Joint with: Bioenergetics in Health and Diseases
Adipose Tissue: Energizing Good Fat

January 15-19, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Silvia Corvera, Kendra K. Bence and Rana K. Gupta

  In Person
  On Demand
Antibodies as Drugs: The Art in Antibody Engineering

May 5-8, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Laura M. Walker and Paul W. H. I. Parren

  In Person
  On Demand
Joint with: Ubiquitin Biology and Disease
Autophagy and Disease

December 3-6, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Eric H. Baehrecke and Anastasia Henry

  In Person
  On Demand
Autophagy and Neurodegeneration: Mechanisms to Therapies

March 26-29, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Ralph A. Nixon, Ana Maria Cuervo and Gilbert Di Paolo

  In Person
  On Demand
Joint with: HIV Vaccines, Immunoprophylaxis and Drugs
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

June 6-10, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Facundo D. Batista, Susan K. Pierce, Oliver Bannard and Mauro N. Gaya

  Livestream
  In Person
  On Demand
Joint with: T and B Cell Collaboration in Germinal Centers and Beyond
B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Tullia C. Bruno, Brad H. Nelson, Daniel Hollern and Marie-Caroline Dieu-Nosjean

  In Person
  On Demand
Joint with: Adipose Tissue: Energizing Good Fat
Bioenergetics in Health and Diseases

January 15-19, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Shingo Kajimura, Anna Krook and Jared Rutter

  In Person
  On Demand
Joint with: Protein-RNA Interactions
Biomolecular Condensates: Emerging Cellular and Biophysical Roles

January 29-1, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Ibrahim Cissé, Jackie Vogel and Rohit V. Pappu

  In Person
  On Demand
Cachexia and Wasting Syndrome in Cancer and Chronic Diseases

May 5-7, 2024 | Buck Institute for Research on Aging, Novato, CA, United States
Scientific Organizers: Bei B. Zhang and Teresa Zimmers

  In Person
  On Demand
Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance

March 17-20, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: James P. Allison, Andrea Schietinger, Antoni Ribas and Padmanee Sharma

  In Person
  On Demand
Cancer Immunotherapy: Mechanisms of Response versus Resistance

March 5-9, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Thomas Gajewski, Nina Bhardwaj and Stanley R. Riddell

  In Person
  On Demand
Joint with: Obesity Causes and Consequences
Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine

February 4-7, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Paul W. Franks, Ewan Pearson and Karin Conde-Knape

  In Person
  On Demand
Cardiovascular Epigenetics and Gene Regulation

April 15-18, 2024 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Roger Foo, Federica Accornero and Enzo R. Porrello

  In Person
  On Demand
Joint with: Epigenetics, Chromatin, Development and Disease
Chromatin Architecture in Development and Human Health

March 12-15, 2023 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Clodagh C. O'Shea, Joanna Wysocka and Eileen E.M. Furlong

  In Person
  On Demand
Joint with: Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade
Circulating Metabolic Intermediates as Fuels and Signals

October 8-11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Sven Enerbäck, Joshua D. Rabinowitz and Sarah-Maria Fendt

  In Person
  On Demand
Computational Design and Modeling of Biomolecules (Rescheduled from January 2022)

March 14-17, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Tim Whitehead, Nir London, Roberto A. Chica and Birte Höcker

  In Person
  On Demand
Joint with: Precision Genome Engineering
Delivery of Nucleic Acid Therapeutics

January 22-25, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Daniel J. Siegwart and Kathryn Whitehead

  In Person
  On Demand
Drug Delivery to the Brain: Challenges and Progress

January 23-26, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Robert G. Thorne and Reina Bendayan

  In Person
  On Demand
Joint with: Stem Cells and Regeneration
Emerging Cellular Therapies

January 22-25, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Dan S. Kaufman,  Kiem and Sonja Schrepfer

  In Person
  On Demand
Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy

January 29-2, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Francesco M. Marincola, Lisa H. Butterfield, David F. Stroncek and Marcela V. Maus

  In Person
  On Demand
Epigenetic Mechanisms and Cancer Treatment

February 4-7, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Tony Kouzarides, Rab K. Prinjha and Marisa S. Bartolomei

  In Person
  On Demand
Joint with: Chromatin Architecture in Development and Human Health
Epigenetics, Chromatin, Development and Disease

March 12-15, 2023 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Shelley L. Berger, Geneviève Almouzni and Luciano Di Croce

  In Person
  On Demand
Joint with: Metabolic and Molecular Mechanisms of NAFLD/NASH
Fibrosis Pathogenesis and Resolution: From Mechanisms to Therapies

March 19-23, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: David Lagares, Boris Hinz and Carine Boustany

  In Person
  On Demand
Joint with: Inflammation in the Lung: Friend or Foe in Viral Infections?
From First Breath: Lung Development, Infection, Repair and Aging

April 23-26, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Carla F. Kim, Benjamin D. Singer and Nan Tang

  In Person
  On Demand
Joint with: Regulation of Barrier Immunity
Fungal Pathogens: Emerging Threats and Future Challenges

February 18-21, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Michail Lionakis, Sarah L. Gaffen and Mari L. Shinohara

  In Person
  On Demand
Joint with: Precision Genome Engineering
Genomic Instability and DNA Repair

March 19-23, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Katharina Schlacher, Irene Chiolo and Ralph Scully

  In Person
  On Demand
Heart Development and Disease: From Genes to Cures

February 12-15, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Sean M. Wu, Wolfram H. Zimmermann and Christine E. Seidman

  In Person
  On Demand
Joint with: Pulmonary Hypertension: State of the Art and Therapeutic Opportunities
Heart Failure: All Cells Considered

June 25-28, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Merry L. Lindsey, Crystal Ripplinger and Zamaneh Kassiri

  In Person
  On Demand
Hematopoiesis

February 25-28, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Trista E. North, Michael G. Kharas and Nina Cabezas-Wallscheid

  In Person
  On Demand
Joint with: B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers
HIV Vaccines, Immunoprophylaxis and Drugs

June 6-10, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Hanneke Schuitemaker, Steven G. Deeks and Dennis R. Burton

  Livestream
  In Person
  On Demand
Hypoxia: From Basic Mechanisms to Emerging Therapies

May 28-31, 2023 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Sonia Rocha, Edurne Berra and M. Celeste Simon

  In Person
  On Demand
Immunity and Aging

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Danica Chen, Sun Hur and Joan Mannick

  In Person
  On Demand
Immunometabolism: From Mechanisms to Pathways to Therapies

March 18-21, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Luke A. J. O'Neill, Evanna Mills and Erika L. Pearce

  In Person
  On Demand
Inborn Errors of Immunity: From Genetics to Basic Immunological Principles to Therapy

December 5-7, 2022 | 
Scientific Organizers: Dusan Bogunovic, Isabelle Meyts and Steven M. Holland

  Livestream
  On Demand
Joint with: Maternal-Fetal Crosstalk: From Association to Mechanism
Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies

January 22-25, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Helen M. Lazear, Carolyn B. Coyne and David M. Aronoff

  Livestream
  In Person
  On Demand
Joint with: From First Breath: Lung Development, Infection, Repair and Aging
Inflammation in the Lung: Friend or Foe in Viral Infections?

April 23-26, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Andreas Wack, Cecilia Johansson and Ivan Zanoni

  In Person
  On Demand
Joint with: Myeloid Cells: Development, Diversity and Distinct Biological Roles
Innate Immunity: From Innate Sensing to Adaptive Responses

April 16-19, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Hao Wu, Russell E. Vance and Andrea Ablasser

  In Person
  On Demand
Long COVID and Post Acute Sequalae of SARS CoV 2 (PASC): Pathogenesis and Treatment

August 27-30, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Steven G. Deeks, Michael J. Holtzman, Resia Pretorius and Catherine A. Blish

  In Person
  On Demand
Joint with: Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies
Maternal-Fetal Crosstalk: From Association to Mechanism

January 22-25, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Rachel Freathy, Louis J. Muglia, Amanda N. Sferruzzi-Perri and Annettee Nakimuli

  Livestream
  In Person
  On Demand
Joint with: Circulating Metabolic Intermediates as Fuels and Signals
Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade

October 8-11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Jorge Henao-Mejia, Eran Elinav and Lora V. Hooper

  In Person
  On Demand
Joint with: Fibrosis Pathogenesis and Resolution: From Mechanisms to Therapies
Metabolic and Molecular Mechanisms of NAFLD/NASH

March 19-23, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: James Trevaskis, Jacquelyn Maher and Quentin M. Anstee

  In Person
  On Demand
Joint with: The Resistant Tumor Microenvironment
Metastasis

May 7-10, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Joan Massagué, Sean J. Morrison and Caroline Dive

  In Person
  On Demand
Joint with: Organelle Membrane Contact Sites in Health and Disease
Mitochondria Signaling and Disease

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Heidi M. McBride and Timothy Wai

  In Person
  On Demand
Joint with: Molecular Basis of Healthy Aging
Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging

March 26-29, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Vamsi K. Mootha and Dan Gottschling

  In Person
  On Demand
Joint with: Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging
Molecular Basis of Healthy Aging

March 26-29, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Amy J. Wagers, Saul A. Villeda and Salvador Aznar Benitah

  In Person
  On Demand
Joint with: Next Generation Antibody Therapeutics: From Discovery to Patient
Multispecific Immune Cell Engagers for Cancer Immunotherapy

February 19-22, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Pablo Umaña, Daniel S. Chen and Marion Subklewe

  In Person
  On Demand
Joint with: Innate Immunity: From Innate Sensing to Adaptive Responses
Myeloid Cells: Development, Diversity and Distinct Biological Roles

April 16-19, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Gwendalyn J. Randolph, Minsoo Kim, Roxane Tussiwand and Muzlifah A. Haniffa

  In Person
  On Demand
Myeloid Cell Diversity: From Fundamental Biology to Disease States

January 28-31, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Andrés Hidalgo, Daniela F. Quail and Lai Guan Ng

  In Person
  On Demand
Myeloid Targeting Strategies for Cancer Treatment

May 6-9, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Miriam Merad and Matthew F. Krummel

  In Person
  On Demand
MASH and Fibrosis: From Molecular Phenotypes to Precision Therapeutics

March 3-6, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Stefano Romeo, Michael Charlton, Silvia C. Sookoian and Gregory Tesz

  In Person
  On Demand
Joint with: Neuroimmune Interactions: From Basic Mechanisms to Novel Therapeutic Directions
Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development

May 15-19, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Li-Huei Tsai, Aaron D. Gitler and Azad Bonni

  In Person
  On Demand
Joint with: Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease
Neurodegenerative Diseases

June 3-6, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Leonard Petrucelli, Stacie Weninger and Soyon Hong

  In Person
  On Demand
New Frontiers in Reconstructing Human Evolution History

May 29-1, 2023 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Sarah A. Tishkoff and Joshua M. Akey

  In Person
  On Demand
Joint with: Multispecific Immune Cell Engagers for Cancer Immunotherapy
Next Generation Antibody Therapeutics: From Discovery to Patient

February 19-22, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Pamela M. Holland and James A. Wells

  In Person
  On Demand
Joint with: The Human Microbiome: Ecology and Evolution (Rescheduled from February 2022)
Novel Approaches Against Emerging Antimicrobial Resistance (Rescheduled from February 2022)

December 4-7, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Man-Wah Tan and Deborah T. Hung

  Livestream
  In Person
  On Demand
Joint with: Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine
Obesity Causes and Consequences

February 4-7, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Giles S.H. Yeo, Karine Clément and Murielle M. Véniant-Ellison

  In Person
  On Demand
Joint with: Mitochondria Signaling and Disease
Organelle Membrane Contact Sites in Health and Disease

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Gia K. Voeltz and Jodi Nunnari

  In Person
  On Demand
Joint with: Stem Cells: Advances in the Application of Stem Cells and their Role in vivo
Organoids as Models of Development and Disease, and their Impact on Drug Discovery

February 5-8, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ajamete Kaykas, Aron B. Jaffe and Prisca Liberali

  In Person
  On Demand
Joint with: Exercise Biology: Signaling, Mechanisms and Benefits
Mammalian Somatosensation: Mechanisms of Itch, Touch, Pain and Interoception in Health and Disease

January 14-17, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Diana Bautista, Rebecca P. Seal and Ishmail John Abdus-Saboor

  In Person
  On Demand
Joint with: Genomic Instability and DNA Repair
Precision Genome Engineering

March 19-23, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Laura Sepp-Lorenzino and Matthew Porteus

  In Person
  On Demand
Joint with: Delivery of Nucleic Acid Therapeutics
Precision Genome Engineering

January 22-25, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Morgan Maeder, Benjamin P. Kleinstiver and Kiran Musunuru

  In Person
  On Demand
Joint with: Biomolecular Condensates: Emerging Cellular and Biophysical Roles
Protein-RNA Interactions

January 29-1, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Gene W. Yeo, Wendy V. Gilbert and Lori A. Passmore

  In Person
  On Demand
Joint with: Targeted Protein Degradation
Proximity Based Therapeutics

January 21-24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ryan Potts and Michelle R. Arkin

  In Person
  On Demand
Joint with: Heart Failure: All Cells Considered
Pulmonary Hypertension: State of the Art and Therapeutic Opportunities

June 25-28, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Marlene Rabinovitch and Kurt R. Stenmark

  In Person
  On Demand
Joint with: Fungal Pathogens: Emerging Threats and Future Challenges
Regulation of Barrier Immunity

February 18-21, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: David Artis, Yasmine Belkaid, Fiona M. Powrie and Kenya Honda

  In Person
  On Demand
Joint with: RNA Modifications in Health and Disease
Regulatory RNAs: Emerging Mechanisms

December 12-15, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Mitchell Guttman, Phillip D. Zamore and Maite Huarte

  In Person
  On Demand
Reimagining Scientific Conferences

November 15-16, 2022 | 
Scientific Organizers: Deborah L. Johnson and Judith Klinman

  Livestream
  On Demand
Joint with: Regulatory RNAs: Emerging Mechanisms
RNA Modifications in Health and Disease

December 12-15, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Eric A. Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo

  In Person
  On Demand
Single Cell Biology: From Development to Cancer

June 18-22, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Mario Suva and Itay Tirosh

  In Person
  On Demand
Single-Cell Biology: Tissue Genomics, Technologies and Disease

January 21-24, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Jason Buenrostro, Lacramioara Bintu and Fei Chen

  In Person
  On Demand
Joint with: Vector Biology: Emerging Concepts and Novel Technologies
Skin-Immune Crosstalk

February 13-16, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Anna Di Nardo, Daniel H. Kaplan and Nathalie Boulanger

  Livestream
  In Person
  On Demand
Joint with: Emerging Cellular Therapies
Stem Cells and Regeneration

January 22-25, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Heinrich Jasper and Emmanuelle Passegué

  In Person
  On Demand
Joint with: Organoids as Models of Development and Disease, and their Impact on Drug Discovery
Stem Cells: Advances in the Application of Stem Cells and their Role in vivo

February 5-8, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Kevin C. Eggan, Kathrin Plath and Elly M. Tanaka

  In Person
  On Demand
Systemic Autoimmune and Autoinflammatory Diseases

February 8-11, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mariana J. Kaplan, Georg Schett and Carola G. Vinuesa

  In Person
  On Demand
Joint with: B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics
T and B Cell Collaboration in Germinal Centers and Beyond

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Shane Crotty, Michela Locci and Jennifer L. Gommerman

  In Person
  On Demand
Joint with: Proximity Based Therapeutics
Targeted Protein Degradation

January 21-24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James E. Bradner, Eric S. Fischer and Brenda A. Schulman

  In Person
  On Demand
Joint with: Ubiquitin Biology (Rescheduled from January 2022)
Targeted Protein Degradation - RESCHEDULED

November 6-9, 2022 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Rajesh Chopra, Nathanael Gray, Anita K. Gandhi and Georg E. Winter

  In Person
  On Demand
Joint with: Mammalian Somatosensation: Mechanisms of Itch, Touch, Pain and Interoception in Health and Disease
Exercise Biology: Signaling, Mechanisms and Benefits

January 14-17, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Jeffrey F. Horowitz, Laurie J. Goodyear and Karyn A. Esser

  In Person
  On Demand
Tuberculosis: The Host-Pathogen Interface

March 24-27, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Marcel A. Behr, Lalita Ramakrishnan and Kevin B. Urdahl

  Livestream
  In Person
  On Demand
Joint with: Novel Approaches Against Emerging Antimicrobial Resistance (Rescheduled from February 2022)
The Human Microbiome: Ecology and Evolution (Rescheduled from February 2022)

December 4-7, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Ruth E. Ley, Alejandro Reyes and C. Jessica Metcalf

  Livestream
  In Person
  On Demand
Joint with: Metastasis
The Resistant Tumor Microenvironment

May 7-10, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Valerie M. Weaver, Jeffrey W. Pollard, Kornelia Polyak and Mara H. Sherman

  In Person
  On Demand
Tumor Metabolism

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Gina DeNicola, Rushika M. Perera and David B. Shackelford

  In Person
  On Demand
Type 2 Diabetes: Understanding its Early Drivers and the Road to Therapeutics

May 1-4, 2023 | Renaissance Palm Springs Hotel, Palm Springs, CA, United States
Scientific Organizers: Christopher J. Rhodes, Lora K. Heisler and Martin G. Myers, Jr.

  In Person
  On Demand
Joint with: Targeted Protein Degradation - RESCHEDULED
Ubiquitin Biology (Rescheduled from January 2022)

November 6-9, 2022 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Eric J. Bennett, Nicolas H. Thomä and Niels Mailand

  In Person
  On Demand
Joint with: Autophagy and Disease
Ubiquitin Biology and Disease

December 3-6, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ivan Dikic and Cynthia Wolberger

  In Person
  On Demand
Understanding Developmental Disorders in the Genomic Age

June 6-8, 2023 | 
Scientific Organizers: Lee A. Niswander and Wendy K. Chung

  In Person
Transposable Elements at the Crossroads of Evolution, Health and Disease

September 3-6, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Kathleen H. Burns, Harmit S. Malik and Irina Arkhipova

  In Person
  On Demand
Unraveling Vascular Layers to Understand Human Disease

March 17-19, 2024 | Buck Institute for Research on Aging, Novato, CA, United States
Scientific Organizers: Rachel J. Roth Flach and Stephanie Wengert Watts

  In Person
  On Demand
Vaccinology During and After COVID-19

September 17-20, 2023 | Atlanta Marriott Marquis, Atlanta, GA, United States
Scientific Organizers: Bali Pulendran, Robert A. Seder and Gagandeep Kang

  Livestream
  In Person
  On Demand
Joint with: Skin-Immune Crosstalk
Vector Biology: Emerging Concepts and Novel Technologies

February 13-16, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: João Pedra, Elena A. Levashina and Maria-Carla Saleh

  Livestream
  In Person
  On Demand
Next-Generation Nanomedicine

September 6-8, 2023 | 
Scientific Organizers: Philip L. Felgner, Anna K. Blakney and Norbert Pardi

  Livestream
Inhibitory Receptors in Immune Homeostasis, Disease and Therapy

January 16-19, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Linde Meyaard, Jonathon D. Sedgwick, Carla V. Rothlin and Alex McCarthy

  In Person
  On Demand
Joint with: Neurodegenerative Diseases
Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease

June 3-6, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Nicola J. Allen, Anna Victoria Molofsky and Francisco J. Quintana

  In Person
  On Demand
Joint with: Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development
Neuroimmune Interactions: From Basic Mechanisms to Novel Therapeutic Directions

May 15-19, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Katerina Akassoglou, Tony Wyss-Coray and Dheeraj Malhotra

  In Person
  On Demand
Microbiota and Cancer Immunity

March 17-20, 2024 | Humanities/Social Sciences Building of Academia Sinica, TaipeiTaiwan
Scientific Organizers: Giorgio Trinchieri, Jenny P.Y. Ting, Hsing-Jien Kung and Shie-Liang Hsieh

  In Person
  On Demand
HIV and (Re)Emerging Viruses: Aligning Lessons Across Pandemics

April 8-11, 2024 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Melanie M. Ott, Priti Kumar, Olivier Schwartz and Alex Sigal

  In Person
  On Demand
Joint with: Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease
Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic

April 9-12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Kate L. Jeffrey, Ramnik Xavier and Xu Zhou

  In Person
  On Demand
Joint with: Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic
Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease

April 9-12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: John Tsang, Shannon J Turley and Alex Marson

  In Person
Autophagosomes and Endolysosomes: From Fundamental Mechanisms to Disease Implications

June 25-28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Christina Towers, Rupert Beale and Leon O. Murphy

  In Person
  On Demand
Joint with: Immune Cell Therapies: Advances in Cancer and Autoimmune Disease
Cancer Immunotherapy: Clinical Lessons to New Modalities

March 16-19, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Christian U. Blank, Stefani Spranger and Anna Christina Obenauf

  In Person
  On Demand
Joint with: Epigenetics in Development and Disease
Interplay of Chromatin Architecture and Transcription Regulation

March 30-2, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Seychelle Vos, John T. Lis and Luca Giorgetti

  In Person
  On Demand
HIV Cure: Antiretroviral Therapy-Free Control of HIV Infection

April 7-10, 2025 | Southern Sun Elangeni & Maharani, Durban, NL, South Africa
Scientific Organizers: Mike McCune, Thumbi Ndung'u, Sharon R. Lewin and Cissy Kityo

  In Person
  On Demand
Joint with: Machine Learning Applied to Macromolecular Structure and Function
Imaging Biomolecules Across Scales: From Atoms to Tissues

March 23-26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Elizabeth Villa, Bridget Carragher and Ilaria Testa

  In Person
  On Demand
DNA Replication Gaps, Cancer and Disease

April 27-30, 2025 | Daejeon Convention Center, DaejeonKorea, Republic of
Scientific Organizers: Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung

  In Person
  On Demand
Biomolecular Condensates: Mechanisms and Therapeutic Opportunities

September 6-9, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mingjie Zhang and Jin Zhang

  In Person
  On Demand
Joint with: Neurodegeneration: Linking Cellular Pathways to Therapeutic Strategies
Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology

June 8-11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Dorothy Schafer, Asya Rolls and Anne Schaefer

  In Person
  On Demand
Joint with: Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology
Neurodegeneration: Linking Cellular Pathways to Therapeutic Strategies

June 8-11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Michael Ward, Erika L Holzbaur and Sarah L. DeVos

  In Person
  On Demand
Joint with: Single Cell Biology: Unique Cells to Tissue Ecosystems
Organoids: Engineering Innovative Approaches for Basic and Translational Insight

May 11-14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Quinton Smith, Matthias Lutolf and Kelly R. Stevens

  In Person
  On Demand
Joint with: Innate Immune Memory: Mechanisms and Consequences
T Cell Differentiation in Tissue Microenvironments

February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Greg M. Delgoffe, Amanda Lund, Nikhil S. Joshi and Laura K. Mackay

  In Person
  On Demand
Joint with: T Cell Differentiation in Tissue Microenvironments
Innate Immune Memory: Mechanisms and Consequences

February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shruti Naik, Keke C. Fairfax and Renato Ostuni

  In Person
  On Demand
Microproteins: from Discovery to Applications

February 6-8, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

  In Person
  On Demand
Tuberculosis: Heterogeneity from Experimental Models to Human Disease

February 16-19, 2025 | Fairmont Copley Plaza, Boston, MA, United States
Scientific Organizers: JoAnne L Flynn, Bryan D. Bryson and Henry C. Mwandumba

  In Person
  On Demand
Fibrosis: Inflammation, Drivers, and Therapeutic Resolution

December 8-11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Valerie Horsley, Michael T. Longaker and Thomas A Wynn

  In Person
  On Demand
Myeloid Cells: Roles in Different Tissue Microenvironments

March 3-6, 2025 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Irina A. Udalova, Ana-Maria Lennon-Duménil and Paul Kubes

  In Person
  On Demand
Joint with: MASH Pathogenesis and Therapeutic Approaches
Obesity and Adipose Tissue

February 23-26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Paul Cohen, Ruth J.F. Loos, Claudio J. Villanueva and Christian Wolfrum

  In Person
  On Demand
Joint with: Obesity and Adipose Tissue
MASH Pathogenesis and Therapeutic Approaches

February 23-26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Elizabeth K. Speliotes, Rebecca A. Taub and Hannele Yki-Järvinen

  In Person
  On Demand
Joint with: Tumor Microenvironment: Metastasis and the Host
Neural Influence on Cancer, Tumor Microenvironment and Cancer Immunology

January 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Brian M. Davis, Michelle Monje and Ihsan Ekin Demir

  In Person
  On Demand
Tumor Metabolism: Environmental Influences and Therapeutic Vulnerabilities

March 16-19, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shannon Mumenthaler, Kathryn E. Wellen and Arkaitz Carracedo

  In Person
  On Demand
Joint with: Genetic Engineering for a Sustainable Future
Future of Agriculture for Sustainability

January 20-23, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Christopher Voigt, Pamela A. Silver and Alvin Tamsir

  In Person
  On Demand
Vaccinology: Horizons Across Disease, Demography and Technology

June 4-7, 2025 | Marriott Marquis Washington, DC, Washington, DC, United States
Scientific Organizers: Rino Rappuoli, Kanta Subbarao, Laurence Zitvogel and Firdausi Qadri

  In Person
  On Demand
Precision Genome Engineering: Translating the Human Genome to the Clinic

March 3-6, 2025 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Fyodor D. Urnov, Claire Booth and Laralynne Przybyla

  In Person
  On Demand
Mitochondrial Biology in Health and Disease

January 13-16, 2025 | NTUH International Convention Center, Taipei, TPE, Taiwan
Scientific Organizers: Lena Pernas, Anne N. Murphy and Johan Auwerx

  In Person
  On Demand
AI in Biomedicine

May 1-3, 2024 | 
Scientific Organizers: Thomas Hartung, Weida Tong and Yvonne Will

  Livestream
  On Demand
Joint with: Non-Coding RNA Biology: New Roles and Diversity
RNA Mediated Regulation of Immunity: Mechanism, Disease and Therapeutics

January 27-30, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Uttiya Basu, Sun Hur and Noam Stern-Ginossar

  In Person
  On Demand
Joint with: RNA Mediated Regulation of Immunity: Mechanism, Disease and Therapeutics
Non-Coding RNA Biology: New Roles and Diversity

January 27-30, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Sebastian Kadener, Irene Bozzoni and Luisa Cochella

  In Person
  On Demand
Malaria: Mechanisms of Immunity & Protection

March 30-2, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Silvia Portugal, Marion Pepper and Melissa Chola Kapulu

  In Person
  On Demand
Joint with: Future of Agriculture for Sustainability
Genetic Engineering for a Sustainable Future

January 20-23, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Carrie Eckert, Jennifer Charlotte Mortimer and Mark Blenner

  In Person
  On Demand
Metabolic and Nutritional Control of Development and Cell Fate

May 7-9, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Lydia Finley and Ralph J. DeBerardinis

  In Person
  On Demand
Joint with: Imaging Biomolecules Across Scales: From Atoms to Tissues
Machine Learning Applied to Macromolecular Structure and Function

March 23-26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Mohammed AlQuraishi, Elizabeth Kellogg and Possu Huang

  In Person
  On Demand
Joint with: Aging: New Frontiers in Rejuvenation and Gerotherapeutics
Somatic Mosaicism in Human Development, Aging, and Diseases

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Jeong Ho Lee, E. Alice Lee and Peter Campbell

  In Person
  On Demand
Joint with: Somatic Mosaicism in Human Development, Aging, and Diseases
Aging: New Frontiers in Rejuvenation and Gerotherapeutics

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Ashley Webb, Morgan Levine and Dario Riccardo Valenzano

  In Person
  On Demand
Delayed and Hidden Consequences of Infection

January 1-4, 2025 | Location to be Determined
Scientific Organizers: Peter J.M. Openshaw, Stacey Lynne Schultz-Cherry and Serena Spudich

  In Person
  On Demand
Positive Strand RNA Viruses: Interdisciplinary Advances in Virology, Pathogenesis, Immunology, and Technology Development

October 21-24, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Kizzmekia S. Corbett-Helaire, William B. Klimstra and Jolanda M. Smit

  In Person
  On Demand
GPCR Drug Discovery Meets Cell Mapping: A Keystone Integration Symposia

October 27-30, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Raymond Stevens, Beili Wu, Andrej Sali and Bei B. Zhang

  In Person
  On Demand
Targeting Dry Age-related Macular Degeneration: Pathophysiology and Emerging Therapies

September 17-20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Wai T. Wong and Aparna Lakkaraju

  In Person
  On Demand
Sleep & Circadian Rhythms: Pillars of Health

February 25-25, 2021 | 
Scientific Organizers: Marie-Pierre St-Onge, Eve Van Cauter, Christian Benedict and Jonathan Cedernaes

  Livestream
  On Demand
Joint with: Immunometabolism in Tissue Homeostasis and Diseases
Trajectories to Heart Failure: Immunometabolic Mechanisms

February 10-13, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Joseph A. Hill, Geneviève Derumeaux, Chiara Giannarelli and Gabriele G. Schiattarella

  In Person
  On Demand
Joint with: Trajectories to Heart Failure: Immunometabolic Mechanisms
Immunometabolism in Tissue Homeostasis and Diseases

February 10-13, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ping-Chih Ho, María Mittelbrunn and Stanley Huang

  In Person
  On Demand
B Cells: Multifaceted Functions and Dysfunctions

February 23-26, 2025 | Fairmont Monte Carlo, Monte CarloMonaco
Scientific Organizers: Rita Carsetti, Ali H. Ellebedy and Hedda Wardemann

  In Person
  On Demand
Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches

February 16-19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Philip Chamberlain and Fleur M. Ferguson

  In Person
  On Demand
Precision Oncology: Emerging Technologies & Implementation

January 12-15, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: John D. Carpten, David Solit and Chanita Hughes-Halbert

  In Person
  On Demand
COVID-19 and the World Response: Are We Prepared for the Next Pandemic?

November 12-16, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Nevan J. Krogan, Ana Fernandez-Sesma, John A. T. Young and Jacqueline M. Fabius

  In Person
  On Demand
Lipids in Cellular Function and Disease

April 6-9, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Valerie B. O'Donnell, Junken Aoki and Vytas A. Bankaitis

  In Person
  On Demand
Joint with: Cancer Immunotherapy: Clinical Lessons to New Modalities
Immune Cell Therapies: Advances in Cancer and Autoimmune Disease

March 16-19, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Katy Rezvani, Nathan Singh and Stephan Mielke

  In Person
  On Demand
Climate Change & Infectious Disease Threats

June 23-26, 2025 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Cecilia Sorensen, Kari Nadeau, Anna Stewart-Ibarra and Desiree LaBeaud

  In Person
  On Demand
Joint with: Neural Influence on Cancer, Tumor Microenvironment and Cancer Immunology
Tumor Microenvironment: Metastasis and the Host

January 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Mikala Egeblad, Julio Aguirre-Ghiso and Manuel Valiente

  In Person
  On Demand
Neurobiology of Ingestive Behavior

April 22-25, 2025 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Daniela Cota, Timo D. Müller and Dana M. Small

  In Person
  On Demand
Joint with: Antibodies as Drugs: Innovative Formats, Design and Engineering
Drug Delivery to the Brain: Emerging Modalities

February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James Gorman, Stina Syvänen and Danica Stanimirovic (in memoriam)

  In Person
  On Demand
Joint with: Organoids: Engineering Innovative Approaches for Basic and Translational Insight
Single Cell Biology: Unique Cells to Tissue Ecosystems

May 11-14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Jose Ordovas-Montanes, Chrysothemis Brown, Karin Pelka and Jeffrey Moffitt

  In Person
  On Demand
Interoception: Neural Sensing and Control of Organ Function

April 22-24, 2025 | Allen Institute, Seattle, WA, United States
Scientific Organizers: Xin Sun, Mark L. Andermann and Rui M. Costa

  In Person
  On Demand
Regenerative Biology of the Female Reproductive System

April 10-12, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Kara McKinley, Margherita Y. Turco, Pradeep Tanwar and Amander Clark

  In Person
  On Demand
Cilia in Development and Disease

October 1-4, 2023 | Location to be Determined
Scientific Organizers: Maxence V. Nachury, Piali Sengupta and Gaia Pigino

Vaccinology

October 1-4, 2023 | Location to be Determined
Scientific Organizers:   and  

Next-Generation Therapeutic Development in Inflammatory Bowel Disease

January 1-4, 2024 | Location to be Determined
Scientific Organizers: Dermot P. B. McGovern, Séverine Vermeire, Ailsa Hart and Thaddeus S. Stappenbeck

Neuropsychiatric and Neurodevelopmental Disorders: Harnessing Rare Variants

January 1-4, 2024 | Location to be Determined
Scientific Organizers: Jennifer G. Mulle, Audrey Thurm, Christa L. Martin and Carrie E. Bearden

Eukaryotic Gene Regulation: New Mechanisms and Technologies

January 1-4, 2024 | Location to be Determined
Scientific Organizers: Shannon M. Lauberth, Lu Bai and Laura A. Banaszynski

CANCELLED: Neurobiology of Reward and Addiction

February 12-14, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Thomas Kash, Camilla Bellone, Michael Taffe and Ziva Cooper

Joint with: Drug Delivery to the Brain: Emerging Modalities
Antibodies as Drugs: Innovative Formats, Design and Engineering

February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Jean-Philippe Julien and Katherine Harris

  In Person
  On Demand
Positive-Strand RNA Viruses

June 18-22, 2022 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Stanley Perlman, Carolyn B. Coyne and Lisa F.P. Ng

  Livestream
  In Person
  On Demand
Joint with: Interplay of Chromatin Architecture and Transcription Regulation
Epigenetics in Development and Disease

March 30-2, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Karen Adelman and Kristian Helin

  In Person
  On Demand
Joint with: Human Microbiome: Diversity, Selection and Adaptation
Host-Microbe Co-Evolution in Human Health: The Microbiome-Pathobiont Continuum

February 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Bana Jabri, Caetano Reis e Sousa and Philippe J. Sansonetti

  In Person
  On Demand
Stem Cell Models for Embryology

February 6-8, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Aryeh Warmflash and Magdalena D. Zernicka-Goetz

  In Person
  On Demand
Influenza: From Correlates of Protection to Next Generation Vaccines

January 1-4, 2023 | Location to be Determined
Scientific Organizers: Florian Krammer, Aubree Gordon and Davide Corti

  In Person
Biomolecular Condensates: Phase-Separated Organizers of Cellular Biochemistry

January 1-4, 2023 | Location to be Determined
Scientific Organizers: J. Paul Taylor and Geraldine Seydoux

Neuronal Cell Biology: A Biology of Extremes

January 1-4, 2023 | Location to be Determined
Scientific Organizers: Timothy A. Ryan and Erin M. Schuman

Long COVID and Other Post-Acute Infection Syndromes

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Akiko Iwasaki, Avindra Nath, Hannah Davis and Daniel M. Altmann

  In Person
  On Demand
Leveraging Genomic Diversity to Promote Animal and Human Health

November 25-29, 2018 | Speke Resort & Conference Centre, KampalaUganda
Scientific Organizers: Michèle Ramsay, Han G. Brunner and Appolinaire Djikeng

  In Person
DNA Replication and Genome Instability: From Mechanism to Disease

January 13-17, 2019 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Karlene A. Cimprich, Mark O'Connor and Johannes C. Walter

  In Person
Integrated Pathways of Disease in NASH and NAFLD

January 20-24, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:

  In Person
Tuberculosis: Mechanisms, Pathogenesis and Treatment

January 17-21, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Christina L. Stallings, Veronique Anne Dartois, Stewart T. Cole and David Barros Aguirre

  In Person
Cancer Vaccines

January 20-24, 2019 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Lélia Delamarre, Robert A. Seder and Nina Bhardwaj

  In Person
Digital Health: From Science to Application

January 21-25, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Geoffrey S. Ginsburg, Sue Siegel and Eric D. Perakslis

  In Person
Windows on the Brain: Formation and Function of Synapses and Circuits and their Disruption in Disease

January 21-25, 2019 | Sagebrush Inn & Suites, Taos, NM, United States
Scientific Organizers: Kristin Scott, Paola Arlotta, Rui M. Costa and Yimin Zou

  In Person
Joint with: Signal Dynamics and Signal Integration in Development and Disease
Cellular Plasticity: Reprogramming, Regeneration and Metaplasia

January 27-31, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Jason C. Mills, Maike Sander and Ben Z. Stanger

  In Person
Joint with: Cellular Plasticity: Reprogramming, Regeneration and Metaplasia
Signal Dynamics and Signal Integration in Development and Disease

January 27-31, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Nicolas Tapon, Liliana Attisano and Raphael Kopan

  In Person
Transcription and RNA Regulation in Inflammation and Immunity

February 2-5, 2019 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Silvia Monticelli, K. Mark Ansel, Sarah Teichmann and Gioacchino Natoli

  In Person
Joint with: B Cell-T Cell Interactions
Molecular Approaches to Vaccines and Immune Monitoring

February 10-14, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:

  In Person
Joint with: Functional Neurocircuitry of Feeding and Feeding Disorders
Obesity and Adipose Tissue Biology

February 10-14, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Matthias Blüher, Philipp E. Scherer and Anne Bouloumié

  In Person
Joint with: Obesity and Adipose Tissue Biology
Functional Neurocircuitry of Feeding and Feeding Disorders

February 10-14, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Roger D. Cone, Lori M. Zeltser and Matthew R. Hayes

  In Person
Autophagy: From Model Systems to Therapeutic Opportunities

February 17-21, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:

  In Person
Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity

February 18-22, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:

  In Person
Genome Engineering: From Mechanisms to Therapies

February 19-23, 2019 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers:

  In Person
Tumor Metabolism

February 24-28, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:

  In Person
Myeloid Cells

February 24-28, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:

  In Person
Joint with: Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics
RNA-Protein Interactions

February 24-28, 2019 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:

  In Person
Joint with: RNA-Protein Interactions
Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics

February 24-28, 2019 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:

  In Person
Phenotypic Drug Discovery: Recent Advances and Insights from Chemical and Systems Biology

March 3-7, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:

  In Person
Joint with: Unraveling the Secrets of Kidney Disease
Diabetes: Innovations, Outcomes and Personalized Therapies

March 3-7, 2019 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:

  In Person
Joint with: Diabetes: Innovations, Outcomes and Personalized Therapies
Unraveling the Secrets of Kidney Disease

March 3-7, 2019 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:

  In Person
Next Generation HIV Vaccines & Therapies

March 27-30, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:

  Livestream
  In Person
  On Demand
Joint with: Myeloid Cells: From Birth to Immunity and Disease
Innate Immune Memory: From Evolutionary Roots to Human Disease

March 6-9, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:

  In Person
  On Demand
Innate Immunity: Complement and Beyond

April 3-6, 2022 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
Joint with: Neurodegeneration: The Biological Pathways Driving the Future of Therapeutic Development
Neuro-Immune Interactions in the Central Nervous System

June 5-9, 2022 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
B Cell-T Cell Collaboration: Regulation and Dysregulation

April 3-6, 2022 | Herrenhausen Palace, HannoverGermany
Scientific Organizers:

  Livestream
  In Person
  On Demand
Cancer Immunotherapy: Decoding the Cancer Immunity Interactome

March 20-24, 2022 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:

  Livestream
  In Person
  On Demand
Progress in Vaccine Development for Infectious Diseases

June 1-4, 2022 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
Joint with: Respiratory Viruses: New Frontiers (Rescheduled from January 2022)
Viral Immunity: Basic Mechanisms and Therapeutic Applications (Rescheduled from January 2022)

June 29-2, 2022 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
Joint with: Tumor Metabolism (Rescheduled from January 2022)
Immunometabolism at the Crossroads of Obesity and Cancer (Rescheduled from January 2022)

September 5-8, 2022 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
Exosomes, Microvesicles and Other Extracellular Vesicles (Rescheduled from February 2022)

October 30-2, 2022 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:

  Livestream
  In Person
  On Demand
Microbiome: Chemical Mechanisms and Biological Consequences

March 10-14, 2019 | Fairmont The Queen Elizabeth, Montreal, QC, Canada
Scientific Organizers:

  In Person
Innate Immune Receptors: Roles in Immunology and Beyond

March 10-14, 2019 | Humanities/Social Sciences Building of Academia Sinica, TaipeiTaiwan
Scientific Organizers: Jenny P.Y. Ting, Shie-Liang Hsieh, Fu-Tong Liu and Michael Gale, Jr.

