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This meeting took place in 2007
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Imaging Immune Responses (J7)
Organizer(s) Ronald N. Germain and Ellen A. Robey
February 25—March 1, 2007
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 25, 2006
Late Abstract Deadline: Nov 27, 2006
Scholarship Deadline: Oct 25, 2006
Early Registration Deadline: Dec 26, 2006
Supported by the Director's Fund
Summary of Meeting:
The cellular events leading to host defense and immunopathology are dynamic in nature and involve the migration, transient arrest, and redistribution of various hematopoietic cells types between blood, secondary lymphoid organs, and peripheral tissues. For this reason, a great deal of excitement has been generated by the recent application of miniaturized versions of clinical imaging tools such as PET scanning and MRI, confocal and especially multiphoton microscopy, and luminescence imaging to living animals, permitting direct spatiotemporal analysis of immune cells within complex tissue environments. However, standards for data analysis and interpretation are just emerging, as are improved methods that bridge the resolution and time gaps between the various methods, allowing analyses to begin with initiation of a response and to follow it through to pathogen/tumor clearance or induction of autoimmune pathology. This meeting will bring together experts who will describe ongoing and future applications of these new imaging methods and provide the attendees with an understanding of the new biological paradigms that are emerging from such investigations. Speakers will discuss both basic and clinically-related advances, including cell-cell interactions in the development of humoral and cell-mediated immune responses, the events underlying autoimmune pathology in models of rheumatoid arthritis and diabetes, the trafficking of hematopoietic stem cells following grafting, signaling events in the thymus, bone marrow, and secondary lymphoid tissues, the sites of Treg activity, and the interplay between tumor cell growth and immune cell effector activity following anti-cancer vaccination.
View Scholarships/Awards
The cellular events leading to host defense and immunopathology are dynamic in nature and involve the migration, transient arrest, and redistribution of various hematopoietic cells types between blood, secondary lymphoid organs, and peripheral tissues. For this reason, a great deal of excitement has been generated by the recent application of miniaturized versions of clinical imaging tools such as PET scanning and MRI, confocal and especially multiphoton microscopy, and luminescence imaging to living animals, permitting direct spatiotemporal analysis of immune cells within complex tissue environments. However, standards for data analysis and interpretation are just emerging, as are improved methods that bridge the resolution and time gaps between the various methods, allowing analyses to begin with initiation of a response and to follow it through to pathogen/tumor clearance or induction of autoimmune pathology. This meeting will bring together experts who will describe ongoing and future applications of these new imaging methods and provide the attendees with an understanding of the new biological paradigms that are emerging from such investigations. Speakers will discuss both basic and clinically-related advances, including cell-cell interactions in the development of humoral and cell-mediated immune responses, the events underlying autoimmune pathology in models of rheumatoid arthritis and diabetes, the trafficking of hematopoietic stem cells following grafting, signaling events in the thymus, bone marrow, and secondary lymphoid tissues, the sites of Treg activity, and the interplay between tumor cell growth and immune cell effector activity following anti-cancer vaccination.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 25
MONDAY, FEBRUARY 26
TUESDAY, FEBRUARY 27
WEDNESDAY, FEBRUARY 28
THURSDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 25
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Scott E. Fraser,
University of Southern California, USA
Observing Dynamic Cell Behavior in Complex Tissues
Observing Dynamic Cell Behavior in Complex Tissues
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Taking Dendritic Cells into Medicine
Taking Dendritic Cells into Medicine
08:00—11:00
Antigen Presentation and the Initiation of T Cell Responses
Meeting has ended...abstracts no longer viewable online.
