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This meeting took place in 2002
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Structural Genomics: From Gene Sequence to Function (J1)
Organizer(s) Gaetano T. Montelione, Barry Honig and Wayne A. Hendrickson
January 5—11, 2002
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 17, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 5, 2001
Sponsored by Pfizer Global Research and Development
Joint Meeting:
Frontiers of Structural Biology (J2)
Summary of Meeting:
Structural Genomics represents a new area at the interface between structural biology and genomic sciences. The various genome sequencing projects provide new opportunities and challenges to the field of structural biology, as many synergies exist between the information provided by the expanding database of linear sequences and three-dimensional structures of proteins. The goals of structural genomics include: (1) Coverage of sequence space in terms of protein structure by determination of a representative three-dimensional (3D) structure from each of 10,000 - 30,000 sequence clusters and homology modeling of all the corresponding proteins; (2) Analysis of the 3D structures of all the proteins coded by entire genomes; and (3) Structure-based Functional Genomics in which the biochemical functions of proteins are identified using clues provided by 3D structure analysis. The field of Structural Genomics is driven by developments in the areas of bioinformatics, molecular biology and protein production, X-ray crystallography, NMR spectroscopy, and homology modeling. Major challenges involve developing a sound scientific basis for target selection, high throughput protein production and crystallization, rapid X-ray crystallographic and NMR data collection, automated methods for generating 3D structures from these data, organization of these data into databases, and retrospective analysis of the data to develop broad understanding of protein evolution and structure / function relationships. Structural Genomics provides a new paradigm for structural biology and pharmaceutical development. This Keystone meeting will bring together key players in the international community to: (1) assess the feasibility and value of high throughput structure determination as a key component of an International Structural Genomics Initiative, (2) assess the scientific validity of various target selection strategies, and (3) foster international cooperation in this nascent field.
View Scholarships/Awards
Structural Genomics represents a new area at the interface between structural biology and genomic sciences. The various genome sequencing projects provide new opportunities and challenges to the field of structural biology, as many synergies exist between the information provided by the expanding database of linear sequences and three-dimensional structures of proteins. The goals of structural genomics include: (1) Coverage of sequence space in terms of protein structure by determination of a representative three-dimensional (3D) structure from each of 10,000 - 30,000 sequence clusters and homology modeling of all the corresponding proteins; (2) Analysis of the 3D structures of all the proteins coded by entire genomes; and (3) Structure-based Functional Genomics in which the biochemical functions of proteins are identified using clues provided by 3D structure analysis. The field of Structural Genomics is driven by developments in the areas of bioinformatics, molecular biology and protein production, X-ray crystallography, NMR spectroscopy, and homology modeling. Major challenges involve developing a sound scientific basis for target selection, high throughput protein production and crystallization, rapid X-ray crystallographic and NMR data collection, automated methods for generating 3D structures from these data, organization of these data into databases, and retrospective analysis of the data to develop broad understanding of protein evolution and structure / function relationships. Structural Genomics provides a new paradigm for structural biology and pharmaceutical development. This Keystone meeting will bring together key players in the international community to: (1) assess the feasibility and value of high throughput structure determination as a key component of an International Structural Genomics Initiative, (2) assess the scientific validity of various target selection strategies, and (3) foster international cooperation in this nascent field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, JANUARY 5
SUNDAY, JANUARY 6
MONDAY, JANUARY 7
TUESDAY, JANUARY 8
WEDNESDAY, JANUARY 9
THURSDAY, JANUARY 10
FRIDAY, JANUARY 11
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, JANUARY 5
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
David Eisenberg,
University of California, Los Angeles, USA
Protein Interactions
Protein Interactions
*
John Kuriyan,
University of California, Berkeley, USA
Thomas A. Steitz,
Howard Hughes Medical Institute, Yale University, USA
The Marvelous Macromolecular Machines of Gene Expression
The Marvelous Macromolecular Machines of Gene Expression
08:00—11:00
Structural Bioinformatics I - Target Selection
Meeting has ended...abstracts no longer viewable online.
*
Barry Honig,
Columbia University / HHMI, USA
Chris Sander,
Memorial Sloan-Kettering Cancer Center, USA
Mapping the Protein Structure Universe
Mapping the Protein Structure Universe
Alexey G. Murzin,
Medical Research Council, UK
Extension of Structural Superfamilies to Sequence Families of Unknown Structure
Extension of Structural Superfamilies to Sequence Families of Unknown Structure
Burkhard Rost,
Columbia University, USA
Target Space for Structural Genomics Revisited
Target Space for Structural Genomics Revisited
Peer Bork,
European Molecular Biology Laboratory, Germany
Prioritising Targets for Structural Genomics
Prioritising Targets for Structural Genomics
08:00—11:00
RNA and the Ribosome
Meeting has ended...abstracts no longer viewable online.
