 Interacts with lncRNAs to Regulate Nuclear Architecture and Cell Differentiation
RNAi Component Ago1 Interacts with lncRNAs to Regulate Nuclear Architecture and Cell Differentiation
Ryan Alexander Flynn,
Stanford University, USA
Short Talk: DNA-PK Leverages Non-Coding RNA Binding to Regulate Nucleolar Functions
Short Talk: DNA-PK Leverages Non-Coding RNA Binding to Regulate Nucleolar Functions
Riki Kurokawa,
Saitama Medical University, Japan
Short Talk: Arginine Methylation of RNA Binding Protein TLS Inhibits Binding to Long Noncoding RNA, Repressing the Histone Acetyltransferase Activity
Short Talk: Arginine Methylation of RNA Binding Protein TLS Inhibits Binding to Long Noncoding RNA, Repressing the Histone Acetyltransferase Activity
Saigopal Somasundaram,
Case Western Reserve University, USA
Short Talk: The DNMT1-Associated lincRNA DACOR1 Reprograms Genome-Wide DNA Methylation in Colon Cancer
Short Talk: The DNMT1-Associated lincRNA DACOR1 Reprograms Genome-Wide DNA Methylation in Colon Cancer
Eric James de Bony de Lavergne,
Ghent University, Belgium
Short Talk: NESPR Long Non-Coding RNA, a New Neuroblastoma-Specific Oncogene
Short Talk: NESPR Long Non-Coding RNA, a New Neuroblastoma-Specific Oncogene
17:00—19:00
Regulation of Differentiation and Development by lncRNAs
Meeting has ended...abstracts no longer viewable online.
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Lynne E. Maquat,
University of Rochester Medical Center, USA
Saba Valadkhan,
Case Western Reserve University, USA
Regulation of Cellular Quiescence by lncRNAs
Regulation of Cellular Quiescence by lncRNAs
Joshua T. Mendell,
HHMI/University of Texas Southwestern Medical Center, USA
lncRNAs in Mammalian Physiology and Disease
lncRNAs in Mammalian Physiology and Disease
Susan B. Carpenter,
University of California, Santa Cruz, USA
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
Gaultier Hericher,
Université Laval – CRCHU de Québec, Canada
Short Talk: Novel Tuna Isoforms Define the Pluripotent Stem Cell State
Short Talk: Novel Tuna Isoforms Define the Pluripotent Stem Cell State
17:00—19:00
Dissecting RNP Functions in vivo
Meeting has ended...abstracts no longer viewable online.
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V. Narry Kim,
Institute for Basic Science, South Korea
Joan A. Steitz,
Yale University, USA
Target-Directed miRNA Decay: Yet Another Function of Ago Proteins
Target-Directed miRNA Decay: Yet Another Function of Ago Proteins
Kristen W. Lynch,
University of Pennsylvania, USA
CELF2 Regulation of Splicing and Polyadenylation in Activated T Cells
CELF2 Regulation of Splicing and Polyadenylation in Activated T Cells
Danielle Widner,
Yale University, USA
Short Talk: RNA-Protein Complex Formation in a Mysterious Large ncRNA
Short Talk: RNA-Protein Complex Formation in a Mysterious Large ncRNA
Qingqing Wang,
University of California, Berkeley, USA
Short Talk: Decipering the Splicing Code of Coordinated RN- Binding Proteins PSI and hrp48 in Sculpting the Drosophila Transcriptome
Short Talk: Decipering the Splicing Code of Coordinated RN- Binding Proteins PSI and hrp48 in Sculpting the Drosophila Transcriptome
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
lncRNAs in Disease: Tools for Discovery
Meeting has ended...abstracts no longer viewable online.