*
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Directed Cell-Cell Interactions in the Development of Adaptive Immunity
Directed Cell-Cell Interactions in the Development of Adaptive Immunity
Jean M. Davoust,
Hôpital Saint-Vincent-de-Paul, France
Langerhans Cell Trafficking and Antigen Capture in the Skin
Langerhans Cell Trafficking and Antigen Capture in the Skin
Ulrich H. Von Andrian,
Harvard Medical School, USA
Cell Entry and Interaction within Lymphoid Tissues
Cell Entry and Interaction within Lymphoid Tissues
Marc K. Jenkins,
University of Minnesota Medical School, USA
Imaging Peptide:MHC II Production During the Primary Immune Response
Imaging Peptide:MHC II Production During the Primary Immune Response
08:00—11:15
Pathogen Recognition Pathways
Meeting has ended...abstracts no longer viewable online.
*
Takashi Fujita,
Institute for Virus Research, Kyoto University, Japan
Triggering Antiviral Responses and Cell Regulation by the Cytoplasmic RNA Helicase RIG-I
Triggering Antiviral Responses and Cell Regulation by the Cytoplasmic RNA Helicase RIG-I
Michel Gilliet,
University Hospital of Lausanne, Switzerland
Short Talk: Activation of Plasmacytoid Dendritic Cell Precursors by an Endogenous Peptide
Short Talk: Activation of Plasmacytoid Dendritic Cell Precursors by an Endogenous Peptide
Teunis B.H. Geijtenbeek,
University of Amsterdam, Netherlands
Short Talk: DC-SIGN Modulates TLR-Induced Immune Responses in Dendritic Cells through Acetylation of NF-kappaB-Subunit p65
Short Talk: DC-SIGN Modulates TLR-Induced Immune Responses in Dendritic Cells through Acetylation of NF-kappaB-Subunit p65
14:30—16:30
Workshop 1: Intravital Multiphoton Imaging
*
Mark J. Miller,
Washington University School of Medicine, USA
Multi-photon Imaging of Antigen Presentation During Listeria monocytogenes Infection
Multi-photon Imaging of Antigen Presentation During Listeria monocytogenes Infection
*
Philippe Bousso,
Institute Pasteur, France
Cellular Orchestration of T Cell Priming In Vivo
Cellular Orchestration of T Cell Priming In Vivo
Ann M. Haberman,
Yale University School of Medicine, USA
Visualization of Germinal Center B Cell Dynamics In Vivo
Visualization of Germinal Center B Cell Dynamics In Vivo
Sarah E. Henrickson,
Children's Hospital of Philadelphia, USA
T Cell Sensing of Antigen Avidity Determines the Kinetics and Character of T Cell-Dendritic Cell Interactions in Lymph Nodes
T Cell Sensing of Antigen Avidity Determines the Kinetics and Character of T Cell-Dendritic Cell Interactions in Lymph Nodes
Reinhold Förster,
Hannover Medical School, Germany
CCR7-Ligands Stimulate the Intranodal Motility of T Lymphocytes in vivo
CCR7-Ligands Stimulate the Intranodal Motility of T Lymphocytes in vivo
Joost B. Beltman,
Leiden University, Netherlands
Lymph Node Topology Dictates T Cell Migration Behavior
Lymph Node Topology Dictates T Cell Migration Behavior
Thorsten R. Mempel,
Massachusetts General Hospital, USA
Conduits Mediate Antigen Transport to Follicular Dendritic Cells in Lymph Nodes
Conduits Mediate Antigen Transport to Follicular Dendritic Cells in Lymph Nodes
Michio Tomura,
Kyoto University Graduate School of Medicine, Japan
Following Cells In Vivo Using Photoconverting Protein KAEDE
Following Cells In Vivo Using Photoconverting Protein KAEDE
14:30—16:30
Workshop 1: Signaling in Pathogen Recognition
*
Tsuneyasu Kaisho,
RIKEN Research Center for Allergy and Immunology, Japan
Critical Involvement of IkappaB kinase-alpha in TLR7/9-Induced Type I IFN Production
Critical Involvement of IkappaB kinase-alpha in TLR7/9-Induced Type I IFN Production
Emmanuel Derudder,
