Skirting Mendel: Non-Classical Mechanisms of Phenotypic Variation, Inheritance and Disease

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MEETING CANCELLED: Skirting Mendel: Non-Classical Mechanisms of Phenotypic Variation, Inheritance and Disease
joint with MEETING CANCELLED: Higher-Order Chromatin Architecture in Time and Space
Organizer(s): J. Andrew Pospisilik, Anne C. Ferguson-Smith and Ben Lehner
Date: March 15 - 19, 2020
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Directors' Fund
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Summary of Meeting:
Recently, there have been new developments in the understanding of mechanisms that control non-genetic phenotypic variation. Referred to also as plasticity, incomplete penetrance or noise, these processes can impose dramatic shifts upon simple and complex genetic traits. Popularized examples include inter- / trans-generational reprogramming paradigms, twin disease discordance, polyphenism in insects (e.g., queen and worker bee), evolutionary capacitance, as well as bi-stability in transcriptional and biological networks. The impact of phenotypic plasticity extends from transcriptional control to population dynamics, and evolution. Finally, figuring out how these impacts affect patient responsiveness and variable disease susceptibility will also help to provide a foundation for modern personalized medicine. One unique aspect of this conference is that it will bring geneticists, chromatin biologists, (epi)genomicists, developmental biologists, mathematicians, physiologists, and a growing community of clinical scientists together for the first time as these researchers all study a component of the molecular mechanisms that establish, buffer and control phenotypic variation. Bringing such diverse disciplines together will help to enable partnerships that will catalyze understanding of trait and disease heterogeneity.
Meeting has been cancelled. Please call our office if you have questions at 970-262-1230 or 1-800-253-0685.


We gratefully acknowledge additional support for this conference from:
American Society of Gene & Cell Therapy (ASGCT)
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novo Nordisk A/S
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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