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Fabrizio d'Adda di Fagagna,
IFOM, The FIRC Institute of Molecular Oncology, Italy
Howard Y. Chang,
Stanford University, USA
Genome Regulation by Long Noncoding RNAs
Genome Regulation by Long Noncoding RNAs
Joakim Lundeberg,
KTH-Royal Institute of Technology, Sweden
Spatial Transcriptome Analysis and Disease
Spatial Transcriptome Analysis and Disease
Coffee Break
Nicholas J. Proudfoot,
University of Oxford, UK
Different Mechanisms Define lncRNA and Protein Coding Gene Transcription Units in Mammalian Cells
Different Mechanisms Define lncRNA and Protein Coding Gene Transcription Units in Mammalian Cells
Jin Chen,
University of California, San Francisco, USA
Systematic Discovery of Novel Peptides from the Noncanonical Translation of Non-Coding Regions
Systematic Discovery of Novel Peptides from the Noncanonical Translation of Non-Coding Regions
Per Johnsson,
Karolinska Institutet, Sweden
Short Talk: Functional Prediction and Validation of lncRNAs using Allele-Sensitive Single-Cell RNA-Sequencing
Short Talk: Functional Prediction and Validation of lncRNAs using Allele-Sensitive Single-Cell RNA-Sequencing
Lydia M. Contreras,
University of Texas at Austin, USA
Short Talk: Novel High-Throughput Tools for in vivo Functional Characterization of Regulatory RNAs
Short Talk: Novel High-Throughput Tools for in vivo Functional Characterization of Regulatory RNAs
Bojan Losic,
Icahn School of Medicine at Sinai, USA
Short Talk: Circular RNA Mediate IBD Genetic Risk
Short Talk: Circular RNA Mediate IBD Genetic Risk
08:00—11:15
RNA Transport and Localization
Meeting has ended...abstracts no longer viewable online.
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Kimberly L. Mowry,
Brown University, USA
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Erik Sontheimer,
University of Massachusetts Medical School, USA
Anne Ephrussi,
European Molecular Biology Laboratory, Germany
Motor-Mediated RNA Transport and Localization
Motor-Mediated RNA Transport and Localization
Robert H. Singer,
Albert Einstein College of Medicine, USA
Neuronal Targets for RNA Binding Proteins
Neuronal Targets for RNA Binding Proteins
Coffee Break
Dierk Niessing,
Ulm University, Germany
Molecular Architecture and Dynamics of mRNA Transport Complexes
Molecular Architecture and Dynamics of mRNA Transport Complexes
Anob Chakrabarti,
Francis Crick Institute, UK
Short Talk: Exploring the Characteristics and Functions of RNA Secondary Structures Bound in vivo by Staufen
Short Talk: Exploring the Characteristics and Functions of RNA Secondary Structures Bound in vivo by Staufen
Hong Cheng,
Shanghai Institute of Biological Science, Chinese Academy of Sciences, China
Short Talk: NRDE2 Negatively Regulates Nuclear Exosome Functions and Controls Embryonic Stem Cell Self-Renewal
Short Talk: NRDE2 Negatively Regulates Nuclear Exosome Functions and Controls Embryonic Stem Cell Self-Renewal
Mehdi Pirouz,
Boston Children's Hospital, USA
Short Talk: The Perlman Syndrome Dis3l2 Exonuclease as Guardian of ER-associated Translation
Short Talk: The Perlman Syndrome Dis3l2 Exonuclease as Guardian of ER-associated Translation
Dhara Patel,
Universite de Montreal, Canada
Short Talk: Complementary 3’UTRs Derived from Overlapping Genes can Promote Cytoplasmic Co-Localization of Distinct mRNAs
Short Talk: Complementary 3’UTRs Derived from Overlapping Genes can Promote Cytoplasmic Co-Localization of Distinct mRNAs
Jernej Murn,
University of California, Riverside, USA
Short Talk: Transcriptional Control of Neuronal Differentiation by an RNA-Binding Protein
Short Talk: Transcriptional Control of Neuronal Differentiation by an RNA-Binding Protein
17:00—19:00
Novel Insights into Functional Mechanism of lncRNAs
Meeting has ended...abstracts no longer viewable online.
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Joshua T. Mendell,
HHMI/University of Texas Southwestern Medical Center, USA
Michael G. Rosenfeld,
University of California, San Diego, USA
eRNAs Mediate Phase Separation of Ligand-Activated Enhancers to License Cooperative Chromosomal Enhancer Assembly
eRNAs Mediate Phase Separation of Ligand-Activated Enhancers to License Cooperative Chromosomal Enhancer Assembly
John L. Rinn,
, USA
The Firre Locus Produces a Trans-Acting RNA Molecule that Functions in Hematopoiesis
The Firre Locus Produces a Trans-Acting RNA Molecule that Functions in Hematopoiesis
Kaveh Daneshvar,
Harvard Medical School, USA
Short Talk: lncRNA DIGIT and BRD3 Protein Form Phase-Separated Condensates and Regulate Endoderm Differentiation.