  In Person
Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment

March 15-19, 2019 | Firenze Fiera - Fortezza da Basso, FlorenceItaly
Scientific Organizers: Erika L. Pearce, Sarah-Maria Fendt, Russell G. Jones and Peter F. Carmeliet

  In Person
Joint with: 3D Genome: Gene Regulation and Disease
Epigenetics and Human Disease

March 17-21, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Cheryl Arrowsmith, Anne Schaefer and Mark A. Dawson

  In Person
Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions

March 24-27, 2019 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Marsha Wills-Karp, Donald Y.M. Leung and Kari Nadeau

  In Person
Innate and Non-Classical Immune Cells in Cancer Immunotherapy

March 24-28, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Nicholas D. Huntington, Eric Vivier, Caroline Robert and Lewis L. Lanier

  In Person
Joint with: Functional Cures and the Eradication of HIV
HIV Vaccines

March 24-28, 2019 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Nicole A. Doria-Rose, Thumbi Ndung'u and Gunilla B. Karlsson Hedestam

  In Person
Joint with: HIV Vaccines
Functional Cures and the Eradication of HIV

March 24-28, 2019 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Lynn Morris, Melanie M. Ott and Kevin V. Morris

  In Person
Lipidomics and Functional Metabolic Pathways in Disease

March 31-4, 2019 | Steamboat Grand, Steamboat Springs, CO, United States
Scientific Organizers: Sarah Spiegel, Charles N. Serhan and Valerie B. O'Donnell

  In Person
Protein Replacement through Nucleic Acid Therapies

April 7-10, 2019 | Steamboat Grand, Steamboat Springs, CO, United States
Scientific Organizers: Pad Chivukula, Jean Bennett and Paloma Giangrande

  In Person
Antibodies as Drugs: New Horizons in the Therapeutic Use of Engineered Antibodies

April 7-11, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Christian Klein, Mark S. Cragg and Germaine Fuh

  In Person
Template Event for Standard Session Proposals Configuration

September 12-12, 2022 | 
Scientific Organizers:

Immunometabolism, Metaflammation and Metabolic Disorders

April 14-18, 2019 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Gökhan S. Hotamisligil, Ruslan Medzhitov and Karine Clément

  In Person
Delivering Therapeutics Across Biological Barriers

May 6-9, 2019 | Royal Dublin Society, Dublin 4Ireland
Scientific Organizers: David Brayden, Claus-Michael Lehr and Kathryn Whitehead

  In Person
Climate Change-Linked Stress Tolerance in Plants

May 13-16, 2019 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Julian I. Schroeder and Julia Bailey-Serres

  In Person
Positive-Strand RNA Viruses

June 9-13, 2019 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Frank van Kuppeveld and Andrea Gamarnik

  In Person
Joint with: Neurodegenerative Diseases: New Insights and Therapeutic Opportunities
Neural Environment in Disease: Glial Responses and Neuroinflammation

June 16-20, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Richard Daneman, Dorothy Schafer, Michael V. Sofroniew and Vanda A. Lennon

  In Person
Joint with: Neural Environment in Disease: Glial Responses and Neuroinflammation
Neurodegenerative Diseases: New Insights and Therapeutic Opportunities

June 16-20, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Valina L. Dawson, Joseph W. Lewcock and Fred H. Gage

  In Person
Microbiome: Therapeutic Implications

October 6-10, 2019 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Justin L. Sonnenburg, Fergus Shanahan and Suzanne Devkota

  In Person
The Malaria Endgame: Innovation in Therapeutics, Vector Control and Public Health Tools

October 30-2, 2019 | Hilton Addis Ababa, Addis AbabaEthiopia
Scientific Organizers: Thierry T. Diagana, Philip Welkhoff and Flaminia Catteruccia

  In Person
Why So Many Ways to Die? Apoptosis, Necroptosis, Pyroptosis and Beyond

November 19-23, 2019 | Casa Grande Hotel, Guarujá, SP, Brazil
Scientific Organizers: Karina R. Bortoluci, Vishva M. Dixit and Andreas E. Strasser

  In Person
Helminths: New Insights from Immunity to Global Health

December 8-12, 2019 | Southern Sun Cape Sun, Cape Town, WC, South Africa
Scientific Organizers: De' Broski R. Herbert, P'ng Loke, Nicola L. Harris and Frank Brombacher

  In Person
Noncoding RNAs: Mechanism, Function and Therapies

January 12-16, 2020 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Howard Y. Chang, Frank Rigo and Lynne E. Maquat

  In Person
Tuberculosis: Immunity and Immune Evasion

January 16-20, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Joel D. Ernst, Jennifer Philips and Daniel L. Barber

  In Person
Hypoxia: Molecules, Mechanisms and Disease

January 19-23, 2020 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: José López-Barneó, Sarah R. Walmsley, Hesham A. Sadek and Jacques Pouysségur

  In Person
Joint with: Cancer Neoantigens, Vaccines and Viruses (Rescheduled from February 2022)
Advances in Checkpoints Immunology from Autoimmunity to Oncology to Infectious Diseases (Rescheduled from February 2022)

June 8-12, 2022 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: David M. Lee, Arlene H. Sharpe and William H. Robinson

  In Person
  On Demand
Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges

January 19-23, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: William R. Sellers, Charles Swanton and Lillian L. Siu

  In Person
AAA+ Proteins: From Atomic Structures to Organisms

January 26-29, 2020 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Walid A. Houry, James Shorter, Antonina Roll-Mecak and Phyllis I. Hanson

  In Person
Tissue Immunity

January 26-29, 2020 | Embassy Suites by Hilton Boulder, Boulder, CO, United States
Scientific Organizers: Bana Jabri, Daniel Mucida and Ramnik Xavier

  In Person
Joint with: Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities
Gene Regulation: From Mechanisms to Disease

January 26-30, 2020 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Karen Adelman and Patrick Cramer

  In Person
Antibodies as Drugs: From B Cell Biology to New Treatments

February 2-6, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Paul Carter, Janine Schuurman and Karl Dane Wittrup

  In Person
Joint with: Engineering the Genome
Emerging Cellular Therapies: Cancer and Beyond

February 8-12, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Crystal L. Mackall, Marina Cavazzana and Stanley R. Riddell

  In Person
Joint with: Emerging Cellular Therapies: Cancer and Beyond
Engineering the Genome

February 8-12, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Vic E. Myer and Erik J. Sontheimer

  In Person
Intra- and Intercellular Mechanisms of Aging

February 9-13, 2020 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Malene Hansen, Johan Auwerx and Heinrich Jasper

  In Person
Joint with: Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus
Brain Therapeutics: Disruptive Technologies and Opportunities

February 16-19, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza

  In Person
Joint with: Brain Therapeutics: Disruptive Technologies and Opportunities
Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus

February 16-19, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Edwin S. Monuki, Maria Lehtinen and Maiken Nedergaard

  In Person
Joint with: Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches
Stromal Cells in Immunity and Disease

February 19-23, 2020 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Scott N. Mueller, Jason G. Cyster, Reina E. Mebius and Theresa T. Lu

  In Person
Advances in Cancer Immunotherapy

August 17-19, 2020 | 
Scientific Organizers: Antoni Ribas and Priti Hegde

  Livestream
  On Demand
2023 Fall Study Group

October 1-31, 2024 | 
Scientific Organizers:

  In Person
RNA Editing and Modifications: From Biology to Therapy

September 30-2, 2020 | 
Scientific Organizers: Jin Billy Li, Stacy M. Horner and Michaela Frye

  Livestream
  On Demand
Joint with: Host-Microbe Co-Evolution in Human Health: The Microbiome-Pathobiont Continuum
Human Microbiome: Diversity, Selection and Adaptation

February 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Suzanne Devkota, Jeff F. Miller and Roberto G. Kolter

  In Person
  On Demand
Joint with: Systems Immunology: Immune Signaling
Immunometabolism Across Scales: From Cells to Systems to Healthspan

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Susan M. Kaech, Vishwa Deep Dixit and Dequina Angelina Nicholas

  In Person
  On Demand
Joint with: Immunometabolism Across Scales: From Cells to Systems to Healthspan
Systems Immunology: Immune Signaling

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Alexander Hoffmann, Eicke Latz and Stacey D. Finley

  In Person
  On Demand
Joint with: B and T Cell Collaboration in Lymphoid and Nonlymphoid Microenvironments
B Cells and Plasma Cells: Fundamental and Translational Biology

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Kim Good-Jacobson, Deepta Bhattacharya and Taras Kreslavsky

  In Person
  On Demand
Joint with: B Cells and Plasma Cells: Fundamental and Translational Biology
B and T Cell Collaboration in Lymphoid and Nonlymphoid Microenvironments

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Stephanie C. Eisenbarth, Jason G. Cyster and Ziv Shulman

  In Person
  On Demand
Myeloid Cells: Functional Heterogeneity with Therapeutic Promise

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Plant Epigenetics and Epigenome Engineering

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Doris Wagner, Xuehua Zhong, Toshiro Ito and Claudia Köhler

  In Person
  On Demand
Joint with: Stromal Immunology in Health and Disease
Fibrosis: Cross Organ Pathology and Pathways to Clinical Development

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Florian Rieder, Tatiana Kisseleva and Marco Prunotto

  In Person
  On Demand
Joint with: Fibrosis: Cross Organ Pathology and Pathways to Clinical Development
Stromal Immunology in Health and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Autoimmunity & Autoinflammation: Translating Basic Mechanisms into Novel Therapeutic Approaches

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Immune Function and Organ Health During Aging
Innate Immunity: Diversity in Host Defense and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Innate Immunity: Diversity in Host Defense and Disease
Immune Function and Organ Health During Aging

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Emerging Concepts in Inflammation Resolution

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Emerging Concepts in Inflammation Resolution
Tumor Microenvironment: Identifying Drivers of Progression and Resistance

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Predicting and Responding to Emerging Viral Infections

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Viral Pathogenesis and Viral Immunity: From Molecular Discoveries to Therapeutics

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: HIV Vaccines: Intersections in Basic and Clinical Science
Decoding HIV Persistence: Strategies to Finding a Cure for HIV infection

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Decoding HIV Persistence: Strategies to Finding a Cure for HIV infection
HIV Vaccines: Intersections in Basic and Clinical Science

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Tuberculosis: Understanding the Disease Across Scales

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Fungal Pathogens: Emerging Threats and Future Challenges

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Cardiometabolism in Health and Disease
Obesity Medications: Unlocking Benefits and Minimizing Side Effects

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Obesity Medications: Unlocking Benefits and Minimizing Side Effects
Cardiometabolism in Health and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Gut-Brain Axis
Islet Biology & Diabetes

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Olov Andersson, Barak Blum, Amelia K. Linnemann and Erica B. Nishimura

  In Person
  On Demand
Joint with: Islet Biology & Diabetes
Gut-Brain Axis

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers

  In Person
  On Demand
Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Human Microbiome: From Models and Mechanism to Medicine
Microbiome Metabolite/Metabolism Discovery and Function in Health and Disease: Bringing Biochemistry into the 21st Century

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Neurodevelopmental Disorders: Risk Factors and Molecular Mechanisms

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
The Ubiquitin Family in Biology and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Computational Advances in Drug Discovery

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Structure, Physiology and Pharmacology of Solute Carrier Transporters

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Giulio Superti-Furga, David Drew and Kathleen M. Giacomini

  In Person
  On Demand
Cancer Immunotherapy: Basic Mechanisms Informing Future Clinical Applications and Optimal Combination Therapies

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Tumor Metabolism: New Frontiers in Diet, Microbiome and Beyond

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Spotlight on the Cancer Cell: Intrinsic Properties and Vulnerabilities for Therapeutics

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Anwesha Dey, Laura D. Attardi and Mariam Jamal-Hanjani

  In Person
  On Demand
Joint with: Autophagy: Mechanisms to Therapy
Membrane Dynamics, Repair and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Membrane Dynamics, Repair and Disease
Autophagy: Mechanisms to Therapy

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Mitochondria Signaling in Physiology and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Proximity Based Biology and Therapeutics

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Nucleic Acid Therapeutics and Targeted Delivery
Precision Genome Engineering: CRISPR and Beyond

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Precision Genome Engineering: CRISPR and Beyond
Nucleic Acid Therapeutics and Targeted Delivery

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Neuroinflammation
Systems Neurology: From a Neurocentric Focus to a System-Wide View for Neurodegeneration

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Systems Neurology: From a Neurocentric Focus to a System-Wide View for Neurodegeneration
Neuroinflammation

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Michael V. Sofroniew, Malu G. Tansey and Robyn S Klein

  In Person
  On Demand
Hematopoiesis

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
iPSCs: Progress, Opportunities, and Challenges

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Stem Cell Models in Embryology

January 1-3, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Immuno-Vaccinology: A New Era in Vaccine Design

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Antibodies as Drugs: Engineering and Computational Tools

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Emerging Cell Therapies 2026

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Wendell A. Lim, Ashley K. Koegel and Robbie G. Majzner

  In Person
  On Demand
Applications of AI in Biology and Medicine

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Leveraging Large Longitudinal Cohorts to Capture Global Genome Variation and Impact Population Health

January 1-4, 2026 | Location to be Determined
Scientific Organizers:

  In Person
  On Demand
Joint with: Microbiome Metabolite/Metabolism Discovery and Function in Health and Disease: Bringing Biochemistry into the 21st Century
Human Microbiome: From Models and Mechanism to Medicine

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Ami S. Bhatt, Tami Lieberman and Harry Sokol

  In Person
  On Demand
RNA Modifications and Processing Mechanisms in Health and Disease

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Michaela Frye, Schraga Schwartz and Yunsun Nam

  In Person
  On Demand

January 15-19, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Silvia Corvera, Kendra K. Bence and Rana K. Gupta

Important Deadlines
Early Registration Deadline: Nov. 15, 2022
Scholarship Deadline: Oct. 11, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 11, 2022
Meeting Summary
# Metabolism and Cardiovascular
Adipose tissue plays a critical role in metabolic health and a better understanding of its biology will guide development of new therapeutics for metabolic diseases. The Keystone meeting on adipose tissue biology has historically been the premier communication venue for research in this area. Our specific goals for this meeting are to address key emerging questions, from physiological to molecular, facilitating synergy between established groups and providing new trainees with a better picture of critical knowledge gaps. These questions are: First, how do different adipose tissue depots contribute to systemic metabolism? Second, how many types of adipocytes exist, and how do they contribute to the functions of different depots? Third, how do adipocytes develop from progenitor cells, and how do elements such as immune cells, vasculature and innervation influence their development? Fourth, how do adipocyte lipid droplets and mitochondria develop, function and influence systemic metabolic homeostasis? We also seek to envision research on adipose tissue in relation to the broader topic of human health. Adipose tissue disfunction, as manifested by obesity and metabolic disease, disproportionally affects groups underrepresented in medicine and research. We will call attention to this inequity through a keynote address and a career development workshop. We will leverage the natural synergy between the meetings on adipose tissue and on bioenergetics with three joint sessions focused on a) mitochondria and their role in cellular and systemic metabolism, b) metabolomics with a focus on metabolic disease, and c) thermogenic adipose tissue.

May 5-8, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Laura M. Walker and Paul W. H. I. Parren

Important Deadlines
Early Registration Deadline: Mar. 5, 2024
Scholarship Deadline: Feb. 13, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 13, 2024
Meeting Summary
# Drug Discovery, Bioengineering and Digital
The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Antibodies have become the most successful and versatile class of biological drugs with well over 100 therapeutic antibodies approved for human use. Antibody engineering for optimized and novel functionalities is providing unprecedented opportunities in our quest to develop innovative treatments for a wide variety of diseases. In recent years, engineered antibody formats have matured from research to clinical stage molecules with engineered antibodies currently representing about 40% of the 1,000+ antibodies in clinical development. This conference will review the translation of fundamental insights in both antibody and pathological mechanisms into next generation therapeutics and will discuss the opportunities and challenges ahead.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

December 3-6, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Eric H. Baehrecke and Anastasia Henry

Important Deadlines
Early Registration Deadline: Oct. 3, 2023
Scholarship Deadline: Aug. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Aug. 30, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

Autophagy is a catabolic process that plays important roles in cell stress management and nutrient homeostasis. Following the landmark discoveries of the molecules controlling autophagy in yeast, genetic studies in multicellular organisms have revealed diverse roles for autophagy in development, physiology and in the etiology and pathogenesis of multiple disorders. Hence, interest in manipulating autophagy to treat human disease has rapidly intensified. The aims of this conference are to:

(1) gather diverse experts together with junior scientists and researchers new to this field in a setting that supports structured and casual interactions,

(2) promote exchange of cutting edge, innovative and unpublished science relevant to the roles of autophagy in healthy and pathologic cell contexts,

(3) expedite discoveries that advance mechanistic knowledge of autophagy and facilitate the discovery and development of novel therapeutic approaches for the treatment of diseases.

This symposium will explore the frontiers of autophagy research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify forms of autophagy in development and disease.  Emphasis will be placed on how our emerging understanding of autophagy may influence disease and the development of therapies. Diverse interdisciplinary leaders of the autophagy field will gather with junior scientists to share discoveries and exchange ideas. The collegial atmosphere of this conference is designed to enable brainstorming and promote collaborations to advance our understanding of the basic mechanisms controlling autophagy, and how their dysregulation contributes to disease. Joint sessions with the meeting on Ubiquitin will foster new connections and collaborations that will mutually advance the ubiquitin and autophagy fields.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 26-29, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Ralph A. Nixon, Ana Maria Cuervo and Gilbert Di Paolo

Important Deadlines
Early Registration Deadline: Jan. 24, 2023
Scholarship Deadline: Jan. 16, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 16, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
# Neurobiology

Autophagy is an essential cellular process required for cellular homeostasis and adaptation to stress. Autophagy malfunction is a common mechanism in the pathogenesis of multiple human diseases including neurodegenerative conditions. The autophagy field has now matured to support expanding initiatives aimed at targeting autophagy with therapeutic purpose.  This Keystone Symposia meeting will highlight this field’s evolution from an exclusively molecular cell biological focus to one that now also addresses expanding biological functions and etiological roles in specific neurodegenerative disease states. The program will also offer initial glimpses of promising clinical translation originating from surging industry interest in autophagy modulation as therapy in the field of neurodegeneration. Particularly innovative is our goal of capturing this bench to bedside scope of autophagy research by featuring new findings from a multidisciplinary panel of academic and industry speakers and a combination of conceptual themes spanning from basic biology of neuronal and glial autophagy to translational medicine and therapeutics.  Appreciation of the brain’s special vulnerabilities to autophagy dysfunction has grown and promising therapeutic responses to autophagy modulation in major neurodegenerative disorders are emerging from preclinical studies.

June 6-10, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Facundo D. Batista, Susan K. Pierce, Oliver Bannard, Mauro N. Gaya and Michelle A. Linterman

Important Deadlines
Early Registration Deadline: Apr. 6, 2023
Scholarship Deadline: Mar. 21, 2023
Global Health Award Deadline: Jan. 31, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Mar. 21, 2023
Meeting Summary
# Immunology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


It is now well appreciated that effective B cell antibody responses are essential for human health and protection against deadly infectious diseases and that on the flipside B cell antibodies are mediators of devastating autoimmune diseases and when released from normal control mechanisms B cell malignancies are common and many remain untreatable. It is also becoming increasingly clear that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on a several factors including the affinity of the B cell antigen receptor (BCR) and how the BCR is wired to the B cell’s activation machinery as well as the quality of the immune environment defined by both antigen-specific T cells and innate immune cells responding to pathogen-derived signals. In this context the generation of long-lived protective immunity versus B cell malignancies or systemic autoimmunity may represent the spectrum of outcomes resulting from different combinations of BCR affinity and wiring and the T cell and innate signals experienced by B cells during activation. If so our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases and therapies for autoimmune diseases and B cell cancers may be greatly accelerated by gaining a detailed understanding of the fundamentals of B cell biology and translating this knowledge to clinical and basic research addressing the most pressing public health priorities of our times in acute and chronic infectious diseases, autoimmunity and B cell malignancies.

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Tullia C. Bruno, Brad H. Nelson, Daniel Hollern and Marie-Caroline Dieu-Nosjean

Important Deadlines
Early Registration Deadline: Aug. 1, 2023
Scholarship Deadline: Jun. 28, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 28, 2023
Meeting Summary
# Cancer
With vaccines, antibody-based immunotherapy, and scientific discoveries of B cell functional mechanisms, major breakthroughs are happening surrounding B cells. This marks a field of research that is poised for exponential growth in acquisition of knowledge and effective therapies. In particular, the novel insights into B cell biology have revealed conserved aspects across disease; for example, B cells are now recognized as critical players in Tertiary Lymphoid Structures (TLS) for both cancer patient response to immunotherapy and the severity of autoimmune disease. Likewise, B regulatory cells use mechanisms to protect from autoimmunity that are common to the mode by which they fuel cancer’s progression and resistance to therapy. By examining data across disciplines, scientists are gleaning major insights that shape the forward progression of the entire field of research.

To foster the process of breakthroughs in the field of B cell research, we have established the B Cells in Cancer Consortium (BC3) to bring together this ever-growing community. Our first year has built a constituency of more than 500 scientists for our virtual seminar series, which is expected to grow given the expansive pace of immunology research driven by the global pandemic. With mRNA vaccines and monoclonal antibody therapies being hot topics now, people are more informed than ever on B cell biology.

This inaugural Keystone Symposia conference will be the first opportunity for this nascent field to meet together, providing a unique opportunity to forge new connections and catalyze future research into the importance of B cell function in cancer. 

Organizer, and Professor of Immunology in the Center of for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology, Dr. Shane Crotty, talks about why you should attend this meeting in the video below:

Dr. Shane Crotty talks about Keystone Symposia











Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 15-19, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Shingo Kajimura, Anna Krook and Jared Rutter

Important Deadlines
Early Registration Deadline: Nov. 15, 2022
Scholarship Deadline: Oct. 11, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 11, 2022
Meeting Summary
# Metabolism and Cardiovascular
The bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. For the last several years since the previous keystone meeting on bioenergetics, the field has been transformed and growing because of several breakthroughs. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a meeting that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. Our specific goals for this meeting are to 1) addressing emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, 2) facilitating synergy between established and new investigators in the field of energy metabolism, and 3) providing new trainees with a better picture of critical knowledge gaps. We assembled inter-disciplinary speakers in the field of mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. This symposium will address key questions in the field, e.g., what initiates bioenergetic defects in metabolic organs? How do the defects lead to pathogenesis? How can we restore the bioenergetic defects to a healthy state? Together with the adipocyte biology symposium, the joint sessions also feature three topics – 1) recent technological innovation in metabolic flux analyses, 2) novel regulators of mitochondrial functions and 3) brown and beige adipocyte and the roles in energy homeostasis. We believe that these topics will create numerous new collaborations and cross-disciplinary interactions.

January 29-1, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Ibrahim Cissé, Jackie Vogel and Rohit V. Pappu

Important Deadlines
Early Registration Deadline: Nov. 29, 2022
Scholarship Deadline: Oct. 27, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 27, 2022
Meeting Summary
# Biochemistry, Structural and Cellular

Since the previous Keystone meeting on Biomolecular Condensates there has been an explosion of interest and novel discoveries implicating intracellular phase transitions as a major route to generation of membraneless biomolecular condensates. Further, the functions associated with the phenomenology of phase transitions and the spatial and temporal regulation afforded by biomolecular condensates are multi-fold. It appears that condensates or some variants thereof are implicated in essentially all aspects of cellular functions, physiology, and disease. The second iteration of the Keystone meeting aims to bring together a strong focus on emerging themes, with a new raft of speakers. The talks will feature a truly diverse group of speakers who will touch upon the physical principles underlying phase transitions, the structural aspects of condensates, and the roles of condensates in providing integrated responses, in space and time, that directly influence cellular functions and pathophysiology.

May 5-7, 2024 | Buck Institute for Research on Aging, Novato, CA, United States
Scientific Organizers: Bei B. Zhang and Teresa Zimmers

Important Deadlines
Early Registration Deadline: Mar. 5, 2024
Scholarship Deadline: Feb. 14, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 14, 2024
Meeting Summary
# Cancer
# Metabolism and Cardiovascular

The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Cachexia is a multifactorial and multi-organ syndrome that is one of the main causes of morbidity and mortality in late stages of chronic conditions such as cancer, chronic obstructive pulmonary disease (COPD), heart failure, and chronic kidney disease (CKD). As such, cachexia is often referred to as “a disease within a disease”. Cachexia is a wasting syndrome characterized by signs and symptoms that may include weight loss, anorexia, decreased muscle strength, increased fatigue, and abnormal biochemistry and increase of inflammatory markers. These changes have been associated with increased morbidity and mortality as well as reduced quality of life.  Furthermore, as cachexia has been estimated to affect 0.5-1% of the population, it poses a substantial health burden and has far reaching impact on patients’ daily lives.  Given the complexity of cachexia being a disease within a disease, the field is challenged with limited mechanistic understanding.  As scientists increasingly study cachexia as a distinct disorder, and not just symptoms of late-stage illness, new advancements are being made uncovering how inflammation and metabolic imbalances drive its pathology.  

This symposium aims to bring together a team of researchers from academia and industry to:

1) provide an overview of the definition of cachexia, with a focus on cancer cachexia;

2) discuss pathways and mechanisms that are altered in cachectic states;

3) highlight recent progress in the discovery of novel interventions for the treatment of cachexia.  
         
At the conclusion of this symposium, participants will become knowledgeable in:
• Cachexia as a disease within chronic diseases
• Altered inflammatory and metabolic pathways as contributing factors underlying cachexia
• Potential therapeutic nodes of intervention to ameliorate cachexia

Co-Organizer, and Professor of Cell, Developmental and Cancer Biology at Oregon Health & Science University, Teresa Zimmers, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 17-20, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: James P. Allison, Andrea Schietinger, Antoni Ribas and Padmanee Sharma

Important Deadlines
Early Registration Deadline: Jan. 16, 2024
Scholarship Deadline: Dec. 6, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 6, 2023
Meeting Summary
# Cancer
# Immunology

The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Immune checkpoint blockade therapy (ICT) has provided lasting cures for a subset of patients with specific cancers. Attempts to expand ICT toward other patients and cancers has revealed some of the limitations of ICT, particularly as monotherapies. This meeting will discuss some of those limitations, touching upon lessons learned from failed clinical trials, mechanisms of resistance to ICT, and new technologies which offer the promise of a more comprehensive understanding of the tumor-immune response. A strong emphasis will also be placed on exploring tumor-immunity beyond T cell biology. A better understanding of why immuno-oncology clinical trials have failed in the past is expected to better inform basic scientists on design of pre-clinical studies that may guide improved clinical trials that avoid the mistakes of the past. Further elucidation of the mechanisms through which cancers are either refractory to initial treatment with ICT or gain resistance over time should provide avenues to predict rationally-designed combinatorial treatments from among the hundreds of thousands to millions of potential combinations. Finally, new technologies, including high dimensional spatiotemporal imaging and T cell engineering, provide new opportunities to expand our knowledge of immunology and therapeutic repertoire sometimes in unexpected ways. This meeting brings together scientists and clinicians from many aspects of tumor immunology to rethink the next steps in the evolution of cancer immunotherapy. It is expected to provide a springboard toward basic science discoveries and new, more effective therapies.

Co-organizer and 2018 Nobel Laureate from the University of Texas MD Anderson Cancer Center, Dr. Jim Allison talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 5-9, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Thomas Gajewski, Nina Bhardwaj and Stanley R. Riddell

Important Deadlines
Early Registration Deadline: Jan. 10, 2023
Scholarship Deadline: Dec. 6, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 6, 2022
Meeting Summary
# Cancer
# Immunology

The notion that the immune system is capable of recognizing and destroying cancer has become a clinical reality with the development, approval, and implementation of novel immunotherapies. Blockade of immune inhibitory receptors, adoptive T cell therapy, vaccination against tumor antigens, and engagement of innate immune pathways have all reached the standard-of-care arena. However, as many patients fail to respond to these therapies, there is much work to be done to bridge the gap and expand the circle of efficacy. Fundamental immunology research is identifying additional molecular and cellular features of regulation of endogenous anti-tumor immune responses. New approaches to T cell engineering are being investigated, and engineering of other immune cells is being pursued. Bioinformatic approaches to streamline neoantigen identification are being utilized, and novel vaccine platforms are being tested. Since a major determinant of efficacy is driven by the biology of the tumor microenvironment, single cell technologies and in situ tissue imaging are being carried out. Interrogation of patient samples is providing a key resource for understanding treatment failure, and molecular details of the tumor, genetics of the host, and the composition of the gut microbiome are features defined already that impact on immunotherapy outcomes. Analysis of each of these dimensions is pointing towards new therapeutic interventions.

February 4-7, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Paul W. Franks, Ewan Pearson and Karin Conde-Knape

Important Deadlines
Early Registration Deadline: Dec. 5, 2023
Scholarship Deadline: Nov. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 5, 2023
Meeting Summary
# Metabolism and Cardiovascular

Obesity prevalence has tripled over the past four decades. Together with its wide range of comorbidities, it accounts for a large proportion of the worldwide non-communicable disease burden. One of the critical barriers in effectively tackling obesity is the prevailing societal perception of it being a simple energy balance problem, one that this meeting seeks to dismantle. In truth there are a myriad of causes that lead to obesity, and as a result a wide array of consequences that emerge. Moreover time is rapidly changing in the field of obesity with the emergence of new and innovative therapies. While the value of model organisms is recognized in the field, this program was designed to focus on the model that matters most: humans.

The goals of this meeting is to explore the latest in:

(1) causes of obesity, including genetics, environmental impacts, and hypothalamic dysfunction;

(2) how the heterogeneity of obesity impacts upon its precision management;

(3) metabolic consequences of obesity, including Type 2 Diabetes, dyslipidemia, as well as cardiovascular, liver and renal disease

(4) innovation in treatment and new molecular targets.

This conference will be paired with another Keystone Symposia conference entitled Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine, where shared scientific sessions will explore cross connectivity of genetics and precision obesity management. These joint conferences will also bring together an interdisciplinary group of investigators with different focus areas within the field, ranging from ‘big data’ to detailed mechanistic studies. Participants of both conferences will also have an opportunity to network at shared meals and poster sessions. This unique environment will lead to new scientific collaborations and the implementation of precision medicine approaches directed at better understanding and treating cardiometabolic disease.

Co-Organizer, and Scientific Director at Novo Nordisk Foundation, Paul W. Franks, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 15-18, 2024 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Roger Foo, Federica Accornero and Enzo R. Porrello

Important Deadlines
Early Registration Deadline: Feb. 14, 2024
Scholarship Deadline: Jan. 23, 2024
Global Health Award Deadline: Dec. 12, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 23, 2024
Meeting Summary
# Genetics, Genomics and RNA
# Metabolism and Cardiovascular

The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Cardiovascular disease (CVD) can cut short an adult life unexpectedly in its prime, and also cause debilitating chronic ill health later in life among an increasingly aging population. It is a significant cause of death worldwide, claiming the lives of 17.9 million annually. Emerging, new discoveries in the fields of epigenetics and epitranscriptomics have opened up refreshing horizons offering new biological perspectives and disease targets; the cross-cutting fields have elucidated modulatable nodal effectors, integrating upstream signals that convey common cellular pathways and mediate fundamental cell state changes in health and disease. For example, by targeting modulatable cell states, these new approaches promise to tackle CVD at its root cause, rather than only delaying disease progression.

Presently, there is a recognized core group of CVD epigenetic and epitranscriptomic researchers that focus primarily on myocardial cell types. This meeting aims to integrate this group, with investigators across cardiac and vascular fields, including researchers examining new systemic drivers that are emerging as key contributors of CVD pathophysiology, such as metabolism and inflammation. The program will cover gene expression control, cardiac cell states, diverse histone and nucleic acid modifications, and even their contribution to inter-cellular cross-talk, featuring an interdisciplinary groups of scientists that bring diverse perspectives based on different cellular, organelle or pathways of interest. The focus on underpinning epigenetic processes will make this symposium unique from other conferences. As the wider biological field of epigenetics is rapidly progressing, with ground-breaking discoveries exponentially increasing, this symposium will also serve as the platform to invite keynote speakers from outside CVD research, to bring fresh perspectives and techniques to the program and to the scientific community.

In the video below, meeting co-organizer Dr. Roger Foo talks about why you should attend this meeting:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 12-15, 2023 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Clodagh C. O'Shea, Joanna Wysocka and Eileen E.M. Furlong

Important Deadlines
Early Registration Deadline: Jan. 11, 2023
Scholarship Deadline: Dec. 6, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 6, 2022
Meeting Summary
# Genetics, Genomics and RNA

The science behind chromatin architecture spans across multiple processes and scales from local DNA polymer folding and chromatin loops, to the organization of the genome into domains and chromosome territories. Such three-dimensional (3D) organization is an important component in the regulation of gene expression, with more recent implications emerging for DNA replication and repair. Furthermore, it has been discovered that genome rearrangements that alter chromatin architecture can lead to devasting developmental defects. This has led to many exciting developments in recent years in the field such as an understanding of the biophysical properties of chromatin organization and function, as well as genetic dissection of topologically associated domains. Therefore, this conference will bring together leaders in the field to discuss fundamental mechanisms driving formation of 3D chromatin structure and its regulation during development as well as how these processes can go awry, leading to human disease. The conference will showcase the interdisciplinary nature of the field, with talks combining state-of-the-art super resolution imaging, sophisticated genetics and single cell regulatory genomics. Additionally, this conference is being held jointly with Epigenetics, Chromatin, Development and Disease, which will encompass themes of chromatin mechanisms, including DNA and RNA modifications, histone modifications, ATP-dependent nucleosome remodeling complexes, histone variants, and chaperones. These two complementary symposia will elucidate the importance of chromatin and epigenetics in cell identity, cellular and transgenerational memory, and will explore functional aspects of nuclear structure and its impact on fundamental biological processes and disease. There will be joint Keynote speakers, as well as joint sessions. By pairing these two conferences together, it is anticipated that there will be a strong interest from researchers and scientists who are working in both fields.

October 8-11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Sven Enerbäck, Joshua D. Rabinowitz and Sarah-Maria Fendt

Important Deadlines
Early Registration Deadline: Aug. 8, 2023
Scholarship Deadline: Jul. 6, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jul. 6, 2023
Meeting Summary
# Metabolism and Cardiovascular
Metabolic diseases such as stroke, heart disease, diabetes, cancer, obesity, and NASH remain major causes of death and disability. One reason is incomplete understanding of energy metabolism and its regulation. New data indicate that metabolites normally viewed as wastes or benign intermediates are actually important fuels and signals. For example, lactate has emerged as an important energy substrate and succinate as a driver of muscle remodeling, reflecting the many underexplored energetic and regulatory roles of circulating metabolic intermediates. The importance of such intermediates opens a new perspective on how energy metabolism is controlled, outside of classical “fuels” like glucose, amino acids and fat. Thus, this field is primed for further break-throughs – both in understanding of new biology and in offering new targets for intervention.

This Keystone Symposia conference will bring together the leading experts in the field to review the latest research and discuss challenges the field is facing. In addition, it will be held jointly with the conference on Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade, to enhance our understanding of how microbial metabolites contribute to these process. The joint pairing will foster new scientific collaborations and the implementation of new technological approaches to understand the intersection of metabolic, microbial and immune interactions.   

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 14-17, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Tim Whitehead, Nir London, Roberto A. Chica and Birte Höcker

Important Deadlines
Early Registration Deadline: Jan. 12, 2023
Scholarship Deadline: Dec. 13, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 13, 2022
Meeting Summary
# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital

The scientific community is increasingly able to predict and design three-dimensional structures of proteins, RNA, macromolecular complexes, and biomolecule-ligand interactions with atomic accuracy. This biomolecular design and modeling interdisciplinary field has impacted fields as diverse as immunology, nanotechnology, biocatalysis, cellular and molecular engineering, drug delivery, vaccinology, and drug discovery. These disparate fields are underpinned by continuing advances in the design and predictive modeling of biomolecules and biomolecular assemblies. This conference is intended to bring the worldwide community of protein designers and modelers together to discuss recent advances. This program is topical as the field of protein design has moved from toy challenges to solving real-world problems. It is important to include computational design and modeling as its own conference as no other venue exists to bring the entire worldwide community to one location. In this watershed moment in the life of the field, this meeting can unite the global community of molecular modelers to build on these successes and push forward as a community to expand the field by diversifying our methods, approaches and ideas. In addition, the field of molecular modeling is naturally positioned to implement and integrate concepts and methodologies in deep learning and artificial intelligence. The huge recent spike in interest in such methods gives this conference a great opportunity to spearhead these developments.

January 22-25, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Daniel J. Siegwart and Kathryn Whitehead

Important Deadlines
Early Registration Deadline: Nov. 21, 2023
Scholarship Deadline: Nov. 2, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 2, 2023
Meeting Summary
# Drug Discovery, Bioengineering and Digital

The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

This meeting will bring together world-renowned experts to educate attendees on the complex science, engineering, and application of nucleic acid delivery systems. Recently, this topic has attracted unprecedented attention, given the overwhelming success of mRNA SARS-CoV-2 vaccines. However, despite their clinical triumphs, the broad application of nucleic acid therapies relies on the development of enabling delivery systems. Delivery is an underappreciated component of nucleic acid therapeutics, and this meeting will highlight cutting-edge strategies to transport these drugs into target cells and organs without toxicity. Briefly, meeting aims are:

1) introduce attendees to the challenges of delivering nucleic acids systemically and intracellularly,

2) highlight exciting clinical applications of nucleic acid delivery technologies,

3) facilitate stimulating conversations between a diverse group of speakers and attendees.

This meeting will provide a rare opportunity to convene experts from a broad array of disciplines, including engineering, materials science, biology, chemistry, and medicine with a focus on nucleic acid delivery. One aspect that makes this conference completely unique is that it will be held jointly with another Keystone Symposia meeting entitled “Precision Genome Engineering.” Through the joint sessions, attendees will hear from gene editing superstars - improbable speakers at a standard delivery conference. Attendees will depart with an expanded network of colleagues, armed with a new appreciation for delivery challenges, solutions, and applications. Ultimately, these experiences will catalyze the development and execution of new ideas that will bring many more nucleic acid therapies to fruition.

Meeting co-organizer from the University of Texas Southwest Medical Center, Dr. Daniel Siegwart, talks about why you should attend this meeting in the video below:

Dr. Daniel Siegwart talks about upcoming Keystone Symposia meeting

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 23-26, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Robert G. Thorne and Reina Bendayan

Important Deadlines
Early Registration Deadline: Nov. 22, 2022
Scholarship Deadline: Nov. 4, 2022
Global Health Award Deadline: Mar. 27, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 17, 2022
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Neurobiology
This Keystone Symposium directly addresses an urgent scientific need for innovative, new approaches to central nervous system (CNS) drug delivery. Indeed, the current shortage of disease-modifying treatments for Alzheimer’s, Parkinson’s and other CNS diseases represent among the most significant unmet health needs of our time. Our ability to effectively tap into the vast potential that protein, oligonucleotide, and gene therapies have for treating CNS disorders has been sharply limited by the typically insufficient brain exposure that results after their systemic or central administration. Even many orally administered small molecules suffer from brain exposure limitations. Among the primary reasons for these limitations are the physical and biochemical barriers that exist at key CNS interfaces, including the blood-brain barrier at the level of the cerebrovasculature, other specialized barriers between the blood and cerebrospinal fluid, and further obstacles hindering drug exchange between cerebrospinal fluid and CNS tissue. CNS drug delivery research lies at the crossroads between many different fields, including physiology, pharmacology, pharmaceutical science, neuroscience, neurosurgery, engineering, genetics, and vascular biology, among others. Surprisingly few conferences to date have focused exclusively on the multidisciplinary challenges associated with CNS drug delivery. The goals of this symposium are (i) to bring together international experts and junior investigators from multiple research fields for the purpose of exchanging new ideas and brainstorming novel solutions to existing CNS drug delivery challenges and (ii) to highlight new methods and perspectives with the potential to change how CNS drug delivery research studies are performed and, ultimately, to transform the field. Sessions are to include a number of short talks chosen to integrate late-breaking developments and new research directions from the field.

January 22-25, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Dan S. Kaufman,  Kiem and Sonja Schrepfer

Important Deadlines
Early Registration Deadline: Nov. 21, 2023
Scholarship Deadline: Oct. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 30, 2023
Meeting Summary
# Cancer

The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Cellular therapies are now becoming a routine part of cancer care, especially for treatment of hematologic malignancies. Based on this success, new cell therapy approaches are rapidly being developed and translated into clinical trials. We have only scratched the surface of how cell therapies can be effectively utilized for better treatment and potential cures for both malignant and non-malignant diseases. However, key challenges remain- such as how to engineer key cell populations more efficiently and effectively. Synthetic biology and other advanced engineering strategies are being employed to improve targeting and safety of cell therapies. Allogeneic cell therapies are gaining in interest and importance, as they likely provide a more cost-effective approach. However, key challenges remain, such as immune compatibility remain a concern and will be explored.

This meeting will highlight both new technologies to build improved cell therapies, as well as diverse cell sources that can be utilized for repair or replacement of diseased or damaged tissues. Strategies to use new cell therapies to treat infectious and autoimmune disease, as well as new approaches to directly engineer cells in vivo will also be discussed. This meeting will be held jointly with the Keystone Symposia on Stem Cells, Regeneration, and Therapeutics. These joint meetings will enable cross-fertilization of investigators with interests that range from basic biology to translational research and clinical trials. These exciting meetings will enable both academic and industry scientists to understand key challenges and advances in these fields to bring new and more effective cell therapies into clinical reality.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 29-2, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Francesco M. Marincola, Lisa H. Butterfield, David F. Stroncek and Marcela V. Maus

Important Deadlines
Early Registration Deadline: Nov. 30, 2022
Scholarship Deadline: Nov. 1, 2022
Global Health Award Deadline: Apr. 4, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 1, 2022
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital

Cellular immunotherapy for the treatment of hematological malignancies and solid tumors is rapidly progressing. Progress depends upon the development of better products that match the challenges limiting effectiveness such as survival and engraftment, trafficking to cancer tissues, engagement with cancer cells, and resilience to immune-suppressive factors while at the same time de-risking toxicity. This can be only achieved following a holistic approach to achieve an optimal therapeutic index. Such estimation goes beyond the selection of antigenic targets based of differential expression between benign and neoplastic tissues as is intuitively done for small molecules, antibodies and other biologics where the engagement of the product with its target is dependent on stable chemistry and predicable pharmacokinetics. Cell therapies instead are affected by complex, active rather than passive biodistribution, and context dependent potency. Thus, a broader range of factors need to be considered like product-dependent variability (fitness, unpredictable pharmacokinetics due non-specific trapping, sequestration and extravasation into normal tissues, and variable rates of in vivo expansion). Individual cancer immune biology may affect differential trafficking to benign compared to malignant tissues under different conditions of chemo-attraction, hampered engagement with cancer cells due to physical or functional barriers, immune suppression, and cellular dysfunction due to unfavorable metabolic conditions. In this meeting we gather expertise from all areas, to propose an integrated path forward to successful implementation of novel cellular therapeutics, particularly for solid tumors.

February 4-7, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Tony Kouzarides, Rab K. Prinjha and Marisa S. Bartolomei

Important Deadlines
Early Registration Deadline: Dec. 5, 2023
Scholarship Deadline: Oct. 31, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 31, 2023
Meeting Summary
# Cancer
# Genetics, Genomics and RNA

This conference will highlight the latest advances in the understanding of epigenetic drivers in cancer and relate this to the current epigenetic treatments of the disease. One unique and compelling aspect of this conference will be the intersection of academia and industry.  Academic presenters will highlight basic research into epigenetic pathways of cancer (i.e., what are the drivers; how they work; how does diet or the environment affect inheritance, susceptibility and mutation accumulation; what are epigenetic mechanism of cancer resistance, metastasis, and tumor plasticity). Industry speakers will relate their latest efforts to target cancer in a personalized manner, and report on emerging developments in anti-cancer therapies currently heading to or in the clinic.  Additionally, there will be an emphasis on examples where academics/clinicians have taken their research towards the clinic, through collaborations with pharmaceutical and biotech companies.

This conference will provide an opportunity for academic, clinical and industry scientists to meet and collaborate.  In addition, young investigators will have the opportunity to learn how basic research is converted into concrete treatments for cancer patients, reinforcing the advantage of thinking about patient benefit and industrial partnering in their research.  Finally, in order to help facilitate their career choices, there will be workshops with panelists from academia and industry reflecting on their choices and experiences, as well as a panel on women in science. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 12-15, 2023 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Shelley L. Berger, Geneviève Almouzni and Luciano Di Croce

Important Deadlines
Early Registration Deadline: Jan. 11, 2023
Scholarship Deadline: Dec. 6, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 6, 2022
Meeting Summary
# Genetics, Genomics and RNA

The mechanisms underlying nucleosome- and chromatin-based functional control of genomes are studied very broadly across biological systems and at an increasing rate. Additionally, the research being conducted in this field is important as it ultimately impacts and informs basic biology, as well as also contributing to a translational importance in human disease. Therefore, this conference will encompass themes of chromatin mechanisms, including DNA and RNA modifications, histone modifications, ATP-dependent nucleosome remodeling complexes, histone variants, chaperones and others, as they intersect with cell identity, cellular and transgenerational memory, with genome function, with nuclear structure, and with biological questions and disease implications. The topics will also encompass newly emerging technologies and computational approaches to study chromatin and nucleosome structure, function and genomic location. This conference is being held jointly with Chromatin Architecture in Development and Human Health, which will focus on 3D genomics. There will be a joint Keynote speaker, as well as joint sessions. By pairing these two conferences together, it is anticipated that there will be a strong interest from researchers and scientists who are working in these fields.