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Structure and Mechanism of the Hepatitis C IRES RNA
Structure and Mechanism of the Hepatitis C IRES RNA
Venki Ramakrishnan,
MRC Laboratory of Molecular Biology, UK
The Atomic Structure of the 30S Ribosomal Subunit: Insights into Antibiotic Function and the Decoding Mechanism
The Atomic Structure of the 30S Ribosomal Subunit: Insights into Antibiotic Function and the Decoding Mechanism
Juli Feigon,
University of California, Los Angeles, USA
Interaction of Nucleolin with Pre-Ribosomal RNA
Interaction of Nucleolin with Pre-Ribosomal RNA
James R. Williamson,
The Scripps Research Institute, USA
RNA-Protein Interactions in the Assembling Ribosome
RNA-Protein Interactions in the Assembling Ribosome
16:00—18:30
Structural Genomics Initiatives I (20-Minute Talks, 5-Minute Questions). Sponsored in part by Bruker Biospin Corporation.
Meeting has ended...abstracts no longer viewable online.
*
Wayne A. Hendrickson,
Columbia University, USA
John C. Norvell,
NIGMS, National Institutes of Health, USA
NIGMS Programs in Structural Genomics
NIGMS Programs in Structural Genomics
Stephen K. Burley,
Rutgers University, USA
Structural Genomics: An X-ray Crystallographic Approach by the NYSGRC
Structural Genomics: An X-ray Crystallographic Approach by the NYSGRC
Sung-Hou Kim,
University of California, Berkeley, USA
Structural Genomics of Minimal Organisms
Structural Genomics of Minimal Organisms
*
Gaetano Thomas Montelione,
Rutgers University, USA
Structural Proteomics of Eukaryotic Protein Families
Structural Proteomics of Eukaryotic Protein Families
Ian A. Wilson,
The Scripps Research Institute, USA
A High Throughput Automated Pipeline for Structural Genomics
A High Throughput Automated Pipeline for Structural Genomics
16:30—18:30
Macromolecular Machines
Meeting has ended...abstracts no longer viewable online.
*
William I. Weis,
Stanford University, USA
Carlos J. Bustamante,
HHMI/University of California, Berkeley, USA
Recent Advances in Single Molecule Biophysics: Reversible Unfolding of a Single RNA Molecule by Force
Recent Advances in Single Molecule Biophysics: Reversible Unfolding of a Single RNA Molecule by Force
Wolfgang P. Baumeister,
Max Planck Institute of Biochemistry, Germany
Electron Tomography: Towards Visualizing Supramolecular Architecture Inside Cells
Electron Tomography: Towards Visualizing Supramolecular Architecture Inside Cells
Ada Yonath,
Weizmann Institute of Science, Israel
High Resolution Studies on the Two Ribosomal Subunits: Flexibility, Conformation Variability and Disorder
High Resolution Studies on the Two Ribosomal Subunits: Flexibility, Conformation Variability and Disorder
08:00—11:00
Structural Genomics Initiatives II (20-Minute Talks, 5-Minute Questions)
Meeting has ended...abstracts no longer viewable online.
Andrzej Joachimiak,
Argonne National Laboratory, USA
High-Throughput Structure Determination Using 3rd Generation Synchrotrons
High-Throughput Structure Determination Using 3rd Generation Synchrotrons
Bi-Cheng Wang,
University of Georgia, USA
Direct Crystallography and the Southeast Collaboratory for Structural Genomics
Direct Crystallography and the Southeast Collaboratory for Structural Genomics
Thomas C. Terwilliger,
Los Alamos National Laboratory, USA
Structural Genomics of M. tuberculosis
Structural Genomics of M. tuberculosis
Shigeyuki Yokoyama,
RIKEN, Japan
Structural Genomics of Thermus thermophilus HB8 and Higher Eukaryotes
Structural Genomics of Thermus thermophilus HB8 and Higher Eukaryotes
Cheryl Arrowsmith,
University of Toronto, Canada
Comparative Structural Proteomics
Comparative Structural Proteomics
Udo Heinemann,
Freie Universitat Berlin, Germany
Progress Report from the Berlin Protein Structure Factory
Progress Report from the Berlin Protein Structure Factory
08:00—11:00
Proteins and Nucleic Acids
Meeting has ended...abstracts no longer viewable online.