CBR Institute for Biomedical Research, USA
Roles for Canonical and Alternative NF-kappaB Activation Pathways in Dendritic Cells
Roles for Canonical and Alternative NF-kappaB Activation Pathways in Dendritic Cells
Esther C. de Jong,
Academic Medical Center, Netherlands
Non-Canonical NF-kappaB Signaling in Dendritic Cells is Required for Indoleamine 2,3-Dioxygenase (IDO) Induction and Immune Regulation
Non-Canonical NF-kappaB Signaling in Dendritic Cells is Required for Indoleamine 2,3-Dioxygenase (IDO) Induction and Immune Regulation
Ranjeny Thomas,
University of Queensland, Australia
RelB-Competent Dendritic Cells Suppress Autoimmune Inflammatory Disease
RelB-Competent Dendritic Cells Suppress Autoimmune Inflammatory Disease
Hiromitsu Hara,
Saga University, Japan
CARD9 is Essential for Myeloid Cell Activation through ITAM-bearing Receptors
CARD9 is Essential for Myeloid Cell Activation through ITAM-bearing Receptors
Yen-Michael S. Hsu,
University of Texas MD Anderson Cancer Center, USA
CARD9 is Required for Innate Immune Responses Against Intracellular Pathogens
CARD9 is Required for Innate Immune Responses Against Intracellular Pathogens
17:00—19:00
Intracellular Signaling by Lymphoid Cells Analyzed in situ
Meeting has ended...abstracts no longer viewable online.
Mark M. Davis,
Stanford University School of Medicine, USA
The Role of Endogenous Peptides in T Cell Activation and Thymic Selection
The Role of Endogenous Peptides in T Cell Activation and Thymic Selection
Richard S. Lewis,
Stanford University School of Medicine, USA
A Molecular Mechanism for Sustained Calcium Signaling During T Cell Activation
A Molecular Mechanism for Sustained Calcium Signaling During T Cell Activation
*
Doreen A. Cantrell,
University of Dundee, UK
Spatial/Temporal Analysis of Inositol Lipid Metabolism During T Lymphocyte Activation
Spatial/Temporal Analysis of Inositol Lipid Metabolism During T Lymphocyte Activation
17:00—19:00
Signaling in Pathogen Recognition
Meeting has ended...abstracts no longer viewable online.
Marco Colonna,
Washington University School of Medicine, USA
Cross Talks between TLRs and ITAM-Dependent Receptors in DC
Cross Talks between TLRs and ITAM-Dependent Receptors in DC
Jürg Tschopp,
University of Lausanne, Switzerland
NLRs and the Inflammasome: Danger Sensing Complexes Involved in Inflammatory Diseases
NLRs and the Inflammasome: Danger Sensing Complexes Involved in Inflammatory Diseases
You-Me Kim,
KAIST, South Korea
Short Talk: the Interaction Between the ER Membrane Protein UNC93B and Toll-like Receptors 3, 7, and 9 is Crucial for TLR Signaling
Short Talk: the Interaction Between the ER Membrane Protein UNC93B and Toll-like Receptors 3, 7, and 9 is Crucial for TLR Signaling
*
Anne O'Garra,
Francis Crick Institute, UK
Molecular Mechanisms for the Regulation of IL-10 Expression in Dendritic Cells, Macrophages and T Cells
Molecular Mechanisms for the Regulation of IL-10 Expression in Dendritic Cells, Macrophages and T Cells
08:00—11:00
B Cell Migration and the Induction of Humoral Immune Responses
Meeting has ended...abstracts no longer viewable online.
*
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Cell Migration Dynamics During the B Cell Immune Response
Cell Migration Dynamics During the B Cell Immune Response
John H. Kehrl,
NIAID, National Institutes of Health, USA
Regulation of B Cell Motility in Lymph Nodes
Regulation of B Cell Motility in Lymph Nodes
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Imaging Germinal Centers
Imaging Germinal Centers
08:00—11:15
Cross-Talk with Other Cells
Meeting has ended...abstracts no longer viewable online.