Short Talk: lncRNA DIGIT and BRD3 Protein Form Phase-Separated Condensates and Regulate Endoderm Differentiation.
Karan Joshua Abraham,
University of Toronto, Canada
Short Talk: Intergenic Non-Coding RNA-DNA Hybrids Maintain Nucleolar Biomolecular Condensates and Ribosome Biogenesis
Short Talk: Intergenic Non-Coding RNA-DNA Hybrids Maintain Nucleolar Biomolecular Condensates and Ribosome Biogenesis
17:00—19:00
Structure and Function of RBPs
Meeting has ended...abstracts no longer viewable online.
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Rui Zhao,
University of Colorado, USA
Douglas L. Black,
University of California, Los Angeles, USA
Splicing Activation by Rbfox Requires Self-Aggregation of its Tyrosine-Rich Domain
Splicing Activation by Rbfox Requires Self-Aggregation of its Tyrosine-Rich Domain
Frédéric H.T. Allain,
ETH Zurich, Switzerland
Interaction of U1snRNP with Drugs and RNA-Binding Proteins in Splicing Regulation
Interaction of U1snRNP with Drugs and RNA-Binding Proteins in Splicing Regulation
Traci M.T. Hall,
NIEHS, National Institutes of Health, USA
Collaborative RNA Recognition Specificity by PUF Proteins
Collaborative RNA Recognition Specificity by PUF Proteins
Andreas Schlundt,
Goethe University Frankfurt, Germany
Short Talk: The Individual Contributions of Single IMP3 RNA-Binding Domains to the Recognition of Clustered Sequences in Target mRNAs
Short Talk: The Individual Contributions of Single IMP3 RNA-Binding Domains to the Recognition of Clustered Sequences in Target mRNAs
Janosch Hennig,
European Molecular Biology Laboratory, Germany
Short Talk: Structural Insights into MLE-Unr-roX2 Complex Assembly during Early Steps of Drosophila Dosage Compensation
Short Talk: Structural Insights into MLE-Unr-roX2 Complex Assembly during Early Steps of Drosophila Dosage Compensation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
lncRNAs: Diversity in Form and Function
Meeting has ended...abstracts no longer viewable online.
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Jeannie T. Lee,
Massachusetts General Hospital, USA
Karissa Y. Sanbonmatsu,
Los Alamos National Laboratory, USA
Two-Dimensional and Three-Dimensional Structure-Function Relationships for Individual Long Noncoding RNAs
Two-Dimensional and Three-Dimensional Structure-Function Relationships for Individual Long Noncoding RNAs
Coffee Break
Lingling Chen,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
lncRNAs of Novel Origin
lncRNAs of Novel Origin
Xiao Liu,
Yale University, USA
Short Talk: A ncRNA Derived from xbp-1 mRNA Cleavage Promotes Axon Regeneration
Short Talk: A ncRNA Derived from xbp-1 mRNA Cleavage Promotes Axon Regeneration
Yoo Jane Han,
University of Chicago, USA
Short Talk: Circular RNAs Expressed from the BRCA1 Pseudogene Regulates Antiviral Immune Signaling in Breast Cancer Cells
Short Talk: Circular RNAs Expressed from the BRCA1 Pseudogene Regulates Antiviral Immune Signaling in Breast Cancer Cells
Prasanth Kannanganattu,
University of Illinois, USA
Short Talk: Nucleolus-Enriched Repeat-Containing Noncoding RNA Regulates rDNA Transcription.
Short Talk: Nucleolus-Enriched Repeat-Containing Noncoding RNA Regulates rDNA Transcription.