Wei Yang,
NIDDK, National Institutes of Health, USA
Crystal Structure of a Y-Family DNA Polymerase in Action: A Mechanism for Error-Prone and Lesion-Bypass Replication
Crystal Structure of a Y-Family DNA Polymerase in Action: A Mechanism for Error-Prone and Lesion-Bypass Replication
Cynthia Wolberger,
Johns Hopkins University School of Medicine, USA
Structural Studies of the ETS-1/PAX5 Complex Bound to DNA
Structural Studies of the ETS-1/PAX5 Complex Bound to DNA
Menachem Shoham,
Case Western Reserve University, USA
Crystal Structure of Colicin E3: Implications for Cell Entry and Ribosome Inactivation
Crystal Structure of Colicin E3: Implications for Cell Entry and Ribosome Inactivation
Ad Bax,
NIDDK, National Institutes of Health, USA
Weak Alignment Offers New Opportunities in NMR Structure Determination
Weak Alignment Offers New Opportunities in NMR Structure Determination
16:30—18:30
Automation and Robotics in Structural Genomics
Meeting has ended...abstracts no longer viewable online.
George T. DeTitta,
Hauptman-Woodward Medical Research Institute, USA
Microbatch Crystallization at High Throughput
Microbatch Crystallization at High Throughput
Janice A. Culpepper,
Gates Foundation, USA
Building a High-Throughput Platform for Structure Determination
Building a High-Throughput Platform for Structure Determination
F. Raymond Salemme,
Imiplex, LLC., USA
ThermoFluor Protein Stability Screens: A Key Element for Effective Integration of High-Throughput Crystallography and Computationally Optimized Combinatorial Chemistry for Drug Discovery
ThermoFluor Protein Stability Screens: A Key Element for Effective Integration of High-Throughput Crystallography and Computationally Optimized Combinatorial Chemistry for Drug Discovery
Wladek Minor,
University of Virginia, USA
Short Talk: Data Acquisition and Analysis in Structural Genomics Era Automatic or Remotely Controlled Expert System
Short Talk: Data Acquisition and Analysis in Structural Genomics Era Automatic or Remotely Controlled Expert System
16:30—18:30
Membrane Proteins
Meeting has ended...abstracts no longer viewable online.
*
Wei Yang,
NIDDK, National Institutes of Health, USA
Donald M. Engelman,
Yale University, USA
Stability and Specificity in Membrane Protein Folding
Stability and Specificity in Membrane Protein Folding
Robert M. Stroud,
University of California, San Francisco, USA
Encoding Selectivity of a Transmembrane Channel
Encoding Selectivity of a Transmembrane Channel
08:00—11:00
Protein Structure Prediction and Design (Joint)
Meeting has ended...abstracts no longer viewable online.
Stephen L. Mayo,
California Institute of Technology, USA
Homme Hellinga,
Duke University Medical Center, USA
Rational Design of Receptors and Sensors
Rational Design of Receptors and Sensors
14:00—16:00
Workshop: International Coordination of Structural Genomics
Thomas C. Terwilliger,
Los Alamos National Laboratory, USA
Udo Heinemann,
Freie Universitat Berlin, Germany
Shigeyuki Yokoyama,
RIKEN, Japan
Report from the International Structural Genomics Organization (ISCO)
Report from the International Structural Genomics Organization (ISCO)
John C. Norvell,
NIGMS, National Institutes of Health, USA
International Aspects of the NIH Funded Protein Structure Initiative
International Aspects of the NIH Funded Protein Structure Initiative
*
Helen M. Berman,
Rutgers University, Center for Proteomics Research, USA
The Protein Data Bank and the International Structural Genomics Community
The Protein Data Bank and the International Structural Genomics Community
16:30—18:30
Structural Genomics of Integral Membrane Proteins
Meeting has ended...abstracts no longer viewable online.
Kurt Wüthrich,
ETH Zürich, Switzerland
Solution NMR Studies of Integral Membrane Proteins Reconstituted in Detergent Micelles
Solution NMR Studies of Integral Membrane Proteins Reconstituted in Detergent Micelles
Stanley J. Opella,
University of California, San Diego, USA
Structure Determination of Membrane Proteins by NMR Spectroscopy
Structure Determination of Membrane Proteins by NMR Spectroscopy
16:30—18:30
Protein Folding and Misfolding
Meeting has ended...abstracts no longer viewable online.
Christopher M. Dobson,
University of Cambridge, UK
Protein Folding, Misfolding and Disease
Protein Folding, Misfolding and Disease
Susan Lindquist,
HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly
Prion Assembly and Disassembly
Arthur L. Horwich,
Yale University, USA
GroEL-GroES-Mediated Protein Folding
GroEL-GroES-Mediated Protein Folding
08:00—11:00
Structural Bioinformatics II - Combining Sequence and Structure to Understand Protein Relationships
Meeting has ended...abstracts no longer viewable online.
*
Jane S. Richardson,
Duke University, USA
Julian Gough,
University of Bristol, UK
Hidden Markov Models in Structural Genomics
Hidden Markov Models in Structural Genomics
Michal Linial,
University of Washington, USA
In Search of New Structures - Comprehensive Sequence-Based Ranking
In Search of New Structures - Comprehensive Sequence-Based Ranking
Mark Gerstein,
Yale University, USA
Integrative Structural Genomics
Integrative Structural Genomics
Barry Honig,
Columbia University / HHMI, USA
Combining Bioinformatics and Biophysics to Understand Protein Structure and Function
Combining Bioinformatics and Biophysics to Understand Protein Structure and Function
08:00—11:00
Signaling and Targeting - I
Meeting has ended...abstracts no longer viewable online.
