Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B


* Karen L. Mohlke, University of North Carolina at Chapel Hill, USA

* James D. Johnson, University of British Columbia, Canada

Joseph Angleson, University of Denver, USA
Melanocortin Receptor-4 Regulates a-Cell Function and the Counter-Regulatory Response to Insulin-Induced Hypoglycemia in Mice

Malin Fex, Lund University, Sweden
Loss of Melatonin Type 1A Receptor Results in Dysregulated Whole-Body Metabolism Characterised by Hyperglucagonemia, Glucose Intolerance and Enhanced Insulin Secretion

YongKyung Kim, University of Colorado Anschutz Medical Campus, USA
PTPN2 Plays a Novel Role in the Beta Cells to Regulate Mitochondrial Function in Type 1 Diabetes Progression

Taiyi Kuo, Columbia University, USA
Identification of C2CD4A as a Human Diabetes Susceptibility Gene with a Role in ß-Cell Insulin Secretion

Haopeng Lin, Alberta Diabetes Institute, Canada
SENP1 in Compensation and Failure of Insulin Secretion with High-Fat Diet

Dapeng Yang, Memorial Sloan Kettering Cancer Center, USA
Sequential CRISPR Screening Uncovers a Novel Role of HHEX in Specifying Human Pancreatic Differentiation

Taylor S. Morriseau, University of Manitoba, Canada
New Insights into the HNF-1aG319S Variant in Early-Onset T2D Among Manitoba Indigenous Youth

Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B


* Jean Buteau, University of Alberta, Canada

* Bridget Wagner, Broad Institute, USA

George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA
Beta Cell Neogenesis and Protection

Julie B. Sneddon, University California, San Francisco, USA
Elucidating Human Endocrine Cell Fate Selection

Seung K. Kim, Stanford University, USA
Alternative Systems to Study Pancreatic Islet Development and Function

Christine A. Beamish, Houston Methodist Research Institute, USA
Short Talk: Loss of Endocrine Cell Identity Correlates with Pre-Surgical HOMA-ß in Patients with Chronic Pancreatitis Undergoing Islet Auto-Transplantation

Mathieu Latreille, Imperial College London, UK
Short Talk: Beta-Cell Dedifferentiation Is Associated with Epithelial-Mesenchymal Transition In Diabetes

Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B


* Amelia K. Linnemann, Indiana University School of Medicine, USA

* Wen-hong Li, University of Texas Southwestern Medical Center, USA

Sebastian Barg, Uppsala University, Sweden
Exocytosis of Insulin and Glucagon Granules in Type-2 Diabetes

Joana Almaca, University of Miami, USA
Control of Islet Hormone Secretion by Vascular Pericytes

Coffee Break

Robin A. Kimmel, University Innsbruck, Austria
In Vivo Imaging of Pancreatic Islet Morphogenesis in Zebrafish

Stephan Speier, Helmholtz Zentrum München, Germany
Imaging Islet Physiology in situ and in vivo

Yu Hsuan Carol Yang, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Innervation Modulates the Functional Connectivity between Pancreatic Endocrine Cells

Nicole Hallahan, University of Sydney, Australia
Short Talk: Reconstruction of the Polar Domains of Pancreatic Beta-Cells Affects Synaptic Protein Localisation and GSIS

Barak Blum, University of Wisconsin, USA
Short Talk: Roundabout Receptors Regulate Three-Dimensional Architecture and Facilitate Synchronized Ca2+ Oscillations In Vivo in the Islet of Langerhans

Molecular and Functional Analysis of Islet Cell Heterogeneity
This session is from Islet Biology

Room: Sweeney Ballroom A-B


* Claes B. Wollheim, University of Geneva Medical Centre, Switzerland

* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

Wen-hong Li, University of Texas Southwestern Medical Center, USA
Functional Heterogeneity of Islet beta Cells

Richard KP Benninger, University of Colorado, USA
Imaging Islet Heterogeneity and Connectivity

Anna Martinez Casals, Science for Life Laboratories, Sweden
Single Cell Protein Variability in Pancreas by CODEX Highly-Multiplexed Imaging

James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Blocks Beta Cell Failure in Diabetic Mice and Associates with Protection from Diabetes in Humans

Lydia Amanda Farack, Weizmann Institute of Science, Israel
Short Talk: Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas Reveals Division of Labor between ‘Basal Secretor’ Extreme Beta Cells and ‘Glucose Responder’ Non-Extreme Beta Cells

Workshop 2: The Human Islet Research Network - Human Pancreas Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B


* Marcela Brissova, Vanderbilt University, USA

* Nicolai M. Doliba, University of Pennsylvania, USA

Catherine Lee May, University of Pennsylvania, USA
The Human Pancreas Analysis Program – Type 1 Diabetes

Alvin C. Powers, Vanderbilt University School of Medicine, USA
The Human Pancreas Analysis Program - Type 2 Diabetes

Xiaoqing Dai, University of Alberta, Canada
Pancreatic a-cell Function and Identity in Type 1 Diabetes Mellitus


Matthew Haemmerle, University of Pennsylvania, USA
The PCBP RNA Binding Proteins as Post-Transcriptional Regulators of ß Cell Identity


Tiffany Richardson, Vanderbilt University, USA
Pancreatic Islet and Exocrine Tissue Innervation is Not Altered in Type 1 Diabetes


Rafael Arrojo e Drigo, The Salk Institute Research Institute, USA
Aging of Human Endocrine Pancreatic Cell Types Is Heterogeneous and Sex-Specific