Filipp Frank,
Emory University, USA
Short Talk: SHAPE-MaP Identifies Two Structural Modules with Distinct Function in the lncRNA Growth Arrest Specific 5 (Gas5)
Short Talk: SHAPE-MaP Identifies Two Structural Modules with Distinct Function in the lncRNA Growth Arrest Specific 5 (Gas5)
Haobo Li,
Massachusetts General Hospital, USA
Short Talk: Inhibition of Novel Long Noncoding RNA lncExACT1 Induces Physiological Cardiac Hypertrophy
Short Talk: Inhibition of Novel Long Noncoding RNA lncExACT1 Induces Physiological Cardiac Hypertrophy
Fu-Kai Hsieh,
Massachusetts General Hospital, USA
Short Talk: The lncRNA HERVH Negatively Regulates Chromatin Targeting and Remodeling Mediated by CHD7
Short Talk: The lncRNA HERVH Negatively Regulates Chromatin Targeting and Remodeling Mediated by CHD7
08:00—11:15
RNP Machines and Regulation
Meeting has ended...abstracts no longer viewable online.
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Eric Lecuyer,
Institut de Recherches Cliniques de Montreal, Canada Joint Institute, Canada
V. Narry Kim,
Institute for Basic Science, South Korea
The Barricade Complex as A Rate-Limiting Blockade against mRNA Deadenylation
The Barricade Complex as A Rate-Limiting Blockade against mRNA Deadenylation
Rui Zhao,
University of Colorado, USA
Structure and Function of the Spliceosome
Structure and Function of the Spliceosome
Coffee Break
Yanli Wang,
Chinese Academy of Sciences, China
CRISPR-Cas Mediated Cleavage of Invading RNAs
CRISPR-Cas Mediated Cleavage of Invading RNAs
Erik Sontheimer,
University of Massachusetts Medical School, USA
Enhancing Genome Editing with New Cas9s and Fully Stabilized Guides
Enhancing Genome Editing with New Cas9s and Fully Stabilized Guides
Huating Wang,
Chinese University of Hong Kong, China
Short Talk: MyoD-Induced Enhancer RNA Interacts with hnRNPL Protein via CAAA Motif to Activate Target Gene Transcription during Myogenic Differentiation
Short Talk: MyoD-Induced Enhancer RNA Interacts with hnRNPL Protein via CAAA Motif to Activate Target Gene Transcription during Myogenic Differentiation
Simone Hoefler,
Leibniz University Hanover, Germany
Short Talk: Structural and Functional Dissection of Eukaryotic snoRNP Complexes Catalyzing rRNA 2'-O-Ribose Methylations
Short Talk: Structural and Functional Dissection of Eukaryotic snoRNP Complexes Catalyzing rRNA 2'-O-Ribose Methylations
Jiarui Song,
Texas A&M University, USA
Short Talk: A Novel Plant-Specific Structural Element within the Arabidopsis Telomerase RNA
Short Talk: A Novel Plant-Specific Structural Element within the Arabidopsis Telomerase RNA
14:30—16:30
Workshop 2: Mechanistic Diversity of lncRNA
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Jay W. Shin,
RIKEN Yokohama, Japan
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Paulo P. Amaral,
University of Cambridge, UK
Gabrijela Dumbovic,
University of Colorado Boulder, USA
The Tug1 lncRNA Locus Is Essential for Male Fertility and Harbors a Tripartite DNA, lncRNA and Protein Functionality
The Tug1 lncRNA Locus Is Essential for Male Fertility and Harbors a Tripartite DNA, lncRNA and Protein Functionality
Karen Wing Yee Yuen,
University of Hong Kong, Hong Kong
Point Centromere Activity Requires an Optimal Level of Centromeric Non-Coding RNA
Point Centromere Activity Requires an Optimal Level of Centromeric Non-Coding RNA
Thomas Alan Dixon-McDougall,
University of British Columbia, Canada
The Identity of the Discontinuous Regions of the lncRNA XIST that Cooperatively Inactivate a Chromosome
The Identity of the Discontinuous Regions of the lncRNA XIST that Cooperatively Inactivate a Chromosome
Jin-Wu Nam,
Hanyang University, South Korea
En Bloc and Segmental Deletions of Human XIST Reveal X Chromosome Inactivation-Involving RNA Elements
En Bloc and Segmental Deletions of Human XIST Reveal X Chromosome Inactivation-Involving RNA Elements
Eddie Grinman,
The Scripps Research Institute – Florida, USA