*
John Kuriyan,
University of California, Berkeley, USA
Susan S. Taylor,
University of California, San Diego, USA
Dynamics of Signaling by cAMP-Dependent Protein Kinase
Dynamics of Signaling by cAMP-Dependent Protein Kinase
Dorothee Kern,
Brandeis University, HHMI, USA
A Signaling Protein ‘In Action’- Structure and Dynamics of a Transiently Phosphorylated Switch
A Signaling Protein ‘In Action’- Structure and Dynamics of a Transiently Phosphorylated Switch
Stephen C. Harrison,
Harvard Medical School, USA
Assembling a Virus
Assembling a Virus
Michael K. Rosen,
University of Texas Southwestern Medical Center, USA
Signaling from Rho GTPases to Actin: Insights from NMR into Biology
Signaling from Rho GTPases to Actin: Insights from NMR into Biology
16:30—18:30
Methods for High Throughput Structure Analysis
Meeting has ended...abstracts no longer viewable online.
Wayne A. Hendrickson,
Columbia University, USA
Synchrotron Crystallography
Synchrotron Crystallography
Ad Bax,
NIDDK, National Institutes of Health, USA
Towards Faster NMR Structure Determination Using Orientational and Chemical Shift Restraints
Towards Faster NMR Structure Determination Using Orientational and Chemical Shift Restraints
16:30—18:30
Signaling and Targeting - II
Meeting has ended...abstracts no longer viewable online.
*
Arthur G. Palmer, III,
Columbia University, USA
Pamela J. Bjorkman,
California Institute of Technology, USA
The MHC Family of Proteins in Immune and Non-Immune Recognition
The MHC Family of Proteins in Immune and Non-Immune Recognition
William I. Weis,
Stanford University, USA
Biochemical and Structural Analysis of Wnt Signaling Components
Biochemical and Structural Analysis of Wnt Signaling Components
08:00—11:00
Structural Bioinformatics III - Structure to Function
Meeting has ended...abstracts no longer viewable online.
*
Jacquelyn S. Fetrow,
Wake Forest University, USA
Christine A. Orengo,
University College London, UK
From Structure to Function; Perspectives from the CATH Domain Database
From Structure to Function; Perspectives from the CATH Domain Database
Diana Murray,
Weill Medical College of Cornell University, USA
Protein-Lipid Interactions in Subcellular Targeting
Protein-Lipid Interactions in Subcellular Targeting
John Moult,
University of Maryland Biotechnology Institute, USA
SNPs, Protein Structure, and Disease
SNPs, Protein Structure, and Disease
Jeffrey Skolnick,
Georgia Institute of Technology, USA
Prediction of Protein Structure and Function on a Genomic Scale
Prediction of Protein Structure and Function on a Genomic Scale
08:00—11:00
Protein Dynamics
Meeting has ended...abstracts no longer viewable online.
Arthur G. Palmer, III,
Columbia University, USA
NMR Methods for Characterizing Protein Motions and Folding
NMR Methods for Characterizing Protein Motions and Folding
Gregory A. Petsko,
Brandeis University, USA
The Role of Dynamics in Controlling Enzyme Action
The Role of Dynamics in Controlling Enzyme Action
Sharon L. Campbell,
University of North Carolina at Chapel Hill, USA
Nitric Oxide Modification of the Ras Protein
Nitric Oxide Modification of the Ras Protein
Peter E. Wright,
The Scripps Research Institute, USA
Protein-DNA and Protein-Protein Interactions in Transcriptional Activation
Protein-DNA and Protein-Protein Interactions in Transcriptional Activation
16:30—18:30
Structural Biology in Drug Design (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Gregory A. Petsko,
Brandeis University, USA
Giovanna Scapin,
Merck Research Laboratories, USA
Selectivity in Homologous Protein Families: Protein Kinases Inhibition
Selectivity in Homologous Protein Families: Protein Kinases Inhibition
Daniel F. Wyss,
Merck Research Laboratories, USA
Structural Evaluation of Drug Targets
Structural Evaluation of Drug Targets
Jonathan M. Moore,
Vertex Pharmaceuticals Incorporated, USA
NMR-Based Strategies for Drug Discovery
NMR-Based Strategies for Drug Discovery
Melissa A. Starovasnik,
Genentech, Inc., USA
The IL-17 Cytokine Family: Surprising Parallels with Neurotrophins
The IL-17 Cytokine Family: Surprising Parallels with Neurotrophins
*Session Chair †Invited, not yet responded.
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