March 19-23, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: David Lagares, Boris Hinz and Carine Boustany

Important Deadlines
Early Registration Deadline: Jan. 19, 2023
Scholarship Deadline: Dec. 29, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 8, 2023
Meeting Summary
# Immunology

Human fibrotic diseases are characterized by progressive tissue scarring in response to overwhelming or chronic injury, ultimately leading to organ failure and death. Fibrotic diseases cause healthcare costs reaching $10 billion per year. These costs are expected to further increase with our aging populations, our increasing capacity to diagnose fibrotic disorders and the emergence of novel infectious agents such as SARS-CoV-2, which can promote the development of fibrosis. Main goal of this meeting will be to identify common and distinct mechanisms driving fibrosis in response to different insults (e.g., viral infection, trauma, oncogenic injury). This conference will also address three emerging questions in the field including: a) mechanisms amplifying and perpetuating tissue fibrosis, such as aging, epigenetics, and mechanobiology, b) the relevance of fibroblast heterogeneity in tissue repair and fibrosis, and c) understanding the mechanisms promoting fibrosis resolution and regeneration to devise novel strategies to truly regenerate fibrotic organs. This forum will also focus on major clinical challenges including the lack of robust fibrosis biomarkers, safety endpoints, and clinical trial endpoints. Advances in these areas will break down barriers in translating anti-fibrotic therapies from bench to bedside. Two additional workshops will also discuss: a) emerging technologies and models to study human fibrosis, and b) fibrosis research funding and academia-industry collaborations. The proposed conference will accelerate fibrosis research and anti-fibrotic drug discovery by fostering interdisciplinary interactions among a diverse group of physicians and scientists from both academic institutions and the pharmaceutical and biotech industry.

April 23-26, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Carla F. Kim, Benjamin D. Singer and Nan Tang

Important Deadlines
Early Registration Deadline: Feb. 23, 2023
Scholarship Deadline: Feb. 6, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 6, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Lung diseases represent leading causes of morbidity and mortality worldwide. Beginning with antenatal development, the lung undergoes changes throughout the life course as a consequence of aging as well as in response to infection and other injurious stimuli. Knowledge gaps exist in how individual cell populations coordinate and respond to these changes in states of health and disease over time. The goals of this Symposium are: 1) to address how specific cell populations contribute to the formation and regeneration of the lung over the life course; 2) to examine metabolism, epigenetics, stress responses, and cell-cell interactions as features that control lung biology and how control mechanisms change over stages of life; 3) to understand how emerging technologies and models will elucidate fundamental mechanisms of lung health and disease; and 4) to articulate how the host immune response to infection determines reparative and regenerative processes. As a result of this meeting, attendees will have a more comprehensive view of dynamic mechanisms that drive pulmonary biology as it relates to health and disease as well as the newest approaches with which to understand these concepts. Through positive interactions, attendees will forge new collaborations in distinct fields of study. Indeed, the unrivaled expertise of the speakers, organized into sessions arranged around diverse topic areas, will create a unique program unavailable via other venues. Ultimately, this Symposium will impact the field of lung biology by bringing together interdisciplinary groups of scientists that will synergize to propel discovery of mechanisms underlying lung health and disease.

February 18-21, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Michail Lionakis, Sarah L. Gaffen and Mari L. Shinohara

Important Deadlines
Early Registration Deadline: Dec. 14, 2023
Scholarship Deadline: Nov. 9, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 9, 2023
Meeting Summary
# Infectious Diseases
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Human pathogenic fungi have emerged as significant causes of morbidity and mortality in patients with acquired immunodeficiency conditions such as HIV/AIDS and receipt of myeloablative chemotherapy and targeted immunosuppressive therapies for autoimmune disorders, neoplastic diseases, and hematopoietic stem cell and solid organ transplantation. In recent years, emerging multidrug resistant Candida auris is responsible for life-threatening outbreaks in healthcare facilities and raises serious concerns to global public health. Furthermore, a recent explosion in the discovery and characterization of novel monogenic inborn errors of immunity that predispose to mucocutaneous and/or invasive tissue-specific fungal disease and the development of clinically relevant animal models of mucocutaneous and invasive fungal infections have collectively enhanced our understanding of cell type-, tissue-, and fungus-specific recognition, effector pathways, and adaptive immune responses. These advances, along with  our improved molecular understanding of fungal virulence traits shows promise for the development of targeted treatment strategies against fungal pathogens.

The goal of this Keystone meeting will be to bring together for the first time scientists who study both fungal virulence and fungal immunology, thus helping to synthesize our current understanding of the cellular and molecular determinants of fungal pathogenesis and mammalian antifungal immunity,. By encouraging cross-disciplinary exchange, conference will advance key priorities of informing precision risk stratification, prophylactic, therapeutic and vaccination strategies to combat life-threatening fungal infections in vulnerable patient populations. This meeting will be held jointly with the Barrier Immunity conference,  to foster interdisciplinary insights and collaborations towards understanding fungal strategies to breach protective barriers, and mechanisms that protect against fungal infection. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 19-23, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Katharina Schlacher, Irene Chiolo and Ralph Scully

Important Deadlines
Early Registration Deadline: Jan. 18, 2023
Scholarship Deadline: Dec. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 28, 2022
Meeting Summary
# Genetics, Genomics and RNA

DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. Reflected in this, genes acting in DNA replication/repair and genome stability are required for disease suppression, and direct therapy responses. Their failure is correlated with genome instability, cancer, neurological defects, developmental delays, aging, metabolic disorders, inflammation and immune responses, and therapeutic drug reactions. Rooting in and extending from the rich history of deep mechanistic understanding of the field, this Keystone conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions in particular with its implications for medical biology, disease and treatment strategies.

February 12-15, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Sean M. Wu, Wolfram H. Zimmermann and Christine E. Seidman

Important Deadlines
Early Registration Deadline: Dec. 13, 2022
Scholarship Deadline: Nov. 10, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 5, 2022
Meeting Summary
# Metabolism and Cardiovascular

Significant advances in recent years in mechanistic understanding of cardiac development, function, and degeneration have stimulated interest in identifying novel therapeutic agents that may help treat children and adult patients with cardiovascular diseases. However, therapies developed in cell and animal models rarely translate well to human patients. The goals of this conference are to advance our understanding of heart formation and homeostatic function and how derangement in these processes lead to diseases and organ dysfunction. Because human cardiovascular tissue is difficult to obtain for experimental perturbation this conference will address the use of a spectrum of cells and engineered tissue models as well as small and large animal models of disease. We anticipate that bringing together scientists with diverse research backgrounds who employ different tools and technologies to address mechanisms of cardiomyocyte and vascular dysfunction will result in new approaches to uncovering cardiovascular biology. Presentations will showcase innovative, molecularly targeted, strategies to treat both rare and common cardiovascular diseases.

June 25-28, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Merry L. Lindsey, Crystal Ripplinger and Zamaneh Kassiri

Important Deadlines
Early Registration Deadline: Apr. 25, 2023
Scholarship Deadline: Apr. 19, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Apr. 19, 2023
Meeting Summary
# Metabolism and Cardiovascular
Heart failure (HF) has conventionally been defined as the inability of the heart to pump sufficiently to meet the needs of the body for oxygen. In addition to HF with reduced ejection fraction (HFrEF), nearly half of patients who present with HF signs and symptoms have preserved ejection fraction (HFpEF). HFrEF presentation includes reduced contractile function and dilation of the left ventricle (LV), while HFpEF presentation includes abnormal LV relaxation and diastolic stiffness. Both HF types have similar hospitalization, morbidity, and mortality rates, and medications that improve outcomes for patients with HFrEF do not show similar benefit to patients with HFpEF. Understanding the cell signaling pathways and molecular mechanisms that trigger HF is a major challenge in cardiovascular medicine. Our conference is conceptually framed around the hypothesis that while HFrEF and HFpEF clearly have distinct etiologies and driving mechanisms, they may share modifiable pathways and biological mediators in common. The convergence among cells involved in inflammation and extracellular matrix deposition will be a major theme. The meeting program includes specific focus on cell heterogeneity, cell-cell cross-talk, individual cell responses, cardiac interactions with other organs, cardiometabolic aspects of all cell types, and approaches to identify new pharma targets. Scientific Relevance: There is a strong need to better understand the cellular and molecular mechanisms of heart failure development. Gaps: 1. Clarify concepts of cardiac remodeling, inflammation, fibrosis, and cell heterogeneity. 2. Develop standard procedures for rigorous assessments. 3. Examine exacerbation of HF development in the setting of co-morbidities. 4. Harness knowledge from other research arenas to develop new strategies to combat HF. 5. Define the use of animal models for optimal use in HF research. 6. Define phenotypes that distinguish subtypes of heart failure (HF): HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Specific Aims: 1. to disseminate and share new knowledge about heart failure, focused on cell and molecular signaling that yields HF; 2. to focus on controversies and knowledge gaps that prevent or limit therapeutic translation; and 3. to promote the educational growth and careers of young scientists. Anticipated outcomes: 1. Attendees will leave this meeting with clear ideas on the most critical experiments needed to accelerate the field forward. 2. There will be a better understanding of the methods that can be applied to better translate basic science to clinical use. 3. Trainees will understand how to advance their careers in the heart failure field. 4. Scientific knowledge and clinical practice will be advanced in that we will have a comprehensive evaluation of the current state of understanding of heart failure and better understand the challenges that remain before we can more completely translate the dynamics of cellular interactions in heart failure. Innovation: We know of no other conference that focuses on the cellular components of heart failure. We will challenge current concepts and fill in the knowledge gaps to help propel the field forward. Bringing together interdisciplinary groups of investigators will ample provide opportunity for cross-fertilization. In particular, we will use approaches in proteomics and big data science to seek paradigm shifts in research strategies.

February 25-28, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Trista E. North, Michael G. Kharas and Nina Cabezas-Wallscheid

Important Deadlines
Early Registration Deadline: Dec. 19, 2023
Scholarship Deadline: Nov. 29, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 29, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative
The deadline to submit an abstract for short talk and poster presentation consideration has passed.   For any questions or issues, please email info@keystonesymposia.org.

Research in the Hematology field has seen explosive growth within the last decade. It has been at the forefront of major revolutions in our understanding of stem cell biology, and the origins and treatment of disease, including advances in genome engineering, insights into the function of the non-coding transcriptome and epigenome, and next-generation sequencing for cancer diagnosis. Further, hematological cells have served as a testing ground for technological advancements such as therapeutic genome engineering and next-generation sequencing efforts for cancer diagnosis. Importantly, development of targeted small molecule therapeutics and the introduction of immune-based (cell) therapies have shown direct clinical benefits, whereas the global pandemic has highlighted the critical need to understand the impact of inflammatory stresses on hematopoietic cell fate.

The mission of the Keystone Symposium on “Hematopoiesis” is to bring together biochemists, geneticists, molecular biologists and clinicians to bridge recent insights into the basic principles and biological mechanisms that control developmental hematopoiesis, hematopoietic stem cell biology, cell fate control with the diagnosis, progression and treatment of aging and inflammatory conditions, and hematologic disorders and malignancies. This conference will highlight innovations in emerging technologies, including single cell multiomics and imaging approaches, which are poised to fundamentally change our understanding in blood development and homeostasis. The program will also feature emerging discoveries, such as insights into the role of clonal hematopoiesis that predisposes individuals to hematopoietic disease and leukemic transformation, and the promising potential to manipulate cells for therapeutic intervention. Finally, the event will provide a platform for investigators from across disciplines and around the globe to establish productive collaborations and stimulate new ideas to enable substantial progress and address ongoing challenges in the hematology field. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 6-10, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Hanneke Schuitemaker, Steven G. Deeks and Dennis R. Burton

Important Deadlines
Early Registration Deadline: Apr. 6, 2023
Scholarship Deadline: Mar. 21, 2023
Global Health Award Deadline: Jan. 31, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Mar. 21, 2023
Meeting Summary
# Infectious Diseases

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Despite the availability of effective treatment and prevention strategies, the HIV pandemic continues, with approximately 1.7 million new infections annually. More effective prevention strategies are needed. The goal of this meeting is to assemble experts on the biology of HIV transmission and emerging prevention methods - including vaccines and PrEP - to discuss the current state-of-the-art in HIV prevention. Specific topics of discussion will include (2) germline vaccination strategies, (2) updates on the vaccine and PrEP efficacy studies, (3) challenges and opportunities of developing novel strategies in an era of increasingly effective prevention methods, particularly long-acting PrEP (cabotegravir) and the dapivirine ring, and (4) next generation vaccine and PrEP approaches. The role that HIV prevention resources and advances have had on the COVID-19 prevention and HIV cure research agendas will also be discussed, with the hope that these three largely complementary areas of investigation will remain highly synergistic.

May 28-31, 2023 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Sonia Rocha, Edurne Berra and M. Celeste Simon

Important Deadlines
Early Registration Deadline: Mar. 28, 2023
Scholarship Deadline: Mar. 13, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Mar. 13, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

Oxygen is essential for life, as such, mechanisms involving sensing and responding to changes in oxygen availability have evolved to allow for organisms to withstand these events. Such adaptive mechanisms act across a multitude of scales and timelines, from changes in atomic structure, through large changes in organisms' function. Hypoxia plays a role in a variety of development processes but also participates, and sometimes, contributes to numerous human pathologies. This area of research thus involves a variety of disciplines, from basic discovery science, through to more applied ones such as medicine and drug discovery, highlighting its breath and importance. The Keystone Symposia conference on hypoxia research is the main home for all hypoxia related research. This meeting aims to bring together all disciplines and research areas involved in hypoxia. We hope to address gaps in our knowledge of responses to changes in oxygen availability; highlight new techniques and reagents to enhance therapeutic targeting of the hypoxic response in general; inform on novel systems where hypoxia research can be conducted to reveal novel mechanisms; and understand how therapeutic targeting of this pathway can allow for better clinical outcome in a variety of diseases. We hope that by sharing knowledge, enhancing collaborations, and training participants from diverse backgrounds, we will improve our knowledge and applications to improve life.

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Danica Chen, Sun Hur and Joan Mannick

Important Deadlines
Early Registration Deadline: Aug. 1, 2023
Scholarship Deadline: Jun. 28, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 28, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
# Immunology

Aging is the single largest risk factor for a wide spectrum of chronic diseases and mortality. An outstanding question in biology is how we lose the ability to maintain homeostasis and become susceptible to diseases and mortality. What has emerged from groundbreaking research over the past decade is that the decline in function of aging organ systems is caused by a discreet number of biological mechanisms, of which immune  dysfunction is a large contributor. Dysfunction of the aging immune system results in suboptimal immune responses to vaccines and infectious diseases in older adults as has been highlighted by the COVID-19 pandemic. Mechanistically, recent single cell sequencing studies suggest that one mechanism contributing to dysfunction of the aging immune system is a widespread basal activation of immune cells across tissues.

This Keystone Symposia conference will provide a venue for researchers from around the world to address recent discoveries and understand how the immune system becomes dysregulated during the aging process and impinges upon tissue functions, organismal healthspan and survival. Questions to be addressed include:

1) How does aging of hematopoietic stem cells contribute to dysfunction of the aging immune system and impact distant tissues?

2) How do changes in innate and adaptive immune function with age compromise immunity?

3) What are the origins of aging-associated inflammation and how does inflammation impact tissue functions, and contribute to aging-related conditions?

4) Are aging-associated changes in the immune system reversible? 5) What are the clinical implications and therapeutic potential for targeting the aging immune system as a new way to treat aging-related diseases and decrease mortality?

To address these questions, the symposium will gather investigators from various fields including biology of aging, immunology, hematopoietic stem cells and hematopoiesis, neurology, and metabolic biology.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 18-21, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Luke A. J. O'Neill, Evanna Mills and Erika L. Pearce

Important Deadlines
Early Registration Deadline: Jan. 17, 2024
Scholarship Deadline: Dec. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 7, 2023
Meeting Summary
# Immunology
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Over the last decade, there has been a resurgence of interest in metabolic pathways in immune cells, with the realization that complex alterations in metabolic processes during immune cell activation link directly to their differentiation and function. As such, correct metabolic re-wiring is beneficial and is a requirement for an appropriate immune response, whilst aberrant metabolic reprogramming can lead to an inappropriate response and have implications for a wide variety of disease states. This meeting will bring together researchers who have a common interest in understanding how metabolism impacts immunity, infection, inflammation and cancer.  Speakers will reflect diverse interests, fresh perspectives and new topics, assembling a collection of experts and new voices that do not commonly attend the same meetings, which will invigorate debate, collaboration and new ideas.

This will be a unique conference covering a collection of  topics from the fundamentals of immunometabolism, which are still being uncovered, to how these fundamentals apply to various disease states, notably in infection, inflammation, obesity and cancer. Topics will reflect excitement emerging directions in the field and innovative recent findings that will stimulate much discussion, including:

1) new techniques to address immunometabolism in vitro and in vivo where there is a pressing need in the field;
2) how microbes contend with immunometabolic changes both in the microbiota and during infection;
3) new findings on macrophage metabolism particularly around newer metabolites that continue to be explored;
4) how mitochondrial metabolism links to changes in other organelles, especially the nucleus;
5) how the metabolic environment in tumors is critical for anti-tumor immunity and finally the translational potential for immunometabolism in immune and inflammatory diseases.

A key overall goal will be to gain a more integrated understanding of how immunometabolism impacts on health and disease, with the aim of stimulating new and unexpected approaches to address key questions in this most exciting aspect of immunology.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

December 5-7, 2022 | Virtual at Your Computer
Scientific Organizers: Dusan Bogunovic, Isabelle Meyts and Steven M. Holland

Important Deadlines
Early Registration Deadline:
Scholarship Deadline: Nov. 24, 2022
Global Health Award Deadline: Nov. 24, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 24, 2022
Meeting Summary
# Immunology
Inborn errors of immunity (IEIs) are a growing group of over 400 genetic disorders in which individuals present with immune deficiency, immune dysregulation, or both. IEIs combine genomics, next generation transcriptomics and epigenomics, biochemistry, as well as innate and adaptive immunology research, with diverse aspects of clinical medicine ranging from clinical genetics and immunology to metabolism, neurology and dermatology, to name only a few. Bridging these canonically isolated fields into a coherent collaborative scientific enterprise is both essential and a challenge. The conference is focused on showcasing the genetic errors of the immune system affecting both the innate and adaptive branches. Moreover, it will greatly evolve this emerging field by identifying, studying and crosspollinating studies which discuss both pro- and anti- inflammatory and infectious immune effectors. Finally, this program will also address knowledge gaps in pathways that regulate these immune effectors and suggest rational approaches to target these in patients.

January 22-25, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Helen M. Lazear, Carolyn B. Coyne and David M. Aronoff

Important Deadlines
Early Registration Deadline: Nov. 21, 2022
Scholarship Deadline: Oct. 20, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 4, 2022
Meeting Summary
# Infectious Diseases

The placenta generally provides a robust barrier to the fetal compartment and relatively few microbes are able to surmount this and other defenses at the maternal-fetal interface to cause congenital infections. Nonetheless, congenital pathogens including human cytomegalovirus, Zika virus, Toxoplasma gondii, and group B streptococcus can cause fetal loss, growth restriction, birth defects, and developmental delays. In addition to pathogenic effects on the fetus and neonate, infections during pregnancy can have distinct impacts on maternal health, owing to the physiologic and immunologic effects of pregnancy. There is a need to better understand the pathogenic mechanisms of congenital infections and immune defenses at the maternal-fetal interface,as well as to develop improved vaccine, treatment, and diagnostic strategies to combat congenital infections. But in many cases these infections can be difficult to study due to limitations in experimental systems and challenges in designing studies with human patients. This symposium will bring together researchers investigating infections in pregnancy from a range of perspectives including basic biology, pathogenesis models, clinical studies, and patient care. Goals of this Keystone Symposium are: i) Highlight new advances in understanding the pathogenic mechanisms of congenital infections. ii) Share new developments in experimental systems for studying congenital infections, as well as new developments in vaccines, therapeutics, and diagnostics. iii) Consider the effects of infections during pregnancy on maternal health, as well as on fetal, infant, and child health. iv) Provide an opportunity for researchers from diverse backgrounds to exchange ideas and develop new collaborations to promote future research on infections during pregnancy.

April 23-26, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Andreas Wack, Cecilia Johansson and Ivan Zanoni

Important Deadlines
Early Registration Deadline: Feb. 23, 2023
Scholarship Deadline: Feb. 6, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 6, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative
# Immunology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Recent and preceding pandemics and epidemics have dramatically shown the capacity of respiratory virus infections to impact public health and bring society to a standstill. Inflammation takes centre stage as it is an important part of the anti-viral response and also sets up subsequent adaptive immune responses and repair, but potentially increases tissue damage and impairs or delays tissue regeneration. The goals of this meeting are: 1) To understand better how inflammation enhances or impedes tissue repair and regeneration; 2) to identify immune mediators that tip the balance between immunopathology and protection and to understand underlying mechanisms; 3) to discuss the role of innate immune cells in driving the inflammatory response and initiating adaptive immunity; 4) to investigate how the crosstalk between immune and nonimmune cells in the lung affects disease outcome; 5) to highlight new avenues and novel targets for treatment of viral infections. Bringing together experts in the host response to viral infections with scientists working on lung development, repair and regeneration will generate synergies that are not normally achieved in single specialised meetings. Coordination with the parallel meeting “From First Breath: Lung Development, Infection, Repair and Aging” will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. Cross-disciplinary interaction will help foster collaborations and develop new angles of treatment of diseases caused by lung infections.

April 16-19, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Hao Wu, Russell E. Vance and Andrea Ablasser

Important Deadlines
Early Registration Deadline: Feb. 16, 2023
Scholarship Deadline: Jan. 12, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 12, 2023
Meeting Summary
# Immunology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Living things in all domains of life have evolved innate immune systems to protect against diverse infectious agents and maintain homeostasis. We still lack a fundamental understanding on how the innate immune system is activated to elicit protective responses, and how it can also overreact to certain insults to harm self. This Keystone meeting aspires to bring together those interested in innate immunity in all its diverse forms. We seek insights into the diversity of innate immune mechanisms, the deep evolutionary origins of innate immunity, the important roles of innate immunity in human disease, and its indispensable function in shaping adaptive immune responses to infections and cancer. The sessions will span those working at multiple levels, from molecular structures to cellular interactions, and to organismal biology and human pathology. We expect cross-disciplinary interactions to fertilize novel insights into the innate immune system, from innate sensing to adaptive responses. This conference will be jointly held with the Vaccinology Keystone meeting. Since the innate immune system is the source of key signals required for vaccines to elicit adaptive responses, we anticipate the two meetings will be highly synergistic.

August 27-30, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Steven G. Deeks, Michael J. Holtzman, Resia Pretorius and Catherine A. Blish

Important Deadlines
Early Registration Deadline: Jun. 27, 2023
Scholarship Deadline: May. 24, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: May. 24, 2023
Meeting Summary
# Infectious Diseases

Many infections, including SARS-CoV-2, cause an acute illness that eventually resolves, with or without injury to host tissues.  However, in some people, the acute infection triggers a chronic disease that is systemic, persistent (months to years) and, for some, profoundly disabling.  Moreover, the proportion of those who have recovered from acute infection but then begin to develop chronic symptoms (aka, Long COVID), or some other major complication such heart disease, stroke, or diabetes mellitus (collectively referred to as the Post-acute Sequelae of SARS-CoV-2, or PASC) is about 50% of this population, depending on how PASC is defined.  

Therefore, this Keystone Symposia conference aims to understand the progression from acute illness to chronic disease as well as address long COVID and PASC, for the first time, with mechanism-based therapeutic strategies.  The conference is designed to be multidisciplinary in nature and will have representation from distinct scientific, technological, and clinical perspectives with geographical, academic, and commercial sector diversity.   It is anticipated that this broad set of perspectives will help to foster interactions leading to synergistic solutions to an unprecedented health care problem. 

Organizer, and Professor of Medicine in Residence at the University of California, San Francisco, Steven G. Deeks, talks about why you should attend this meeting in the video below:

Dr. Steven Deeks talks about Keystone Symposia

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 22-25, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Rachel Freathy, Louis J. Muglia, Amanda N. Sferruzzi-Perri and Annettee Nakimuli

Important Deadlines
Early Registration Deadline: Nov. 21, 2022
Scholarship Deadline: Oct. 20, 2022
Global Health Award Deadline: Oct. 20, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 4, 2022
Meeting Summary
# Developmental, Reproductive and Regenerative
# Immunology

Recent advances in data acquisition have occurred on an unprecedented scale across the globe. We can now sequence the genome, or assay the human transcriptome or metabolome at relatively low cost. Rich, multidimensional data resources are accumulating in large population biobanks linked to electronic health records. Such resources hold the promise of solving previously intractable questions and offer great potential to understand the biology of healthy pregnancy and of adverse pregnancy outcomes, with the ultimate aim of improving outcomes for all women and babies. To date, these resources have made it very easy to generate associations, e.g. between genetic, nutritional or microbial factors and pregnancy outcomes. However, separating mere associations from key causal mechanisms and pathways remains challenging. By bringing together researchers and clinicians from a range of disciplines to share their methodologies and approaches, this Keystone meeting will be poised to capitalize on the growing body of data, to truly understand mechanisms that will be crucial to maternal-fetal biology and medicine. With its diverse organizing committee, and by holding joint sessions with the 'Infections in Pregnancy' meeting, this meeting will bring together groups of investigators, who would not normally have an opportunity to meet. This will catalyze new ideas for future collaborations and research directions. Goals of this keystone meeting are to: (i) highlight research that is moving the field from association to mechanism, especially in the light of growing data availability (ii) catalyze opportunities for sharing of expertise and experience from multiple approaches and disciplines (iii) enable junior researchers to present and engage with the full range of attendees and participate in discussions

October 8-11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Jorge Henao-Mejia, Eran Elinav and Lora V. Hooper

Important Deadlines
Early Registration Deadline: Aug. 8, 2023
Scholarship Deadline: Jul. 6, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jul. 6, 2023
Meeting Summary
# Immunology
# Metabolism and Cardiovascular
# Microbiota and Flora
Interactions between the host microbiota and the immune system play critical roles in protective immune responses against pathogens and determine the efficacy of vaccines and immunotherapies, which vary at different stages of life. Moreover, in mammals, alterations in the composition of host microbiota significantly contribute to chronic inflammatory processes, impacting most tissues throughout the organism. However, the mechanisms by which microbiota regulate the immune system in various tissues to impact health and disease at different life stages remains largely undetermined.

This Keystone Symposia conference will bring together leading experts in the field who are developing novel approaches in genomics, metagenomics, metabolomics and imaging technologies to establish the mechanisms by which specific components of the microbiota regulate immune responses in different tissue contexts. In addition, this conference is being held jointly with the Keystone Symposia conference on Circulating Metabolic Intermediates as Fuels and Signals. The joint pairing will foster new scientific collaborations and the implementation of new technological approaches to understand the intersection of metabolic, microbial and immune interactions as it relates to human health and disease.    

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 19-23, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: James Trevaskis, Jacquelyn Maher and Quentin M. Anstee

Important Deadlines
Early Registration Deadline: Jan. 19, 2023
Scholarship Deadline: Dec. 29, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 29, 2022
Meeting Summary
# Metabolism and Cardiovascular

Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) represents the hepatic manifestation of the Metabolic Syndrome and is emerging as a key driver of morbidity and mortality, particularly when present in the context of severe liver fibrosis. The histological hallmarks of NASH including steatosis, lobular inflammation and hepatocyte ballooning are well-characterized, however while it is widely recognized that NASH is a progressive disease, the pathogenic and molecular mechanism/s that initiate and drive NASH remain largely unknown. The primary purpose of this meeting is to bring together a broad group of scientific and clinical researchers to highlight and discuss the current evidence exploring the key biological processes involved in NASH and liver fibrosis. Insulin resistance, hepatocyte lipid management/lipotoxicity and inflammation in the context of steatosis and NASH will be reviewed. Advances in our understanding of the molecular and genetic regulation of NAFLD/NASH and the progression to liver fibrosis will also be highlighted. Finally, as NASH is an unmet medical need, we will integrate the earlier fundamental biology discussion with updates on clinical progress of therapeutic agents, and combinations of agents, for the treatment of NASH and liver fibrosis. The parallel joint meeting with one focused on key cellular drivers and mediators of fibrosis in organs beyond the liver allows for cross-functional discussion and deeper understanding of pathobiology of fibrotic disease.

May 7-10, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Joan Massagué, Sean J. Morrison and Caroline Dive

Important Deadlines
Early Registration Deadline: Mar. 7, 2023
Scholarship Deadline: Feb. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 7, 2023
Meeting Summary
# Cancer
# Immunology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Most cancer deaths are caused by distant metastasis. Yet the mechanisms that regulate distant metastasis are poorly understood. Metastasis is a very inefficient process in which few disseminated cancer cells survive, and even fewer proliferate, but little is known about why. The meeting will address the nature of metastasis initiating cells as well as their phenotypic plasticity, genetic and epigenetic evolution. Speakers will address the characterization of circulating cancer cells and how recent advances in imaging and DNA analysis are assisting the clinical management of metastasis. They will discuss why cancer cells sometimes go dormant after metastasis. Finally, they will discuss the metabolic regulation of metastasis and how the metabolic environment influences the survival of cancer cells during metastasis.

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Heidi M. McBride and Timothy Wai

Important Deadlines
Early Registration Deadline: Dec. 13, 2023
Scholarship Deadline: Nov. 8, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 8, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
Mitochondria play complex roles in cellular physiology and homeostasis that have profound impacts on human health and disease. Fundamental insights have been gained from cell biology approaches that led to a deeper understanding of mitochondria as signaling platforms and metabolic engines that drive changes in cell fate. The challenge has been to understand these roles in a holistic and inclusive way, a task that often requires multidisciplinary and the development of new technologies to bridge gaps in the field.

The primary goal of this symposium is to highlight exiting new areas of mitochondrial research, focused on:

1) aspects of mitochondrial dynamics and quality control,
2) mitochondrial contributions to metabolic rewiring in cell fate decisions,
3) links between mitochondria and immunity with intriguing new discoveries of mitochondrial transfer between cells.

The program will focus on the impact and mechanisms of mitochondrial behavior in a variety of contexts including cancer metabolism, inflammation, neurodegenerative disease and metabolic disorders led by established and emerging experts in the field. Understanding how mitochondria relay intracellular signals in the control of cell fate changes and within homeostasis remains a major challenge. As much of this signaling involves contact sites with other organelles, this conference will be held jointly with another Keystone Symposia meeting entitled, Organelle Membrane Contact Sites in Health and Disease.  The joint conferences will examine metabolic flux in the broadest context. Interactions between scientists at all levels will provide new opportunities for collaboration as research moves to integrate findings into a deeper understanding of mitochondrial contributions to health and disease. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 26-29, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Vamsi K. Mootha and Dan Gottschling

Important Deadlines
Early Registration Deadline: Jan. 25, 2023
Scholarship Deadline: Jan. 16, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 16, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

Mitochondrial dysfunction is associated with conditions ranging from severe, inborn errors of metabolism to the very aging process itself. Inherited mitochondrial diseases are rare and tend to be associated with severe defects in the organelle, while aging and age-associated degeneration is universal and tends to be associated with a more subtle, quantitative decline in mitochondrial function. This Keystone conference will address key questions surrounding mitochondrial pathogenesis. Talks will explore the underlying mechanisms and their specificity, looking at whether therapies developed for orphan diseases can be used to treat age associated disorders and vice versa. By bringing together established and emerging rare mitochondrial disease and aging researchers this conference will explore mechanisms of mitochondrial dysfunction across a vast continuum. The ensuing cross-fertilization is expected to result in the synthesis of new testable hypotheses that will help to drive the entire field forward.

March 26-29, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Amy J. Wagers, Saul A. Villeda and Salvador Aznar Benitah

Important Deadlines
Early Registration Deadline: Jan. 25, 2023
Scholarship Deadline: Jan. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 30, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

This meeting will explore the biological mechanisms that regulate trajectories of aging and enhance organismal resilience. Speakers will share lessons learned from multiple organ systems, organisms, and experimental model systems, with a broad scope spanning molecular to systems approaches. Emphasis will be placed on recent technological and conceptual innovations and translational opportunities that have opened new frontiers in the effort to protect health during aging. Particular topics of focus will include discussion of accelerated trajectories of aging as a result of stress, disease, genetic, epigenetic and external (sleep, nutrition, light and other pollution) influences, unique opportunities created by Machine Learning and Artificial Intelligence for meta-analyses of aging trajectories and biomarkers, and novel therapeutic approaches including gene therapies, senolytic, senomorphic and immune modulating drugs, and cellular replacement therapies. Although the research areas covered in this meeting touch on several cross-cutting themes, many of the invited speakers and anticipated attendees do not typically interact, attending instead more narrow, organ- or cell type-specific conferences limited to consideration of the intersection with aging biology of just one of the focus areas proposed for inclusion in our conference (e.g., Aging and Regeneration, or Immunosenescence, or Neurodegeneration and Aging, or Gerontology). In this regard, our proposed conference will offer much greater opportunities for cross-fertilization of ideas and catalysis of novel research directions and collaborations than other aging-related meetings). In assembling the draft program, we also paid particular attention to ensuring representation of a diverse spectrum of researchers, in terms of primary discipline, experimental approach, education and training, geography and institutional affiliation, ethnicity, gender and career stage. We anticipate that the diversity of our roster of speakers, together with the intimate format of the Keystone Symposium, will provide a highly conducive atmosphere for the open, active and interdisciplinary exchange of ideas, as well as crucial opportunities for more junior scientists to receive mentorship and professional feedback and advice. Specific Aims of the meeting include: 1. To disseminate and discuss new information and novel concepts relevant to aging and resilience. 2. To develop integrative models of aging physiology and identify promising opportunities for advancing geroprotective therapies. 3. To catalyze new, interdisciplinary collaborations and novel lines of scientific investigation, based on cross-cutting interests and technological synergies. 4. To support the career development of early stage investigators, particularly those from demographic groups historically underrepresented in biological sciences.

February 19-22, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Pablo Umaña, Daniel S. Chen and Marion Subklewe

Important Deadlines
Early Registration Deadline: Dec. 15, 2022
Scholarship Deadline: Nov. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 28, 2022
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Technologies

The last decade has seen significant growth in the pre- and clinical development of synthetic immunotherapies of cancer using bi-/multi-specific immune cell engaging molecules. This meeting will focus on the latest developments in the field, on emerging biological understanding of the mechanism of action of immune cell engagers and of mechanisms of primary and secondary resistance. Researchers from academia and industry will cover novel technologies and approaches to enhance safety, efficacy and tumor specificity, including addressing resistance, adding synergistic immune cell agonism, engaging alternative immune cells, novel molecular formats, conditional tumor activation and generation of adaptive responses.

April 16-19, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Gwendalyn J. Randolph, Minsoo Kim, Roxane Tussiwand and Muzlifah A. Haniffa

Important Deadlines
Early Registration Deadline: Feb. 16, 2023
Scholarship Deadline: Jan. 12, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 12, 2023
Meeting Summary
# Immunology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here/span> to submit.  For any questions or issues, please email info@keystonesymposia.org.


It is increasingly appreciated that myeloid cells participate critically in a variety of physiological and pathophysiological processes and that targeting myeloid cells, either at the stage of their development or as they mature, may be successfully harnessed in the treatment of cancers or infectious disease. The application of a fast-growing omics technologies are being applied by the field to aid in our quest to increase understanding of myeloid cell diversity and the potential of targeting them therapeutically. At the same time, fundamental questions about myeloid cell identity and function remain unknown. This conference will address these frontiers as it aims to attract speakers and attendees across the full breadth of the field. Key talks will be included to focus on the application of new technologies in the field, the advances they bring, best-practice application, and potential complications in analysis. Significant focus will also be given to the role of myeloid cells in cancer and metastasis, including the fast-growing area of how neutrophils aid tumor metastasis. Basic science that covers myeloid cell development and function will be interspersed with talks on the role of myeloid cells in disease states. In the last decades, the number of outstanding scientists in the field has grown tremendously, and the meeting will showcase this growth through inclusion of many new faces in the field.

January 28-31, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Andrés Hidalgo, Daniela F. Quail and Lai Guan Ng

Important Deadlines
Early Registration Deadline: Nov. 28, 2023
Scholarship Deadline: Oct. 24, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 24, 2023
Meeting Summary
# Immunology

Understanding the fundamental mechanisms governing myeloid biology in steady-state and inflammatory contexts is imperative to developing treatments to combat cancer, cardiovascular disease, neurodegeneration and other diseases. With the rising use of single cell technologies, the vast extent of myeloid diversity and heterogeneity is being unveiled for the first time, exposing new knowledge gaps in our fundamental understanding of myeloid development and function.

This Keystone Symposia meeting will explore transformative research concepts that challenge current views of myeloid biology. The central goals of this meeting are to:

(1) leverage cutting-edge imaging technologies to link spatial niches with myeloid education and function;

(2) dissect the developmental and genetic drivers of myeloid cell function in the bone marrow in steady-state, inflammation and aging;

(3) challenge current concepts of how we define myeloid cell subsets versus functional states;

(4) present advances on how metabolism and lifestyle are potent regulators of myeloid biology in various physiologic contexts.

Attendees will learn about new tools and resources that are available to study the diversity of myeloid cells in various experimental contexts and will be challenged to rethink existing dogma that underestimates the breadth of myeloid identities in health and disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 6-9, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Miriam Merad and Matthew F. Krummel

Important Deadlines
Early Registration Deadline: Mar. 6, 2024
Scholarship Deadline: Jan. 31, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 31, 2024
Meeting Summary
# Cancer
# Immunology
The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

While most successful clinical cancer immunotherapy strategies target T cell effector function, there is clear evidence that tumor-associated myeloid cells play a key role in the modulation of tumor growth and tumor immunity, but also tumor response to treatment. Yet targeting tumor-associated myeloid cells has proven difficult and there is a paucity of myeloid drug targets used in clinical oncology. This meeting will focus on myeloid cells with or without antigen presenting cell (APC) function, including dendritic cells, macrophages and monocyte-derived cells which have both the ability to shape the immune microenvironment of tumor lesions and instruct T cell effector and regulatory programs. The  program will highlight the diversity of the tumor-associated APC compartment and describe its cellular and molecular composition and spatial distribution in tumor lesions. We will discuss some of the most promising technology to unravel the diversity of these APC programs as well as the functional contributions of specific APC to cancer progression and response to treatment. Importantly, Finally, this conference will integrate efforts from across academia and industry in order to establish strategies for the development of novel myeloid cell targeted therapies for the clinical treatment of cancer.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 3-6, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Stefano Romeo, Michael Charlton, Silvia C. Sookoian and Gregory Tesz

Important Deadlines
Early Registration Deadline: Jan. 4, 2024
Scholarship Deadline: Nov. 28, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 14, 2023
Meeting Summary
# Metabolism and Cardiovascular

The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Fatty liver disease (FLD) comprises a spectrum of conditions in which excess in liver fat coexists with inflammation, fibrosis and increased risk of cancer. The incidence and prevalence of FLD is increasing rapidly, affecting  approximately one in four people globally, with concurrent increases in liver related morbidity and mortality.  Despite more than a decade of research from academia and industry, clinical trials have failed to bring effective treatments for FLD with fibrosis. The complex and variable interactions between environmental and genetic susceptibility and protective factors have played central roles.  Assessing severity of disease and response to therapy have been similarly challenging. 

This meeting will dive into FLD metabolic, genetic and molecular diversity to identify novel strategies to tackle this disease. The program will examine the latest advances in noninvasive measurements to both assess treatment efficacy and identify subpopulations at risk for liver related events and mortality. Sessions will explore novel drug targets deriving from human genetics studies of variants protective against FLD. Ultimately, these advances will pave the way to precision therapeutics to treat MASH, fibrosis and cancer.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 15-19, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Li-Huei Tsai, Aaron D. Gitler and Azad Bonni

Important Deadlines
Early Registration Deadline: Mar. 15, 2023
Scholarship Deadline: Feb. 15, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 15, 2023
Meeting Summary
# Neurobiology

The aging of world societies has brought with it an increased burden of neurodegenerative disease. Age-related neurological disorders have proven relatively resistant to intervention, however, recent expansion and refinement of various -omics technologies has resulted in the identification of novel genetic risk loci and key biological hubs mediating neurodegeneration. Genome editing and induced pluripotent stem cell technologies have also revolutionized disease modeling in human cells. These approaches have resulted in a growing appreciation that disruptions in metabolism, neuroimmune interactions and neurovascular coupling, among other mechanisms, are critical players in degenerative disease. Further, advancements in biomarker identification are allowing both for earlier diagnosis of disease and for more targeted treatments. Equally important, a number of novel concepts provide great hope for effective therapeutic interventions. We bring together leaders from all of these areas, with diverse ideas, expertise and experience, to push forward the common goal of understanding the molecular, cellular and circuit level etiologies underlying neurodegenerative disease, and to facilitate effective treatment of such disorders.

June 3-6, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Leonard Petrucelli, Stacie Weninger and Soyon Hong

Important Deadlines
Early Registration Deadline: Apr. 3, 2024
Scholarship Deadline: Feb. 28, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 28, 2024
Meeting Summary
# Neurobiology

The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

As the population ages, the incidence of neurodegenerative diseases is increasing, thus creating a major public health problem given the virtual lack of effective treatments for these complex diseases. Fortunately, new technological advances impacting basic science, genetics and translational research are enabling the discovery of novel risk genes and disease pathways, and the development and testing of potential therapeutics. Indeed, modern genomic, epigenomic and biological tools including gene editing, spatial transcriptomics, single molecule fluorescence, viral vector engineering, and organoid development have greatly contributed to discoveries revealing the importance of immune mechanisms, RNA metabolism, and lysosomal biology in neurodegenerative disease pathogenesis.

This conference will bring together leaders in basic, clinical and translational research to discuss their latest findings and novel concepts on these topics. In addition, the program will highlight new and emerging models, tools and technologies allowing a more comprehensive understanding of neurodegenerative diseases. Finally, the pairing of this conference with the Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease conference will foster interdisciplinary insights and collaborations towards identifying immune pathology and therapeutic targets for multiple neurodegenerative disorders, where promising new treatments are emerging.   

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 29-1, 2023 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Sarah A. Tishkoff and Joshua M. Akey

Important Deadlines
Early Registration Deadline: Mar. 29, 2023
Scholarship Deadline: Mar. 13, 2023
Global Health Award Deadline: Feb. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Apr. 11, 2023
Meeting Summary
# Genetics, Genomics and RNA
This meeting will shed light on the latest innovations in the field of Human Evolutionary Genomics which has broad implications across diverse fields including Anthropology, Evolutionary Biology, Genomics, and Biomedicine. The goals of the meeting are to: (1) bring together interdisciplinary researchers to address critical questions about genomic diversity, human origins, recent population histories, and the genetic basis of adaptation to diverse environments, (2) highlight the importance and challenges of including minority and indigenous populations in human genomics research, and (3) develop interdisciplinary approaches for using ancient DNA to reconstruct human history. The anticipated outcomes will be to: (1) Facilitate novel collaborative efforts among researchers who may not normally have an opportunity to interact, (2) Develop a set of standards based on ethical approaches for research on indigenous populations and ancient DNA from global populations, and (3) Determine novel approaches for identifying and characterizing functionally important variation in the human genome and the role of gene regulation in shaping human phenotypic diversity. This meeting will bring together researchers with expertise in computational biology, anthropology, evolutionary biology, functional genomics, and bioethics to address fundamental questions about human evolutionary history. These individuals would typically attend meetings in their own scientific specialties; thus, this meeting will play a critical role in fostering novel interdisciplinary approaches for solving complex problems about human evolutionary history. We will discuss novel methods for identifying ancient introgression in modern human genomes, reconstructing ancient phenotypes, identifying how gene regulation has shaped adaptive traits, and reconstructing complex demographic histories.