Investigating the Role of a Synaptically Targeted Intronic lncRNA in Memory Storage
Investigating the Role of a Synaptically Targeted Intronic lncRNA in Memory Storage
Rotem Ben Tov Perry,
Weizmann Institute of Science, Israel
Regulation of Neuroregeneration by Long Noncoding RNAs
Regulation of Neuroregeneration by Long Noncoding RNAs
Qing Lyu,
University of Rochester, USA
B2M RNA Facilitates HSV-1 Gene Expression via Interacting with ASH2L and VP16
B2M RNA Facilitates HSV-1 Gene Expression via Interacting with ASH2L and VP16
Karoline Kragh Ebbesen,
Aarhus University, Denmark
Unraveling the Biogenesis and Function of the Circular RNA ciRS-7
Unraveling the Biogenesis and Function of the Circular RNA ciRS-7
14:30—16:30
Workshop 2: RNA Modifications and Regulated RNA Processing
Erin K. Borchardt,
Yale University, USA
Investigating RNA Pseudouridylation Patterns in Viral Infection
Investigating RNA Pseudouridylation Patterns in Viral Infection
Marisa J. L. Aitken,
MD Anderson Cancer Center, USA
hnRNP K Overexpression Drives Myeloid Malignancy via Interaction with RUNX1
hnRNP K Overexpression Drives Myeloid Malignancy via Interaction with RUNX1
Alexander M. Price,
Children's Hospital of Philadelphia, USA
Adenovirus Co-Opts Cellular m6A Modification Machinery to Facilitate Viral RNA Splicing and Protein Production
Adenovirus Co-Opts Cellular m6A Modification Machinery to Facilitate Viral RNA Splicing and Protein Production
*
Ramesh S. Pillai,
University of Geneva, Switzerland
RNA Modifications and Regulation of Gene Expression
RNA Modifications and Regulation of Gene Expression
Sushant Bangru,
University of Illinois, Urbana-Champaign, USA
Temporal Control of ESRP2 Licenses Fetal-to-Adult Switch in Alternative Splicing Required for Hepatocyte Maturation
Temporal Control of ESRP2 Licenses Fetal-to-Adult Switch in Alternative Splicing Required for Hepatocyte Maturation
*
Bobby J. Hogg,
NHLBI, National Institutes of Health, USA
hnRNP L-Dependent Protection of Normal mRNAs from NMD Subverts Quality Control in B Cell Lymphoma
hnRNP L-Dependent Protection of Normal mRNAs from NMD Subverts Quality Control in B Cell Lymphoma
Eleonora D'Ambra,
Sapienza University of Rome, Italy
Study of FUS-Dependent circRNAs Function and Localization in Murine Motor Neurons
Study of FUS-Dependent circRNAs Function and Localization in Murine Motor Neurons
Xiao Song,
Northwestern University, USA
SRSF3 Promotes Glioblastoma Progression Via Splicing Regulation of Alternative Exons
SRSF3 Promotes Glioblastoma Progression Via Splicing Regulation of Alternative Exons
17:00—18:45
RNA and RBP in Disease (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Susan L. Ackerman,
University of California, San Diego, USA
*
Joakim Lundeberg,
KTH-Royal Institute of Technology, Sweden
Fabrizio d'Adda di Fagagna,
IFOM, The FIRC Institute of Molecular Oncology, Italy
Sequence-Specific Inhibition of Noncoding RNA Generated at Dysfunctional Telomeres Improves Progeric Phenotypes and Extends Lifespan in two Animal Species
Sequence-Specific Inhibition of Noncoding RNA Generated at Dysfunctional Telomeres Improves Progeric Phenotypes and Extends Lifespan in two Animal Species
Mofang Liu,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
A Novel Function of MIWI/piRNA in Activating Translation of Spermiogenic mRNAs during Spermiogenesis
A Novel Function of MIWI/piRNA in Activating Translation of Spermiogenic mRNAs during Spermiogenesis
Frank W. Rigo,
Ionis Pharmaceuticals, USA
Targeting RNA with Antisense Oligonucleotides to Treat Disease
Targeting RNA with Antisense Oligonucleotides to Treat Disease
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Xiang-Dong Fu,
University of California, San Diego, USA
*
Saba Valadkhan,
Case Western Reserve University, USA
*
Piero Carninci,
RIKEN Center for Integrative Medical Sciences, Japan
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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