*
Kenneth L. Rock,
University of Massachusetts Medical School, USA
How Dying Cells Alert the Immune System to Danger
How Dying Cells Alert the Immune System to Danger
Laurence Zitvogel,
Institut Gustave Roussy, France
DC and NK Cells
DC and NK Cells
Anna M. Keller,
Netherlands Cancer Institute, Netherlands
Short Talk: Costimulatory Ligand CD70 is Delivered to the Immunological Synapse by Shared Intracellular Trafficking with MHC Class II
Short Talk: Costimulatory Ligand CD70 is Delivered to the Immunological Synapse by Shared Intracellular Trafficking with MHC Class II
Yatin M. Vyas,
Children's Hospital of Pittsburgh, USA
Short Talk: Antiparallel Segregation of Notch Components in the Immunological Synapse Directs Reciprocal Signaling in Allogeneic Th:DC Conjugates
Short Talk: Antiparallel Segregation of Notch Components in the Immunological Synapse Directs Reciprocal Signaling in Allogeneic Th:DC Conjugates
Yvette van Kooyk,
Vrije University Medical Center, Netherlands
Regulation of DC Cross Talk with other Immune Cells by C-Type Lectins and Carbohydrates
Regulation of DC Cross Talk with other Immune Cells by C-Type Lectins and Carbohydrates
14:30—16:30
Workshop 2: New Technologies for Functional, High Resolution Imaging
*
Bridget S. Wilson,
University of New Mexico Health Science Center, USA
High Resolution Imaging Methods to Probe Fc[epsilon]RI Membrane Organization and Behavior
High Resolution Imaging Methods to Probe Fc[epsilon]RI Membrane Organization and Behavior
Pavel Tolar,
Francis Crick Institute, UK
Imaging the B-Cell Receptor Signaling in the Immunological Synapse
Imaging the B-Cell Receptor Signaling in the Immunological Synapse
Carles Rentero,
University of Barcelona, Spain
Membrane Organization at T Cell Activation Sites and Immunological Synapse
Membrane Organization at T Cell Activation Sites and Immunological Synapse
Valarie A. Barr,
National Cancer Institute, National Institutes of Health, USA
Cbl-Dependent Internalization of TCR-Induced, LAT-Nucleated Signaling Complexes
Cbl-Dependent Internalization of TCR-Induced, LAT-Nucleated Signaling Complexes
Aaron K. Neumann,
University of New Mexico, USA
Distribution and Lateral Mobility of DC-SIGN on Immature Dendritic Cells
Distribution and Lateral Mobility of DC-SIGN on Immature Dendritic Cells
David M. Haaland,
Sandia National Laboratories, USA
Hyperspectral Confocal Imaging of Live Cell Immune Response to Cytokines
Hyperspectral Confocal Imaging of Live Cell Immune Response to Cytokines
Matthias Gunzer,
Helmholtz Centre for Infection Research, Germany
The Power of Single- and Multibeam 2-Photon Microscopy for High-Resolution and High-Speed Deep Tissue and Intravital Imaging
The Power of Single- and Multibeam 2-Photon Microscopy for High-Resolution and High-Speed Deep Tissue and Intravital Imaging
14:30—16:30
Workshop 2: Intercellular Interactions Regulating DC Function
*
Shannon J. Turley,
Genentech, Inc., USA
Presentation of Intestinal Self by Dendritic Cells and Lymph Node Stroma
Presentation of Intestinal Self by Dendritic Cells and Lymph Node Stroma
Ena Ladi,
University of California, Berkeley, USA
Visualizing Dendritic Cell Interactions of Migrating Thymocytes in Real-time Using Two-Photon Microscopy
Visualizing Dendritic Cell Interactions of Migrating Thymocytes in Real-time Using Two-Photon Microscopy
John P. Driver,
The Jackson Laboratory, USA
Activated NKT Cells Inhibit Autoimmune Diabetes Through Tolerogenic Maturation of Dendritic Cells
Activated NKT Cells Inhibit Autoimmune Diabetes Through Tolerogenic Maturation of Dendritic Cells
Flavio A. Salazar Onfray,
Institute of Biomedical Sciences, Chile
Functional Gap Junctions Facilitate Melanoma Antigen Cross-Presentation in Human Dendritic Cells and are Recruited to the Immunological Synapses Contributing to T Cell Activation