February 19-22, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Pamela M. Holland and James A. Wells

Important Deadlines
Early Registration Deadline: Dec. 15, 2022
Scholarship Deadline: Nov. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 28, 2022
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology
Therapeutic antibodies have become the predominant class of new drugs gaining FDA and have positively impacted the most patients for treating various human diseases, including cancer, autoimmune, and infectious diseases. Over the past 30 years, major technological advances have facilitated the discovery and development of monoclonal antibody therapies, and new strategies are continually emerging to enhance their clinical potential. Though substantial progress has been made, new opportunities and challenges continue to evolve in this rapidly moving field. Multiple advances in antibody technology to expand antibody attributes have already translated into improved clinical activity in multiple therapeutic areas. Yet they also unveil major challenges with respect to target validation, MOA, protein design, development time, and managing increasing costs of antibody manufacturing. The aim of this conference will be to provide a diverse program comprised of academic and industry scientists that addresses the challenges and opportunities relevant to antibody drug discovery and development. Specifically, this conference will focus on 1) target identification and novel discovery platforms, 2) advances in protein engineering to improve functional properties and new antibody modalities and delivery methods and 3) an overview of emerging clinical therapeutics in oncology, infectious disease and autoimmunity/inflammation. We envision this program will offer investigators an overview of antibody therapy development from bench to bedside and also highlight cutting edge technological and clinical advancements of interest to a broad spectrum of scientists.

December 4-7, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Man-Wah Tan and Deborah T. Hung

Important Deadlines
Early Registration Deadline: Oct. 5, 2022
Scholarship Deadline: Nov. 12, 2021
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 25, 2022
Meeting Summary
# Immunology
# Infectious Diseases

This meeting was rescheduled from February 2022. 

Meeting Summary

It has become clear that infectious diseases are among the greatest threats to human health and global stability.  Chief among these threats is the rise in antibiotic resistance, which endangers our ability to treat otherwise curable infection.  The capacity to discover and develop novel agents to fill the pipeline as existing antibiotics are lost to increasing resistance has to date been limited.  The goal of this Keystone Symposia conference is to present cutting-edge approaches to antibiotic discovery, including application of expanded chemical space, systems chemical biology, and artificial intelligence; and novel strategies for treating resistant infection, including CRISPR, vaccines, antibodies, phages and conjugates. The promise, challenges, and development paths of these new approaches and strategies will be discussed in the context of lessons learned from prior antibiotic development programs, and new innovations in clinical and regulatory pathways. Additionally, this conference will be held jointly with “The Human Microbiome: Ecology and Evolution.”  This pairing will help to facilitate exploration of the impact of antibiotics on the microbiome and the microbiome on antibiotic resistance.

February 4-7, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Giles S.H. Yeo, Karine Clément and Murielle M. Véniant-Ellison

Important Deadlines
Early Registration Deadline: Dec. 5, 2023
Scholarship Deadline: Oct. 31, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 31, 2023
Meeting Summary
# Metabolism and Cardiovascular

Obesity prevalence has tripled over the past four decades. Together with its wide range of comorbidities, it accounts for a large proportion of the worldwide non-communicable disease burden. One of the critical barriers in effectively tackling obesity is the prevailing societal perception of it being a simple energy balance problem, one that this meeting seeks to dismantle. In truth there are a myriad of causes that lead to obesity, and as a result a wide array of consequences that emerge. Moreover time is rapidly changing in the field of obesity with the emergence of new and innovative therapies. While the value of model organisms is recognized in the field, this program was designed to focus on the model that matters most: humans.

The goals of this meeting is to explore the latest in:

(1) causes of obesity, including genetics, environmental impacts, and hypothalamic dysfunction;

(2) how the heterogeneity of obesity impacts upon its precision management;

(3) metabolic consequences of obesity, including Type 2 Diabetes, dyslipidemia, as well as cardiovascular, liver and renal disease

(4) innovation in treatment and new molecular targets.

This conference will be paired with another Keystone Symposia conference entitled Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine, where shared scientific sessions will explore cross connectivity of genetics and precision obesity management. These joint conferences will also bring together an interdisciplinary group of investigators with different focus areas within the field, ranging from ‘big data’ to detailed mechanistic studies. Participants of both conferences will also have an opportunity to network at shared meals and poster sessions. This unique environment will lead to new scientific collaborations and the implementation of precision medicine approaches directed at better understanding and treating cardiometabolic disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Gia K. Voeltz and Jodi Nunnari

Important Deadlines
Early Registration Deadline: Dec. 13, 2023
Scholarship Deadline: Nov. 28, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 28, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

In recent years, there has been an explosion of new structures and functions for membrane contact sites (MCSs), generating an excitement in the field of cell biology that continues to draw in a talented pool of scientists from diverse backgrounds. At MCS, the tethering of organelles serves to create specialized domains, which confer unique functions and provide a direct conduit for intracellular communication. These regions at MCSs integrate organelle biogenesis and dynamics, and on a molecular level, facilitate the transfer of lipids and calcium and thus are central to cellular homeostasis and have implications for human disease. The MCS field renaissance necessitates a meeting dedicated solely to MCS structure and functions. As such, an MCS Keystone Symposium will help to drive the field forward, forge interdisciplinary approaches and collaborations, foster early-career scientists, and lead to an updated model of cell structure and function. 

This meeting will address the following key questions in the field:
1) What is the most recent unpublished work on MCSs functions, protein composition, and new types of MCSs? 
2) What are the challenges and new technical and experimental approaches to identify and study MCSs?
3) What interdisciplinary approaches need to be fostered?

Due to their heterogeneous localization, cell variability, and small size, the visualization and characterization of MCSs remains complicated and requires joint efforts from various fields of expertise, novel tools, and the development of advanced techniques in light and electron microscopy.

Additionally, this conference will be paired with Mitochondria Signaling and Disease.   The joint conferences will share a keynote and joint sessions.  Participants of both conferences will also have an opportunity to network at shared mealtimes and poster sessions.  It is anticipated that this will lead to new scientific collaborations and the implementation of new technological approaches.  The conference will provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 5-8, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ajamete Kaykas, Aron B. Jaffe and Prisca Liberali

Important Deadlines
Early Registration Deadline: Dec. 29, 2022
Scholarship Deadline: Nov. 3, 2022
Global Health Award Deadline: Apr. 10, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 29, 2022
Meeting Summary
# Developmental, Reproductive and Regenerative

Stem cell and tissue-derived organoids are three-dimensional, in vitro cellular models that faithfully recapitulate many features of a variety of organ systems. As such, they represent human tissue avatars, and have been used to study stem cell biology, organ development, the earliest stages of organismal development, and disease. The goals of this symposium are to highlight the impact of organoids in our understanding of development and disease, how organoids are being used in drug discovery, and their potential as therapeutics. Attendees will be exposed to the latest advances and discoveries that have resulted from the establishment and use of organoids in basic research and drug discovery. Together with the Stem Cell meeting, we expect that attendees will also form new connections and collaborations with researchers across the academic and industry communities.

January 14-17, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Diana Bautista, Rebecca P. Seal and Ishmail John Abdus-Saboor

Important Deadlines
Early Registration Deadline: Nov. 14, 2023
Scholarship Deadline: Oct. 24, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 24, 2023
Meeting Summary
# Neurobiology

This conference will explore recent advances in our understanding of mammalian somatosensation. Our speakers will include world-renowned leaders studying mechanisms underlying itch, touch and pain, in health and disease, as well a rising stars in the field. Topics will span receptors and signaling mechanisms, neural circuits, and behavior, and will highlight the use of cutting-edge tools for discovery. We will include time for discussions with speakers, and networking opportunities during poster sessions. We will also reserve time for short talks that will be selected from abstracts submitted by trainees and junior faculty. Our goals are to encourage the sharing of novel, unpublished data, to facilitate dynamic discussion and debate, and promote new collaborations in the field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 19-23, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Laura Sepp-Lorenzino and Matthew Porteus

Important Deadlines
Early Registration Deadline: Jan. 18, 2023
Scholarship Deadline: Dec. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 28, 2022
Meeting Summary
# Genetics, Genomics and RNA

Gene editing is revolutionizing biology and therapeutics. An ever-expanding toolbox of editing enzymes and delivery solutions enable the precise manipulation of the genome and it if fueling a diverse pipeline of clinical candidates. Emerging clinical data from gene edited cell therapies and preclinical data from in vivo delivered gene editing drug candidates are demonstrating the feasibility, versatility, and potential for efficacy and safety in humans. Furthermore, there is great interest and investment into gene editing for crops and livestock. The Symposium will cover most aspects of the genome editing field: from fundamental biochemistry to tool development, to applications in biology, agriculture, and medicine. The meeting will bring together scientists from academia and biopharma, including regulators and ethicists. It will also uniquely bring together scientists who have studied natural genome editing systems and natural DNA damage repair with scientists trying to develop novel genome editing systems. Significance: Genome editing is a powerful and precise tool to change the sequence of cellular DNA for both better understanding human disease and the treatment of human disease. The basic understanding of how genome editing works, the development of new tools in genome editing, and the translation to clinic are changing on a rapid basis. There is broad interest in genome editing from basic scientists to foundations to industry. The specific aims of this meeting are: • Provide an update on the state of understanding of the biochemistry of genome editing • Relate genome editing to natural genome editing and DNA damage repair processes • Provide an update on the latest tools in translational genome editing • Provide an update on pre-clinical work using genome editing to provide better treatments for patients. • Provide an update on the clinical trial results using genome editing in humans for both ex vivo and in vivo uses. • Have an open discussion on the ethics of human genome editing. The outcome of this meeting is increased communication between different experts to enhance the safety and efficacy of genome editing for therapeutic use. The meeting will bring together expertise that is different than many similar meetings.

January 22-25, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Morgan Maeder, Benjamin P. Kleinstiver and Kiran Musunuru

Important Deadlines
Early Registration Deadline: Nov. 21, 2023
Scholarship Deadline: Nov. 2, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 2, 2023
Meeting Summary
# Genetics, Genomics and RNA

The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

The Keystone Symposium on Precision Genome Engineering has become one of the leading conferences in the field. It highlights the latest developments in technology, emerging challenges, and progress in preclinical and clinical applications to bring together a broad mix of scientists working across all stages of genome editing. The program will cover  small and large sequence editing strategies and technologies towards the goal of developing precision genetic medicines.

This meeting will be jointly hosted with the Nucleic Acid Delivery symposium, which together will stimulate discussion and innovation between two fields that have traditionally been distinct but are becoming increasingly interconnected as gene editing approaches advance into the clinic. Delivery remains a critical hurdle for broad implementation of gene editing across diverse areas of human disease. Through these joint meetings, attendees will gain a deeper understanding of the current state of the delivery field, forging connections to catalyze new innovations and collaborations.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 29-1, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Gene W. Yeo, Wendy V. Gilbert and Lori A. Passmore

Important Deadlines
Early Registration Deadline: Nov. 29, 2022
Scholarship Deadline: Oct. 27, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 27, 2022
Meeting Summary
# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA

Ribonucleic acid (RNA) binding proteins (RBPs) are a major category of regulators encoded by more than two thousand human genes. Over the last few years, millions of protein-RNA interactions in a myriad of cellular contexts have been measured by increasingly scalable technologies, providing opportunity for deeper connections with genetics and disease. In parallel, stunning breakthroughs in microscopy and structural methods have revealed fundamental insights into protein-RNA interactions. This meeting addresses growing excitement from both the basic and translational life sciences community in imagining protein-RNA interactions as a treasure trove of new biology and drug targets. The specific aims of our meeting are to (1) provide a forum to assemble multi-disciplinary leaders in various themes in the RNA community to cross-fertilize emerging ideas in fundamental protein-RNA science, (2) introduce a diversity of new-comers to the newest methods and results in the field and (3) introduce and identify new targets and modalities for therapeutic opportunities. This meeting will be held jointly with Biomolecular Condensates which is a natural collaboration as RNA binding proteins play major roles in condensation of protein-RNA/DNA interactions.

January 21-24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ryan Potts and Michelle R. Arkin

Important Deadlines
Early Registration Deadline: Nov. 16, 2023
Scholarship Deadline: Oct. 26, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 26, 2023
Meeting Summary
# Drug Discovery, Bioengineering and Digital
The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Drug discovery is undergoing a revolution that moves away from occupancy driven pharmacology to proximity based therapeutics that take advantage of event driven pharmacology. Induced proximity medicines or multi-specifics mobilize a cell’s natural biological mechanisms to tackle disease causing proteins through bringing together effectors and targets. Proximity based therapeutics have the potential to unlock new target space and make significant inroads to drug the “undruggable” genome. This conference will focus on understanding the opportunities and challenges in this exciting new area.

This meeting will concentrate on 4 key areas:
1) Controlling Post-Translational Modifications by Induced Proximity;
2) Emerging Proximity Biology for Target Degradation;
3) Stabilizing Protein-Protein Interactions with Molecular Glues;
4) Predicting and Discovering Ternary Complexes.

We will bring together interdisciplinary groups of scientists, including biologists and chemists, from both academic and industry to explore the latest findings in this field and accelerate its growth. Importantly, this meeting will be held jointly with the Keystone Symposium on Targeted Protein Degradation, to leverage the synergy between these two fields in terms of translating basic science into therapeutic potential.

Meeting organizers Michelle Arkin from the University of California, San Francisco, and Ryan Potts, from Amgen, Inc. about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 25-28, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Marlene Rabinovitch and Kurt R. Stenmark

Important Deadlines
Early Registration Deadline: Apr. 25, 2023
Scholarship Deadline: Apr. 19, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Apr. 19, 2023
Meeting Summary
# Metabolism and Cardiovascular
Significance: Pulmonary arterial hypertension is a progressive condition in which narrowing and obliteration of blood vessels results in elevated resistance to flow that culminates in heart failure. Current approved therapies improve survival and quality of life but new research approaches that tackle the complexities of pulmonary hypertension will allow us to identify, develop and pursue those agents that reverse disease. The goal of this meeting is therefore to showcase scientific advances in six areas that impact vascular and immune cell function i) mitochondrial dynamics (ii) epigenomics and integrated omics (iii) aging and sex determinants (iv) genetics and data science (v) bioengineering and regeneration and (vi) inflammation. Innovation: We will invite a keynote speaker who can speak to the future of gene editing in pulmonary hypertension and heart failure and we will also invite investigators with expertise in the above areas of interest who do not work on pulmonary hypertension to engage our seasoned and young investigators in a way that will lead to innovative scientific approaches. We will challenge our pulmonary hypertension speakers to relate their focus of investigation to others in the field, to establish relationships and bridge gaps that will identify therapeutic possibilities beyond targeting one pathway or molecule. The pitfalls of current animal models and culture systems will be addressed in light of the complexities of the disease and workshops will highlight (i) novel imaging technology and (ii) decision making of clinical and industry experts in moving basic discovery to the patient. The six themes designated above are of interest to both Heart Failure and Pulmonary Hypertension investigators.

February 18-21, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: David Artis, Yasmine Belkaid, Fiona M. Powrie and Kenya Honda

Important Deadlines
Early Registration Deadline: Dec. 14, 2023
Scholarship Deadline: Nov. 9, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 9, 2023
Meeting Summary
# Immunology
# Infectious Diseases

The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

The barrier surfaces of multicellular organisms are immunologically active, highly innervated and sites where host genetic and environmental signals are integrated to regulate local and systemic physiology. These tissues are sites of infection and chronic inflammatory diseases including atopic dermatitis, asthma, allergy, inflammatory bowel diseases and cancer. However, fundamental gaps in knowledge remain regarding the complex interplay between structural components of tissues such as the epithelium, sensory apparatus, stroma or vasculature and microbial factors and inflammatory mediators at barrier sites.

This Keystone Symposia conference is designed to explore new cross-disciplinary paradigms in barrier immunity through integration of emerging topics in understanding of host-microbe interactions and environmental factors with sensory networks of the epithelia, nervous and immune systems. This conference will showcase how a multidisciplinary and global approach to barrier immunity will guide development of new therapeutic strategies for the treatment of multiple infectious and inflammatory diseases including asthma, allergy, inflammatory bowel diseases and cancer. This meeting will be held jointly with the Fungal Pathogenesis conference,  to foster interdisciplinary insights and collaborations towards understanding fungal strategies to breach protective barriers, and mechanisms that protect against fungal infection. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

December 12-15, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Mitchell Guttman, Phillip D. Zamore and Maite Huarte

Important Deadlines
Early Registration Deadline: Oct. 12, 2023
Scholarship Deadline: Sep. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 25, 2023
Meeting Summary
# Genetics, Genomics and RNA

RNAs serve as regulators of all aspects of biology: modulating chromatin structure, promoting and repressing transcription, regulating the rates of mRNA translation and degradation, controlling protein trafficking, and defending against viruses and selfish genetic elements. Recent work has revealed key insights into the mechanisms by which RNAs fulfill these regulatory roles. To fully understand the fundamental principles of RNA biology, we must move from thinking about RNAs by class or size (e.g., small RNAs or long RNAs) and towards an integrated perspective about shared aspects of RNAs as critical regulators of cell biology across all life forms (including viruses, prokaryotes, and higher eukaryotes). Briefly, the specific aims of this meeting are to:

(1) Gather the larger regulatory RNA community – specifically scientists who may not otherwise attend the same meetings;

(2) Identify synergies and the potential for novel collaborative approaches based on shared mechanistic ideas across broad fields;

(3) Assimilate fields that have been evolving on parallel tracks to integrate ideas and advance our understanding of the molecular mechanisms underlying RNAs as regulatory molecules.

This meeting will aim to highlight how advances in RNA mechanisms are being leveraged to develop distinct classes of RNA-based therapeutics. This meeting will be held jointly with the RNA Modification Keystone Symposium, which will be highly synergistic given that modifications of RNA diversify and control regulatory RNA functions.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

November 15-16, 2022 | Virtual at Your Computer
Scientific Organizers: Deborah L. Johnson and Judith Klinman

Important Deadlines
Early Registration Deadline:
Scholarship Deadline:
Short Talk Abstract Deadline:
Poster Abstract Deadline:
Meeting Summary
# Drug Discovery, Bioengineering and Digital
A free eSymposium event exploring pandemic lessons in reducing carbon footprint, engaging new audiences and rethinking strategies for scientific exchange.Scientific conferences have long been the medium of scientific exchange, inspiration and collaboration that drive the scientific endeavor forward. During the pandemic, we have all been forced to reimagine how to engage virtually to accomplish these goals, with varying degrees of success. This eSymposia virtual meeting will convene leading conference organizations, virtual platform hosts and scientists from around the world to explore best practices in virtual conferencing, and hybrid events (in-person and virtual platforms) for maintaining the efficacy and vibrance of scientific exchange.We will discuss lessons learned from the pandemic in how to engage audiences online by creating interactive and collaborative environments in the virtual world.  The program will examine benefits of virtual formats, such as inclusivity of more diverse audiences (globally, economically etc.), and enhanced access to the latest scientific discoveries.  We will explore challenges:  how to replicate serendipitous networking opportunities that occur in-person; how to forge relationships that can change the course of careers, and how to catalyze collaborations that alter research trajectories toward new and innovative ideas.  We will also discuss how to optimize hybrid events to seamlessly integrate the interactions and discourse between in-person and virtual attendees.Together we aim to outline new ways to enhance the engagement of the scientific community and promote scientific advancement in more carbon-neutral ways moving forward, and ultimately shape the future of scientific conferences for the betterment of science, and future of our planet.  It is time to invest in developing novel ways of connecting and collaborating to facilitate scientific advances, and the pandemic has provided an unexpected proving ground to guide us towards a more sustainable future.

December 12-15, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Eric A. Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo

Important Deadlines
Early Registration Deadline: Oct. 12, 2023
Scholarship Deadline: Sep. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 25, 2023
Meeting Summary
# Genetics, Genomics and RNA

Chemical modifications of RNA nucleotides, collectively referred to as the epitranscriptome, represent an additional layer of information encoded in transcribed RNA sequences to regulate their activities. Emerging research in this field focuses on characterizing the structural diversity of RNA modifications and elucidating their roles in biological pathways, which is supported by new technology development and mechanistic analysis capabilities. These advances are deepening our understanding of the function and regulation of RNA modifications, as well as their roles in human infection, immunity and disease. These basic discoveries in epitranscriptomics are being translated toward the clinic at an accelerating rate, with the advancement of RNA-based medicines, such as mRNA-based COVID-19 vaccines or antisense oligonucleotides (ASOs).

This conference will bring together leading experts focused on RNA modifications, technology development and medicine to discuss cutting edge research, evaluate data standards in the field and identify opportunities for the translational potential of targeting RNA modification pathways. We anticipate that participants of this conference will benefit by sharing results on this rapidly advancing topic, but also in defining the future direction of the field and creating new collaborations to accelerate progress. This meeting will be held jointly with the Regulatory RNAs: Emerging Mechanisms Keystone Symposium, which will be highly synergistic given that modifications of RNA diversify and control regulatory RNA functions.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 18-22, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Mario Suva and Itay Tirosh

Important Deadlines
Early Registration Deadline: Apr. 18, 2023
Scholarship Deadline: Mar. 29, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Mar. 29, 2023
Meeting Summary
# Biochemistry, Structural and Cellular

Single cell genomics has become a central method for analysis of biological systems and its utility will further expand in the next few years. While the initial focus in single cell genomics was on generation of methods and atlases, we are now witnessing the integration of single cell approaches in various fields of biology, with a growing number of studies that provide deep biological insights. In this meeting we will focus on cellular heterogeneity, plasticity and spatial interactions, in the context of development and cancer, two areas in which single cell biology is having an important impact. Moreover, single cell studies are providing a renewed demonstration that cancer hijacks mechanisms of development, highlighting the need to bring together researchers from both fields. The meeting will primarily include sessions that focus on single cell analysis of particular tissues, in each case highlighting recent insights into the development and cancer of these tissues and the connections between these processes. We will also have sessions on computational analysis and recent technology developments in single-cell genomics. Speakers include a combination of experts in cancer research, development and physiology of specific organs, and the single cell community.

January 21-24, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Jason Buenrostro, Lacramioara Bintu and Fei Chen

Important Deadlines
Early Registration Deadline: Nov. 16, 2023
Scholarship Deadline: Oct. 26, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 26, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

We are currently in the midst of a single-cell biology revolution: recent advances in DNA sequencing and microscopy have shed light on the diversity of cell types in tissues and in response to signals. So far, much of the field has been focused on building cellular atlases in healthy tissues and disease, which is the necessary first step in understanding cellular systems. However, it is now imperative that we address the next steps: measuring the single-cell dynamics over time, perturbing regulators of cellular functions and defining the importance of cell-cell interactions. Moreover, we are now in a position to apply single-cell tools to define cellular mechanisms of disease for perturbation and treatment.

To tackle these emerging challenges and opportunities, this conference will encompass the latest advances in single-cell genomics, spatial technologies, and opportunities to perform large-scale perturbation to identify regulators of cellular functions. Speakers will be at the cutting edge of technology development and application of these emerging toolsets to map cellular states in health and disease. The conference will look towards the future, highlighting how cell intrinsic regulators define cellular function, how cells define tissue function, and how cellular composition and function is altered in disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 13-16, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Anna Di Nardo, Daniel H. Kaplan and Nathalie Boulanger

Important Deadlines
Early Registration Deadline: Dec. 14, 2022
Scholarship Deadline: Nov. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 28, 2022
Meeting Summary
# Immunology
# Infectious Diseases

Skin is a barrier environment where immune cells interact with the unique skin environment to maintain tissue homeostasis and induce immune responses. Skin immune cells can be recruited from the circulation, but many reside in the skin where they are strategically located at the barrier interface within a complex stromal matrix in proximity with commensal bacteria and the external environment. Recent discoveries have radically changed our knowledge of the skin immune system including the interplay between different skin-resident immune cell types and the realization that skin immune cells interact with non-immune compartments in the skin. Skin-resident immune cells are shaped by the cutaneous microbiome and interact with the peripheral nervous system. These complex interactions result in efficient host defense against many pathogens, but some bacteria, fungi, viruses and vector-borne pathogens have evolved mechanisms to evade these systems. This conference will bring together immunologists, skin biologists, and dermatologists to introduce all groups to these new discoveries, challenges, and therapeutic opportunities. We will provide the attendees with a clear understanding that the host skin is a complex environment designed to tolerate commensals and respond to pathogens. Joining with a concurrent vector-borne disease meeting will enable microbiologists and vector biologists to exchange knowledge with immunologists and skin biologists, allowing for consideration of how new discoveries regarding skin-immune cross talk can inform our understanding of vector-borne pathogen transmission.

January 22-25, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Heinrich Jasper and Emmanuelle Passegué

Important Deadlines
Early Registration Deadline: Nov. 21, 2023
Scholarship Deadline: Oct. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 30, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative

The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Regenerative medicine relies on a deep mechanistic understanding of tissue stem cell biology and innovative approaches to reprogram cells and tissues. This Keystone Symposia conference brings together leading researchers who study the biology of tissue stem cells and tissue regeneration and who have employed this knowledge to develop therapeutic applications in regenerative medicine. The program explores these processes across diverse tissue types, and thus encompasses stem cell populations and regenerative pathways across biological systems, ranging from hematopoietic stem cells to vascular systems to the retina. A particular focus will be on promoting tissue regeneration even in the absence of endogenous stem cells (as in the retina) as well as on rejuvenation approaches based on in vivo partial reprogramming.

This conference will run in parallel with our recurring Keystone Symposia meeting on Emerging Cellular Therapies and will feature two joint scientific sessions that explore cellular approaches in regenerative medicine and gene therapy applications. It is anticipated that facilitating interactions beween speakers and attendees of these two programs will foster new and synergistic collaborations as well as catalyze new ventures to develop and exploit regenerative strategies for therapeutic benefit. 

Co-Organizers Dr. Heinrich Jasper and Dr. Emmanuelle Passegué talk about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 5-8, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Kevin C. Eggan, Kathrin Plath and Elly M. Tanaka

Important Deadlines
Early Registration Deadline: Dec. 29, 2022
Scholarship Deadline: Nov. 28, 2022
Global Health Award Deadline: Apr. 10, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 29, 2022
Meeting Summary
# Developmental, Reproductive and Regenerative

Stem Cells are defined by their ability to both self-renew and differentiate into multiple cell types. It is increasingly apparent that stem cells and their progeny underlying many critical aspects of development, tissue homeostasis, regeneration and repair. Advances in molecular and cellular biology have also stretched our understanding of how stem cell biology underlies these processes. Experimental and therapeutic interventions based on principals extracted from the stem cell field are now increasingly used to manipulate differentiated cell fates and overcome disease pathology. We plan a meeting that will unify the stem cell and aligned organoid field for one of the first major in-person gatherings to reflect on the discipline broadly and to discuss new important discoveries in this established field. the co-organization with the organoids field will help ensure that these two disciplines, one emerging and one well established are a major convening event for our community.

February 8-11, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mariana J. Kaplan, Georg Schett and Carola G. Vinuesa

Important Deadlines
Early Registration Deadline: Dec. 7, 2023
Scholarship Deadline: Nov. 1, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 21, 2023
Meeting Summary
# Immunology

Systemic autoimmune diseases and autoinflammatory syndromes comprise a broad range of conditions characterized by dysregulation of the immune system, giving rise to activation of immune cells, inappropriate inflammation and multiorgan damage. They represent a poorly understood group of conditions that in many cases disproportionately affect women and minorities and have a very significant impact in morbidity and mortality. The pathogenesis of this heterogenous group of diseases remains incompletely characterized and there are no existing cures. Therefore, individuals affected by these diseases require long-term treatment, making systemic autoimmune diseases be a mounting public health concern across the world. 

As such, this meeting will focus of reviewing novel areas pertaining to the understanding of key immune mechanisms that may play important pathogenic roles in the initiation, perpetuation and development of organ damage in systemic autoimmune diseases and autoinflammatory syndromes.  In addition, the program will cover  key aspects of diagnosis and treatment of these conditions, taking into consideration the development of important technological advances in the study of this diseases at the bench with critical implications for translational approaches.

The meeting will address novel areas of knowledge in the understanding of the pathophysiology of systemic autoimmune diseases and novel discoveries in autoinflammatory diseases that have emerged recently. We will bring together a diverse and interdisciplinary group of scientists from academia, government and industry, young and senior investigators to interact and exchange ideas on novel aspects of immunology, molecular biology, bioinformatics, and medicine.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Shane Crotty, Michela Locci and Jennifer L. Gommerman

Important Deadlines
Early Registration Deadline: Aug. 1, 2023
Scholarship Deadline: Jun. 28, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 28, 2023
Meeting Summary
# Immunology
T cell - B cell interactions are fundamental for many immune responses. The COVID-19 pandemic and the successful development of COVID-19 vaccines have highlighted the extreme value of T:B interactions for protective immunity. For example, the development of antibodies able to neutralize variants as diverse as Omicron—after not one or two, but after three mRNA immunizations with the same ancestral SARS-CoV-2 Spike—is a dramatic example of the importance of germinal centers in protective immunity, and the brilliance of the immune system in rapidly evolving T-dependent B cell responses capable of neutralizing extreme viral variants the T and B cells never previously encountered in the germinal centers.

There remains much to be learned about the critical importance of T:B interactions and germinal centers for vaccines and infectious diseases, but also much broader aspect of medicine. For example, T:B interactions are important in many autoimmune diseases, which will be a key component of this conference. Moreover, this conference will be held jointly with the Keystone Symposium on B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics, with joint sessions covering T:B interactions in cancer.  This Keystone T:B conference originally started in 2016 as a gathering place for scientists to discuss shared and unique biology of T follicular helper (Tfh) cells and germinal centers in diverse contexts, and the conference is now in its 5th iteration.

Organizer, and Professor of Immunology in the Center of for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology, Dr. Shane Crotty, talks about why you should attend this meeting in the video below:

Dr. Shane Crotty talks about this upcoming Keystone Symposia meeting.











Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 21-24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James E. Bradner, Eric S. Fischer and Brenda A. Schulman

Important Deadlines
Early Registration Deadline: Nov. 16, 2023
Scholarship Deadline: Oct. 26, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 26, 2023
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Technologies

The deadline to submit an abstract for short talk consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

This  Keystone Symposium will focus on advances in the rapidly evolving field of targeted protein degradation (TPD). In the past five years this field has moved from proof of concept to the development of degrader drugs in clinical trials. Clinical impact has brought a sense of urgency and broadened interest for formulating and clarifying a new science of degradation. TPD has focused on cullin ring ligases and their substrate receptors cereblon and VHL with other degradation pathways such as autophagy, ERAD, heat shock chaperones and monovalent degraders, etc, also emerging as part of the TPD field. Currently small molecule degraders induce the formation of non-native protein-protein interactions. It is in the context of discoveries of the mechanistic details that drive ternary complex formation and the sharing of these developments that this field will continue to gain momentum. To elaborate the biophysics, chemistry, cell biology and genetic basis for this new science, the TPD symposia will assemble leaders from around the world to share insights across diverse disciplines. There will a strong emphasis on renewing the spirit of face to face exchanges among subject matter experts with the idea to maximize interactions, formulate questions and foster new collaborations. Importantly, this meeting will be held jointly with the Keystone Symposium on Proximity Based Therapeutics, to leverage the synergy between these two fields in terms of translating basic science into therapeutic potential.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

November 6-9, 2022 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Rajesh Chopra, Nathanael Gray, Anita K. Gandhi and Georg E. Winter

Important Deadlines
Early Registration Deadline: Sep. 6, 2022
Scholarship Deadline: Nov. 26, 2021
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 22, 2022
Meeting Summary
# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital

This meeting is a reschedule of Targeted Protein Degradation originally scheduled for January 2022.  PROGRAM IS NOW AVAILABLE!

Meeting Summary

This Keystone Symposia conference will highlight the recent exciting advances in targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional molecules that bind the target for ubiquitin-mediated degradation by complexing them with Cereblon (CRBN), von Hippel-Lindau or other E3 ligases. Alternatively, E3 ligase components such as CRBN, DCAF15 and UBR7 can also be used as a ‘template’ to bind IMiD or sulphonamide-like compounds (the so called ‘Molecular Glues’) to degrade multiple context specific proteins by the selected E3 ligases. The ‘template or hijacking approach’ results in the degradation of neo-substrates, some of which would be difficult to drug using conventional approaches The chemical properties necessary for drug discovery, the rules by which neo-substrates are selected by ligase receptors and defining the optimal components of the ubiquitin proteasome for protein degradation are still to be fully elucidated. This conference will bring together early pioneers in the field, emerging scientists and experts from industry and academics to describe how these challenges are being addressed. Furthermore, experts who have used IMiD agents and proteasome inhibition in the clinic in real world practical applications of protein degradation agents have been invited to speak at this conference. Another unique aspect of this conference is with it being paired with the Keystone Symposia conference on Ubiquitin Biology. Protein ubiquitination regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead to human disease. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. By pairing these meetings, participants will be able to network and foster new collaborations between these two related areas of science.

January 14-17, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Jeffrey F. Horowitz, Laurie J. Goodyear and Karyn A. Esser

Important Deadlines
Early Registration Deadline: Nov. 14, 2023
Scholarship Deadline: Oct. 24, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 24, 2023
Meeting Summary
# Metabolism and Cardiovascular

A physically active lifestyle is known to be a key component for sustained overall health and well-being; and exercise is also often a first-line approach for the treatment and/or prevention of many chronic diseases. Despite the overwhelming evidence supporting the health benefits of exercise, the molecular, cellular, tissue, and systemic responses to exercise that underlie these beneficial health effects of exercise/physical activity remain unresolved. Expanding understanding about the underpinnings to the beneficial health effects of exercise is critical for optimizing lifestyle programs to improve human health across the lifespan.  

Speakers at this conference will present new findings addressing the impact of circadian rhythms, sleep, epigenetics, and sex on the adaptive responses to exercise.  Sessions at this conference will also address the effects of exercise on inflammation, brain function/cognition, and cross-talk among different tissues.  The overall goal of this conference is to provide a forum for scientists to discuss the complex responses to exercise to help to advance knowledge about the mechanisms behind many health benefits of exercise.  In addition, this conference will also provide an environment to foster connections and potential future collaborations for the attendees.

Co-Organizer, and Professor of Movement Science and Director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology, Jeffrey Horowitz, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 24-27, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Marcel A. Behr, Lalita Ramakrishnan and Kevin B. Urdahl

Important Deadlines
Early Registration Deadline: Jan. 24, 2024
Scholarship Deadline: Dec. 19, 2023
Global Health Award Deadline: Oct. 24, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 19, 2023
Meeting Summary
# Infectious Diseases
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Tuberculosis afflicts millions of people each year, yet most individuals are thought to clear infection without manifesting disease. Understanding why only a fraction of infected individuals are susceptible to disease represents a critical gap in research and medicine. The Mycobacterium tuberculosis lifecycle involves entry, survival, proliferation and exit, spanning timelines of minutes to months or even years. At each step, host attempts to thwart and eliminate infection can be overcome by bacterial countermeasures.

This meeting will bring together researchers who study the tuberculosis host-pathogen interface, from the scale of molecules, to individual cells, to the cellular aggregates or granulomas that are the hallmark structures of tuberculosis. The program will also cover research on nontuberculous mycobacteria, as well as other pathogens with similar “lifestyle” aspects to M. tuberculosis and studies of host processes in other contexts, with the goal of achieving a more complete understanding of tuberculosis disease processes. New tools and methodologies that enable new discoveries in interrogating the tuberculosis host-pathogen interface will be highlighted. We aim for this “holistic” approach to enhance understanding of basic infection biology to inform new strategies for global elimination of this age-old pathogen.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

December 4-7, 2022 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Ruth E. Ley, Alejandro Reyes and C. Jessica Metcalf

Important Deadlines
Early Registration Deadline: Oct. 5, 2022
Scholarship Deadline: Nov. 12, 2021
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 25, 2022
Meeting Summary
# Genetics, Genomics and RNA
# Immunology
# Infectious Diseases
# Metabolism and Cardiovascular
# Microbiota and Flora

This meeting was rescheduled from February 2022. 

Meeting Summary

This Keystone Symposia conference will explore the evolutionary and ecological forces shaping the interplay between the human host and microbiome.  The microbiome is implicated in a widening set of disease conditions, yet many questions remain as to how its diversity and composition are assembled and maintained.  This program is designed to take on the topic of the microbiome across scales, integrating the latest understanding of human microbiome diversity across time and space, and delving into the molecular interactions that shape the associations.  This conference aims to understand how movement of human populations, past and present, shape patterns of microbiome diversity. The program will include sessions on deciphering evolutionary dynamics linking microbiota to the human host, as well as discussions on understanding the co-evolution of humans with the microbiome at level of interactions at the molecular scale.  Other topics will assess how interactions between host and microbiome can be harnessed for health.  Through integration of patterns, processes and theory derived from human and non-human systems, attendees will gain an integrated view of microbiome diversity across modern human populations, and their interactions in host health.

May 7-10, 2023 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Valerie M. Weaver, Jeffrey W. Pollard, Kornelia Polyak and Mara H. Sherman

Important Deadlines
Early Registration Deadline: Mar. 7, 2023
Scholarship Deadline: Feb. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 7, 2023
Meeting Summary
# Cancer

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


The tumor is an evolving tissue comprised of cancer cells interacting with a complex cellular and non-cellular tumor microenvironment (TME), which manifests as a systemic disease. The TME, which is spatially and functionally heterogeneous, reflects the tumor cell’s genotype and the host age and immune and metabolic states. The TME also exhibits tissue-specific features and has distinct primary and metastatic tissue phenotypes. These diverse TME features can either drive or restrain tumor progression and metastasis, and will modulate tumor treatment response. Our understanding of how this complex, evolving TME influences malignancy has expanded to include induction of chronic adaptive changes in the tumor and the host that manifest at the organelle, cellular, organ, and systemic level. This meeting will present recent work describing specific cellular and non-cellular features of the primary and metastatic tissue-specific TME, and will highlight their impact on tumor evolution, aggression and treatment response. The conference co-organizers have developed a program that will bring together experts from diverse fields including academia, research institutions and industry to explore the latest findings in the TME. The conference will provide an up-to-date overview of the recent advances in basic, translational and clinical TME research. The meeting will emphasize new areas of TME investigation, particularly as it relates to tumor adaptation, progression and metastasis, and treatment resistance. Effort will be exerted to ensure that junior investigators, especially from underrepresented groups, are provided with time to present their work, receive feedback and interact with senior investigators.

February 12-15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Gina DeNicola, Rushika M. Perera and David B. Shackelford

Important Deadlines
Early Registration Deadline: Dec. 12, 2023
Scholarship Deadline: Nov. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 7, 2023
Meeting Summary
# Cancer

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.

Cancer is a major cause of mortality worldwide. Increased understanding of mechanisms that drive cancer will provide new avenues to reduce incidence and to treat the disease. Aberrant metabolism is a critical hallmark of cancer cells that enable adaptation to a variety of external and internal stressors. Thus, identifying and targeting key metabolic dependencies in cancer cells remains an important strategy for blocking cancer progression.

This meeting brings together researchers focusing on identifying cancer cell intrinsic mechanisms alter metabolic state and how these pathways integrate with differential activity of key metabolic organelles such as the mitochondria and the lysosome. The inter-connections between nutrient acquisition and utilization and changes in the tumor microenvironment will also be explored. As an increasing appreciation for differences in metabolic dependencies in primary versus metastatic disease emerges, this meeting will also focus on discussing unique metabolic vulnerabilities of metastatic cells as they seed and grow in secondary organ sites. The meeting also brings together investigators at the cutting edge of new imaging and quantitative tools for measuring tumor metabolism in vitro and in vivo. Finally, the program will explore the latest developments in targeting tumor metabolism and the next steps required for effectively translating preclinical findings into patients. The numerous short talk opportunities and breakfast topic discussions will help to foster discussion and collaboration between investigators at all career stages.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 1-4, 2023 | Renaissance Palm Springs Hotel, Palm Springs, CA, United States
Scientific Organizers: Christopher J. Rhodes, Lora K. Heisler and Martin G. Myers, Jr.

Important Deadlines
Early Registration Deadline: Mar. 23, 2023
Scholarship Deadline: Feb. 13, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 13, 2023
Meeting Summary
# Metabolism and Cardiovascular

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.


Early detection and consequential intervention are key to good treatment outcomes and avoidance of complications for most diseases. Arguably, this may not be the case for Type-2 diabetes (T2D) where measures of elevated glucose and HbA1C, historically related to a predicted onset of retinopathy, occur too late in the pathogenesis of the disease. We require improved markers of T2D are necessary to better diagnose and treat this prevalent disease at early stages. With the advent of precision medicine, now is the time to re-examine the pathogenesis of type 2 diabetes at the molecular level. Which subsets of T2D define the rate of progression to certain diabetes complications? Can early molecular drivers of the disease be better identified? What factors contribute to dysfunctional inter-organ communication and altered metabolic homeostasis? Does pancreatic ß-cell failure really define the disease? If detected early enough, can we envision ways to reverse, or even prevention, of T2D be practically envisioned? With several commonly used T2D therapies soon coming off of patent this may be conceivable. Nonetheless, there remains a need for more effective therapeutic approaches, not just for T2D, but also for its comorbidities. This Keystone Symposium will examine the current knowledge of T2D pathogenesis and the therapeutic landscape - with a view towards earlier diagnosis, more effective and tailored T2D treatment regime(s) that also prevent or significantly delay the journey to complications and comorbidities.

November 6-9, 2022 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Eric J. Bennett, Nicolas H. Thomä and Niels Mailand

Important Deadlines
Early Registration Deadline: Sep. 6, 2022
Scholarship Deadline: Nov. 26, 2021
Global Health Award Deadline: Jan. 9, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 22, 2022
Meeting Summary
# Biochemistry, Structural and Cellular

This meeting is a reschedule of Ubiquitin Biology originally scheduled for January 2022.  PROGRAM NOW AVAILABLE!

