Higher-Order Chromatin Architecture in Time and Space joint with Skirting Mendel: Non-Classical Mechanisms of Phenotypic Variation, Inheritance and Disease Scientific Organizers: Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas Date: March 15 - 19, 2020
Location: Whistler Conference Centre, Whistler, BC, Canada Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program will also include workshops on: (1) Leading computational methods to identify biologically relevant patterns in Hi-C data, (2) New genome mapping and imaging technologies, and (3) New data resources available through the 4D Nucleome consortium. Finally, we will conclude with a session devoted to novel tools for imaging and engineering the 3D genome. Overall, the 2020 Keystone meeting is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease. Scholarship Deadline: November 12 2019 details
Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.
IT’S NOT TOO LATE TO SUBMIT YOUR ABSTRACT. Abstracts received can no longer be considered for short talks. Abstracts may be submitted for poster presentations up to 6 weeks prior to meeting start date based on availability
We gratefully acknowledge additional support from these exhibitors at this conference:  |