Functional Gap Junctions Facilitate Melanoma Antigen Cross-Presentation in Human Dendritic Cells and are Recruited to the Immunological Synapses Contributing to T Cell Activation
Lesley Ann Smyth,
Kings College London, UK
A Novel Pathway of Antigen Presentation by Dendritic Cells; Implications for Infectious Diseases
A Novel Pathway of Antigen Presentation by Dendritic Cells; Implications for Infectious Diseases
Payal Watchmaker,
University of Pittsburgh, USA
Memory CD8+ T Cells Protect Dendritic Cells from CTL-Mediated Killing: Helper Function of Memory CD8+ T Cells
Memory CD8+ T Cells Protect Dendritic Cells from CTL-Mediated Killing: Helper Function of Memory CD8+ T Cells
Fabienne Brilot,
Rockefeller University, USA
NK Cell Survival Mediated Through the Regulatory Synapse With Dendritic Cells Requires IL-15Ralpha
NK Cell Survival Mediated Through the Regulatory Synapse With Dendritic Cells Requires IL-15Ralpha
17:00—19:00
Lymphocyte Behavior Outside the Lymph Node
Meeting has ended...abstracts no longer viewable online.
*
Ellen A. Robey,
University of California, Berkeley, USA
Cell Interactions and Migration in the Thymus
Cell Interactions and Migration in the Thymus
Matthew F. Krummel,
University of California, San Francisco, USA
Visualizing Cellular Decision-Making in Lymphocytes
Visualizing Cellular Decision-Making in Lymphocytes
Ute Frevert,
New York University School of Medicine, USA
Intravital Imaging of the Liver Phase of a Malaria Infection
Intravital Imaging of the Liver Phase of a Malaria Infection
Mark C. Coles,
University of York, UK
Imaging Lymphoid Tissue Development and Maturation
Imaging Lymphoid Tissue Development and Maturation
17:00—19:00
DC Migration and Antigen Uptake
Meeting has ended...abstracts no longer viewable online.
*
Colin Watts,
University of Dundee, UK
Regulation of Cytoskeleton during DC Migration and Antigen Uptake
Regulation of Cytoskeleton during DC Migration and Antigen Uptake
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
TLR-Induced Gene Expression
TLR-Induced Gene Expression
Pierre Guermonprez,
Kings College London, UK
Short Talk: the IFN Inducible p47 Small GTPase IGTP is Involved in Cross-presentation by MHC Class I in Dendritic Cells
Short Talk: the IFN Inducible p47 Small GTPase IGTP is Involved in Cross-presentation by MHC Class I in Dendritic Cells
Gwendalyn J. Randolph,
Washington University, USA
Origins and Migratory Fate of Pulmonary Dendritic Cells
Origins and Migratory Fate of Pulmonary Dendritic Cells
08:00—11:00
Longitudinal Imaging of Immune Responses
Meeting has ended...abstracts no longer viewable online.
Robert M. Hoffman,
AntiCancer, Inc., USA
Tri-Color Imaging of the Interaction of the Host Immune System and Tumor Cells in the Living Mouse
Tri-Color Imaging of the Interaction of the Host Immune System and Tumor Cells in the Living Mouse
John C. Boothroyd,
Stanford University School of Medicine, USA
Dissecting Virulence and Reactivation in Toxoplasmosis Using In Vivo Imaging
Dissecting Virulence and Reactivation in Toxoplasmosis Using In Vivo Imaging
*
Chien Ho,
Carnegie Mellon University, USA
Recent Cellular Imaging Studies Using Nano-sized Iron Oxide Particles: A New Non-invasive Approach to Detect Cardiac Transplant Rejection by MRI
Recent Cellular Imaging Studies Using Nano-sized Iron Oxide Particles: A New Non-invasive Approach to Detect Cardiac Transplant Rejection by MRI
Kamal M. Khanna,
University of Connecticut Health Center, USA
Short Talk: Imaging the Endogenous CD8 T Cell Response to Infection: From Naïve to Memory
Short Talk: Imaging the Endogenous CD8 T Cell Response to Infection: From Naïve to Memory
Matthias G. von Herrath,
Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Short Talk: Real-Time Imaging of the Pancreas During Development of Diabetes
Short Talk: Real-Time Imaging of the Pancreas During Development of Diabetes
08:00—11:30
DC in Tolerance/Immunity
Meeting has ended...abstracts no longer viewable online.