Meeting Summary

Protein ubiquitylation regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead human disease, most notably neurodegenerative disorders. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. Several key questions regarding ubiquitin biology remain unanswered. Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes? What are the major factors that limit ubiquitin proteasome function during disease pathogenesis? How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system? The specific goals of the proposed meeting are: 1- Establish detailed connections between the diverse cellular pathways regulated by the ubiquitin system. 2- Determine the structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes. 3- Identify emerging themes using by pathogens to subvert the ubiquitin system 4- Foster enhanced collaboration between academia and the biotechnology industry toward the goal of developing therapeutics targeting the ubiquitin system. This joint meeting with “Targeted Protein Degradation” will provide a cross-disciplinary understanding of the various genetic and chemical approaches to identify mechanisms to specifically target individual proteins for degradation. One key outcome will be the establishment of collaborations between ubiquitin biologists studying how individual pathways are regulated by ubiquitin and industry leaders developing tools to both activate and inhibit ubiquitin pathway components.

December 3-6, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ivan Dikic and Cynthia Wolberger

Important Deadlines
Early Registration Deadline: Oct. 3, 2023
Scholarship Deadline: Aug. 30, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Aug. 30, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
The covalent attachment of ubiquitin to target proteins plays a central role in regulating a vast array of processes in eukaryotic cells. Building upon seminal work elucidating the role of ubiquitination in proteostasis as well as the mechanisms underlying the ubiquitin enzyme cascade, ongoing studies have revealed an expanded regulatory role for ubiquitin and ubiquitin-like proteins, as well as variations in the ubiquitin conjugation machinery.

This conference will bring together researchers from academia and industry to share the latest research into the role of ubiquitin family of proteins in different biological pathways, the mechanisms underlying novel roles for ubiquitin, and the development of new therapeutic strategies targeting the ubiquitin-proteasome system. There will be sessions devoted to the dynamics and specificity of the ubiquitin system, insights into the mechanisms by which ubiquitin is conjugated to biological molecules, regulatory roles of ubiquitin in health and disease, and novel approaches to targeting the ubiquitin system. Workshops featuring talks selected from abstracts will provide a forum for sharing late-breaking results and opportunities for junior investigators to feature their work. Joint sessions with the meeting on Autophagy and Disease will foster new connections and collaborations that will mutually advance the ubiquitin and autophagy fields.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 6-8, 2023 | 
Scientific Organizers: Lee A. Niswander and Wendy K. Chung

Important Deadlines
Early Registration Deadline: Apr. 6, 2023
Scholarship Deadline: Apr. 11, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Apr. 11, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative
Developmental disorders are the number one cause of infant mortality in the US and Europe and the impact on child health is lifelong. Each birth defect is rare but collectively structural birth defects are highly common. Recent advances in genetic sequencing have greatly improved our chances of linking gene variants to birth defects. However, assigning disease causality remains difficult, which is further complicated by a lack of understanding of how gene variants lead to disease mechanism. To address this challenge, gene discovery must be coupled with mechanism discovery. Birth defects research requires a collaborative understanding of patient phenotype, genetic variation and biological mechanisms. In order to fully utilize the genetic information, we need to understand the relevance of any genetic variant to the disease phenotype. This requires communication between clinicians (such as clinical geneticists, dysmorphologists, pediatricians) and research biologists (such as genomicists, epidemiologists, developmental, cellular and molecular biologists). We need animal models to study structural birth defect candidate genes, and given the large number of candidate genes identified, non-mammalian animal models as well as cell/iPSC modeling for rapid screening. The ultimate goal is to better understand the molecular and cellular pathogenesis in order to improve diagnosis and treatment for patients and to identify preventative strategies.

September 3-6, 2023 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Kathleen H. Burns, Harmit S. Malik and Irina Arkhipova

Important Deadlines
Early Registration Deadline: Jul. 6, 2023
Scholarship Deadline: Jun. 1, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 1, 2023
Meeting Summary
# Genetics, Genomics and RNA

Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states.

The aims of this conference are to:

1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales;

2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity;

3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging;

4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences.

Accelerating advances in the field will attract new investigators who will benefit greatly from this meeting, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 17-19, 2024 | Buck Institute for Research on Aging, Novato, CA, United States
Scientific Organizers: Rachel J. Roth Flach and Stephanie Wengert Watts

Important Deadlines
Early Registration Deadline: Jan. 16, 2024
Scholarship Deadline: Jan. 2, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 2, 2024
Meeting Summary
# Metabolism and Cardiovascular
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

The vascular system is an integral part of every organ. The contribution of the vascular system goes beyond its role to simply move blood. New data link disease etiologies to molecular changes within the different cellular layers of the blood vessels – the endothelium, media, adventitia and perivascular adipose tissue. This meeting “dissects” these layers as they contribute to systemic disease progression, and fills a niche not covered by other meetings due to the unique, translational theme of the program rather than having a more developmental focus.  The event will bring several fields of vascular biologists together to discuss:

1) Translational perspectives of how we can improve health by improving vascular function
2) Utilization of new technologies and tools to understand more about the vascular components within multiple organ systems
3) Opportunities for understanding therapeutic implications of new molecular discoveries in the vasculature

Finally this conference will provide an opportunity for interaction between academia and industry representation, to enable collaborations that will advance translational medicine.

Meeting Co-Organizer, and Research Fellow at Pfizer Inc., Rachel J. Roth Flach, talks about why you should attend this meeting in the video below:

Rachel J. Roth Flach talks about upcoming meeting on Unraveling Vascular Layers

And the other meeting Co-Organizer, Stephanie Wengert Watts from Michigan State University and The Watts Lab, adds her take in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

September 17-20, 2023 | Atlanta Marriott Marquis, Atlanta, GA, United States
Scientific Organizers: Bali Pulendran, Robert A. Seder and Gagandeep Kang

Important Deadlines
Early Registration Deadline: Jul. 18, 2023
Scholarship Deadline: Jun. 14, 2023
Global Health Award Deadline: May. 16, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 14, 2023
Meeting Summary
# Immunology

Since its emergence, SARS-CoV-2 has radically transformed virtually every dimension of our lives and fueled an urgent global imperative to develop safe and effective vaccines. The stunning pace at which COVID-19 vaccines have been developed is unprecedented in the history of vaccinology, and has been catalyzed by the rapid harnessing of innovative new technologies (e.g. mRNA vaccines) and major public and private investments. The COVD-19 pandemic offers a unique vantage point from which to survey vaccinology as it was for the past two centuries since Jenner (Vaccinology B.C. [Before COVID-19]), as it now is, during the time of COVID-19, and to contemplate what it could be, in the post COVID era (Vaccinology A.C.).This meeting will bring together an interdisciplinary team of experts to discuss the lessons learnt from the COVID-19 pandemic, with a particular focus on the immunology of vaccination.

Equally important has been the world’s focus on the economics, politics and ethics of how to ensure global equitable access to COVID-19 vaccines. This virus has certainly shone a spotlight on the field of Vaccinology, positioned as it is, at the focal point of immunology, microbiology, public health, clinical medicine, economics, sociology, ethics and international diplomacy. Thus, some talks will also be focused on these broader issues. It is hoped that this meeting will stimulate debate that helps enhance pandemic preparedness by redefining the way we conceive of, make, test, license and distribute vaccines globally.


Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 13-16, 2023 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: João Pedra, Elena A. Levashina and Maria-Carla Saleh

Important Deadlines
Early Registration Deadline: Dec. 14, 2022
Scholarship Deadline: Nov. 28, 2022
Short Talk Abstract Deadline:
Poster Abstract Deadline: Nov. 28, 2022
Meeting Summary
# Infectious Diseases

Arthropod vectors transmit several infectious agents that infect millions of people globally and cause over 700,000 deaths annually. Rapid unplanned urbanization, increased travel and trade bring humans into frequent contact with arthropod vectors, while climate change fuels their spread worldwide. Innovative concepts and technologies are strengthening vector control worldwide and redefining how to study these arthropods. Therefore, this Keystone Symposia conference will focus on cutting-edge areas of research, such as synthetic biology, microbiome and immunometabolism. The program was designed to embrace the reinvigorated aspects of arthropod vector epidemiology, physiology and reproduction. Furthermore, this conference is being held jointly with “Skin and Immune Crosstalk at Barrier Surfaces”. Entomologists, immunologists and microbiologists will discuss emerging insights into critical molecular mechanisms that occur at the vector-host interface. This conference will provide a collegial forum for intellectual exchange between investigators at various career levels, which will help to generate original thinking to tackle the complexity of vector biology. Currently, there is no high-profile venue to discuss biological mechanisms and disease transmission that occur and are influenced by arthropod vectors as well as the fundamental interactions between vectors, pathogens and host. The program will develop and explore central paradigms in vector biology, foster collaborations between investigators with distinct expertise and provide mentoring for the next generation of scientists.

September 6-8, 2023 | Virtual at Your Computer
Scientific Organizers: Philip L. Felgner, Anna K. Blakney and Norbert Pardi

Important Deadlines
Early Registration Deadline:
Scholarship Deadline:
Short Talk Abstract Deadline:
Poster Abstract Deadline: Aug. 30, 2023
Meeting Summary
# Drug Discovery, Bioengineering and Digital

Nanomedicines have revolutionized our ability to create medicines for previously untreatable diseases as well as novel therapies in a rapid and scalable manner. In the past five years, the approvals of novel nanomedicine-based drugs such as small interfering RNAs and messenger RNA vaccines have catalyzed the field. However, there are still many challenges in the field that preclude clinical translation of new technologies. These challenges include improving the delivery efficiency and safety profile of nanoparticles and novel strategies to target specific cells and tissues, among others.

This conference will bring together leading academic and industrial leaders in the field that are currently developing nanomedicines with highly interdisciplinary expertise in biochemistry, molecular biology, formulation sciences, immunology and AI/big data. In addition, the technologies and scientific questions being presented in the meeting ‘Nanomedicine’ will likely lead to new scientific collaborations and the implementation of new technological approaches that will propel the field forward. We anticipate that our approach of integrating nanomedicine specialists with varied backgrounds will create a unique environment that will spark new collaborations and inspire new innovations.

Meeting Co-Organizer, and Professor in Residence, Physiology and Biophysics at UC-Irvine School of Medicine, Philip Felgner, talks about why you should attend this meeting in the video below:

Dr. Philip Felgner discusses our meeting on Next-Generation Nanomedicine.

Partnership with University of California, Irvine

Thanks to the generosity of our partners at the University of California, Irvine, this event will now be held as a hybrid conference, with an in-person component at the prestigious Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, located in the heart of Orange County, Southern California. We would like to invite you to attend the in-person event and interact with a diverse group of researchers, students, and industry partners from the region. The UCI Physiology and Biophysics Department, Center for Translational Vision Research, and UCI donors have graciously offered to sponsor breakfast and lunch meals during your attendance.

The hybrid format will accommodate both in-person and remote participants and will be broadcast live at the Beckman Center and to global virtual audiences. Note poster sessions and career roundtables will still be held virtually during the meeting, and in-person attendees will be provided with individual secluded areas to participate virtually in these sessions. Please bring your laptops and earphone devices to participate in the virtual poster sessions and career roundtables.

To attend in-person you will need to pay the registration fee for the virtual event through the Keystone Symposia website. During checkout, you will be given the option to RSVP to the In Person event. There is no additional registration fee for attending in-person.

January 16-19, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Linde Meyaard, Jonathon D. Sedgwick, Carla V. Rothlin and Alex McCarthy

Important Deadlines
Early Registration Deadline: Nov. 16, 2023
Scholarship Deadline: Oct. 25, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 25, 2023
Meeting Summary
# Immunology

The deadline to submit an abstract for short talk and poster presentation consideration has passed.   For any questions or issues, please email info@keystonesymposia.org.

While the field of inhibitory immune receptors has been growing steadily over the past 20 years, interest has accelerated tremendously since the application of blocking antibodies for these receptors as cancer therapies. As a general class of molecules, inhibitory immune receptors comprise hundreds of receptors across both innate and adaptive immunity. The increasing understanding of their relevance across broad facets of biology stimulates early attempts to harness them as therapeutic targets. Deeper insights into the mechanisms, characteristics and applications of these receptors continue to emerge rapidly, especially as they begin to be leveraged therapeutically outside the checkpoint receptors targeted in cancer. 


This meeting brings together scientists and physicians working on different aspects of inhibitory immune receptors biology across a range of disciplines in academia and industry. The meeting program reflects just how deeply this area penetrates into many areas of diverse biology and medicine and the interest at a global level.

Co-organizer, and Yale University School of Medicine Professor, Dr. Carla Rothlin, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 3-6, 2024 | Santa Fe Community Convention Center, Santa Fe, NM, United States
Scientific Organizers: Nicola J. Allen, Anna Victoria Molofsky and Francisco J. Quintana

Important Deadlines
Early Registration Deadline: Apr. 3, 2024
Scholarship Deadline: Feb. 28, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 28, 2024
Meeting Summary
# Neurobiology

The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Interactions between the nervous system and the immune system are increasingly recognized as being essential to health throughout the lifespan, as well as contributing to dysfunction in neurological disorders. This conference explores emerging topics in neuroscience, immunology and neuroimmunology to present the latest cutting-edge research across these disciplines. The program will highlight technological advances that are defining the heterogeneity of immune cells and their targets in the CNS and PNS, as well as across disease states.  In addition, we will explore how this heterogeneity impacts the function of the immune system itself, but also influences organism health and behavior.

Sessions will cover topics including: neuroimmune interactions in disease; impact of pathogens on brain function; immune regulation of behavior; glial interactions in neuroimmune signaling; brain-periphery interactions; microglia function.  Finally, the pairing of this conference with the Neurodegenerative Diseases conference will foster interdisciplinary insights and collaborations towards identifying immune pathology and therapeutic targets for multiple neurodegenerative disorders, where promising new treatments are emerging. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 15-19, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Katerina Akassoglou, Tony Wyss-Coray and Dheeraj Malhotra

Important Deadlines
Early Registration Deadline: Mar. 15, 2023
Scholarship Deadline: Feb. 15, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 15, 2023
Meeting Summary
# Neurobiology

Emerging evidence supports the role of the neuro-immune axis as a determinant of the onset and progression of neurological diseases. This Symposium focuses on the latest advances in understanding how neuroimmune functions affect cognition, autoimmunity, and neurodegeneration in the CNS. The Symposium will intersect scientific areas of microglial biology, the blood-brain barrier, neurogenesis, cognitive decline, aging, neurological diseases and psychiatric disorders. Emphasis will be placed on innovative technologies including multiomics, state-of-the-art imaging technologies, and genome engineering that drive basic discoveries and therapeutics. The Symposium will explore the convergence of diverse pathways to regulate the neuro-immune axis and determine their contribution to brain physiology and pathology. The Symposium will feature novel therapeutic strategies targeting neuroimmune mechanisms in neurological diseases. The ultimate goal of this Symposium would be to inspire creative ideas and promote multidisciplinary collaborations for studying CNS function and dysfunction and harnessing the immune system for drug discovery for devastating neurological diseases. The Symposium is designed to foster the exchange of ideas from across fields, thus providing a novel way to think about neurologic disease. We are bringing together a highly diverse group of speakers, who normally would not have an opportunity to meet, with a wide range of expertise ranging from regulation of neuronal activity and glial cell biology, to metabolomics and neurovascular interactions, adaptive and innate immunity. The meeting will highly benefit from being held jointly with the Neurodegeneration Symposium, as neuroimmune mechanisms underlying neurological diseases will be discussed including multiple sclerosis, Alzheimer’s disease, and brain trauma.

March 17-20, 2024 | Humanities/Social Sciences Building of Academia Sinica, TaipeiTaiwan
Scientific Organizers: Giorgio Trinchieri, Jenny P.Y. Ting, Hsing-Jien Kung and Shie-Liang Hsieh

Important Deadlines
Early Registration Deadline: Jan. 17, 2024
Scholarship Deadline: Dec. 26, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 26, 2023
Meeting Summary
# Biochemistry, Structural and Cellular
# Cancer
# Immunology
# Microbiota and Flora
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

The concept of inflammation being linked to tumor promoting and even initiating a tumor microenvironment has evolved to include a complex network of interactions: innate and acquired immune response to the tumor; metabolism in tumor and immune cells; local and systemic effects of the microbiota on tumor predisposition, promotion, response to chemotherapy, radiotherapy, and immune therapy; and finally cancer co-morbidities and therapeutic side effects. The metabolic tumor environment affects innate and immune cell metabolism and activity thus modulating tumor progression and the response to therapy, particularly immunotherapy, but also chemotherapy and radiotherapy. Innate signaling also affects the tumor microenvironment and a complex cross-talk involving innate receptors, trained immunity, and class I Major Histocompatibility Complex (MHC) regulates both inflammation and anti-tumor immunity. Also, rapid progress in experimental animals and more recently in cancer patients, is unraveling a complex interaction between the microbiota at epithelial surfaces and within the primary tumor and metastatic sites with response to therapy. This, in turn, is raising the hope to be able to predict patient response to different types of therapy and to target the microbiota for improving therapy response, decreasing toxicity and preventing co-morbidity.

This conference will cover new scientific areas that bring together aspects of cancer biology and immunity that are often only discussed at separate specialized meetings. The presence of both basic and clinical investigators will expose the participants to these new concepts and provide an opportunity to discuss and explore the clinical translation of this rapidly emerging new understanding of cancer immunobiology. Finally, as there is a growing interest regarding health differences that adversely affect ethnically distinct and/or disadvantaged populations, an afternoon workshop on Effects of Race and Ethnicity on Microbiome: Impacts on Cancer Health Disparities will be incorporated into the program.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 8-11, 2024 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Melanie M. Ott, Priti Kumar, Olivier Schwartz and Alex Sigal

Important Deadlines
Early Registration Deadline: Feb. 7, 2024
Scholarship Deadline: Jan. 17, 2024
Global Health Award Deadline: Nov. 7, 2023
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 17, 2024
Meeting Summary
# Infectious Diseases

The deadline to submit an abstract for short talk and poster presentation has passed. For any questions or issues, please email info@keystonesymposia.org.

This conference brings together researchers studying HIV, and emerging and re-emerging viruses of global concern to advance knowledge on pathogenesis, evolution, prevention, treatment, and long-term sequelae. The goal is to gain a better understanding of molecular mechanisms and apply lessons learned from one outbreak to another with a focus on deploying recent technological advances such as NGS, gene editing, antibody, and mRNA therapeutics to tackle emerging infections. The program will cover infections ranging from HIV to SARS-CoV-2, monkeypox, Influenza, hemorrhagic fevers, and others, featuring  experts from around the globe. The influence of an underlying HIV condition on other viral infections on the trajectory of other diseases will also be discussed. We anticipate identifying unique and common aspects of viral disease mechanisms, as well as potential interventions. The conference will also feature interactive poster sessions, selected abstracts for oral presentations, and networking opportunities.

Meeting organizers Dr. Melanie M. Ott, Dr. Olivier Schwartz and Dr. Alex Sigal talk about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 9-12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Kate L. Jeffrey, Ramnik Xavier and Xu Zhou

Important Deadlines
Early Registration Deadline: Feb. 8, 2024
Scholarship Deadline: Jan. 18, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 18, 2024
Meeting Summary
# Immunology
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Over 3 decades ago, Charles Janeway predicted pathogen sensing was mediated by germline-encoded pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs). Since then, a multitude of endosomal and cytoplasmic sensors, their ligands and downstream signal transduction pathways that initiate innate immunity have been defined. Emerging techniques such as cellular and spatial transcriptomics are informing us where in the human body, and in what diverse disease contexts, these pattern recognition receptors (PRRs), and associated gene circuits, are implicated. Furthermore, metabolic and chromatin analyses are illuminating acute and chronic adaptation of innate immune cell transcriptional programs. The next frontier in innate immunity will be understanding how innate sensor-ligand interactions, and the individual cellular programs that ensue, work in complex systems of tissue and microorganismal microenvironments. Of particular importance will be grasping innate immunity resolution during homeostasis and how it can be leveraged, or avoided, for treatment of infectious, autoimmune, neurodegenerative, cardiovascular and oncological diseases.

This conference will provide multidisciplinary perspectives on new horizons and the unexpected in innate immunity. The program will highlight innovative techniques and novel read outs of innate immunity at the molecular, cellular and tissue level to place importance of innate immunity in human health. We will also take a deep dive into clinical aspects of disease and contemporary drug discovery approaches to harness for innate immune modulation. This meeting will be a unique forum for researchers from diverse and traditionally non-overlapping fields (immunology, metabolism, artificial intelligence, drug discovery, structural biology), to build fresh ideas and collaborations for the next chapter of innate immune discovery and translation. The conference will be held jointly with the Keystone Symposium  on Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease, to enable cross-disciplinary insights and collaborations towards utilization of systems immunology tools to advance our understanding of innate immunity in health and disease.

Meeting co-organizer Dr. Kate Jeffrey talks about why you should attend this meeting in the video below:

Dr. Kate Jeffrey talks about her upcoming Keystone Symposia.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 9-12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: John Tsang, Shannon J Turley and Alex Marson

Important Deadlines
Early Registration Deadline: Feb. 8, 2024
Scholarship Deadline: Jan. 18, 2024
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 18, 2024
Meeting Summary
# Immunology
The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Unraveling the complexity of the immune system has been traditionally approached by experimental immunologists studying individual molecules, cell types, or cell-cell interaction pairs. These efforts have contributed significantly to our understanding of the mechanisms that control immune system function. However, immune responses emerge from complex interactions among heterogenous and dynamic elements that act across many biological scales. However, understanding the emergent properties of immune responses and how those differ across individuals in the human population are often beyond the limits of biological intuition and requires integration of quantitative, high-dimensional datasets combined with computational modeling and analyses. To address this need, researchers are combining diverse top-down and bottom-up approaches from immunology and computational and systems biology, leading to a new field of systems immunology. In parallel, advances in synthetic biology, gene editing (e.g., CRISPR), and the clinical success of immune cell therapies in cancer have propelled synthetic immune cell engineering to the forefront.

Very few meetings, if any, integrate these two exciting developments - systems and engineering immunology – on equal footings to highlight and discuss technology and immunological advances and knowledge gaps. There is much natural synergy between systems immunology – with the goal of having a predictive and quantitative understanding of the immune system – and immune cell engineering. For example, systems immunology would empower precise engineering and deployment of synthetic immune cells, which in turn can help advance fundamental understanding of the immune system itself. Through both plenary presentations and workshops, this meeting aims to foster interactions between these two emerging communities of researchers and practitioners. The program will highlight the latest technological advances and their applications in cancer, infectious diseases, and autoimmunity, and facilitate discussions on challenges integrating both fields as well as emerging challenges and opportunities. The conference will be held jointly with the Keystone Symposium  on Innate Immunity, to enable cross-disciplinary insights and collaborations towards utilization of systems immunology tools to advance our understanding of innate immunity in health and disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 25-28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Christina Towers, Rupert Beale and Leon O. Murphy

Important Deadlines
Early Registration Deadline: May. 7, 2025
Scholarship Deadline: Mar. 27, 2025
Short Talk Abstract Deadline: Mar. 27, 2025
Poster Abstract Deadline: Jun. 4, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

Organelle quality control, nutrient regulation, and signaling all converge at the lysosome. In particular, macroautophagy is a process by which a double membrane structure engulfs cytoplasmic material for lysosomal degradation. This meeting will bring together leaders and innovative thinkers within the broad fields of autophagy and endolysosomes to disentangle the complex mechanisms of lysosome-mediated quality control, nutrient regulation, and cell signaling. The meeting will highlight new discoveries surrounding endolysosomes and their intersections with autophagosomes.

Over the last two decades it has become increasingly clear that lysosomes and autophagic machinery play an important role in many disease processes including infection, cancer, metabolism and neurodegeneration. This meeting will emphasize the fundamental mechanisms of lysosome trafficking, signaling, and autophagy while also highlighting the impact of these discoveries on human health. We will include leaders from academia and industry while also featuring diverse speakers across career-stage and international representation. Abstracts will be chosen that showcase novel late-breaking discoveries and early-stage scientists in the field. The sessions will be designed to bring together experts from around the world and foster discussion and collaborations; ultimately to broaden our understanding of the diverse roles played by the autophagy machinery in health and disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 16-19, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Christian U. Blank, Stefani Spranger and Anna Christina Obenauf

Important Deadlines
Early Registration Deadline: Jan. 28, 2025
Scholarship Deadline: Dec. 11, 2024
Short Talk Abstract Deadline: Dec. 11, 2024
Poster Abstract Deadline: Feb. 20, 2025
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology

Cancer immunotherapy, in particular checkpoint inhibition targeting CTLA-4 and/or PD-(L)1 has revolutionized treatment and outcomes for many late-stage cancer patients. While checkpoint inhibitors are used in earlier and earlier stages and celebrate unparalleled response rates as neoadjuvants, some patients are intrinsically refractory to these treatments due to insufficient immune cell infiltration or T cell responses within the tumor. The major question remains, how to treat these patients.

This conference will assemble top experts in the field to address the unmet clinical needs, and discuss how immunotherapy can reach patient populations that currently do not benefit.  The program will explore how to overcome barriers to immune cell entry into tumors, as well as insufficient activation of anti-tumor immune responses. In addition, diverse immune cell therapies will be covered, from T-cell based mainstays like TILs, gene-modified T cells, and CAR-T cells, to emerging modalities deploying innate immune cells like dendritic and NK cells.  A major theme will focus on what we can learn from clinical failures with regards to improving the design immunotherapies, as well as how to strategically combine them with cellular therapies for optimal outcomes. This bedside to bench perspective will provide critical insight to drive scientific and clinical advances beyond current limitations.

This conference will be held jointly with the Keystone Symposium on Immune Cell Therapies: Advances in Cancer and Autoimmune Disease to enable cross-disciplinary insights and collaborations towards better outcomes for all cancer patients.  

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 30-2, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Seychelle Vos, John T. Lis and Luca Giorgetti

Important Deadlines
Early Registration Deadline: Feb. 19, 2025
Scholarship Deadline: Jan. 9, 2025
Short Talk Abstract Deadline: Jan. 9, 2025
Poster Abstract Deadline: Mar. 6, 2025
Meeting Summary
# Genetics, Genomics and RNA

The goal of this meeting is to bring together researchers who are studying both the mechanisms of eukaryotic gene expression and the structural and functional organization of the genome. The integration of these two areas is critical if we are to understand cell type specific gene regulation in development and disease. The rapid convergence of these fields necessitates a meeting of this scope that brings diverse perspectives together to focus on how these processes relate to each other and develop a holistic understanding.

The specific aims of this conference are to:

  1. Bring researchers at all stages of their careers together to discuss novel findings at the intersection of genome organization and transcription regulation.
  2.  Connect information obtained across scales from the atomic level to microscopic observations to understand how cell-type specific gene expression can be achieved
  3. Define open questions in the field that require synergy between different techniques and fields.

Traditional transcription meetings have focused on the basic mechanisms underlying transcription whereas genome organization meetings are dedicated to large-scale genome structure. It has become increasingly clear that the two fields are highly synergistic and interconnected and more crosstalk between the fields is required to fully understand each process. This meeting helps address this critical need. This conference will foster greater communication and synergy between laboratories studying related transcriptional processes at different size scales. This will catalyze in new approaches and collaborations to address questions at the interface of gene expression and genome organization.

Finally, this conference will be held jointly with the Keystone Symposium on Epigenetics in Development and Disease to allow attendees to appreciate the interplay between these two closely related fields and network across both domains. Joint sessions and meals will foster cross-disciplinary interactions, insights and collaborations towards integrating these fields and providing a holistic understanding of epigenetics in the context of chromatin architecture.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 7-10, 2025 | Southern Sun Elangeni & Maharani, Durban, NL, South Africa
Scientific Organizers: Mike McCune, Thumbi Ndung'u, Sharon R. Lewin and Cissy Kityo

Important Deadlines
Early Registration Deadline: Feb. 25, 2025
Scholarship Deadline: Jan. 14, 2025
Global Health Award Deadline: Nov. 5, 2024 11:59 PM
Short Talk Abstract Deadline: Jan. 14, 2025
Poster Abstract Deadline: Mar. 17, 2025
Meeting Summary
# Infectious Diseases

Recent gains in controlling the global HIV/AIDS epidemic may be threatened: key HIV incidence rates are declining only modestly, the sustainability of current programs to expand ART remains unclear, and the “youth bulge” in sub-Saharan Africa is contributing to a growing at-risk population. Although much effort has been devoted to prevention and treatment of HIV disease, these interventions face major technical and/or implementation challenges. Thus, an alternative approach to lifelong ART therapy is needed: one that will either completely eliminate HIV from the body or durably suppress viremia in the absence of ART.

This Keystone Symposium will convene investigators from around the world to focus on strategies for eradication and durable remission. In particular, we will address how to achieve this goal in low-and-middle-income countries (LMIC) wherein the epidemic continues to rage. Together, we will tackle important questions including:

  1. What is the biology of the rebound competent reservoir of HIV?
  2. How can this reservoir be measured, quantitatively and qualitatively, with minimally invasive tools?
  3. What therapeutic approaches might reduce the size of the reservoir and/or keep it at bay upon interruption of ART?
  4. How can we assure that such interventions will be available to all of those in need, wherever they may reside?

This meeting is unique from any other in the past in the sense that it not only directly addresses the need for a curative intervention in LMICs, it is also being held in one such country, organized by and drawing key participation from stakeholders from these hard-hit regions.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 23-26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Elizabeth Villa, Bridget Carragher and Ilaria Testa

Important Deadlines
Early Registration Deadline: Feb. 4, 2025
Scholarship Deadline: Dec. 19, 2024
Short Talk Abstract Deadline: Dec. 19, 2024
Poster Abstract Deadline: Feb. 27, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

One of the most remarkable aspects of biological systems is their ability to operate across vast size and time scales to perform their functions. In order to understand those functions, imaging methodologies need to characterize, and preferably integrate, these scales from the atomic to tissue level. This symposium will bring together experts in various macromolecular imaging technologies to collectively integrate these tools into workflows for examining molecular processes across functional scales.

The program will cover recent technological advances in imaging modalities that have transformed our ability to study the architecture of cells and their molecular components.  For example, cryo-electron microscopy has emerged as a kingpin of structural biology in just a few years, with the ability to determine high-resolution structures of macromolecular complexes that were once considered challenging due to their size, conformational or compositional variability, or environment. However, these biomolecular complexes do not act in isolation; it is essential to understand how they assemble with other proteins, and in turn, are embedded in cellular networks to perform their functions. Therefore, the conference will integrate imaging modalities that enable the study of macromolecular machinery in the context of its natural environment, the cell. In particular, super-resolution fluorescence microscopy, is a powerful new technique for locating molecules within cells with high precision, while cryo-electron tomography has recently realized its potential to observe macromolecular networks in situ. Attendees will discover the latest advances in diverse imaging technologies, how to best apply these tools to their work and most importantly how this array of tools can be collectively leveraged to reveal new biology, from structural to functional insights.

This conference will be held jointly with the Keystone Symposium on Machine Learning Applied to Macromolecular Structure and Function to enable cross-disciplinary insights and collaborations towards integrating the state-of-the-art in cryoEM/ET technologies with machine learning capabilities.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 27-30, 2025 | Daejeon Convention Center, DaejeonKorea, Republic of
Scientific Organizers: Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung

Important Deadlines
Early Registration Deadline: Mar. 11, 2025
Scholarship Deadline: Jan. 28, 2025
Short Talk Abstract Deadline: Jan. 28, 2025
Poster Abstract Deadline: Apr. 3, 2025
Meeting Summary
# Cancer
# Genetics, Genomics and RNA

In this new meeting, we will delve into the captivating biology of DNA replication stress and single-stranded DNA (ssDNA) replication gaps as it relates to cancer development, progression and treatment. This meeting will cover exciting new discoveries and reveal mechanistic underpinnings with implications for treatment, such as:

  • While historically overshadowed by the focus on DNA double-stranded breaks (DSBs), recent transformative findings have positioned gaps as the key lesions sensitizing cancer cells to chemotherapy.
  • Gap filling mechanisms can enable the acquisition of chemotherapy resistance and lead to widespread mutagenesis propelling cancer genome evolution.
  • Oncogene expression or tumor suppressor loss induces gap formation that typically activates cell death or senescence. Yet these protective pathways are blocked in cancer cells, allowing them to proliferate. Understanding these key mechanisms is essential for designing more effective cancer therapies.

The implications of these discoveries are profound, as they compel us to reevaluate the design of cancer therapies while also unveiling new possibilities for biomarkers of chemotherapy response and targets for more effective cancer cell elimination.

By exploring the links between gap repair, tumor mutation burden, and immune checkpoint inhibitors, this meeting aims to enhance our understanding of how these pathways can be harnessed to stimulate natural immunity and improve cancer treatment outcomes. During this conference, we will gather distinguished leaders in the field, who will share their expertise and discuss the fundamental mechanisms driving gap formation, regulation, and their impact on and relationship to replication stress and cancer. By embracing an interdisciplinary approach, combining state-of-the-art super-resolution imaging, sophisticated genetics, and mechanistic analysis, we aim to shed light on the hidden pathways that govern gap metabolism and exploit their potential for innovative anti-cancer therapies.

We will also explore how these findings can synergize with emerging strategies, including targeted therapies and immunotherapy, to pave the way for more effective treatments. Importantly, we expect strong interest from pharmaceutical companies that are currently re-examining their anti-cancer drugs as gap inducers and/or gap repair disruptors, and therefore seek tools, biomarkers and insight in this developing field. The timeliness and significance of the meeting is underscored by the swiftly evolving body of literature and reviews concerning DNA replication stress, gaps and cancer therapy response, and this meeting provides the opportunity to make connections and collaborations to advance scientific and translational impacts in the field.

September 6-9, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mingjie Zhang and Jin Zhang

Important Deadlines
Early Registration Deadline: Jul. 17, 2024
Scholarship Deadline: Jun. 5, 2024
Short Talk Abstract Deadline: Jun. 5, 2024
Poster Abstract Deadline: Aug. 14, 2024
Meeting Summary
# Biochemistry, Structural and Cellular

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.

Phase separation-mediated biological condensate formation is being recognized as a general mechanism for forming broad ranges of cellular organelles that are free of or not enclosed by lipid membranes. Formation of biological condensates has far-reaching implications in understanding operation logistics of cells. In parallel, the concept of biological condensate formation is providing previously unrecognized opportunities for developing therapeutic opportunities for various diseases and for numerous other translational applications. However, despite the explosive expansion in the past decade, the field of biological condensate formation research is still very young. Biological condensates are complex soft matters. The field needs more experts from polymer chemistry, soft matter physics, physical chemistry, etc. to develop and optimize theories underlying biological condensate formation. These theoretical frameworks will in return help to enhance our understanding of how biological condensates regulate cellular functions and to device better strategies for harnessing the phase separation processes for translational applications. This symposium aims to bring leading scientists from broad areas of biological condensate research to communicate current status and future challenges of the field, to discuss how potential cross-disciplinary collaborations may move the field forward, and to explore opportunities of targeting biological condensates for translational purposes.

Meeting Co-Organizer, and Professor of Pharmacology, Chemistry and Biochemistry, and Biomedical Engineering at the University of California, San Diego, Jin Zhang, talks about why you should attend this meeting in the video below:


Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 8-11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Dorothy Schafer, Asya Rolls and Anne Schaefer

Important Deadlines
Early Registration Deadline: Apr. 22, 2025
Scholarship Deadline: Mar. 11, 2025
Short Talk Abstract Deadline: Mar. 11, 2025
Poster Abstract Deadline: May. 15, 2025
Meeting Summary
# Immunology
# Neurobiology

Neuroimmune interactions are an essential driver of inflammation in the nervous system. While previous efforts have focused on these mechanisms in the brain specifically, recent advances have revealed that these interactions extend throughout the body, playing essential roles in regulating a broad range of physiological systems.  Indeed, immune modulation of overall neural circuit function regulates  peripheral organ homeostasis.

There is currently no meeting that brings together investigators studying neuroimmune interactions in the context of peripheral organs with those studying the brain, to integrate our understanding  of complex, system-wide neural-immune interactions.  This meeting will do just that, providing a unique environment to draw cross-disciplinary insights and provide a holistic view of neuroimmune interactions that permeate the body and do not act isolation. In addition, incorporation of industry leaders with academic and clinical experts will spark new ideas  and collaborations towards novel neural-immune signaling-targeted therapies against neurodegenerative, neuropsychiatric, and peripheral organ disorders.

This conference will be held jointly with the Keystone Symposium on Neurodegeneration: Linking Cellular Pathways to Therapeutic Strategies to spark innovative cross-disciplinary insights and collaborations towards understanding neuroimmune drivers of neurodegenerative disease and identifying novel therapeutic targets. 

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 8-11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Michael Ward, Erika L Holzbaur and Sarah L. DeVos

Important Deadlines
Early Registration Deadline: Apr. 22, 2025
Scholarship Deadline: Mar. 11, 2025
Short Talk Abstract Deadline: Mar. 11, 2025
Poster Abstract Deadline: May. 15, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Neurobiology

Neurodegenerative diseases are common but largely untreatable, despite massive investments from both academic and industry sectors. Tackling these diseases will require a collective and integrated effort to address the challenges of identifying, understanding, and translating cellular mechanisms of neurodegeneration into effective therapies.

This meeting will take an innovative approach by assembling speakers and attendees across diverse fields, creating synergy between geneticists, cell biologists, computational biologists, clinicians, and patients to broaden, deepen and integrate our understanding of these diseases. These experts will illustrate how genomics, technology, computational advances, and a focus on convergent cellular pathways will drive innovation and discovery in the field, irrespective of entrenched models. The program will feature new voices in the field, who will generate discussion around new and innovative ideas and directions.

Specifically, the program will:

  1. Leverage human genetics and genomics to identify convergent and divergent disease pathways;
  2. Explore new findings in key cellular pathways of neurodegeneration and aging;
  3. Highlight transformative technologies that enable cell biology at scale in the context of neurodegenerative disease;
  4. Demonstrate how discoveries are translated into new therapies with an eye towards enhancing inclusion in clinical research and trials;
  5. Engage with key stakeholders regarding the digital era of neuroscience.

We anticipate that attendees will leave this meeting with a deeper appreciation of how genetic discoveries inform and inspire mechanistic inquiries about cellular disease mechanisms, and how new discoveries and new technologies are driving a revolution in how neurodegenerative diseases are classified and treated.

This conference will be held jointly with the Keystone Symposium on Neuroimmune Interactions: A Systems-Wide Perspective on Whole Organism Physiology to spark innovative cross-disciplinary insights and collaborations towards understanding neuroimmune drivers of neurodegenerative disease and identifying novel therapeutic targets.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 11-14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Quinton Smith, Matthias Lutolf and Kelly R. Stevens

Important Deadlines
Early Registration Deadline: Mar. 25, 2025
Scholarship Deadline: Feb. 11, 2025
Short Talk Abstract Deadline: Feb. 11, 2025
Poster Abstract Deadline: Apr. 17, 2025
Meeting Summary
# Developmental, Reproductive and Regenerative
# Drug Discovery, Bioengineering and Digital

This conference explores the biomedical relevance of innovative engineering approaches, such as 3D bioprinting, synthetic gene networks, programmable biomaterials, and microfluidic systems, for controlling human organoid organization at multiple scales. These approaches hold tremendous potential for developing novel preclinical drug testing models, disease models, and tissues for regenerative medicine applications, while also advancing our understanding of basic human biology.

This meeting will explore the latest emerging methods in organoid bioengineering, as well as their applications and utility for advancing scientific discovery and medical practice.  It fills a unique need in the scientific community not fulfilled by other conferences, as it focuses on the intersection of organoid biology and engineering with clinical insights. The program will address critical gaps in knowledge by bringing together scientists across disciplines to challenge current research paradigms and employ transformative approaches and methods. The goal is to consolidate the field, move it forward, and bridge it with other areas of disease relevance to enable the greatest impact to science and medicine. The anticipated outcomes include new scientific knowledge, collaborations, changes in clinical practice, and training, with attendees taking away valuable insights on advancing the field using innovative engineering approaches and translational applications.

This conference will be co-located with the Keystone Symposium on Single Cell Biology: Unique Cells to Tissue Ecosystems to enable cross-disciplinary insights and collaborations towards understanding the complex cellular ecosystem that makes up tissues and model organoids.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Greg M. Delgoffe, Amanda Lund, Nikhil S. Joshi and Laura K. Mackay

Important Deadlines
Early Registration Deadline: Dec. 12, 2024
Scholarship Deadline: Oct. 31, 2024
Short Talk Abstract Deadline: Oct. 31, 2024
Poster Abstract Deadline: Jan. 9, 2025
Meeting Summary
# Immunology

Normal and pathological immune responses function across tissues that harbor unique metabolic, environmental, and cellular microenvironments. Therefore the mechanisms that recruit and activate leukocytes, define their interstitial function and survival, or promote their retention in particular tissues are crucial to understanding how to boost, redirect, or restrict immune responses across the spectrum of health and disease. While the topic of tissue specific immunity has been touched on in other meetings, this is the first conference to integrate discussion across diverse tissues and disease contexts.  The program will cover how various tissues shape the immune responses that are generated within, while highlighting emerging technologies that are enabling advancements in this field.

The speaker lineup will attract a vast array of multidisciplinary scientists thinking about T cell differentiation in tissues in the context of diverse diseases, such as cancer, autoimmunity, and infection. In addition, as a joint meeting with the Keystone Symposium on Innate Immune Memory, the intersections of audiences and researchers will enable dynamic cross-talk, cross-disciplinary insights and collaboration towards understanding the interconnectedness of innate and adaptive immunity, and interplay with tissue microenvironments.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 2-5, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shruti Naik, Keke C. Fairfax and Renato Ostuni

Important Deadlines
Early Registration Deadline: Dec. 12, 2024
Scholarship Deadline: Oct. 31, 2024
Short Talk Abstract Deadline: Oct. 31, 2024
Poster Abstract Deadline: Jan. 9, 2025
Meeting Summary
# Immunology

Inflammatory memory is remnant of anti-pathogen responses that may be adaptive or maladaptive, leading to inflammatory, metabolic, and neurodegenerative diseases, and cancers. This meeting will highlight epigenetic mechanisms and consequences of inflammatory memory for human health and disease. Sessions will thus focus on mechanisms underlying:

  1. formation and maintenance of innate memory across a spectrum of immune and non-immune cell types
  2. inter and transgenerational inheritance of memory and disease phenotypes
  3. the contribution of inflammatory training to chronic diseases
  4. the role of environmental pollutants in inflammatory imprinting and disease susceptibility

This symposium will bring together experts in innate immunity, epigenetics, and disease biology, spanning diverse cell types and disease indication, to facilitate interdisciplinary interactions in this emerging field. The conference will be held jointly with the Keystone Symposium on T Cell Differentiation in Tissue Microenvironments to enable cross-disciplinary insights and collaborations towards understanding interconnectedness of innate and adaptive immunity. This provides a unique opportunity to understand non-cognate memory in adaptive immune cells and the beneficial role of innate training in anti-pathogen and vaccine responses. In addition, the meeting will include panel discussions on controversial topics including mechanisms of transgenerational inheritance in mammals and the role of inflammatory memory in inflammaging. This dynamic forum on inflammatory memory will bridge a number of different research communities and provide insights that forecast future directions in modulation of immune memory for therapeutics across a wide range of diseases.

