Proteomics in Cell Biology and Disease
Scientific Organizers: Jennie R. Lill, Forest M. White and Kathryn S. Lilley
Date: September 20 - 23, 2020
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Proteomics enables the acquisition of critical biological information regarding the activation state of enzymes, pathways, and signaling networks in a variety of biological matrices. Single dimensional proteomics analyses on abundant material have become very routine and now the challenges faced within the field are those associated with working on low level materials, often from multiple in vivo samples, and using workflows able to capture dynamic cellular processes. How is the field working towards keeping up with genomics and transcriptomics to tackle single cell analyses? How can multiplexing be increased beyond 2-10 plex experimentation? Furthermore, how can data from the various other “omics” fields be integrated with proteomics to give a more global view of the dynamic cellular environment? This meeting aims to answer many of these questions, focusing on the advances in sample preparation, instrumentation, and computational analysis of proteomic data, while also discussing many of the remaining challenges in continuing to push the boundaries of low-level and multiplexed proteomic analyses for basic research and clinical translatability. By bringing together a multidisciplinary team of experts we will create an innovative and passionate environment for researchers in the field of translational proteomics. This meeting will discuss gaps in technologies that can be used to analyze complex biological matrices, low level signaling events, challenging multi-variant and cross omics analyses. We hope to: - Learn from each other about cutting edge sample preparation methods that enable increased sensitivity and functional analysis of proteins. To discover how increased sample multiplexing in a single experiment is bringing proteomics into the range of processing sufficient clinical samples to achieve meaningful data. To understand how close we are to making single cell proteomics a reality. - Find out what instrumentation, data acquisition methods, and informatic pipelines allow researchers to answer critical yet challenging questions, while also learning what is not yet feasible. - Discuss how we can better work together as a community to disseminate these methods and analytical tools, much in the same was as has been starting to happen in the open source computational programming world. We hope the meeting stimulates a cross pollination of ideas, a clear understanding on what the next wave of innovation needs to be to help progress the field, and for us to help further build a proteomics community that is ready to tackle even more complex biological problems. Our aim is to foster collaborations and scientific advances by bringing together established, senior faculty with junior faculty and trainees from across a broad range of fields to discuss the latest innovations in the areas of sample preparation, instrumentation and proteo-informatic and biostatistical tools for proteomic analysis. A critical focus of the meeting will be on new technologies needed to further improve the feasibility of looking at multicellular dimensions & multiplexed analyses in proteomics. By having a diverse set of talks on current biological applications, as well as advances in more established methodologies, this meeting will highlight the application of high sensitivity proteomics to real-world translational questions related to both intracellular pathways signaling mechanisms at both the translational and post translational modification level.
Registration opens in January 2020