Higher-Order Chromatin Architecture in Time and Space
joint with Skirting Mendel: Non-Classical Mechanisms of Phenotypic Variation, Inheritance and Disease
Scientific Organizers: Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas
Date: March 15 - 19, 2020
Location: Whistler Conference Centre, Whistler, BC, Canada
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program will also include workshops on: (1) Leading computational methods to identify biologically relevant patterns in Hi-C data, (2) New genome mapping and imaging technologies, and (3) New data resources available through the 4D Nucleome consortium. Finally, we will conclude with a session devoted to novel tools for imaging and engineering the 3D genome. Overall, the 2020 Keystone meeting is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.
Scholarship Deadline: November 12 2019 details
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Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.
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We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG010979-01
Funding for this conference was made possible (in part) by 1R13HG010979-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This grant is funded by the National Human Genome Research Institute (NHGRI) and co-funded by the National Institute Of Biomedical Imaging And Bioengineering (NIBIB).