Meeting Co-Organizer and Associate Professor of Dermatology at the Icahn School of Medicine at Mount Sinai, Dr. Shruti Naik, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 6-8, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

Important Deadlines
Early Registration Deadline: Dec. 17, 2024
Scholarship Deadline: Nov. 6, 2024
Short Talk Abstract Deadline: Nov. 6, 2024
Poster Abstract Deadline: Jan. 15, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

The Keystone Symposia meeting on “Microproteins: from discovery to applications” will bring together leaders and rising stars in the emerging field of microproteins, proteins encoded on small open reading frames (smORFs) found in regions of the genome previously thought to be non-coding. Microproteins have been shown to act as key players in physiology and disease, such as development, metabolism, cardiac function, neurological function, the immune system, and several forms of cancer. In recent years, much effort has been placed on annotating microproteins and developing tools to study their activities. The field must now place more emphasis on studying the physiological impact of microproteins across organisms and translating microprotein biology into novel therapies.

In this meeting we aim to share new strategies for triaging the vast pool of translated smORFs in order to focus on those most likely to be functional. We will also learn about strategies to reveal microprotein functions through novel computational and experimental techniques. In addition, we will hear about the latest examples of microproteins implicated in disease and how they might be leveraged for new therapeutic development. Finally, we will hear from researchers who view smORF translation through different but complementary perspectives, including a source for antigens reporting on changes in cellular state, opportunities for de novo gene birth, and inspiration for de novo design of mini-proteins. In summary, this meeting will foster dynamic discussions and new collaborations between scientists from diverse backgrounds and career stages which will propel microprotein research along new and unexpected trajectories.

Meeting Co-Organizer, and Assistant Professor in the School of Pharmacy & Pharmaceutical Sciences at the University of California, Irvine, Thomas Martinez, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 16-19, 2025 | Fairmont Copley Plaza, Boston, MA, United States
Scientific Organizers: JoAnne L Flynn, Bryan D. Bryson and Henry C. Mwandumba

Important Deadlines
Early Registration Deadline: Dec. 19, 2024
Scholarship Deadline: Nov. 12, 2024
Global Health Award Deadline: Sep. 17, 2024 4:59 PM
Short Talk Abstract Deadline: Nov. 12, 2024
Poster Abstract Deadline: Jan. 23, 2025
Meeting Summary
# Infectious Diseases

Tuberculosis (TB) is the world’s leading cause of infectious disease death. The quest to end this pandemic is challenged in part by an incomplete understanding of the immune responses necessary for protection against disease. Key to this issue is the heterogeneity that exists across many aspects of the disease, from mycobacterial physiology, to cellular responses to Mtb infection, to human responses to infection and vaccination.

The goal of this meeting is to bring together scientists from across the globe to deconstruct the monolith of TB, by dissecting pathogen and host heterogeneity across molecular and clinical aspects of disease. We will examine Mtb diversity alongside cellular heterogeneity that governs immune cell responses to the pathogen.  In addition, the program will cover heterogeneity in tissue-level response to infection, as well as human and non-human primate responses to vaccination,. A key focus of our meeting will be to highlight molecular, clinical, and technological advances that enable better characterization and definition of the variable elements that have the strongest impact on disease outcomes. We expect this meeting to identify emerging host and bacterial biomarkers of disease progression that characterize cohorts of individuals with TB for targeted approaches to treatment that will be more effective against this heterogenous disease. By bringing together diverse scientists from across the spectrum of TB research, this meeting will foster new collaborations to integrate human observations with  experimental models,  immunologic insights and molecular profiling, to generate new therapeutic paradigms that are so desperately needed against this disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

December 8-11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Valerie Horsley, Michael T. Longaker and Thomas A Wynn

Important Deadlines
Early Registration Deadline: Oct. 22, 2024
Scholarship Deadline: Sep. 10, 2024
Short Talk Abstract Deadline: Sep. 10, 2024
Poster Abstract Deadline: Nov. 14, 2024
Meeting Summary
# Immunology

This long-standing symposium will serve as an engaging platform for world-renowned researchers across the globe, both early-career and established, to exchange ideas, showcase pioneering findings, and foster fruitful collaborations on topics of clinical innovations, immunobiology, and mechnobiology in the field of fibrosis research. Workshops on multiomics and lessons across tissues combined with poster sessions, and in-depth discussions, will provide unparalleled opportunities for mentoring, training, and interactive scientific exchanges. With its wide-ranging scope of topics and unique opportunities for cross-industry and -disciplinary collaborations spanning different organ systems, no other event rivals the comprehensive platform offered by this program.

Meeting co-organizer, Dr. Valerie Horsley, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 3-6, 2025 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Irina A. Udalova, Ana-Maria Lennon-Duménil and Paul Kubes

Important Deadlines
Early Registration Deadline: Jan. 14, 2025
Scholarship Deadline: Dec. 5, 2024
Short Talk Abstract Deadline: Dec. 5, 2024
Poster Abstract Deadline: Feb. 10, 2025
Meeting Summary
# Immunology

Myeloid cells are essential components of the innate immune system and play a key role in the pathogenesis of many diseases. We now have a good understanding of their development and diversity, as well as their distinct biological roles. However, how myeloid cell responses are shaped by the tissue microenvironment, including interaction with other cells, mechanics and osmotic influences in specific locations, remains less studied.

This meeting will address the different mechanisms underlying signaling, epigenetic, and metabolic adaptations of myeloid cells to their chemical and physical environment. It will bring new biochemical and biophysical concepts to the classical immunological and modern genomic views of myeloid cells.  Importantly, we will integrate these various aspects of how myeloid cells interact with their tissue environment, to unravel this complex relationship.

The meeting will bring together interdisciplinary groups of scientists who normally would attend more specialized meetings, to collectively integrate their knowledge and advance the field. To facilitate these cross-disciplinary interactions we will feature workshops and panel discussions on topics such as immune-mechano-sensing, which will engage attendees to think outside their typical siloes and integrate new perspectives.  Attendees of this meeting will form new conceptual views on the inter-connected life of myeloid cells in tissues, and develop new collaborations at the intersection of disciplines to advance their research, and the field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 23-26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Paul Cohen, Ruth J.F. Loos, Claudio J. Villanueva and Christian Wolfrum

Important Deadlines
Early Registration Deadline: Jan. 8, 2025
Scholarship Deadline: Dec. 4, 2024
Short Talk Abstract Deadline: Dec. 4, 2024
Poster Abstract Deadline: Jan. 30, 2025
Meeting Summary
# Metabolism and Cardiovascular

Obesity is a major risk factor for type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease, and many types of cancer. Collectively, these associated diseases are the leading causes of morbidity and mortality worldwide. A deeper understanding of the biology of adipose tissue and pathophysiology of obesity will be critical to address this major threat to human health.

To that end, the Obesity and Adipose Tissue Keystone meeting aims to:

  1. highlight cutting-edge science spanning basic molecular and cellular biology to human studies
  2. showcase the latest advances in the genetics of human obesity and body fat distribution;
  3. identify emerging mechanisms of disease and therapeutics.

We anticipate that attendees will be exposed to the latest, unpublished work driving this field and will leave the meeting inspired to make new contributions to the study of obesity and adipose tissue. Our meeting fills a unique need by spanning from basic biology to human genetics and population-based studies. Our meeting will also unite scientists in academia and industry to highlight both disease mechanisms and therapeutics. By providing this broad picture of adipose tissue and obesity, we hope to foster new collaborations and motivate a new generation of scientists to pursue creative multidisciplinary approaches to shape this field.

This conference will be held jointly with the Keystone Symposium on MASH Pathogenesis and Therapeutic Approaches to encourage cross-disciplinary insights and collaborations towards understanding underlying mechanisms of how obesity leads to liver disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 23-26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Elizabeth K. Speliotes, Rebecca A. Taub and Hannele Yki-Järvinen

Important Deadlines
Early Registration Deadline: Jan. 8, 2025
Scholarship Deadline: Dec. 4, 2024
Short Talk Abstract Deadline: Dec. 4, 2024
Poster Abstract Deadline: Jan. 30, 2025
Meeting Summary
# Metabolism and Cardiovascular

With the rise of obesity we have seen an increase in metabolic dysfunction-associated fatty liver disease (MAFLD) which affects about 30% of the population in developed countries. MAFLD is caused by excess deposition of fat in the liver and can progress to metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis and liver cancer. About 5% of the general population has MASH and presently there are no effective medical treatments for the condition making it a large unmet medical need. Identifying the drivers of MASH and developing therapies to ameliorate it will be critical to curbing the liver disease epidemic.

This meeting will cover the latest on:

  1. the genetic etiology of the condition
  2. metabolic and inflammatory drivers of the disease
  3. preclinical modelling of the disease
  4. non invasive markers for diagnosis
  5. existing and emerging therapeutics

This conference will held jointly with the Keystone Symposium on Obesity and Adipose Tissue to encourage cross-disciplinary insights and collaborations towards understanding underlying mechanisms of how obesity leads to liver disease. This is a synergistic pairing, given that lipodystrophy has long been known to promote severe MAFLD and ways to reduce overall obesity are also being tried for MAFLD, such as with bariatric surgery and now GLP-1 and dual GLP-1/GIP agonists. Joint sessions on human genetics and therapeutics across MASH and obesity will facilitate interaction between endocrinologists, hepatologists, adipose and liver biologists for synergy.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Brian M. Davis, Michelle Monje and Ihsan Ekin Demir

Important Deadlines
Early Registration Deadline: Dec. 3, 2024
Scholarship Deadline: Oct. 22, 2024
Short Talk Abstract Deadline: Oct. 22, 2024
Poster Abstract Deadline: Dec. 30, 2025
Meeting Summary
# Cancer
# Neurobiology

In the past, consensus dictated that nerves or neural activity were not involved in cancer development and progression. However, recent high-profile studies have revealed that neurons may in fact play roles in all aspects of cancer progression, from inception to metastasis. These insights suggest that manipulating the nervous system may provide novel therapeutic strategies against cancer.

This meeting has been designed to explore these emerging findings, specifically addressing:

  1. How do nerves contribute to cancer initiation, growth and metastasis?
  2. How do neuro-immune interactions shape the tumor microenvironment?
  3. Are there current neuron-targeted therapeutics that can be repurposed as adjuvant cancer therapies?

Additional goals of this meeting are to provide a forum for new investigators in this emerging field to present their most recent findings, recruit trainees and participate in workshops that will help them build a successful research program to drive the field forward. Most importantly, this meeting is designed to provide a supportive environment that will stimulate cross-pollination by experts from established disciplines (e.g., oncology, immunology, neuroscience) and to facilitate the development of networks and collaborations that will serve these scientists and the field for years to come.  Ultimately, the goal is to catalyze interdisciplinary advances and translational insights in neuro-oncology to support transformative clinical impacts.

This conference will be held jointly with the Keystone Symposium on Tumor Microenvironment: Metastasis and the Host to enable cross-disciplinary insights and collaborations towards identification and targeting of neural drivers and/or suppressors of metastatic disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 16-19, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shannon Mumenthaler, Kathryn E. Wellen and Arkaitz Carracedo

Important Deadlines
Early Registration Deadline: Jan. 28, 2025
Scholarship Deadline: Dec. 10, 2024
Short Talk Abstract Deadline: Dec. 10, 2024
Poster Abstract Deadline: Feb. 20, 2025
Meeting Summary
# Cancer
# Metabolism and Cardiovascular

Tumor metabolism is a fundamental hallmark of cancer. The utilization of nutrients as fuel for cancer cell growth and spread has been a major field of study. Increasingly, our attention has shifted to the importance of dynamic crosstalk between cancer cells and nonmalignant cells within the microenvironment, as well as systemic metabolic features, in driving tumor evolution. However, a mechanistic and systems level understanding of the consequences of these metabolic interactions is missing.

This meeting brings together a diverse and multidisciplinary group of researchers to focus on studying tumor metabolism in context, including influences from the local and systemic environment. The program will focus on metabolic heterogeneity across spatiotemporal scales, from intracellular regulatory networks to diverse inter-cellular interactions within the tumor microenvironment. We will delve into therapeutic strategies aimed at addressing metabolic vulnerabilities.  Specifically, we will explore emerging research on biomarker discovery, the pursuit of novel therapeutic targets, and comprehensively review lessons learned in recent attempts to target cancer metabolism. Attendees will gain exposure to novel technologies, model systems, and computational approaches to tackle the complexities of tumor metabolism. We will discuss the opportunities for convergence of scientific disciplines to impact fundamental and clinical aspects of cancer research.  The meeting will spark thought-provoking dialogue on future directions in the tumor metabolism field, spanning mechanistic to translational perspectives including novel clinical trial strategies and how to ensure diversity and equity in our research and clinical approaches.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 20-23, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Christopher Voigt, Pamela A. Silver and Alvin Tamsir

Important Deadlines
Early Registration Deadline: Dec. 4, 2024
Scholarship Deadline: Oct. 23, 2024
Short Talk Abstract Deadline: Oct. 23, 2024
Poster Abstract Deadline: Dec. 30, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Microbiota and Flora

This meeting will integrate recent multidisciplinary advances in genetic engineering, chemistry, imagining, and artificial intelligence that are transforming agricultural practice, productivity and sustainability. The program will cover genome editing advances side-by-side with novel engineering approaches to develop integrative strategies to solve complex problems in agriculture. This includes the advanced engineering of plants and symbiotic soil microbiota to enhance crop productivity and resilience. For example, to solve the classic problem of nitrogen fixation, the program will cover various strategies, from progress in self-fertilizing plants, to engineering bacteria to deliver fixed nitrogen, to new catalysts that chemically synthesize ammonia, to bionic leaves that combine elements of chemistry and microbial systems. In addition, approaches to control insects using gene drives or through their microbiome will be presented, addressing a core issue in agriculture. Advances in field imaging and artificial intelligence will explored with the long-term goal of integrating these systems with advances in genetic engineering. 

The diverse line-up of topics will attract researchers from disparate fields to interact and collaboratively work towards innovative and cross-disciplinary solutions for the future of agricultural sustainability. Furthermore, the conference will be co-located with the Keystone Symposium on Genetic Engineering for a Sustainable Future to enable cross-disciplinary insights and collaborations towards novel sustainable solutions enabled by genetic engineering tools and technologies.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 4-7, 2025 | Marriott Marquis Washington, DC, Washington, DC, United States
Scientific Organizers: Rino Rappuoli, Kanta Subbarao, Laurence Zitvogel and Firdausi Qadri

Important Deadlines
Early Registration Deadline: Apr. 16, 2025
Scholarship Deadline: Mar. 5, 2025
Global Health Award Deadline: Jan. 20, 2025 11:59 PM
Short Talk Abstract Deadline: Mar. 5, 2025
Poster Abstract Deadline: May. 14, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Immunology
# Infectious Diseases

Now that vaccinology has conquered the important childhood infections, the field aims to extend the benefits of vaccines more broadly across diseases and demographies. This meeting will cover new horizons in vaccine development and design to protect against more challenging infectious agents, as well as non-infectious diseases. Specifically, attendees will learn about the latest insights into vaccines against:

  • emerging infections
  • antimicrobial resistant infections
  • chronic infectious diseases
  • diseases of poor countries
  • infections in the elderly
  • cancer
  • autoimmune and neurodegenerative disease

This new vaccine ambition is supported by the incredible advances in science and technology that make it technically possible to develop vaccines against many new targets, and by innovative approaches to vaccine development for emerging infections and for diseases of poor countries. The program will cover a wide variety of these new technologies that are transforming vaccinology, such as reverse vaccinology, structure-based antigen design, adjuvants, nucleic acid vaccines (especially RNA), viral vectors, systems biology, and controlled human infections. They are supported by scientific advances in human immunology, genomics, synthetic biology, molecular structure of antigens and antigen-antibody complexes, germinal centers, and microbiome, all of which will be highlighted to inform vaccine design strategies.

This meeting will span technology and biology of vaccine design, to multidisciplinary global approaches to health equity in vaccine development, production and distribution, including lessons learned from the COVID-19 pandemic. These include plans promoted by CEPI, NIH, Bill and Melinda Gates Foundation and Wellcome Trust to change the way vaccines are developed to enhance global access in times of urgency, and otherwise.

Each session will be spearheaded by a keynote speaker who will frame the discussion, followed by field leaders and innovators providing emerging advances across academic, industry, government and non-profit sectors. We will also feature rising stars and trainees in plenary and workshop sessions to encourage new voices and ideas to drive the field forward. The meeting will provide the unique opportunity to make cross-disciplinary and cross-sector connections and collaborations to catalyze translational advances and impacts.

This meeting will be held jointly with the Gates Grand Challenges meeting to encourage interdisciplinary insights and collaborations between scientists, clinicians and policy makers towards societal impacts.  Attendees of the Keystone Symposia conference are invited to attend Gates Grand Challenges joint programming on June 4, included with the Keystone Symposia registration fee.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 3-6, 2025 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Fyodor D. Urnov, Claire Booth and Laralynne Przybyla

Important Deadlines
Early Registration Deadline: Jan. 14, 2025
Scholarship Deadline: Dec. 5, 2024
Short Talk Abstract Deadline: Dec. 5, 2024
Poster Abstract Deadline: Feb. 10, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Genetics, Genomics and RNA

This meeting will connect a broad network of researchers who share a common goal of using CRISPR-based genome engineering approaches to understand and treat human disease. Specifically, the program will bridge early stage research focused on developing and using CRISPR tools to understand disease mechanisms, through applications of these technologies in preclinical models and current therapeutic strategies for oncology and genetic disease.

Specifically, this conference aims to:

  1. Highlight the utility of CRISPR approaches to elucidate disease mechanisms from academic and industry perspectives.
  2. Discuss advances in preclinical models that prove safety and efficacy to enable CRISPR strategies to proceed toward clinical applications.
  3. Address ongoing scientific and regulatory barriers to getting genome editing-related therapies to patients.
  4. Bring together researchers across the spectrum of disease-relevant research to spark new ideas and collaborations with the ultimate goal of accelerating the path of CRISPR approaches to the clinic.

The program will address major strategic challenges that delay or impede the path to the clinic, to provide solutions that will accelerate clinical impacts.  These include: how to focus broader outcomes of a target discovery campaign into a preclinical efficacy and safety effort for a clinic-bound program?  How do lessons from preclinical efforts inform clinical deployment strategies, and how do early-stage clinical data enable “fast-follow” efforts?   What are the avenues for regulatory harmonization to accelerate path to clinic?

Attendees will gain deep insight into how to better approach discovery, development, preclinical and clinical studies to accelerate their path to the clinic.  Specifically, attendees will explore how to:

  1. Optimize screen design to accelerate translation to preclinical studies
  2. Streamline preclinical studies by de-risking key components early on
  3. Design dose-escalation trials using CRISPR-Cas using generalizable principles

Ultimately, attendees will learn how to approach a disease indication and architect an end-to-end “disease to phase 1/2' program using best practices approaches in functional genomics, preclinical studies, and early-stage clinical trial design.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 13-16, 2025 | NTUH International Convention Center, Taipei, TPE, Taiwan
Scientific Organizers: Lena Pernas, Anne N. Murphy and Johan Auwerx

Important Deadlines
Early Registration Deadline: Nov. 26, 2024
Scholarship Deadline: Oct. 15, 2024
Short Talk Abstract Deadline: Oct. 15, 2024
Poster Abstract Deadline: Dec. 23, 2024
Meeting Summary
# Biochemistry, Structural and Cellular

This meeting seeks to address two overarching gaps in our understanding of mitochondria: how do these bacterial descendants accomplish constant and bidirectional signaling at different scales?; why does the dysfunction of these endosymbionts cause such varied disease depending on host tissue and age, despite that they carry out conserved tasks? To address these gaps, we will highlight emerging and interdisciplinary themes in mitochondrial biology that have not been addressed in previous meetings.  Specifically, the program will cover new horizons such  as the plasticity of the outer mitochondrial membrane as an import/export platform, mitochondrial signaling beyond the cell, and the tissue-specific functions of mitochondria

The goals of this meeting are to:

  1. advance mechanistic understanding of mitochondrial biology and signaling integrated across molecular, cellular and tissue levels.
  2. catalyze interdisciplinary and translational insights into mitochondrial implications in various disease states;
  3.  nucleate a community of mitochondria researchers spanning diverse perspectives and career stages to collaboratively drive the field forward;
  4. provide a platform and workshops to feature rising stars in the field and mentor young scientists.

Attendees of this meeting will have the unique opportunity to engage with emerging and established leaders from diverse scientific backgrounds, participate in cutting-edge discussions on the forefront of mitochondria research horizons, and ultimately shape the future of the field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 1-3, 2024 | Virtual at Your Computer
Scientific Organizers: Thomas Hartung, Weida Tong and Yvonne Will

Important Deadlines
Early Registration Deadline:
Scholarship Deadline:
Short Talk Abstract Deadline:
Poster Abstract Deadline: Mar. 20, 2024
Meeting Summary
# Drug Discovery, Bioengineering and Digital

The deadline to submit an abstract for short talk and poster presentation consideration has passed. For any questions or issues, please email info@keystonesymposia.org.

Artificial intelligence (AI) and machine learning are rapidly advancing biomedicine by enabling novel insights into disease mechanisms, earlier diagnosis, improved prognostics, and enhanced precision medicine. This meeting will showcase cutting-edge applications of AI across diverse areas of biomedicine including oncology, neurology, cardiology, immunology, and genetics.

Sessions will highlight real-world examples of how AI can address long-standing challenges in biomedicine through automated analysis of complex biomedical data. Talks will focus on the near-term translatability of AI technologies and practical hurdles that must still be overcome. Discussions will also address responsible and ethical implementation of AI in biomedicine.

Speakers will represent leading researchers across academia, industry, clinical medicine, and government. Collectively they will provide a comprehensive overview of the current state and future directions of AI in transforming biomedicine to improve human health.


Overall Meeting Purpose:

To showcase cutting-edge applications of AI that are transforming diverse areas of biomedicine and driving translational discoveries to improve human health. The meeting will provide a comprehensive landscape of how AI is impacting biomedical research and clinical practice today, along with insights into future directions.

January 27-30, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Uttiya Basu, Sun Hur and Noam Stern-Ginossar

Important Deadlines
Early Registration Deadline: Dec. 10, 2024
Scholarship Deadline: Oct. 29, 2024
Short Talk Abstract Deadline: Oct. 29, 2024
Poster Abstract Deadline: Jan. 6, 2025
Meeting Summary
# Genetics, Genomics and RNA
# Immunology

Noncoding RNAs, the RNA epigenome, and RNA processing mechanisms have recently emerged as crucial topics at the forefront of gene expression control, igniting the field of molecular immunology. In the context of immune cells, these RNA-based mechanism can influence gene expression programs, signaling pathway activation and cellular activation states with broad implications for immune system function, and dysfunction.

This meeting will bring together a diverse group of immunologists, molecular biologists, RNA chemists, and systems biologists to discuss and advance the integration of RNA, epigenetics and immunity. This is the first meeting of its kind to focus entirely on the intersection of these fields, convening scientists working on noncoding RNA, RNA sensors, and RNA epi-transcriptomics in the context of the immune system. The breadth of topics covered in the meeting illustrates the broad appeal and the dynamic nature of the field, which spans basic immunological questions to applied and translational research.  RNA plays diverse roles in immune system development, pathophysiological outcomes and therapeutics, as demonstrated by the recent pandemic, and thus we expect diverse representation of speakers and attendees across academic, clinical, biotech and pharmaceutical sectors to collectively address key questions in the field and identify therapeutic applications of knowledge.

The conference will be held jointly with the Keystone Symposium on Non-coding RNA Biology: New Roles & Diversity to enable cross-disciplinary insights and collaborations towards mechanisms and impacts of ncRNA on immune system function.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 27-30, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Sebastian Kadener, Irene Bozzoni and Luisa Cochella

Important Deadlines
Early Registration Deadline: Dec. 10, 2024
Scholarship Deadline: Oct. 29, 2024
Short Talk Abstract Deadline: Oct. 29, 2024
Poster Abstract Deadline: Jan. 6, 2025
Meeting Summary
# Genetics, Genomics and RNA

Recent investigation into non-coding RNAs (ncRNAs) have revealed a wide range of key functions in both cellular and organismal processes. These molecules come in different sizes and shapes, ranging from small to large, linear to circular, and basic nucleotides to heavily modified structures. Some ncRNAs are known to regulate gene expression at both transcriptional and post-transcriptional levels by facilitating or disrupting interactions between RNA-RNA, protein-RNA or DNA-RNA complexes. However, while the field has focused on identification of ncRNAs and molecular mechanisms, their diverse in vivo functions and activities are only beginning to emerge.

In this meeting, we aim to reveal these essential functions of ncRNAs to fill this knowledge gap.. The sessions are organized to promote cross-talk and synergy between researchers working on different types of RNAs, to elucidate common mechanisms of action or impacts on common cellular processes and outcomes. The goal is to unite different sub-fields of ncRNA research, by bringing together scientists studying different systems, approaches and types of ncRNAs, as well as mRNAs with non-coding functions, to collectively address key roles in cellular and organismal biology.

The conference will be held jointly with the Keystone Symposium on RNA Mediated Regulation of Immunity: Mechanism, Disease and Therapeutics to enable cross-disciplinary insights and collaborations towards mechanisms and impacts of ncRNA on immune system function.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 30-2, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Silvia Portugal, Marion Pepper and Melissa Chola Kapulu

Important Deadlines
Early Registration Deadline: Feb. 18, 2025
Scholarship Deadline: Jan. 8, 2025
Global Health Award Deadline: Oct. 15, 2024 11:59 PM
Short Talk Abstract Deadline: Jan. 8, 2025
Poster Abstract Deadline: Mar. 6, 2025
Meeting Summary
# Infectious Diseases

Progress against malaria remains a global challenge, and improvements achieved in the last decades have recently slowed down and plateaued. Novel research and implementation strategies are needed, and a renewed combination of innovative approaches to tackle this global health problem.  The key will be to uncover the mechanisms by which children develop protection against severe malaria after only a few infections, as well as the determinants of naturally acquired immunity after years of exposure. With these insights we can design effective prevention and treatment strategies to finally conquer this formidable foe.

This conference aims to reveal these central immunologic principles to combat malaria by integrating mechanistic and clinical research advances.  The program will:

  1. reveal new insights into the fundamental aspects of immune protection against severe malaria.
  2. explore how clinical immunity against mild malaria develops over the course of repeated infections, while still allowing for asymptomatic carriage of parasites.
  3. highlight emerging data from the latest next generation vaccines trials, as well as immunization strategies aimed at blocking transmission.
  4. examine passive immunization approaches or drug administration to induce naturally acquired immunity to malaria
  5. integrate multiomics and modeling approaches to better understand both the natural development of immunity and the impact of interventions.

Attendees will learn about emerging scientific discoveries, method development and clinical practice approaches to empower their work.  The conference will provide a multitude of networking opportunities for trainees and field leaders alike, promoting connections and collaborations that will drive innovative advances.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 20-23, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Carrie Eckert, Jennifer Charlotte Mortimer and Mark Blenner

Important Deadlines
Early Registration Deadline: Dec. 4, 2024
Scholarship Deadline: Oct. 23, 2024
Short Talk Abstract Deadline: Oct. 23, 2024
Poster Abstract Deadline: Dec. 30, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Genetics, Genomics and RNA
# Microbiota and Flora

Climate change and its global societal and environmental impacts are an area we must address immediately to ensure a healthy and sustainable future. At this nexus lies the opportunity to develop a vibrant and sustainable global bioeconomy by harnessing research collaboration across disciplines to best address the challenges at hand. Advances in genetic transformation technologies and genetic tool development in a rapidly growing number of organisms have greatly improved our understanding of underlying design principles for engineering of both plants and microbes towards more sustainable agriculture, plant feedstocks, and bioproduction of a growing number of chemicals and products to displace those currently derived from fossil fuels. Innovative and grand scale ideas will be required to solve the climate crisis, and we have an opportunity to make a real impact by gathering genetic engineering experts across plant and microbial communities to share strategies, tools, technologies, and scalable methods to address global problems. With a combination of academic, government, and industry perspectives, we can build on what we are uncovering in basic and applied research as well as industrial advances in strategies, technology and scaling up for viable implementation of global solutions. This unique meeting will bring together genetic engineers with plant scientists and microbiologists and climate scientists to address big picture problems and serve to develop a collective and coordinated vision for the future.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 7-9, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Lydia Finley and Ralph J. DeBerardinis

Important Deadlines
Early Registration Deadline: Mar. 20, 2025
Scholarship Deadline: Feb. 6, 2025
Short Talk Abstract Deadline: Feb. 6, 2025
Poster Abstract Deadline: Apr. 16, 2025
Meeting Summary
# Developmental, Reproductive and Regenerative
# Metabolism and Cardiovascular

Metabolism supports many developmental processes, including programmed cell death, proliferation, migration and cell fate control, all of which are essential for development of complex organisms, including humans. The field of developmental metabolism aims to determine how nutrient availability and the regulation of metabolic pathways support and instruct processes such as tissue patterning, developmental timing, organ function, and cell fate control. Elucidating the role of metabolism in these processes requires new analytical approaches, rigorous models of developmental biology and a thorough assessment of the impact of metabolic anomalies on development.

This meeting will bring together researchers at the interface of metabolism and development with the goal of providing complementary perspectives in this emerging field. We will convene investigators studying the mechanisms that link nutrients and metabolic pathways to normal development and developmental anomalies, connecting discoveries across humans, mice and other model organisms. The program will cover modern tools for metabolic analysis that are now enabling the dissection of mechanistic connections between metabolic pathways and developmental biology. Integrating these new technologies with genetic and epidemiological insights will provide a holistic understanding of how nutrition and metabolism safeguard development, and how these processes can go awry. This meeting will drive new research frontiers in the exciting field of developmental metabolism, outline pressing questions in the field, and showcase the powerful role of metabolites in establishing and maintaining cell fitness across developmental timescales.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 23-26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Mohammed AlQuraishi, Elizabeth Kellogg and Possu Huang

Important Deadlines
Early Registration Deadline: Feb. 4, 2025
Scholarship Deadline: Dec. 19, 2024
Short Talk Abstract Deadline: Dec. 19, 2024
Poster Abstract Deadline: Feb. 27, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

This meeting will focus on the intersection of machine learning with structural biology, bringing together researchers working on development of core computational methods for proteins and molecules, their integration with experimental data, and their application at scale to biological problems.

The meeting aims to:

  1. present the latest methodological developments in this fast moving field, including design and prediction of stable structures and conformational ensembles
  2. showcase how machine learning is changing the practice of structural biology
  3. illustrate how the availability of large structural databases opens the door to new types of biological questions
  4. build bridges between method developers focused on de novo prediction and design and those incorporating experimental structural data
  5. delineate the frontiers of machine learning for macromolecular structures  and function

Attendees will gain a better understanding of what is currently possible using state-of-the-art tools, where the most promising applications are, and what new developments lie over the horizon. By engaging related but normally disparate fields, this meeting will spark new collaborations spanning method developers, data generators, and biological hypothesis testers to ultimately drive applications that will advance biology and medicine. Typically these communities are siloed, with machine learning conferences covering key methodological developments but lacking attendees from the life sciences. Conversely, the most exciting applications of protein structure prediction are typically presented at biology-focused symposia such as Keystone, which attract few machine learning researchers. This meeting will connect these critical communities together to collectively address gaps between these fields and accelerate the development of machine learning approaches that will shape the future of structural biology.  This first-of-its-kind conference will act as a nexus to spur innovative methodology and applications to serve unmet needs and yield transformative insights in structural biology.

This conference will be held jointly with the Keystone Symposium on Imaging Biomolecules Across Scales:  From Atoms to Tissues to enable cross-disciplinary insights and collaborations towards integrating the state-of-the-art in cryoEM/ET technologies with machine learning capabilities.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Jeong Ho Lee, E. Alice Lee and Peter Campbell

Important Deadlines
Early Registration Deadline: Dec. 23, 2024
Scholarship Deadline: Nov. 14, 2024
Short Talk Abstract Deadline: Nov. 14, 2024
Poster Abstract Deadline: Jan. 27, 2025
Meeting Summary
# Developmental, Reproductive and Regenerative
# Genetics, Genomics and RNA

The study of somatic mosaicisms has provided new insight into our fundamental understanding of human development, aging, and diseases. The comprehensive analysis of somatic mosaicism allows us to trace lineage evolution from the fertilized egg to human embryo to adult organs, along with defining the developmental and aging process at single-cell resolution. Furthermore, somatic mosaicisms have been identified as the genetic source of many human diseases with previously unknown etiology.

This meeting will serve as a forum for exchange of emerging research concepts and directions in the field of somatic mosaicism, and provide an opportunity for new investigators to enter this exciting new field. The meeting will integrate diverse aspects of somatic mosaicism, from mechanisms to translational disease insights. Specifically, the program will cover: 

  1. the development of new sequencing and bioinformatic tools for accurately detecting somatic mosaicism;
  2. the involvement of somatic mosaicism in human development and aging;
  3. somatic mosaicisms in disease biology, and modeling thereof;
  4. translational efforts to help patients with somatic mosaicism driven diseases.

This meeting will bring together scientists and clinicians from developmental and aging biology, bioinformatics, systems biology, molecular and genetic biology, medicine, and the pharmaceutical industry to collaboratively explore the intersection of these diverse fields and collectively advance our understanding of somatic mosaicism in health and disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Ashley Webb, Morgan Levine and Dario Riccardo Valenzano

Important Deadlines
Early Registration Deadline: Dec. 23, 2024
Scholarship Deadline: Nov. 14, 2024
Short Talk Abstract Deadline: Nov. 14, 2024
Poster Abstract Deadline: Jan. 27, 2025
Meeting Summary
# Biochemistry, Structural and Cellular
# Developmental, Reproductive and Regenerative

The aging field has undergone a transformation in recent years. While the investigation of basic mechanisms remains a pillar in longevity research, therapeutic development in industry is rapidly accelerating. Further, new advances in machine learning and artificial intelligence have changed the way we measure and think about the aging process.

This meeting will span basic mechanisms of aging, rejuvenation strategies, and therapeutic development, with a central focus on epigenetics. Epigenetics has emerged as a central hallmark of aging and the reversible nature of epigenetic states presents an exciting opportunity for therapeutic intervention. Additionally, machine learning and artificial intelligence leverage epigenetic states to generate invaluable tools for measuring biological age. Attendees will hear from pioneers in each of these areas, representing diverse perspectives and backgrounds. Potential workshops include: “New horizons in artificial intelligence,” “Therapeutics for healthy aging,” and “The regenerative potential of stem cells in aging”. This program is a unique opportunity to bring together leaders in the aging field from academia and industry who share the common goals of promoting healthy aging and combating age-associated disease.

The conference will be co-located with the Keystone Symposium on Somatic Mosaicism in Human Development, Aging, and Diseases to enable cross-disciplinary insights and collaborations.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 1-4, 2025 | Location to be Determined
Scientific Organizers: Peter J.M. Openshaw, Stacey Lynne Schultz-Cherry and Serena Spudich

Important Deadlines
Early Registration Deadline:
Scholarship Deadline:
Short Talk Abstract Deadline:
Poster Abstract Deadline:
Meeting Summary
# Immunology
# Infectious Diseases
The long-term effects COVID-19 have brought into sharp focus the delayed consequences of acute infections. Such effects have been evident for many years: infants hospitalized with respiratory syncytial virus are at risk of recurrent wheeze in later childhood; scarlet fever can be followed by glomerulonephritis or rheumatic fever affecting the heart, joints and brain; measles can be followed by subacute sclerosing panencephalitis. The range and variety of these effects are only now becoming evident and the mechanism linking acute infection with delayed consequences are becoming better understood. The mechanisms of latency and persistence, the long-term alterations in the microbiome that may result from apparently transient infections and the reprogramming of the immune system are now being elucidated in molecular detail, but there is much still to learn. The overall goal of this meeting is to better understand the mechanism(s) associated with long-term sequelae, the populations most at risk and possible intervention strategies that might mitigate long-range effects. The meeting will appeal to research scientists, clinicians and industry delegates from diverse disciplines. Bringing together experts from fields that would not typically attend the same meeting will be invaluable, providing opportunities for trainees to present their research and build interdisciplinary networks.

October 21-24, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Kizzmekia S. Corbett-Helaire, William B. Klimstra and Jolanda M. Smit

Important Deadlines
Early Registration Deadline: Sep. 4, 2024
Scholarship Deadline: Jul. 23, 2024
Short Talk Abstract Deadline: Jul. 23, 2024
Poster Abstract Deadline: Sep. 30, 2024
Meeting Summary
# Infectious Diseases

Positive-strand RNA viruses have proven to be a crucial global health priority that is experiencing a unique moment, which is fueled by the momentum of the COVID-19 pandemic and driven by the influx of new knowledge and technologies. The success of recent scientific breakthroughs take advantage of existing basic virological understanding and advances in molecular genetics, merging with other fields such as human immunology, structural biology, and vaccine development. Together, these mergers have opened new frontiers and created exciting new opportunities in virology research. This meeting will take a tour of new knowledge in positive-strand RNA virology starting with virus-host interactions and ending with technological and clinical development. The interdisciplinary nature of the meeting will provide novel insights across virology, viral immunity, vaccinology and more.  In addition, we will explore a diverse array of positive-strand RNA viruses, including understudied viruses, revealing common themes and distinctions that might be leveraged for clinical utility.  Throughout the meeting, we will highlight young fresh investigators alongside field leaders to bring forth new ideas and perspectives for discussion that will advance the field in innovative directions.

Meeting Co-Organizer and Assistant Professor of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health, Kizzmekia Corbett-Helaire, and meeting Co-Organizer and Professor/Principal Investigator in the Laboratory of Molecular Virology at the University of Groningen, Jolanda Smit, talk about why you should attend this meeting in the video below:

   

October 27-30, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Raymond Stevens, Beili Wu, Andrej Sali and Bei B. Zhang

Important Deadlines
Early Registration Deadline: Sep. 10, 2024
Scholarship Deadline: Jul. 30, 2024
Short Talk Abstract Deadline: Jul. 30, 2024
Poster Abstract Deadline: Oct. 3, 2024
Meeting Summary
# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital
The field of structural biology is being revolutionized by the rapid advancements in both light and electron microscopies. Combined with X-ray crystallography and NMR spectroscopy, the range of biophysical measurements now extends from the atomic to the cellular level. The amount and spatiotemporal resolution of the resulting data provides an unprecedented opportunity for modeling of large systems, including the whole cell. Application of these experimental and computational advances towards the G protein-coupled receptor (GPCR) signaling field creates enormous opportunities for advancing drug discovery. In this symposium, we will combine imaging across the scales as it applies to drug discovery, from molecular to cellular to organ level, with an example focus on GPCRs. Data integration across the scales, underpinned by varied types of modeling, is one of the most challenging areas of both basic and applied science today, and the focus of many of the top labs around the world.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

September 17-20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Wai T. Wong and Aparna Lakkaraju

Important Deadlines
Early Registration Deadline: Jul. 30, 2024
Scholarship Deadline: Jul. 1, 2024
Short Talk Abstract Deadline: Jul. 1, 2024
Poster Abstract Deadline: Aug. 27, 2024
Meeting Summary
# Neurobiology

The deadline to submit an abstract for short talk consideration has passed.  We will continue to accept abstracts for poster presentation until four weeks before the start of the meeting – click here to submit.  For any questions or issues, please email info@keystonesymposia.org.

Age-related macular degeneration (AMD) is the majority cause of irreversible vision loss worldwide in older patients.  In particular, the non-exudative forms of AMD, including intermediate AMD, geographic atrophy, as well as atrophy and fibrosis that occurs as complications of exudative AMD, are areas of unmet need and major drivers of legal blindness.  The broad goal of this meeting is to bring together basic scientists, clinician-scientists, and drug-developers working in retinal disease to share data, perspectives, and innovations on how these unmet needs can be addressed.  

Specifically, this meeting aims to:

(1) clarify the cellular and molecular mechanisms contributing to AMD disease progression at each stage,

(2) explore the rationale and evidence supporting individual molecular targets for potential intervention,

(3) discuss the platforms on which therapies for non-exudative AMD can be delivered to patients, and

(4) anticipate the future horizon for available therapies in this area and how this may be expanded.  

Attendees, including trainees and young scientists, will benefit from focused talks and small-group interactions, taking away specific learnings on how non-exudative AMD may be addressed therapeutically. This will cover the range from basis hypotheses on cellular dysfunction to potential and ongoing clinical investigations of therapies and novel platforms currently underway.  

Unlike other existing conferences in the field, this meeting will bring together a cross-disciplinary group of participants from basic, translational, and clinical research to bring focus on one of the largest challenges to healthy vision today.   This will be the only smaller (100-300 attendee) meeting focused on addressing this important unmet need through the involvement of scientists representing the full spectrum of the drug discovery process, from molecular mechanisms to clinical trial design. This Keystone Symposium will be unique in its focus, breadth, and format in bringing together a diverse group of attendees at different levels of training/seniority to confer on understanding and finding treatments for this key retinal disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 25-25, 2021 | Virtual at Your Computer
Scientific Organizers: Marie-Pierre St-Onge, Eve Van Cauter, Christian Benedict and Jonathan Cedernaes

Important Deadlines
Early Registration Deadline: Feb. 20, 2021
Scholarship Deadline: Nov. 1, 2020
Short Talk Abstract Deadline:
Poster Abstract Deadline: Dec. 1, 2020
Meeting Summary
# Metabolism and Cardiovascular
# Neurobiology
Altered lifestyle behaviors (e.g. shift work, jet lag, delayed sleep and meal timing) disrupt sleep and impair circadian rhythms, resulting in dysregulation of important physiological and psychological parameters such as blood pressure, glucose, hormones, and vigilance, thereby contributing to increased chronic disease burden, and increasing the risk of cancer, cardiovascular disease, and cognitive impairment/accelerated aging. However, there is a need to bridge sleep and circadian biology scientists to foster dialogues for advancing research in these fields. The goal of this conference is to bring together scientists studying the timing of lifestyle behaviors, including sleep, food intake, and exercise, on chronic disease risk to uncover important next steps for this research area. This conference will cover concepts related to sleep, circadian rhythms, and chronobiology. Concepts will not only cover the biology of sleep and circadian rhythms, such as genetic and hormonal controls, but also how behaviors alter sleep and circadian rhythms, and how these changes challenge our biological systems and impart negative consequences on health. Importantly, this conference will cover the bi-directional relation between lifestyle behaviors, health outcomes, and sleep and circadian rhythms. As a result, the field will be energized with new avenues for collaborations, research, and knowledge.

February 10-13, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Joseph A. Hill, Geneviève Derumeaux, Chiara Giannarelli and Gabriele G. Schiattarella

Important Deadlines
Early Registration Deadline: Dec. 18, 2024
Scholarship Deadline: Nov. 7, 2024
Short Talk Abstract Deadline: Nov. 7, 2024
Poster Abstract Deadline: Jan. 21, 2025
Meeting Summary
# Metabolism and Cardiovascular

Metabolic alterations and inflammatory abnormalities are key contributors to the development of cardiovascular diseases. Recent evidence shows that a chronic low-grade inflammatory response of metabolic origin, termed “metainflammation,” is a defining feature of various cardiovascular diseases, including heart failure and atherosclerosis. Consequently, this Keystone Symposium will bring together leading investigators in the areas of cardiac biology, immunity, vascular inflammation, and obesity-induced cardiovascular disease to elucidate immunometabolic mechanisms in the trajectory to heart failure. Sessions will encompass a broad range of topics highlighting the importance of, and mechanisms whereby, metabolic inflammation contributes to the pathogenesis of myocardial dysfunction and vascular dysfunction.