Maries F. van den Broek,
University Hospital Zurich, Switzerland
In Vivo Models for Studying Peripheral Tolerance
In Vivo Models for Studying Peripheral Tolerance
Pamela S. Ohashi,
Princess Margaret Cancer Centre, Canada
Signaling Molecules Modulating Tolerance and Autoimmunity
Signaling Molecules Modulating Tolerance and Autoimmunity
Tim D. Sparwasser,
Institute of Infection and Immunology, Germany
Short Talk: Ovalbumin-Specific Immunity in the Absence of Dendritic Cell Activation after Depletion of Regulatory T Cells in DEREG Mice
Short Talk: Ovalbumin-Specific Immunity in the Absence of Dendritic Cell Activation after Depletion of Regulatory T Cells in DEREG Mice
Alexander Y. Rudensky,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Foxp3 as the Regulatory T Cell Lineage Specification Factor
Foxp3 as the Regulatory T Cell Lineage Specification Factor
*
Ira Mellman,
Genentech, Inc., USA
DC Maturation: Transformation and Function
DC Maturation: Transformation and Function
Sebastian Amigorena,
Institut Curie, France
Antigen Cross Presentation in Dendritic Cells
Antigen Cross Presentation in Dendritic Cells
14:30—16:30
Workshop 3: Immune Imaging in Translational and Clinical Settings
*
Darrell J. Irvine,
Massachusetts Institute of Technology, USA
Imaging Dendritic Cell Chemotaxis: Chemokine-Releasing Microspheres as Vaccine Adjuvants and Tools to Analyze Directed DC Migration
Imaging Dendritic Cell Chemotaxis: Chemokine-Releasing Microspheres as Vaccine Adjuvants and Tools to Analyze Directed DC Migration
Katalin Mikecz,
Rush University Medical Center, USA
Anti-CD44 Antibody Treatment, but not CD44 Deficiency, Dramatically Alters Leukocyte Recruitment in Inflamed Mouse Joints
Anti-CD44 Antibody Treatment, but not CD44 Deficiency, Dramatically Alters Leukocyte Recruitment in Inflamed Mouse Joints
Melanie P. Matheu,
University of California, Irvine, USA
Imaging Effector Memory T Cell Response and Suppression by Potassium Channel Blockade
Imaging Effector Memory T Cell Response and Suppression by Potassium Channel Blockade
Tatyana Chtanova,
University of California, Berkeley, USA
Visualizing the Immune Response Against T. Gondii
Visualizing the Immune Response Against T. Gondii
Heather D. Hickman,
NIAID, National Institutes of Health, USA
Visualization of Early Immune Interactions After Vaccinia Virus Infection In Vivo
Visualization of Early Immune Interactions After Vaccinia Virus Infection In Vivo
Tomasz Zal,
University of Texas MD Anderson Cancer Center, USA
Dynamics of Endogenous Foxp3+ Regulatory T Cells in Subcutaneous and Metastatic Tumors
Dynamics of Endogenous Foxp3+ Regulatory T Cells in Subcutaneous and Metastatic Tumors
David A. Schaer,
Memorial Sloan-Kettering Cancer Center, USA
Imaging T Cell Responses Against Melanoma
Imaging T Cell Responses Against Melanoma
Dorian B. McGavern,
NINDS, National Institutes of Health, USA
Visualizing the Immunotherapeutic Clearance of a Persistent Viral Infection
Visualizing the Immunotherapeutic Clearance of a Persistent Viral Infection
14:30—16:30
Workshop 3: Interplay between DC Subsets in Induction of Immunity and Tolerance
*
William R. Heath,
University of Melbourne, Australia