Specifically, the program will cover:

1) HFrEF (ischemic, hypertensive, and other)
2) vascular biology
3) HFpEF (cardiometabolic and other phenogroups).

Each session will span basic studies through translational research and clinical insights, integrating these perspectives to gain a holistic understanding of disease pathology. To our knowledge, this is the first international congress focusing on “metabolic inflammation” and its consequences in the heart and vasculature. This is an exciting and timely topic in light of the global pandemic of obesity, metabolic stress, and diabetes. Attendees will benefit from comprehensive coverage of these topics by international thought leaders, and a highly interactive and dynamic atmosphere to encourage connection and collaboration.

The conference will be held jointly with the Keystone Symposium on Immunometabolism in Tissue Homeostasis and Disease to enable cross-disciplinary insights and collaborations towards understanding immunometabolic underpinnings of cardiovascular disease.

Meeting Co-Organizer, and Professor in the Department of Internal Medicine at UT Southwestern Medical Center, Joseph Hill, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 10-13, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ping-Chih Ho, María Mittelbrunn and Stanley Huang

Important Deadlines
Early Registration Deadline: Dec. 18, 2024
Scholarship Deadline: Nov. 7, 2024
Short Talk Abstract Deadline: Nov. 7, 2024
Poster Abstract Deadline: Jan. 21, 2025
Meeting Summary
# Immunology
# Metabolism and Cardiovascular

Metabolic processes and enzymes provide regulatory circuits that tailor the behavior of immune cells in response to local and systemic metabolic states. Progress in the field of immunometabolism over the past 5 years has opened new horizons and potential therapeutic strategies for diseases of aging, cancer, and metabolic disorders. However, our understanding of the intersection of immunity and metabolism remains largely restricted to the cellular and molecular levels. To facilitate the translational impact of immunometabolism, this meeting will bring together leading scientists in the areas of aging, cardiovascular diseases, cancer, and microbiome to explore beyond the molecular and cellular level, to collectively address unmet medical needs that can be targeted with immunometabolic interventions.

Specifically, the program will cover the following topics:

1) Immunometabolic crosstalk in tissues and systemic aging;
2) vascular biology;
3) cancer and cancer immunotherapies harnessing immunometabolism;
4) Microbiome-mediated immunometabolic regulations;
5) Metabolite-guided signaling regulations in immune responses.

Each session will integrate basic research with translational and industry perspectives to achieve a comprehensive and holistic understanding. The meeting will feature highly interactive discussions and brainstorming sessions, driving interdisciplinary interactions and collaborations that will broaden the scope and impact of the field of immunometabolism.

The conference will be held jointly with the Keystone Symposium on Trajectories to Heart Failure: Immunometabolic Mechanisms to enable cross-disciplinary insights and collaborations towards understanding immunometabolic underpinnings of cardiovascular disease.

Meeting Co-Organizer and Head of the Immunometabolism and Inflammation Laboratory at Centro de Biología Molcular Severo Ochoa, María Mittelbrunn, talks about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 23-26, 2025 | Fairmont Monte Carlo, Monte CarloMonaco
Scientific Organizers: Rita Carsetti, Ali H. Ellebedy and Hedda Wardemann

Important Deadlines
Early Registration Deadline: Jan. 7, 2025
Scholarship Deadline: Dec. 3, 2024
Short Talk Abstract Deadline: Dec. 3, 2024
Poster Abstract Deadline: Jan. 30, 2025
Meeting Summary
# Immunology

B cells protect against infection and reduce inflammation but also cause autoimmunity and dampen anti-cancer responses. This meeting will discuss diverse B cell functions, novel insights into B cell biology, and strategies to exploit B cell function for better health.

More specifically, the program will cover the following topics:

  1. Antigen-mediated B cell differentiation pathways and memory formation, including plasma cells, and regulation of the durability of antibody responses
  2. Role of regulatory and pathogenic B cells in cancer and autoimmune diseases; development of novel strategies to target B cells.
  3. Novel strategies to fight infectious diseases caused by common, emerging, and neglected pathogens, including viruses, with implications for pandemic preparedness.
  4. B cell fate decisions: what molecular determinants orchestrate B cell development and differentiation?

The pandemic has accelerated the progress of basic science and human studies in B cell research, and it is time to use the knowledge acquired to meet future challenges and solve long-standing questions. This meeting brings together an international group of experts on B cells across diverse model systems and human immunology to integrate their findings and discover new strategies and mechanisms targeting B cells to improve human health. The speaker line-up represents diversity across gender, career stage, race, and ethnicity to provide an inclusive and dynamic community and inspire trainees with diverse role models as they pursue their careers.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 16-19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Philip Chamberlain and Fleur M. Ferguson

Important Deadlines
Early Registration Deadline: Dec. 19, 2024
Scholarship Deadline: Nov. 12, 2024
Short Talk Abstract Deadline: Nov. 12, 2024
Poster Abstract Deadline: Jan. 23, 2025
Meeting Summary
# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital

This keystone symposium will focus on advances in the rapidly evolving fields of targeted protein degradation and chemically-induced proximity. In recent years, there has been a major acceleration in the translation of targeted protein degraders from basic research studies into clinical trials, bringing with it the need to better understand and predict the clinical pharmacology of targeted protein degradation. Through the sharing of these results, the field will continue to gain momentum in bringing advances in TPD to patients.

In parallel, a resurgence of interest in induced proximity has fostered the creation of modalities that hijack other cellular processes, including autophagy, endocytosis, immune signaling, protein chaperones, and transcription. The scope of application, and the therapeutic potential, of these approaches is still emerging, and this meeting will provide a forum to bring together subject matter experts across disciplines, to foster new collaborations in these fledgling scientific areas.


This meeting will bring together experts across diverse disciplines, working at each stage of the TPD and induced proximity field, from new technology development to clinical implementation.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 12-15, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: John D. Carpten, David Solit and Chanita Hughes-Halbert

Important Deadlines
Early Registration Deadline: Nov. 21, 2024
Scholarship Deadline: Oct. 15, 2024
Short Talk Abstract Deadline: Oct. 15, 2024
Poster Abstract Deadline: Dec. 19, 2024
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital

In the past decade, Precision Medicine has significantly advanced the field of oncology by taking into account individual variability in genes, environment, and lifestyle for disease treatment and prevention.  Specifically, new technologies and biomedical informatics tools have allowed for rapid matching of targeted cancer therapies to tumors harboring specific genetic mutations or genetic biomarkers associated with drug efficacy. Recent efforts have enabled drug development against previous “undruggable” targets such as KRAS, which will further empower oncologists to more effectively treat patients.  Yet, with all of the progress and impact that Precision Oncology has had on patient outcomes, these benefits have not been available equitably, especially considering patients from underrepresented groups. 

This meeting will bring together thought leaders across the continuum of translational and clinical cancer research to highlight recent advances and progress in Precision Oncology, including targeted therapeutic development, innovations in technologies for molecular profiling, and Precision Oncology clinical trial updates.  The meeting will also address a major gap in current Precision Oncology approaches, namely lack of diversity in discovery datasets and clinical trials, as well as disparities in access to these health care innovations. We will discuss the sources and impacts of these deficiencies, and strategies to correct them. The outcomes of this meeting will improve our ability to develop and implement the most effective approaches for precision care  and accelerate clinical advances for ALL cancer patients, across diverse demographics.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

November 12-16, 2023 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Nevan J. Krogan, Ana Fernandez-Sesma, John A. T. Young and Jacqueline M. Fabius

Important Deadlines
Early Registration Deadline:
Scholarship Deadline:
Short Talk Abstract Deadline:
Poster Abstract Deadline:
Meeting Summary
# Infectious Diseases
This meeting aims to bring together researchers from the seven continents to explore the infectious diseases currently being addressed across the globe. Some of them prevalent, such as malaria, HIV, COVID, TB and others are more neglected, emerging or rare. A large part of the vision of the meeting will focus on collaborations in research, through academia, industry and the management of science communication. We will highlight how the scientific world broke down silos during this current pandemic and the implications of this as we prepare for the next one and how science could be conducted as we battle all diseases. Part of the global theme of the conference will be reflected in poster sessions organized by continents and afflictions. In addition, we propose special panel discussions featuring adjacent topics to the meeting.

April 6-9, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Valerie B. O'Donnell, Junken Aoki and Vytas A. Bankaitis

Important Deadlines
Early Registration Deadline: Feb. 25, 2025
Scholarship Deadline: Jan. 14, 2025
Short Talk Abstract Deadline: Jan. 14, 2025
Poster Abstract Deadline: Mar. 13, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

Lipids are ubiquitous molecules that play essential roles in health and disease. They comprise the membranes that hold our cells together, act as diverse signaling molecules and provide critical fuel for cell metabolism. Dysfunction in lipid biology is a core theme in all forms of human disease, ranging from genetic sphingolipidoses, atherosclerosis, thrombosis, inflammation and auto-immunity, to Alzheimer’s disease, cancer and infection. The analysis of lipids using mass spectrometry, termed lipidomics, is facilitating a global explosion of research into the role(s) of these molecules in disease. Lipidomics is also driving a revolution in clinical analysis of lipids as biomarkers and diagnostic molecules.

This conference will explore the latest advances in lipid functions and roles in disease.  The meeting will act as a catalyst for bringing together interdisciplinary discoveries in lipidomics, ranging from basic biochemistry and cell biology to clinical studies.  The program will move beyond methodologies, to address new innovations in systems lipidomics, uniting multidimensional data to solve major questions relating to the roles of lipids in human disease.  Session will cover emerging discoveries on:

  1. Signaling, where lipids play mechanistically important roles in cancer, metabolic disorders, and neurological disorders.
  2. Biochemistry of circulating and vascular lipids and their metabolic pathways.
  3. The role of lipids in inflammation and ferroptosis.
  4. Lipidomics research in the context of infectious disease, in terms of the host, viruses, novel bacterial lipids and anti-microbial resistance.

This meeting will focus primarily on the biology and biochemistry of lipids, as applied to biomedicine. Bringing together several different communities of lipid researchers, the meeting will stimulate collaboration and the application of basic underpinning science to clinical translation, while training the next generation of lipid researchers. The meeting will include a workshop, led by members of LIPID MAPS, focused on the use of informatics resources and databases. We also aim to highlight industry partners in the areas of instrumentation and lipid standards to provide the foundation for insightful advances in the field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

March 16-19, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Katy Rezvani, Nathan Singh and Stephan Mielke

Important Deadlines
Early Registration Deadline: Jan. 28, 2025
Scholarship Deadline: Dec. 11, 2024
Short Talk Abstract Deadline: Dec. 11, 2024
Poster Abstract Deadline: Feb. 20, 2025
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology

Immune cell therapies have fundamentally altered the paradigm of cancer care. The first generation of these treatments confirms that ex vivo manipulation of immune cells can provide meaningful clinical response. However, many barriers to broader success remain. Among the most critical unsolved problems in this field is achieving consistent success in the treatment of solid tumors, hindered by the need for immune cell trafficking, infiltration into the microenvironment and overcoming immune suppression.

This conference will highlight recent advances in mechanistic understanding of the immune: cancer interface and developments in technology that enable the design of more effective immune cell therapies. The program will feature an explosion of activity from both academic and industry investigators, with regards to isolating the many biological limitations of existing treatments and innovative strategies to overcome them and improve patient outcomes. Specifically, we will explore how cancer cells evade current cell therapies, revealing the core biological pathways that lead to treatment failure. Additionally, we will cover advanced genome and protein engineering methods, and how they can be applied to improve immune cell function and enable greater precision of cellular therapies.

The program will also take a broader view beyond oncology and T-cell based therapies to explore applications against autoimmune diseases as well as emerging advances in engineering other immune cell types. Finally, we will address health equity issues in the field, and discuss ways to ensure equitable access to these potentially life-saving therapies across diverse communities, which is of critical importance.

This conference will be held jointly with the Keystone Symposium on Cancer Immunotherapy: Clinical Lessons to New Modalities to enable cross-disciplinary insights and collaborations towards better outcomes for all cancer patients.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 23-26, 2025 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Cecilia Sorensen, Kari Nadeau, Anna Stewart-Ibarra and Desiree LaBeaud

Important Deadlines
Early Registration Deadline: May. 6, 2025
Scholarship Deadline: Mar. 25, 2025
Short Talk Abstract Deadline: Mar. 25, 2025
Poster Abstract Deadline: Jun. 2, 2025
Meeting Summary
# Infectious Diseases

The impacts of climate change are increasingly prevalent around the globe, presenting urgent and complex threats to human health. In particular, climate changes are impacting the prevalence, intensity and geographic distribution of infectious diseases worldwide, putting new populations at risk and posing new challenges to human health in regions where patients, clinicians and public health departments are unprepared.  As climate change accelerates in this century, the problem will only continue to grow unless we adequately assess, address and prepare for these climate-sensitive threats. 

This conference will explore emerging research around how climate change is and will impact vector-borne disease and emerging zoonoses, from tropical to arctic regions around the globe. The program will span molecular to epidemiological insights, integrating our understanding of how environmental changes promote the emergence and spread of various infectious diseases with strategies for how to monitor and control such outbreaks. We will focus on critical areas of emerging climate and health science in the context of infectious disease:

  1. Utilizing data science and artificial intelligence tools to inform our understanding of current and future infectious disease threats
  2. Immunological, epigenetic and exposomic insights into individual susceptibility to climate-sensitive infections
  3. Modeling climate-sensitive health risks and outcomes to study and predict regional and global threats
  4. Mitigation strategies and health co-benefits
  5. Developing and implementing early warning systems to activate public health measures against outbreaks

With a health equity and justice lens, this conference will highlight evidence-based solutions, such as clinical and public health interventions, to protect the health of the most affected vulnerable and marginalized populations. Participants will explore the policy context surrounding climate and health action to address mitigation, adaptation, and resilience solutions urgently needed.

This conference will be the first of its kind to convene diverse scientific researchers across biomedical, clinical, technological, epidemiological, and global health communities, to engage in critical dialogues and collectively advance the science and strategies around climate change and infectious disease.  Only by bringing together these diverse perspectives and expertise can we tackle the enormity of this emerging global health threat.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Mikala Egeblad, Julio Aguirre-Ghiso and Manuel Valiente

Important Deadlines
Early Registration Deadline: Dec. 3, 2024
Scholarship Deadline: Oct. 22, 2024
Short Talk Abstract Deadline: Oct. 22, 2024
Poster Abstract Deadline: Dec. 30, 2025
Meeting Summary
# Cancer

The mortality from cancer remains high and the vast majority of cancer patients die from metastatic, treatment-resistant disease. No major genetic drivers of metastatic disease have so far been identified. Rather, the concept is developing that metastasis is regulated by complex interactions with the host and diverse microenvironmental niches. Cancer cells can adapt to and shape the microenvironments of the distant organs. Conversely, the metastatic niches can foster cancer cell growth while microenvironmental changes driven by age, life style choices, and comorbidities can generate fertile soil for the disseminating cancer cells to survive and expand.

The aims of this meeting are to:

  1. Address existing knowledge gaps in tumor-host interactions and mechanisms that drive metastasis;
  2. Explore opportunities to better study metastasis in patients and diverse model systems;
  3. Highlight emerging research areas, including the effects of the nervous system, the macro-environment, and cancer cell chromosomal instability on metastasis;
  4. Support new ideas and innovation in metastasis research by highlighting rising stars in the field as plenary speakers and workshop presenters.

The meeting will bring together a diverse set of cancer biologists, systems biologists, engineers, and translational scientists that rarely have the opportunity to interact, to collectively asses the many drivers of metastatic disease and generate a new, host-centric view of metastasis. This interdisciplinary meeting will spark new collaborations and inspire new research directions toward identifying novel vulnerabilities that can be targeted to conquer metastatic cancer.

This conference will be held jointly with the Keystone Symposium on Neural Influence on Cancer, Tumor Microenvironment and Cancer Immunology to enable cross-disciplinary insights and collaborations towards neural drivers and/or suppressors of metastasis.

Meeting Organizers, Drs. Mikala Egeblad, Julio Aguirre-Ghiso and Manuel Valiente, talk about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 22-25, 2025 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Daniela Cota, Timo D. Müller and Dana M. Small

Important Deadlines
Early Registration Deadline: Mar. 4, 2025
Scholarship Deadline: Jan. 23, 2025
Short Talk Abstract Deadline: Jan. 23, 2025
Poster Abstract Deadline: Mar. 31, 2025
Meeting Summary
# Metabolism and Cardiovascular
# Neurobiology

Understanding how the brain coordinates the intake, use and storage of calories at the whole-body level and how the environment impacts eating behavior, has direct clinical implications for obesity prevention and management. This is even more timely in light of novel hormone-derived therapies that shut down appetite through their action on the brain, providing new promise to tackle the disease.

This meeting has the ambition to cover the latest research advances, across circuits and systems levels, to disentangling how the brain receives and processes nutrient-related information to control eating behavior.  The program will explore the impact of environmental context and the role of sensory mechanisms, motivation and decision making processes in shaping this behavior. Through work done in humans and animal models, the conference will provide cutting-edge knowledge on neuroendocrine mechanisms integrating food intake with whole body metabolic responses. Breakthrough studies pinpointing brain-related mechanisms of action of novel anti-obesity therapies that have recently entered the market or are in clinical development will be highlighted. The conference will integrate academic, industry and clinical perspectives, providing an inclusive setting for rich exchange and interdisciplinary discussion to drive therapeutic advances. The meeting will engage researchers across diverse expertise, integrating neuroscience, neurometabolism, psychobiology, physiology, endocrinology, nutrition, biochemistry and pharmacology, to holistically understand the mechanisms and impacts of how neurobiology drives feeding behavior in the context of health and disease.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James Gorman, Stina Syvänen and Danica Stanimirovic (in memoriam)

Important Deadlines
Early Registration Deadline: Dec. 23, 2024
Scholarship Deadline: Nov. 13, 2024
Short Talk Abstract Deadline: Nov. 13, 2024
Poster Abstract Deadline: Jan. 27, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Neurobiology

Better treatments are urgently needed for a range of devastating brain diseases, including prevalent neurodegenerative diseases, brain tumors and metastases, and rare genetic conditions. One major challenge in development of experimental CNS disease therapies is the lack of efficient tailored strategies for their delivery to the brain and spinal cord. This is the only conference to focuses entirely on scientific and technological advances and challenges in delivering new therapies, across a wide range of modalities, to appropriate compartments in the CNS.

The principal goals are to:

  1. Showcase scientific advances in understanding, mapping and identifying targets to exploit for drug delivery across brain barriers
  2. Share advances in discovery, design and development of novel CNS drug delivery technologies for delivery of established and emerging therapeutics, including receptor-mediated transcytosis approaches, as well as delivery by viruses, cells, nanoparticles and other vehicles.
  3. Address translational successes and challenges with in vitro and in vivo models of complex brain transport and disease processes, that are critical for designing and evaluating brain delivery technologies
  4. Provide updates on and critical evaluation of clinical trials using various brain delivery approaches, and discuss lessons learned including reverse translational hypotheses to guide future studies.

The conference will spur multidisciplinary interactions and collaborations between scientists and trainees from academia, government and industry, including a wide range of biotech and biopharmaceutical companies. Importantly, participants include basic, translational and clinical scientists from diverse backgrounds, bridging fields of drug delivery, neuroscience, bioengineering, drug discovery and development.  Collectively these diverse perspectives will generate innovative insights and new directions to finally tackle this enormous challenge in medicine.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

May 11-14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Jose Ordovas-Montanes, Chrysothemis Brown, Karin Pelka and Jeffrey Moffitt

Important Deadlines
Early Registration Deadline: Mar. 25, 2025
Scholarship Deadline: Feb. 11, 2025
Short Talk Abstract Deadline: Feb. 11, 2025
Poster Abstract Deadline: Apr. 17, 2025
Meeting Summary
# Biochemistry, Structural and Cellular

How individual cells coordinate tissue functions across cellular to organ level scales is a rapidly advancing area primed for discoveries. With increasingly powerful single-cell approaches we can now rapidly catalog the cell types, subsets, and states present in tissues, as well as localize these cells in space and in relation to each other, within the context of healthy and diseased contexts. These advances have precipitated a critical turning point in the field, where single cell data can now be effectively translated into biological and medical insights.

In this meeting we will build upon insights derived from studying individual cells to understand the rules and regulators of tissue structure, function and dysfunction. Specifically, the program will focus on:

  1. biologically driven conceptual and technical advances in deconstructing and reconstructing tissues;
  2. leveraging natural human and animal variation to identify new cell states and their clinical implications for translational research and drug discovery;
  3. the development of novel methods to identify cellular and spatial modules that underlie health and disease.

This meeting will integrate biological concepts with experimental and computational approaches, bringing together scientists across techniques, tissues, organisms, and diseases to yield cross-disciplinary insights and advances. We hope that our meeting will provide a collaborative place for investigators who may not typically interact in the current structure of single-cell meetings to come together and share ideas and insights. By bringing these communities together we aim to  catalyze the next stage of discoveries in this field towards translational impacts.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 22-24, 2025 | Allen Institute, Seattle, WA, United States
Scientific Organizers: Xin Sun, Mark L. Andermann and Rui M. Costa

Important Deadlines
Early Registration Deadline: Mar. 4, 2025
Scholarship Deadline: Jan. 22, 2025
Short Talk Abstract Deadline: Jan. 22, 2025
Poster Abstract Deadline: Mar. 31, 2025
Meeting Summary
# Neurobiology

Interoception is poorly understood compared to the other senses of sight, hearing, smell, touch, and taste, and our mechanistic understanding of how the brain receives and reacts to signals from inside the body, is just beginning to be explored. Most of our peripheral organs and tissues are innervated by nerves that connect them with the central nervous system, and increasing evidence demonstrates critical central neuronal control of peripheral organ function. Conversely,  there is increasing awareness and interest in how signals from tissues such as the heart, lung, intestine, pancreas, and spleen impact neuronal activity in the brain. Such fundamental crosstalk involving interoception is at play in both normal physiology and disease pathogenesis.

This inaugural Keystone Symposium on Interoception will address major questions in the field, including:

  1. the delineation of full circuits from peripheral tissues to the brain and back;
  2. the molecular identity of neurons at specific nodes in these pathways;
  3. critical signals between neurons and tissues;
  4. alterations in interoceptive processing in the context of disease, including both peripheral and central nervous system abnormalities;
  5. therapeutic opportunities using neuromodulation of interoception circuits (e.g. vagus nerve stimulation) to treat chronic diseases.

Interoception studies provide the missing link between research initiatives centered on the brain and the peripheral modulation of internal organs. This Interoception Keystone Symposium will serve as a nucleation point in this fast-growing field, bringing together neurobiologists, immunologists, physiologists, stem cell biologists, systems biologists, pharmacologists, bioengineers, and theorists, to integrate their perspectives and derive cross-disciplinary insights in understanding this sixth sense and its implications in health and disease.  The event will serve as a platform to inspire and nurture a diverse cohort of young investigators who will shape the future of the field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

April 10-12, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Kara McKinley, Margherita Y. Turco, Pradeep Tanwar and Amander Clark

Important Deadlines
Early Registration Deadline: Feb. 26, 2025
Scholarship Deadline: Jan. 15, 2025
Short Talk Abstract Deadline: Jan. 15, 2025
Poster Abstract Deadline: Mar. 19, 2025
Meeting Summary
# Developmental, Reproductive and Regenerative

The female reproductive tract is a treasure trove of insights into regenerative biology, as it is subject to extensive, repeated remodeling and regeneration associated with follicle development, ovulation, the menstrual cycle, and pregnancy. The female reproductive system is also a prime target for stem cell-based models and regenerative medicine. The rapid development of in vitro models recapitulating human-specific aspects of embryo implantation, reproductive pathologies and more are vastly accelerating our understanding of reproductive biology and revealing new treatment strategies.  These systems are facilitating the emergence of novel approaches to modulate regeneration or generate “replacement parts” as promising treatments for infertility. This meeting will cover these exciting new advances that are transforming the field of reproductive biology and medicine. In addition, the program will explore how normal regenerative mechanisms are usurped by reproductive cancers, to reveal new avenues to alleviate the substantial morbidity and mortality burdens of these diseases, while also highlighting pathways that may be exploited to enhance healthy cell renewal in these systems.

Most importantly, this conference will provide a critical venue to gather scientists, clinicians and biological engineers to collectively advance this field and address the substantial unmet clinical needs in reproductive health, including fibroids, endometriosis, menopause, infertility, reproductive cancers and gender affirming care. Despite its rich biology and immense public health relevance, the female reproductive tract and its associated biology have been traditionally understudied and underserved areas of research, and the scientific community currently lacks convening mechanisms for researchers focused on these important topics. This Keystone Symposium will cultivate cross-disciplinary collaborations and consolidate a new community that will be necessary to tackle major challenges in the field, which include the development of appropriate preclinical models and eliminating racial inequities in reproductive health outcomes. Finally, a major goal of the meeting is to create opportunities to bring in and empower junior researchers to grow and advance this important field.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

October 1-4, 2023 | Location to be Determined
Scientific Organizers: Maxence V. Nachury, Piali Sengupta and Gaia Pigino

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The importance of cilia in disease and development creates a point of convergence for developmental biologists studying the Hedgehog pathway and left-right axis patterning, for cell biologists interested in compartmentalized signal transduction, for biochemists working on microtubule motors, and for human geneticists studying ciliopathies. This program emphasizes frontier approaches and novel themes, such as the emerging role of cholesterol as a second messenger in Hedgehog signaling, GPCR signaling in neuronal cilia and the evolutionary conservation of cilium-based signaling. This program is built around the central question of how compartmentalization of signaling pathways by cilia enables novel and distinct signaling modalities. This emphasis on signaling and disease is distinct from the focus of other cilia-centered meetings that are projected to take place in 2020 and 2021.

October 1-4, 2023 | Location to be Determined
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January 1-4, 2024 | Location to be Determined
Scientific Organizers: Dermot P. B. McGovern, Séverine Vermeire, Ailsa Hart and Thaddeus S. Stappenbeck

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# Immunology
While there has been significant advances in the treatment of inflammatory bowel disease the majority of patients treated with these therapies do not go into remission. Many patients require surgery for disease complications including fibrotic strictures and fistulizing disease for which there remain no effective therapies. Molecular and clinical heterogeneity may expalin this variation and this meeting will address staregies for addressing this. The aim of the meeting is to address: novel therapeutic approaches for treating IBD; basic advances leading to a better understanding of the natural history of IBD; potential environmental interventions in IBD; cutting edge technologies and analytic approaches for complex diseases such as IBD. Attendees will learn about new technologies that are being applied to complex diseases such as IBD as well as about novel 'molecular' approaches to sub-classify disease and how these approaches may lead to improved outcomes for IBD patients. This meeting fills a niche bringing together leaders both in translational research in IBD and those using and developing cutting-edge technologies and analytic approaches to study complex biology. Currently there are 2 meetings annually dedicated to IBD. These are very clinically orientated and also tend to be rather introspective lacking engagement from other disciplines. One aim of this meeting is to bring experts studying complex systems together with people studying IBD to develop novel approaches to these diseases.

January 1-4, 2024 | Location to be Determined
Scientific Organizers: Jennifer G. Mulle, Audrey Thurm, Christa L. Martin and Carrie E. Bearden

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# Genetics, Genomics and RNA
# Neurobiology
This is an unprecedented time in psychiatric genetics. There are now hundreds of rare genetic variants that are strongly associated with neuropsychiatric traits and psychiatric diseases. Many individual teams are making progress studying a given gene or genomic interval, and the time is right for knowledge transfer across teams. This conference is driven by three emerging concepts. First, the discovery of rare variants with large effects for neuropsychiatric disorders provides a new avenue for understanding the underlying mechanisms of more common disorders. Second, these rare variants are often associated with multiple neurodevelopmental or neuropsychiatric disorders, suggesting that there are common underlying biological pathways that confer susceptibility to disease; this finding simultaneously suggests that genetic and epigenetic modifiers play a key role in determining the phenotype of specific individuals. Third, large scale collaborative efforts and harmonized frameworks for data collection are starting to enable more fine-grained, quantitative and even longitudinal phenotyping of probands and relatives, allowing us to move beyond the relatively gross characterization of categorical Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnoses. These new findings underscore the need for interaction between geneticists, neurobiologists and clinical scientists, and this meeting sets the stage for such cross-cutting collaborations.

January 1-4, 2024 | Location to be Determined
Scientific Organizers: Shannon M. Lauberth, Lu Bai and Laura A. Banaszynski

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# Genetics, Genomics and RNA
The regulation of gene expression is essential for ensuring normal developmental processes. Dysregulation of gene expression programs can have profound effects on cellular functions and underlies many diseases. Since the monumental discovery of RNAPII just over 50 years ago, it has become increasingly clear that gene control is a dynamic and highly regulated process. This meeting will explore unexpected layers in the regulation of gene expression. We will discuss new advances in the roles of regulatory factors, cis elements, and epigenetic mechanisms. New insights into genome transcription and regulation will be revealed through structural biology, with significant advances in Cryo-EM, and functional genomics in eukaryotic systems. This meeting will also include approaches for advancing our understanding of the evolution of gene regulation. Finally, this meeting will bring together innovative approaches and technologies including single cell measurements of gene expression, cutting-edge imaging, and long read sequencing to uncover secrets of the regulatory genome.

February 12-14, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Thomas Kash, Camilla Bellone, Michael Taffe and Ziva Cooper

Important Deadlines
Early Registration Deadline: Dec. 12, 2023
Scholarship Deadline: Nov. 30, 2023
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Meeting Summary
# Neurobiology

THIS EVENT HAS BEEN CANCELLED

Drug abuse and addiction have an enormous negative impact on society. The past decade has seen exciting developments in the ability to probe and measure brain function both in humans and in model organisms. However these findings often do not move beyond the species of interest, suggesting one of the barriers to the field is that these communities of researchers do not robustly engage with one another. The goal of this meeting is to bring together top addiction researchers who study humans, non-human primates and rodents to identify the most critical and tractable problems of addiction. The goal of this interdisciplinary meeting is to enable more rigorous translational and reverse translational science that will lead to both better understanding of the neurobiology of reward and addiction and to more effective treatments for addiction. 

Co-Organizer, and Director of the Bowles Center for Alcohol Studies and John Andrews Distinguished Professor in the Department of Pharmacology at the UNC School of Medicine, Thomas Kash, talks about why you should attend this meeting in the video below:

February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Jean-Philippe Julien and Katherine Harris

Important Deadlines
Early Registration Deadline: Dec. 23, 2024
Scholarship Deadline: Nov. 13, 2024
Short Talk Abstract Deadline: Nov. 13, 2024
Poster Abstract Deadline: Jan. 27, 2025
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Immunology

Antibodies are a mainstay as therapeutics, with emerging formats, combinations and innovative delivery methodologies promising to expand their reach across disease indications. This meeting will showcase trailblazing approaches in the design and engineering of novel biologic modalities as linked to their pre-clinical development and selected early outcomes in the clinic.

Specifically, the topics covered will engage discussions around:

1) antibody-based protein degraders,
2) next-generation antibody drug conjugate technologies
3) precision biologics
4) increasing accessibility of antibody drugs on a global scale
5) advances in combination biology and modalities
6) Fc domain engineering

In addition, two workshops will stimulate discussions around 1) an evolving landscape of regulatory considerations for new biologics, and 2) artificial-intelligence and machine-learning. These topics will draw from examples across medical indications, ranging from cancer to infectious diseases to autoimmune diseases and diseases of the central nervous system. Thus, this meeting will engage a vast audience, bring different arenas together within the antibody as drugs community and allow the field as a whole to challenge current paradigms and establish new research directions.

This conference is co-located with the Keystone Symposium on Drug Delivery to the Brain: Emerging Modalities to encourage cross-disciplinary insights and collaborations towards novel treatment modalities for brain diseases.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

June 18-22, 2022 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Stanley Perlman, Carolyn B. Coyne and Lisa F.P. Ng

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# Infectious Diseases
The Keystone Symposia conference on positive-strand RNA viruses provides an international forum for research on human, animal, insect, plant and bacterial viruses with positive-strand RNA genomes. This group of viruses contains many clinically relevant and well-known pathogens (e.g., Enterovirus 71, hepatitis C virus, Dengue and West Nile virus, and Coronaviruses). Given their high rates of mutation and their capacity for zoonosis, positive-strand RNA viruses represent constant threats to the global human population, as evidenced by the recent Zika virus (ZIKV) epidemic and the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). Detailed analyses into viral transmission and spread, evolution and epidemiology, tissue tropism, host immune response and viral countermeasures, as well as the development of novel antiviral therapeutics and vaccines is critical to combat these viruses. This conference brings together experienced and junior experts to share their latest findings in molecular and cell biology, virology, immunology, vaccinology, and antiviral drug development applied to the field of positive-strand RNA viruses. There are no other conferences solely focused on positive-strand RNA viruses. Smaller conferences (e.g. the European Picornavirus (EuroPic) focus on select virus families while other very large conferences (e.g. the American Society for Virology (ASV)) focus on nearly all viral species. The very focused nature of smaller conferences and the very diffuse nature of very large conferences both limit the ability of experts specializing in complementary but non-overlapping areas to share their research, establish new collaborative efforts, and gain insights into the latest findings of others in the field.

March 30-2, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Karen Adelman and Kristian Helin

Important Deadlines
Early Registration Deadline: Feb. 19, 2025
Scholarship Deadline: Jan. 9, 2025
Short Talk Abstract Deadline: Jan. 9, 2025
Poster Abstract Deadline: Mar. 6, 2025
Meeting Summary
# Developmental, Reproductive and Regenerative
# Genetics, Genomics and RNA

Epigenetic modifications to our genomes impact chromatin organization and gene activity during organismal development, homeostasis and aging. Histone and DNA modifying enzymes, as well as chromatin remodelers, are frequently disrupted in developmental disorders and disease states, inspiring the development of numerous potential therapeutics to target these epigenetic regulators. Moreover, cellular metabolism can dramatically alter the availability of substrates for epigenetic enzymes, connecting the epigenetic state of a cell to its metabolic state.

To catalyze new discoveries in this important area, we bring together experts in epigenetics, leading minds in metabolism, and researchers studying diseases linked to epigenetic dysregulation to collectively drive the field forward. This conference provides an ideal environment to foster interactions and seed new collaborations between those studying the function and mechanisms of epigenetic regulators and those defining the clinical impact of their  disruption. The program will critically evaluate the mechanistic importance of histone modifications, non-catalytic roles for epigenetic complexes, and models for the establishment of epigenetic memory and inheritance.

Attendees will explore emerging science at the forefront of the field and be inspired to jump into new frontiers that will define the future of epigenetics research.  Trainees in particular will benefit from exposure to new ideas, with invaluable networking opportunities with field leaders and rising stars.

Finally, this conference will be held jointly with the Keystone Symposium on Chromatin Architecture, Transcription & Gene Regulation to allow attendees to appreciate the interplay between these two closely related fields and network across both domains. Joint sessions and meals will foster cross-disciplinary interactions, insights and collaborations towards integrating these fields and providing a holistic understanding of epigenetics in the context of chromatin architecture.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Bana Jabri, Caetano Reis e Sousa and Philippe J. Sansonetti

Important Deadlines
Early Registration Deadline: Jan. 3, 2025
Scholarship Deadline: Nov. 21, 2024
Short Talk Abstract Deadline: Nov. 21, 2024
Poster Abstract Deadline: Jan. 28, 2025
Meeting Summary
# Immunology
# Infectious Diseases
# Microbiota and Flora

Mammals and microbes have co-evolved over 250 million years and host-microbial interactions are central to health and disease. This meeting will bring together groups of scientists working on pathogens, commensals, microbial sensing, innate immunity, evolution, and disease pathogenesis to integrate knowledge and collectively address major questions in the field.

This meeting will explore the:

1) impact of viruses on the host, in particular endogenous retroelements and chronic viral infections

2) impact of commensal bacteria and fungi and persistent intracellular pathogens on the host

3) definition of a pathobiont

4) co-evolution of host-microbial interactions

5) role of microbes in disease

To further expand the scope of the meeting we will organize two workshops: one on neuronal control of host-microbial interactions and one on the interface of nutrition, microbiome and disease. The interdisciplinary nature of the meeting and its focus on host-microbe interactions across microbial species will give investigators a broad perspective on host-microbial interactions and encourage them to go beyond traditional disciplinary boundaries.

The conference will be held jointly with the Keystone Symposium on Human Microbiome: Diversity, Selection and Adaptation to enable cross-disciplinary insights and collaborations towards a more comprehensive and integrative understanding of the holobiont.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

February 6-8, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Aryeh Warmflash and Magdalena D. Zernicka-Goetz

Important Deadlines
Early Registration Deadline: Dec. 6, 2023
Scholarship Deadline: Nov. 1, 2023
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Poster Abstract Deadline: Nov. 21, 2023
Meeting Summary
# Developmental, Reproductive and Regenerative

In recent years, dramatic experiments have revealed the ability of multiple types of stem cells grown under controlled conditions to self-organize into structures that resemble native tissues. Self-organizing two- and three-dimensional cultures which reflect events in the early embryo, here called “embryoids”, can be perturbed and observed to a degree impossible for mammalian embryos developing in utero, and have opened the door to making progress on previously intractable questions. Furthermore, human embryoids represent one of the only experimental windows we have into the early stages of our own development.

A key current challenge is to go beyond proof of principle demonstrations that these models are possible and use them to explore important questions in developmental biology. This meeting will bring together researchers with backgrounds in biology, physics, and engineering, working on a variety of embryoid systems, as well as actually embryos, to address the following aims:

1. How well do embryoids reflect actual development and what are gold standards for determining this, particularly for human where access to embryos is limited?
2. How can we use embryoids to answer questions that cannot be addressed with embryos alone: what knowledge has been gained so far and what are key questions which can be answered?
3. What ethical questions are posed by human embryoids and how can consensus be achieved?

While there are meetings on human development and on organoids, no current meetings focus directly on the field of embryoids and the unique challenges and opportunities posed by this field.

Meeting Co-Organizers, Dr. Aryeh Warmflash and Dr. Magdalena Zernicka-Goetz, talk about why you should attend this meeting in the video below:

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 1-4, 2023 | Location to be Determined
Scientific Organizers: Florian Krammer, Aubree Gordon and Davide Corti

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# Immunology
# Infectious Diseases
Next generation influenza virus vaccines are urgently needed to improve protection from antigenically drifted seasonal influenza viruses. The current SARS-CoV-2 pandemic also highlights the need for broadly protective vaccines that would enhance our pandemic preparedness for influenza viruses. Scientific discoveries and initiatives towards universal influenza virus vaccines have moved the field forward in recent years. What this conference is trying to do to further advance development of these vaccines is unique. This conference will address the design of next generation influenza virus vaccines starting at epidemiology, disease and transmission, bridging to immunology and structural biology and finally to vaccine design and ongoing clinical trials with universal influenza virus vaccines. In this conference we will bring scientists from many disciplines together to focus on the ultimate goal, a universal influenza virus vaccine. We believe that this meeting will catalyze vaccine development and will help to bring aspects into this process that are important but usually not considered.

January 1-4, 2023 | Location to be Determined
Scientific Organizers: J. Paul Taylor and Geraldine Seydoux

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# Biochemistry, Structural and Cellular
Liquid-liquid phase separation (LLPS) has recently emerged as a pervasive and fundamental strategy for organizing cellular contents and regulating biological processes. Indeed, LLPS has been revealed to regulate a staggering and rapidly expanding array of cellular activities, including aspects of DNA replication, transcription, DNA repair, RNA metabolism, receptor signaling, synapse formation, and more. In cells, LLPS leads to the assembly of biomolecular condensates that span a vast range of sizes and complexities, from nanometer-scale structures composed of a few peptide chains, such as the nucleosome core, to micron-scale structures composed of thousands of biomolecules, such as the pre- and post-synaptic compartments of neurons. In addition, it is increasingly appreciated that disturbance of biological phase transitions is a primary driver of disease, most notably in neurodegeneration and cancer.

January 1-4, 2023 | Location to be Determined
Scientific Organizers: Timothy A. Ryan and Erin M. Schuman

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# Biochemistry, Structural and Cellular
# Neurobiology
Neurons are a perfect example of the biology of extremes. Most neurons in the brain must live without dividing for 7-9 decades of life. Individual cells cover spatial expanses that are truly enormous compared to the molecular scale. Although cell somas of neurons are comparable in size to many other types of cells in the body, neurons are polarized cells and the output compartment, the axon, of an individual cell in the brain can extend up to 40 cm in a rodent and probably much further in a human, i.e. 20,000 times more than typical cells. The molecular basis of how neurons are built and sustained at these “extremes” is a central problem in neuronal biology. The tools needed to understand basic questions like protein and lipid synthesis and turnover in neurons as well the metabolic basis of synaptic performance are just beginning to emerge. These properties are all thought to be particularly impactful in diseases associated with aging, such as most neurodegenerative diseases. As these rapid and major ongoing advances in neuronal cell biology continue, they have allowed for a mechanistic understanding and therapeutic intervention in many neurologic diseases. This conference will convene leaders in the field, together with trainees and emerging investigators, to address cutting-edge advances in this rapidly evolving field.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Akiko Iwasaki, Avindra Nath, Hannah Davis and Daniel M. Altmann

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# Infectious Diseases

The Keystone Symposium meeting scheduled for 2025-2026, on 'Long COVID and Other Post-Acute Infection Syndromes,' will assemble global experts from various fields to explore critical dimensions of these debilitating conditions. The symposium aims to delve into challenges and potential solutions for achieving a consensus on clinical phenotypes, diagnostic criteria, diagnostic biomarkers, clinical trial design and endpoints, and treatments. Addressing the epidemiology of long COVID, the discussions will encompass demographics and comorbidities that influence both risk and recovery. Employing machine learning methodologies to identify symptom clusters biological signatures and potential treatments will contribute to unraveling the multifaceted nature of Long COVID. Exploring underlying heterogeneity of disease mechanisms, the meeting will cover persistent SARS-CoV-2 infection, autoimmunity, microbiome dysbiosis, latent virus reactivation, chronic inflammation, metabolic, autonomic and endocrine abnormalities, organ damage, coagulation, and immune deviation. Advances made in both clinical studies and animal models of long COVID will be discussed. A potential connection between long COVID and neurodegenerative diseases will be examined. Exploration into the pathophysiology of PAIS will provide key insights into the disease pathogenesis and potential avenues for therapy. The symposium will shed light on overlaps and distinctions between long COVID, ME/CFS, post-Lyme disease, and other PAIS, seeking common clinical phenotypes, underlying disease mechanisms and therapeutic targets. Furthermore, the meeting will spotlight ongoing and upcoming clinical trials, underscoring their pivotal role in advancing the understanding of disease mechanisms, therapeutic options, and enhancing outcomes for individuals living with Long COVID and PIAS. Our ultimate objective is to catalyze collaborative interactions among researchers, clinicians, and patients from diverse backgrounds, fostering a proactive and accelerated approach to unraveling the complexities of Long COVID and other PAIS, and formulating effective strategies for diagnosis, treatment, and care.