The Role of Dendritic Cell Subsets in Naive and Memory Responses to Infection
The Role of Dendritic Cell Subsets in Naive and Memory Responses to Infection
Alice O. Kamphorst,
Emory University, USA
Antigen Targeting to CD8- DCs In Vivo
Antigen Targeting to CD8- DCs In Vivo
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
Activation of Macrophages through Plasmacytoid Dendritic Cell-Derived Type I Interferon Secures Control of Murine Coronavirus Infection
Activation of Macrophages through Plasmacytoid Dendritic Cell-Derived Type I Interferon Secures Control of Murine Coronavirus Infection
Peter Siegfried Jähn,
Milteniy Biotec GmbH, Germany
Functional Dichotomy of Plasmacytoid Dendritic Cells: Specific Activation of T-Cells Versus Production of Type I Interferon
Functional Dichotomy of Plasmacytoid Dendritic Cells: Specific Activation of T-Cells Versus Production of Type I Interferon
Juergen M. Ruland,
Technical University of Munich, Germany
CARD9 Couples Dectin-1/Syk Signaling to NF-kappaB Activation for Antifungal Immunity
CARD9 Couples Dectin-1/Syk Signaling to NF-kappaB Activation for Antifungal Immunity
Heli Uronen-Hansson,
BioInvent, Sweden
Role of CD103+ DCs in the Generation of Intestinal Immune Responses
Role of CD103+ DCs in the Generation of Intestinal Immune Responses
Florent Ginhoux,
Singapore Immunology Network, Singapore
Developmental Regulation of Chemokines Expression Controls the Recruitment of Langerhans Cells Precursors to the Skin
Developmental Regulation of Chemokines Expression Controls the Recruitment of Langerhans Cells Precursors to the Skin
17:00—19:00
Application of Clinical Imaging Methods to Animal Models
Meeting has ended...abstracts no longer viewable online.
Anna Moore,
Michigan State University, USA
In Vivo Imaging of Inflammation in Type 1 Diabetes
In Vivo Imaging of Inflammation in Type 1 Diabetes
*
Diane Mathis,
Harvard Medical School, USA
Imaging beta-Cell Destruction in situ
Imaging beta-Cell Destruction in situ
David Piwnica-Worms,
Washington University at St. Louis, USA
Molecular Imaging: Strategies to Probe Signal Transduction in Immune Responses In Vivo
Molecular Imaging: Strategies to Probe Signal Transduction in Immune Responses In Vivo
17:00—19:00
DC Instruction of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.
Muriel Moser,
Université Libre de Bruxelles, Belgium
Injection of anti-CTLA4 mAb in primed mice induces adaptive regulatory T cells with anti-inflammatory properties
Injection of anti-CTLA4 mAb in primed mice induces adaptive regulatory T cells with anti-inflammatory properties
*
Yong-Jun Liu,
Sanofi, USA
Th Instruction by DCs
Th Instruction by DCs
Philipp Alberts,
Northern Biologics, Canada
Short Talk: Dendritic Cells Control the Expression of a VAMP8 Positive Membrane Compartment to Allow for Regulated IL12 Release
Short Talk: Dendritic Cells Control the Expression of a VAMP8 Positive Membrane Compartment to Allow for Regulated IL12 Release
Edith Margarethe Janssen,
La Jolla Institute for Allergy and Immunology, USA
Viral Modification of DC Function
Viral Modification of DC Function
08:00—11:00
DC in Autoimmunity and Allergy
Meeting has ended...abstracts no longer viewable online.
Diane Mathis,
Harvard Medical School, USA
DC in Diabetes
DC in Diabetes
Irah King,
McGill University, Canada
Short Talk: GM-CSF Triggers Accelerated Myelopoiesis During EAE
Short Talk: GM-CSF Triggers Accelerated Myelopoiesis During EAE
*
Fiona M. Powrie,
University of Oxford, UK
Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cells
Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cells
Bart N. Lambrecht,
VIB, Ghent University, Belgium
DC in Asthma
DC in Asthma
Kristin V. Tarbell,
NIDDK, National Institutes of Health, USA
Short Talk: DC-Expanded, Islet-Specific, Regulatory T Cells Increase Endogenous Foxp3+ Cells and Restore Normoglycemia in Diabetic NOD Mice
Short Talk: DC-Expanded, Islet-Specific, Regulatory T Cells Increase Endogenous Foxp3+ Cells and Restore Normoglycemia in Diabetic NOD Mice
13:30—15:30
Workshop 4: DC in Tolerance Induction
*
Matthew L. Albert,
Genentech, Inc., USA
Antigen Persistence is Required for Efficient Cross-Priming of Minor Histocompatibility Antigen Specific CD8+ T Cells
Antigen Persistence is Required for Efficient Cross-Priming of Minor Histocompatibility Antigen Specific CD8+ T Cells
Michael Y. Gerner,
NIAID, National Institutes of Health, USA
Defective Direct Presentation by DC Limits CD4 T Cell Help and Causes Tolerogenic Anti-Tumor CD8 T Cell Responses
Defective Direct Presentation by DC Limits CD4 T Cell Help and Causes Tolerogenic Anti-Tumor CD8 T Cell Responses
Anne Hosmalin,
Institut Cochin, Inserm U1016, Université Paris Descartes, France
Human Plasmacytoid Dendritic Cells Perform Cross-Presentation
Human Plasmacytoid Dendritic Cells Perform Cross-Presentation
Phillip J. Sanchez,
National Jewish Medical and Research Center, USA
The Expression of CD70 on Dendritic Cells in vivo and its Role in Primary and Memory CD8+ T Cell Responses
The Expression of CD70 on Dendritic Cells in vivo and its Role in Primary and Memory CD8+ T Cell Responses
Connie M. Krawczyk,
Van Andel Research Institute, USA
The Effect of Jagged Expression on Dendritic Cell-Mediated Th Differentiation
The Effect of Jagged Expression on Dendritic Cell-Mediated Th Differentiation
Jan C. Dudda,
Twincore, Germany
The Way of Regulatory T Cells from Thymus to Periphery is Imprinted by Tissue-Specific Dendritic Cells and Crucial for the Suppression of Autoimmunity
The Way of Regulatory T Cells from Thymus to Periphery is Imprinted by Tissue-Specific Dendritic Cells and Crucial for the Suppression of Autoimmunity
16:00—18:15
DC in Cancer
Meeting has ended...abstracts no longer viewable online.
A. Karolina Palucka,
Tha Jackson Laboratory for Genomic Medicine, USA
DCs as Vectors and Targets in Cancer Immunotherapy
DCs as Vectors and Targets in Cancer Immunotherapy
Pierre G. Coulie,
University of Louvain, Brussels, Belgium
Possible Mechanism of Tumor Regression Following MAGE Vaccination of Melanoma Patients.
Possible Mechanism of Tumor Regression Following MAGE Vaccination of Melanoma Patients.
*
Carl G. Figdor,
Radboud University Medical Center, Netherlands
DC Cell Immunotherapy: Monitoring, Migration and Targeting
DC Cell Immunotherapy: Monitoring, Migration and Targeting
Lieping Chen,
Yale University, USA
B7-H1/PD-1 Pathway in Immune Tolerance
B7-H1/PD-1 Pathway in Immune Tolerance
18:15—19:15
Concluding Keynote Address
Meeting has ended...abstracts no longer viewable online.
Ralph M. Steinman,
Rockefeller University, USA
Dendritic Cells and Vacine Biology
Dendritic Cells and Vacine Biology
*Session Chair †Invited, not yet responded.
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