November 25-29, 2018 | Speke Resort & Conference Centre, KampalaUganda
Scientific Organizers: Michèle Ramsay, Han G. Brunner and Appolinaire Djikeng

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# Genetics, Genomics and RNA
Genomic variation is a driving force of animal and human health, and susceptibility to disease. Yet our knowledge rarely spans human ethnic genomic diversity and genomic variation between animal breeds, limiting their translational impact. This symposium aims to: 1) Highlight translational genomics in humans and animals (clinical medicine and animal breeding for health and productivity; 2) Explore synergies and cross-disciplinary learning; 3) Explore opportunities to leverage genomic diversity to push the current boundaries to translation; and 4) Address translation and affordability in low- and middle-income settings. Large-scale genomics initiatives like Genome England, the US Precision Medicine initiative, and the Human Heredity and Health in African Consortium are providing extraordinarily large data sets to explore useful genotype-phenotype connections. Equivalent initiatives for animal data are starting. This meeting will explore the translation of genomic research in animals and humans, high and low-resourced environments, ethnic diversity, and cultural context. Identifying common strands in animal and human health opens up opportunities for repurposing of ideas and applications, and for finding innovative solutions for translational genomics through cross-boundary communities of practice.

January 13-17, 2019 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Karlene A. Cimprich, Mark O'Connor and Johannes C. Walter

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# Biochemistry, Structural and Cellular
# Cancer
# Genetics, Genomics and RNA
This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.

January 20-24, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
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# Biochemistry, Structural and Cellular
# Immunology
# Metabolism and Cardiovascular
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has risen precipitously over the past two decades in parallel with the worldwide obesity epidemic; however, there are no approved therapies. The more advanced form of the disease, non-alcoholic steatohepatitis (NASH), is associated with progressive fibrosis and an increased risk of liver cancer. Despite the growing number of systemic and liver-specific abnormalities identified in patients with NAFLD, a clear hierarchy of the relative importance of specific defects has not emerged. Furthermore, a clear understanding of which individuals are at highest risk for progression to advanced liver disease and cancer remains elusive. Thus, the field lacks an integrated understanding of risk prediction, pathogenesis and validated biomarkers to predict or track disease progression without reliance on liver biopsies. Therefore, the goals of this conference are to: 1) Explore genetic and ethnic contributions to NAFLD development; 2) Clarify underlying pathogenic defects in NAFLD and NASH, focusing on the specific contributions of lipotoxicity, the microbiome, innate immune signaling and drivers of fibrosis; and 3) Highlight emerging prognostic and diagnostic biomarkers that are yielding new, more streamlined clinical trial designs to evaluate novel therapies. As a result of this conference, attendees should gain a more holistic understanding of the unmet needs and new paths to advancing our understanding of NAFLD pathogenesis, diagnosis and therapy. The multidisciplinary nature of the topics and speakers promises to generate novel insights that represent convergent expertise and opinion. In doing so, new paradigms are likely to emerge that greatly inform the expanding number of emerging diagnostic markers and therapeutic agents. The conference comes at a propitious time when there is already sufficient basic translational and clinical research to extract important new insights, focus on unmet needs and refine research strategies for the future.

January 17-21, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Christina L. Stallings, Veronique Anne Dartois, Stewart T. Cole and David Barros Aguirre

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# Infectious Diseases
The Mycobacterium tuberculosis (TB) research and development landscape has seen many exciting breakthroughs over the past two decades. New diagnostics have emerged, innovative research has significantly reduced biological uncertainties and two novel drugs have been launched. In addition, public-private partnerships have been formed, which have dedicated massive efforts aimed at dramatically shortening TB therapy, tackling resistant disease, and developing new vaccines. However, shifts in funding priorities and a false sense of success could threaten the current focus and momentum, which would have catastrophic consequences, making the timing of this conference of paramount importance. This conference seeks to: 1) Reignite collaborative and multidisciplinary research by bringing together experts in basic science, translational research, and drug discovery and development; 2) Bring together young brilliant minds and established investigators to encourage new discussions and the exchange of innovative ideas for strategies moving forward; and 3) Foster cross-fertilization at the interface between research and development, all aspects of which are critical if we are to tackle the TB pandemic and achieve the next innovative leap.

January 20-24, 2019 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Lélia Delamarre, Robert A. Seder and Nina Bhardwaj

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# Cancer
# Immunology
The success of immunotherapy in the treatment of cancer patients has proved the long-standing hypothesis that endogenous adaptive immune responses against the tumor can be harnessed to mediate protection by immune checkpoint blockade. This approach has shown impressive control of disease and improved survival in up to 50% of patients with certain tumors. Genetic and immune analysis of human cancers suggests that one mechanism of resistance to immune checkpoint blockade may be due to lack of tumor-specific T cells. In principle, vaccines have the potential to overcome this defect by either expanding low-level existing tumor-specific T cell responses or priming tumor-specific T cells. Recent advances in next-generation sequencing have improved our understanding of defining cancer antigens. Application of this will require vaccine delivery approaches that can induce potent and broad T cell immunity in an efficient manner for personalized therapy. This Keystone Symposia conference will highlight recent insights in the characterization of immunogenic cancer antigens, the biology and underlying mechanisms of T cell priming, and the development of novel approaches designed to expand T cell responses. Part of the meeting will also be devoted to the development of technologies to monitor T cell responses in response to immune interventions.

January 21-25, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Geoffrey S. Ginsburg, Sue Siegel and Eric D. Perakslis

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# Drug Discovery, Bioengineering and Digital
# Genetics, Genomics and RNA
# Technologies
This conference is the first digital health meeting to focus specifically on the scientific foundations and health applications of digital technologies. Taking a novel sensor or new device from concept to clinic is remarkably complex, and the technologies are evolving rapidly. Digital technology offers novel capabilities that have great potential to drive chronic disease understanding and management at both an individual and population level, including the ability to deliver real-time interventions that can be connected to a healthcare system, in a community setting or in limited-resource settings. The increased use of digital capture devices has become a universal part of everyday life; however, more research is needed to provide evidence that wearables and even more sophisticated implantable medical devices will transform healthcare delivery quality and costs. This Keystone Symposia conference focuses on: 1) The scientific/medical gaps in knowledge and opportunities to fill them; 2) Required methodologies for medical and technical validation; and 3) Specifics of data and knowledge management. The conference explores the landscape at the intersection of digital technologies, molecular/genomic data and healthcare data by examining how these data streams can interface to enable precision health, drive research (patient-reported outcomes, continuous phenotypes) and impact clinical care (monitoring, feedback, adherence). The conference aims to enhance participants’ understanding of the state of the art for capturing digital phenotyping and of consumer/patient access and comprehension, regulatory jurisdiction, health care provider/system readiness, clinical utility, personal utility, integration with the electronic health record, quality standards and ethical considerations. It brings together clinicians, scientists, technology innovators, health economists and regulators to discuss and develop the new models of cross-disciplinary collaboration and business that will be required to deliver quality digital health strategies and solutions, and to illuminate areas of synergy between the academic, public and private sectors to inform a research agenda for the next five years.

January 21-25, 2019 | Sagebrush Inn & Suites, Taos, NM, United States
Scientific Organizers: Kristin Scott, Paola Arlotta, Rui M. Costa and Yimin Zou

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# Neurobiology
A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and function of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity. Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same process, no small highly interactive “Keystone Symposia-style” meeting brings these three groups together in the same room. This symposium will bring together leaders working on synapse development and function, circuit structure and function, and the study of brain disease, believing with confidence that mutually beneficial insights will emerge from discussing each other’s work.

January 27-31, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Jason C. Mills, Maike Sander and Ben Z. Stanger

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# Cancer
# Developmental, Reproductive and Regenerative
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.

January 27-31, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Nicolas Tapon, Liliana Attisano and Raphael Kopan

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# Biochemistry, Structural and Cellular
# Developmental, Reproductive and Regenerative
The discovery and study of the major developmental signaling pathways (Notch, Hh, Wnt, RTK) has illuminated how patterning and growth are controlled in metazoans. These pathways are reiteratively used during development and adult life, acting to maintain stem cells and direct tissue repair and regeneration. When they are disrupted, cancer develops. This conference embraces recent progress in quantitative biology, mathematical modelling, single cell analysis and intravital imaging. It also presents a major opportunity to bring together knowledge from developmental systems with adult homeostasis, regeneration and cancer, as well as to elucidate how different developmental signals are integrated to influence cellular decision-making processes. The pairing with the conference on Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia enables an in-depth exploration of the parallels between plasticity/pluripotency in development, regeneration and disease. In summary, the conference aims to: 1) Explore the commonalities between signaling in development, regeneration, and homeostasis, 2) Leverage quantitative, single cell and systems biology to study the dynamics and integration of developmental signaling across scales, and 3) Highlight how perturbations in developmental pathways cause diseases such as cancer.

February 2-5, 2019 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Silvia Monticelli, K. Mark Ansel, Sarah Teichmann and Gioacchino Natoli

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# Biochemistry, Structural and Cellular
# Immunology
The immune system is a heavily armed but carefully tuned defense mechanism that must mount protective responses against invading pathogens, while at the same time avoiding excessive inflammation and inappropriate responses that can lead to severe tissue damage and disease. Properly regulated immune responses are the result of a complex interplay between chromatin modifications, transcription factors and post-transcriptional regulators that operate collectively within each cell to regulate the gene expression programs that control immune cell differentiation, maintenance of cell identity, and the orchestration of functional responses in a dynamic environment. Recent technical advances in genomics and single-cell analyses have brought new ideas and perspectives to investigation of the regulation of gene expression, and our understanding of the mechanisms and regulatory networks that operate in the immune system is advancing at an unprecedented rate. This meeting will be important to define the most impactful questions and future challenges in the field of transcriptional and post-transcriptional control of immune cells, and it will bring together rapidly expanding and evolving communities. The exchange of scientific knowledge and technical capabilities will foster opportunities for collaborations and interdisciplinary interactions among groups of scientists working on disparate aspects of regulation of gene expression in inflammation and immunity, highlighting the latest innovations and discoveries while shaping future directions for the field.

February 10-14, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Peter D. Kwong, Brandon J DeKosky,   and Jeffrey B. Ulmer

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# Immunology
# Infectious Diseases
Vaccines address public health issues ranging from pandemic outbreaks to childhood disease. Despite this diversity, molecular approaches are beginning to find broad application. This Keystone Symposia conference seeks to bring together antibody aficionados, B cell immunologists, structural biologists, and vaccine developers from government, academia, biotechnology, and major pharmaceutical companies to review the utility of structure-based vaccine design and antibody-based immune monitoring, and in doing so hope to transform standard approaches of vaccine development. This meeting aims (1) to provide examples of the ”antibody-to-vaccine” paradigm for RSV, CMV and other pathogens that have resisted standard vaccinology; (2) to describe procedures whereby B cells can be taught to make the right antibodies; (3) to describe molecular approaches for vaccine improvement; and (4) to discuss how molecular approaches can be used to speed development (as may be needed, for example, in the case of pandemics) and to reduce developmental and regulatory costs (for vaccines in general and in particular to enable provision to the developing world). Overall, we seek to integrate molecular approaches for vaccine development and read-out with other transformative advances including mRNA delivery, next-generation sequencing of B cell transcripts, and control of B cell-T cell interactions. This conference will be held jointly with a Keystone Symposia conference on B Cell-T Cell Interactions and several shared sessions will highlight synergistic areas of research between these communities.

February 10-14, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Matthias Blüher, Philipp E. Scherer and Anne Bouloumié

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# Metabolism and Cardiovascular
Obesity is a growing worldwide epidemic, increasing co-morbid conditions, such as diabetes. The joint conferences on “Obesity and Adipose Tissue Biology” and “Functional Neurocircuitry of Feeding and Feeding Disorders” are aimed to foster cross-talk between these research areas. Adipose tissue is an endocrine organ that is both controlled by and sends signals to the brain and other organs. In addition, obesity causes an inflammatory state in the adipose tissue. The recognition that brown/beige adipose tissue is active in adult humans has triggered interest in understanding the physiology and relative importance of these tissues. Exercise and bariatric surgery are known to elicit profound metabolic benefits in type 2 diabetes, although the underlying mechanisms remain unclear. This conference will bring together cell biologists, biochemists, geneticists, physiologists, drug developers and clinical researchers, thereby facilitating knowledge exchange and interactions leading to elucidation of better treatments for obesity and diabetes. Specifically, it will examine recent advances in our understanding of brown/beige adipose tissue function; obesity-induced adipose inflammation; control of adipose tissue, appetite and energy metabolism; endocrine and paracrine signaling via secreted factors; molecular mechanisms of metabolic signaling; emerging topics, including long noncoding RNA and the gut microbiome; and approaches to drug development and the treatment of obesity and diabetes.

February 10-14, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Roger D. Cone, Lori M. Zeltser and Matthew R. Hayes

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# Metabolism and Cardiovascular
# Neurobiology
The Keystone Symposia conference on neuronal control of appetite is a well-attended conference that is the leading gathering for scientific exchange among those studying the central control of energy homeostasis. The monogenetic syndromes of obesity in mouse and man played a fundamental role in the development of this field, and hence the field has heavily emphasized the control of feeding in models of obesity. However, many disorders of feeding and energy storage, including anorexia nervosa, disease cachexia, pediatric failure to thrive, Prader-Willi disease and progeria are important untreated medical conditions. The goal of this conference will be to gather world leaders in the neural control of feeding and energy homeostasis, along with leaders in the pathophysiology of feeding and energy homeostasis. There is currently no conference in the field that brings together these disparate groups of scientists. For example, recent annual conferences of the Society for the Study of Ingestive Behavior had few talks on anorexia or cachexia. The 2017 Keystone Symposia conference on Neural Control of Appetite began to expand the biological breadth of feeding behaviors under investigation, and this proposed conference will further broaden this field by covering fundamental advances in the neural circuitry underlying feeding, while including entire sessions devoted to anorexia nervosa, disease cachexia, and feeding disorders across the lifespan. Additionally, while the Keystone conference on Obesity and Adipose Tissue Biology has been heavily focused on the hypothalamic control of homeostatic feeding, this conference will have entire sessions devoted to brainstem and telencephalic control of feeding.

February 17-21, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
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# Biochemistry, Structural and Cellular
Autophagy is a homeostatic process strategically positioned at the intersection of metabolism and intracellular quality control, with broad physiological and medical manifestations ranging from metabolic imbalance to neurodegeneration, infections, immune disorders, cancer and aging. In yeast, the formation and organization of the autophagosomal apparatus follows a highly prescribed sequence, starting with the pre-autophagosomal structure and ending in autophagosomal fusion with the yeast vacuole. However, in other model organisms, as well as in mammals, the autophagy machinery and its regulators show both similarities and notable differences relative to yeast. The goals/aims of the conference are: 1) Compare and contrast autophagy in yeast and higher organisms with a focus on both the shared regulators and on those factors that have no counterparts in yeast. 2) Cover the intersection of autophagy with energy metabolism, innate immune signaling and endomembrane damage. 3) Cover how signaling cascades regulate the process of selective autophagy whereby substrates are recruited to forming autophagosomes by receptors and molecular tags such as ubiquitin, galectins, or through other modalities. The conference will cover fundamental principles as outlined above and how they apply to basic and translational aspects of human disease. Intersections with several other stress response processes will be addressed.

February 18-22, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
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# Cancer
# Immunology
Significant progress has been made in the field of immunology over the past two decades. Therapeutic agents such as anti-TNF, anti-CD20, anti-CTLA4, and more recently, anti-PD1 have benefited countless patients. This is a unique time for immunologists and clinical scientists to learn from the sheer number of clinical trials assessing immune targets for treatment of cancer and autoimmunity. Currently, there are more than 500 clinical studies testing combinations of checkpoint inhibitors with other pathway antagonists, which will begin to uncover the “immune mechanisms” driving the disease process. This is highlighted by the observation that more than 10-20% of patients treated with anti-PD1 and/or CTLA4 later suffer from autoimmunity (e.g., anti-PD1 treatment is linked to Type 1 diabetes and anti-CTLA-4 treatment is linked to inflammatory bowel disease). Response rate to cancer treatment is greater in patients with autoimmune predisposition; therefore the autoimmune side effect is in part associated with patient genetics. The meeting topics will include discussions of combination immunotherapies, the genetics of patient response, and strategies to reprogram adaptive and innate immunity, which are key to harnessing the immune system to fight cancer and autoimmune diseases. The meeting will end with a special closing lecture on the future of immunotherapy.

February 19-23, 2019 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
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# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
# Technologies
The use of programmable nucleases such as CRISPR-Cas systems, ZFNs and TALENs has revolutionized cell biology by providing the ability to manipulate specific genetic and epigenetic states within living cells. These systems have been broadly applied as tools in research settings and increasingly are being developed to create improved models of disease and engineer cells for therapeutic purposes. Together with other DNA modifying systems such as recombinases, integrases and transposases, it is now possible to introduce mutations that will model human disease, build complex synthetic signaling networks to perform regulated functions and design cells to target specific disease states. Improvements to the methods involved requires understanding enzyme structures and mechanisms and how they intersect with cellular DNA repair systems. The intersection of this basic science with engineering approaches and improved cellular models is revolutionizing our understanding and treatment of human disease. The goal of this Keystone Symposium is to bring together people developing and studying genome engineering tools with groups who are applying them to build new disease models, identify disease mechanisms and drug targets, and develop cell-based therapeutics and genetic medicines. In addition to covering engineering of human and animal cells, this meeting will also highlight the emerging field of genome engineering to identify new anti-microbial and anti-viral drugs and applications towards next generation antibiotics. Invited talks will explore a broad range of topics covering new technologies, fundamental basic research, through the development of screening approaches, stem cell-based models of disease and design and development of cellular therapeutics.

February 24-28, 2019 | Keystone Resort, Keystone, CO, United States
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# Cancer
# Metabolism and Cardiovascular
The fact that tumor cells have altered metabolism compared to their tissues of origin has been known for more than 90 years. Some commonly used chemotherapies, such as methotrexate, target metabolic enzymes. Over the past decade there has been a revival of interest in developing new therapies that target metabolic vulnerabilities of tumor cells. Dramatic improvements in technologies for monitoring tumor metabolism by mass spectrometry and by multiple modes of imaging have revealed that tumors evolve diverse alterations in metabolism in order to grow in the primary tissue and in metastatic sites. This conference will bring together scientists with a wide spectrum of expertise who are world leaders in this rapidly moving field. The conference includes talks from pharmaceutical scientists who are developing first-in-class drugs that target metabolic enzymes. In addition there will be presentations from academic scientists who are studying not only changes in metabolism in tumor cells, but also changes in metabolism in cells in the tumor microenvironment and in the whole body. The conference will also include poster sessions, short talks chosen from poster abstracts and plenty of time for discussion of each talk.

February 24-28, 2019 | Eldorado Hotel & Spa, Santa Fe, NM, United States
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# Immunology
Myeloid cells regulate tissue homeostasis, immunity, and inflammation, whereas their dysregulation contributes to cancer, metabolic, inflammatory diseases, and degenerative diseases. This Keystone Meeting will cover areas of long-standing interest as well as topical areas in the field of myeloid cell biology, including ontogeny and tissue specification, myeloid cell activation, immunometabolism, immunity and infection, mucosal immunity, and cancer immunology. Multiple myeloid cell populations will be discussed, including tissue resident macrophages, monocytes, dendritic cells, and neutrophils. The meeting will highlight the diverse approaches being used to study myeloid cell biology, including genomic analyses, single cell profiling, imaging, and metabolic profiling. Both basic and translational aspects of myeloid cell research will be covered. The goals of the meeting are to share recent advances in this rapidly evolving field, stimulate interactions between interdisciplinary groups of scientists, and define future areas of investigation in myeloid cell research.

February 24-28, 2019 | Whistler Conference Centre, Whistler, BC, Canada
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# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
Recent evidence suggests that the human genome encodes ~1500 RNA binding proteins (RBPs) and this number may further increase by identifying additional RBPs that do not contain canonical RNA binding motifs. These proteins control gene expression at transcriptional and post-transcriptional levels in development and disease. As mutations in many RBPs have been linked to human diseases, various RBPs and their regulated events may be potential drug targets. The proposed meeting on RNA-protein interactions will address some long-standing problems as well as emerging paradigms. For example, as both nascent and regulatory RNAs are intimately associated with chromatin, understanding of genetic and epigenetic control of gene expression would be incomplete without understanding the regulatory roles of RNAs and RBPs involved. The goal of the proposed meeting is to bring together leaders in RNA research to (1) brainstorm on novel concepts, (2) share new technology development, and (3) explore new disease mechanisms. We anticipate the attendees of this meeting to take home fresh ideas and academic ties. The field will benefit from the presentation of leaders to consolidate the leading edges in RNA research. INNOVATION: The meeting will be highly mechanism-oriented, rather than centering on a specific biological process or disease theme, which will bring together scientist across multiple fields. This meeting will be coupled with another Keystone Symposia meeting on 'Long Non-Coding RNAs: From Molecular Mechanism to Functional Genetics', as individual regulatory RNAs must enlist specific RBPs to execute their biological functions. The intertwined sessions on these related topics will thus present a cohesive theme on RNA biology and medicine.

February 24-28, 2019 | Whistler Conference Centre, Whistler, BC, Canada
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# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
Although emerging evidence points to the critical importance of the long non-coding transcriptome in human physiology and pathology, the clinical potential of long non-coding RNAs (lncRNAs) as therapeutic and prognostic targets remain largely unexplored. The increasing availability of high-throughput technologies and newly developed computational methodologies are rapidly making it possible to address this gap in our knowledge. However, optimal use of these new capabilities and recognition of their power in transforming the field of lncRNA research require the formation of new collaborative and training efforts. This conference specifically aims to: 1) Communicate the latest available technologies and developing methodologies for lncRNA functional genetics to the lncRNA community; 2) Bridge the already thriving lncRNA mechanistic and basic research to the clinical need for novel, effective diagnostic, prognostic and therapeutic targets; 3) Highlight and promote the emerging feasibility of performing lncRNA functional genetics; and 4) Stimulate the formation of new collaborative efforts that will accelerate the integration of the lncRNA research into the existing body of biological knowledge.

March 3-7, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
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# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital
Unlike conventional target-centric drug discovery, Phenotypic Drug Discovery (PDD) places its focus on disease-relevant phenotypes and agnosticism with regard to molecular mechanism of action. Thus, it offers unique opportunities in terms of discovery of novel biology and first-in-class therapeutics but is matched with significant challenges, a number of which can be addressed by recent advances in chemical and systems biology. A key aspect of the conference will be to share information and processes on how best to employ phenotypic strategies to discover novel biology and effectively prosecute drug discovery programs. Specific topics will include: chemical biology advances and case studies in target identification; case studies of recently advanced clinical candidates and approved drugs; functional genomics and systems biology advances and case studies; project prosecution including lessons learned from lead optimization and pre-clinical development; complex cell-based models and new assay modalities. With few non-commercial meetings covering drug discovery as a discipline, this conference has the stature and breadth to bring together accomplished and influential scientists from industry and academia as demonstrated by the 2016 conference. Its scope will be broader than other PDD and Chemical Biology meetings since it will cover the entire range of activities and technologies from phenotypic assay systems, to target identification and FDA approval of novel therapeutics. Given that there is still an emphasis on target centric discovery in pharmaceutical companies, this conference can be instrumental in further promoting a shift in mindset and contributing to the consolidation of PDD as an integral part of the drug discovery paradigm. The vision for this conference would be to share success stories of newly approved drugs and late stage clinical candidates, along with key lessons and best practices, to inform future PDD projects.

March 3-7, 2019 | Whistler Conference Centre, Whistler, BC, Canada
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# Metabolism and Cardiovascular
Diabetes remains a public health challenge of epidemic proportions. Modern treatment algorithms are evolving to recommend greater focus on personalized approaches to diabetes care. However, as diabetes remains a disease characterized by excess elevation of a plasma biomarker, glucose, further refinement of our understanding of the disease and its comorbidities is required to provide optimal guidance for precision medicine. Advancement of research technologies and the ability to handle large data sets have enabled systems biology approaches to unravel different etiologies and pathophysiological consequences of diabetes. Future diabetes discovery efforts will focus on pairing knowledge about genetic risk and environmental triggers of diabetes-associated pathologies. Using deep phenome characterization and molecular network analyses diabetes, researchers will be able to launch modern translational approaches to diabetes care innovation. The objectives of the conference are to provide directional guidance for future pressure points of diabetes care and focus on specific diabetes complications representing particular unmet needs. Further, cutting-edge discoveries of genetic risk determinants and their molecular mechanisms will be presented together with lively debates about the translatability of such insights into novel curative therapies.

March 3-7, 2019 | Whistler Conference Centre, Whistler, BC, Canada
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# Metabolism and Cardiovascular
Approximately one in 11 people in the world suffers from kidney disease. The incidence of kidney disease is increasing, especially in the developing world. This issue was recently reviewed and emphasized in a Lancet article (Global Health Atlas). Acute and chronic kidney disease is associated with a highly significant increase in cardiovascular death. Chronic kidney disease (CKD) represents a leading cause of death in the United States. There is no cure for this disease, with current treatment strategies relying on blood pressure control through blockade of the renin-angiotensin system. Such approaches only delay the development of end-stage kidney disease and can be associated with serious side effects. Recent identification of several novel mechanisms contributing to CKD development - including vascular changes, loss of podocytes and renal epithelial cells, matrix deposition, inflammation and metabolic dysregulation - has revealed new potential therapeutic approaches for CKD. This conference will review clinical and observational studies in the kidney disease area, highlight recent advances in basic biology of kidney and kidney disease, assess emerging strategies and agents for CKD treatment, and discuss major obstacles in drug development. The conference will also encourage collaborations among clinicians and researchers from academic institutes and pharmaceutical laboratories to accelerate innovation in this field. There has not been a conference in the area in kidney disease that brings together clinicians, basic scientists and industry to foster collaboration. Small focused conferences have been organized by the International Society of Nephrology, but these conferences are limited to a single special topic. Furthermore, more than half of kidney disease is caused by diabetes; pairing the conference with a conference focused on diabetes affords the opportunity to understand the role of diabetes in the development of kidney complications.

March 27-30, 2022 | Fairmont Banff Springs, Banff, AB, Canada
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# Immunology
# Infectious Diseases
Despite the many years of research, a successful vaccine or cure for HIV-1 remains among the highest priority areas of unmet need in infectious disease. As such, this Keystone Symposia conference was designed to bring together scientists working in the fields of HIV vaccines and/or the pathway to a cure. The program was designed to highlight recent results in both areas. The conference seeks to foster collaborations that will build upon these new results to help accelerate progress and treatment methods. The sessions in this program were developed to include a focus on novel approaches to vaccine development including vaccine immunology, passive therapies, and genetic vaccination. Additionally, results from ongoing human vaccine clinical trials will also be integrated into the conference. Moreover, sessions focused on a cure for HIV will address the problem of viral latency and how it is controlled and will emphasize cure-related human clinical trials. The conference organizers hope to elicit and identify areas of future investigation, encourage new partnerships, and collectively generate the knowledge required to design better vaccines, treatment methods, and networks that will facilitate transformative approaches to prevention and cure for this disease.

March 6-9, 2022 | Fairmont Banff Springs, Banff, AB, Canada
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# Immunology

This meeting will proceed as planned. As the omicron surge wanes, we expect it will be safe to convene in-person by this time and will be implementing special COVID-19 safety measures to protect the health and safety of all attendees. It is critically important to both the science, and the scientific community, that we do so, to ensure scientific exchange, connection and innovation that have been stifled by the pandemic. The Science Must Go On.

Memory characteristics of innate immune responses (also termed ‘trained immunity’) have been recognized only recently, with a multitude of studies demonstrating their importance for long-term broad protection against infections. Innate immune memory has been demonstrated to have deep evolutionary roots in plants and invertebrates, but also plays an important role in the host defense of vertebrates in general, and mammals in particular. In humans, innate immune memory is important for host defense against infections, and may enhance anti-tumor immunity, but can also contribute to pathogenesis in inflammatory and autoimmune diseases. The emergence of novel types of immunotherapy is having a profound impact on disease outcomes in several major pathologies such as cancer, autoimmune diseases and even severe infections. However, the immunotherapeutic research has largely focused on targeting adaptive immune cells (e.g., checkpoint inhibitors, CAR-T cells, monoclonal antibodies), with relatively little attention to innate immune cells. This conference intends to change this by serving as an international forum to highlight innate immune processes of relevance to immunotherapies. This meeting is a unique platform, in which researchers from several important fields (immunology, evolutionary biology, cancer biology, infectious diseases and physiology, clinical and health sciences) will be able to interact and exchange ideas, methods and build collaborations: this is emerging as one of the most exciting areas in immunology, and the proposed Keystone Symposium has the chance to give a strong impetus to this novel field of research.

April 3-6, 2022 | Snowbird Resort, Snowbird, UT, United States
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# Immunology
This meeting will proceed as planned. As the omicron surge wanes, we expect it will be safe to convene in-person by this time and will be implementing special COVID-19 safety measures to protect the health and safety of all attendees. It is critically important to both the science, and the scientific community, that we do so, to ensure scientific exchange, connection and innovation that have been stifled by the pandemic. The Science Must Go On!

Innate immunity is a pillar of the host’s defense against infection and noxious self. Pathogen or danger recognition systems (PRRs) including TLRs, inflammasomes, and RIG-I-like receptors are broadly recognized as central nodes of innate immune responses and have a solid place in the immunologists’ hearts. The complement system, however, albeit being the evolutionary oldest PRR, is often perceived as the ‘Stiefkind’ of innate immunity and generally evokes less excitement. This view is changing: complement has recently been up-graded from a mere lytic pathogen-killer to an intracellularly-active orchestrator of normal cell physiology. This, together with the realization that an increasing number of human diseases, among those COVID-19, involve complement perturbations has spurred a regained interest in complement biology and its therapeutic targeting. Our knowledge, however, of how complement exerts non-canonical activities and how it intersects with other PRRs is sparse. This conference will provide a timely account of recent paradigm shifts in our understanding of complement/PRR-instructed immunity with a specific eye on emerging roles in basic cellular processes including regulation of chromatin structure, metabolism, cell death, clearance of cellular debris/corpses, and maintenance of normal CNS function. A second focus is on exploring how aberrant function of these new PRR activities contribute to infection and autoimmunity but also to less intuitive clinical conditions like changes in cognition and behavior. This holistic and ‘complement-inclusive’ vantage-point on PRR biology brings together interdisciplinary investigators from academia and industry for cross-fertilization of novel ideas and collaborations towards biomedical progress in harnessing complement to combat human disease.

June 5-9, 2022 | Keystone Resort, Keystone, CO, United States
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# Immunology
# Neurobiology
This conference aims to assemble leading geneticists, neuroscientists, and immunologists in an effort to explore important questions regarding the role of the immune system in the central nervous system during both health and disease. The goals of this meeting are the following: • Bring together different disciplines to investigate fundamental topics of neuroimmunology, such as immune control of CNS development, neuronal connectivity, myelination, circulation, as well as the role of the immune system in autoimmune and neurodegenerative diseases of the CNS. • Focus on the applications of emerging technologies to questions in neuroimmunology, such as -omics technologies, system biology and imaging. • Foster collaborations between immunologists, neuroscientists, and geneticists. • Encourage collaborations between academia and industry for the development of new avenues of intervention for multiple sclerosis and neurodegenerative diseases The anticipated outcomes of this meeting will include an increased awareness of the importance of the interplay between the immune system and the nervous system, the dissemination of the most up to date information in neuroimmunology, the application of new technologies to thus far intractable questions in neuroimmunology, and increased cross-discipline collaborations. This meeting will be held conjointly with the Keystone Meeting on Neurodegeneration; this combination will be beneficial in that it will emphasize the crossover between neurodegeneration and neuroimmunology. As neuroimmunology is a recently reinvigorated field this meeting will provide a critical opportunity to foster cross-disciplinary thinking.

April 3-6, 2022 | Herrenhausen Palace, HannoverGermany
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# Immunology

This meeting is full.  If you would like to be placed on a waitlist, please contact our office at info@keystonesymposia.org.  LiveStream and OnDemand options are still available.

B cell-T cell collaboration leads, via the germinal center reaction, to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, we have an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved. However, many aspects of this remarkable process as it plays out in infections, vaccine responses, and chronic immunological diseases remain unknown. In particular, we still do not understand how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. We do not fully appreciate the spectrum of ‘non-canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if we hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune disease. This meeting brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. We aim to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.

March 20-24, 2022 | Fairmont Chateau Whistler, Whistler, BC, Canada
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# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology
This meeting will proceed as planned. As the omicron surge wanes, we expect it will be safe to convene in-person by this time and will be implementing special COVID-19 safety measures to protect the health and safety of all attendees. It is critically important to both the science, and the scientific community, that we do so, to ensure scientific exchange, connection and innovation that have been stifled by the pandemic. The Science Must Go On.

Although there has been rapid advancement in the understanding of cancer immunity, application of this evolving body of knowledge is impeded by divisions between disciplines and the challenges inherent in remaining abreast of a rapidly developing field. Widening knowledge gaps span the interface between clinical and basic data, as well as between scientists who are focused on disparate immune components of the tumor microenvironment and between systems biology, bioinformatics data and their practical application. In bringing together translational physicians, basic immunologists and cutting-edge systems biologists, this conference will foster interdisciplinary cooperation such that cutting-edge discoveries made in the bioinformatics field will help drive translation and lab-based investigation. Additionally, it will provide a showcase for novel imaging and profiling technologies, fostering their widespread adoption by the cancer immunity field as a whole. Finally, it will highlight recent advances in our understanding of epigenetic control of T cell function. A goal of the conference is to bring together these different groups of scientists and to accelerate the application of new technologies and systems biology approaches to their own research efforts. A well-organized cancer immunity conference focused on bringing together translational and basic investigation, along with cutting edge systems biology and technology approaches represents a novel construct previously not fulfilled by other, isolated silo-like meetings. The disciplines gathered for this conference would not normally co-attend meetings. This program is aimed at addressing these widening knowledge gaps which are being promulgated by a rapidly evolving field.

June 1-4, 2022 | Beaver Run Conference Center, Breckenridge, CO, United States
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# Immunology
# Infectious Diseases
Vaccines are the cornerstones of modern medicine saving millions of lives every year. Due to the fast progress in better understanding the biology of certain pathogens coupled with recent technological advancements in the fields of immunology, structural biology and nanomaterial development, we have entered a new golden age of vaccinology. This meeting will focus on presenting state-of-the-art vaccine technologies (mRNA, viral vectors, protein nanoparticles, adjuvants), recent advancements in understanding (and potentially manipulating) vaccine-induced immune responses and key aspects of structure-based antigen design that allows us to develop better vaccine immunogens. Combining these overlapping and strongly synergistic aspects of vaccine development we aim to foster collaborations between conference participants that may result in novel, very effective vaccines in the future. Most currently used vaccines have been developed by empirical research without the involvement of immunologists, structural biologists or biomedical engineers. It has become evident in recent years that the empirical approach is not sufficient for successful vaccine development against hard-to-target pathogens. To successfully combat these pathogens we need to better understand how we can induce protective immune responses against them and need to develop better adjuvants, vaccine platforms or immunization schemes. This 'combined' approach requires a tight cooperation between interdisciplinary groups of scientists that we aim to bring together in this Keystone meeting. Other Keystone meetings in the fields of immunology can potentially synergize with our proposed symposium.

June 29-2, 2022 | Keystone Resort, Keystone, CO, United States
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# Immunology
# Infectious Diseases

This meeting is a reschedule of Viral Immunity: Basic Mechanisms and Therapeutic Applications originally scheduled for January 2022.  PROGRAM IS NOW AVAILABLE! 

Meeting Summary

Viruses infect millions annually, causing severe illness and threatening global public health, as exemplified by the recent SARS-CoV-2 pandemic. Limiting the impact of viral infection requires a multi-layered understanding of viral immunity, from basic research on viral recognition and host immune response, to the clinical applications of novel antiviral and host-targeted therapies and vaccines. Despite recent advances, the mechanisms of both rapid host recovery as well as severe and fatal disease outcomes, are far from clear. This Keystone Symposia conference will cover a wide range of topics in viral immunity including innate immunity and inflammation, adaptive T and B cell immunity, novel vaccine development, human immunology across anatomical sites, and innovative computational analyses. Animal models will be examined alongside human and clinical studies, and multi-disciplinary integration will enhance perspectives. A key outcome will be fostering collaborations across different approaches such as viral models and host systems, and across different communities from academia to government to industry. The overall objective of this conference is to provide a unique opportunity for cross-disciplinary interaction and knowledge exchange. Joint efforts in understanding viral immunity are needed for the rational design and development of immunotherapies and vaccines towards seasonal, emerging, and re-emerging viruses.

September 5-8, 2022 | Keystone Resort, Keystone, CO, United States
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# Immunology
# Metabolism and Cardiovascular

This meeting is a reschedule of Immunometabolism at the Crossroads of Obesity and Cancer originally scheduled for January 2022.  PROGRAM IS NOW AVAILABLE!

Meeting Summary

The field of immunometabolism has generally been split into two largely separate areas: the study of the intrinsic cellular metabolic pathways driving immune response, and the study of leukocytes regulating systemic metabolism. However, the fields rarely have the chance to interact, yet it is critical to the field. This Keystone Symposia conference will bring these fields of systemic and cellular immunometabolism together for the first time. This conference highlights the interdependence of both arms of immunometabolism, using the settings of obesity and obesity driven cancer as the ideal examples to explore and synergize these areas of research. In addition, linking diet, obesity and immunity is very relevant to the current COVID-19 pandemic, which is disproportionately affecting patients with obesity and type 2 diabetes. Moreover, by holding this conference jointly with the Keystone meeting on Tumor Metabolism, the program will integrate immunometabolism with cutting edge knowledge and tools in metabolism of cancer cells and the microenvironment to drive the field forward. Furthermore, this conference will cover sessions on new concepts and state of the art technologies that can lead to deeper insights in the field of immunometabolism with the goal of connecting metabolic processes at the organismal, tissue, and cellular levels, as well as sessions on understanding the effects of diet, microbiome and obesity in immune system function and cancer pathogenesis and therapy. Finally, innovative strategies for targeting immunometabolism as therapeutics for cancer, obesity and other disorders, including the approaches of improving immunotherapy and direct targeting of tumor-intrinsic pathways in cancer will also be covered.

October 30-2, 2022 | Eldorado Hotel & Spa, Santa Fe, NM, United States
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# Biochemistry, Structural and Cellular

This meeting is a reschedule of Exosomes, Microvesicles and Other Extracellular Vesicles originally scheduled for February 2022.  PROGRAM IS NOW AVAILABLE!

Meeting Summary

Extracellular vesicles (EVs), including exosomes, microvesicles and others are membranous nanovesicles, contain bioactive molecules such as lipids, proteins, RNA and metabolites derived from the cell of their origin. EVs carry these important cargo molecules throughout the body, signaling to distant tissues and orchestrating systemic responses. The profile of cargo they carry provides a cell-specific signature, which can reveal important insights about the cell of origin, and pathophysiological mechanisms. As such, there is growing excitement about their potential use as disease biomarkers, and/or therapeutic entities. The goal of this meeting is to disseminate the latest discoveries regarding both basic biology and clinical utility of EVs. In particular, the program will explore the role of EVs in human disease pathogenesis, novel therapeutic approaches with EVs, and biomarker developments. In addition to scientific insights, the meeting will cover new methodologies, tools and technologies for studying EVs, to enable further advancements in characterization of EV processes and facilitate translational impact into diagnostic and therapeutic applications. By integrating research in basic science with the clinical perspectives, this meeting will foster cross-disciplinary discussions and collaborations to drive the field forward towards medical impacts. In addition, the program format features panel discussions and workshops to spur insightful discussions and encourage interactions between young investigators and distinguished international experts for training, mentorship and networking opportunities.

March 10-14, 2019 | Fairmont The Queen Elizabeth, Montreal, QC, Canada
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# Biochemistry, Structural and Cellular
# Metabolism and Cardiovascular
Both the Unified Microbiome Initiative (Alivisatos et al., Science, 2015) and the National Microbiome Initiative have emphasized the need to move beyond sequencing to better understand the fundamental molecular and chemical mechanisms that shape microbial communities in host and environmental habitats. Understanding the chemistry of microbiomes has broad implications, including providing functional annotations for the vast “dark matter” of microbial genomes, insights into the chemical languages that link microbes to each other and to their habitat, and translational implications for precision medicine, environmental health, and sustainable living. This symposium brings together scientists in biology and chemistry who rarely interact to address common questions. The interdisciplinary collaborations that result will profoundly accelerate basic microbiome research as well as help understand the role of the microbiome in human health and disease. We will emphasize speakers that employ innovative new methods and/or hypothesis-driven research to understand microbial systems at the molecular level. There is an emphasis on speakers with innovative paradigm-shifting research programs in chemistry, synthetic biology, genome editing, precision medicine, etc. Finally, many of the program speakers may not normally be invited to give talks at traditional microbiome conferences; instead the program features key innovators w ho are making significant and exciting contributions to this emerging field.

March 10-14, 2019 | Humanities/Social Sciences Building of Academia Sinica, TaipeiTaiwan
Scientific Organizers: Jenny P.Y. Ting, Shie-Liang Hsieh, Fu-Tong Liu, Michael Gale, Jr. and Siamon Gordon

Important Deadlines
Early Registration Deadline: Jan. 17, 2019
Scholarship Deadline: Nov. 27, 2018
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# Immunology
# Infectious Diseases
Innate immune receptors include a plethora of membrane-associated proteins as well as intracellular receptors that directly bind or sense the presence of pathogen-associated molecular patterns (PAMPs). The importance of innate immune receptors was first appreciated in infectious diseases and autoinflammatory disorders, but it is now clear that their roles extend beyond innate immunology. The crucial roles of these receptors in many clinically relevant fields, and their newly documented role in non-immune cells, underscore their importance in biologic processes and diseases. This conference will address the ligands and signaling mechanisms of a diverse set of innate immune receptors as well as the profound impacts of innate immune receptors on the microbiome, which in turn has impacts on multiple organ systems. The program includes discussion of the intrinsic functions of innate immune receptors within adaptive immune cells, non-immune cells such as epithelial and endothelial cells, and their roles in cancer and stem cells. The pleitrophic effects of this important receptor class have far-reaching consequences for critical biological processes such as cancer cell death and signaling, DNA damage, stress response, stem cell proliferation/differentiation, vaccine adjuvanticity, age-related dementia, metabolic disorders and microbiome balance. By the nature of the topic, this conference brings together an interdisciplinary group of investigators to catalyze cross-fertilization of ideas and stimulate important medical advances.

March 15-19, 2019 | Firenze Fiera - Fortezza da Basso, FlorenceItaly
Scientific Organizers: Erika L. Pearce, Sarah-Maria Fendt, Russell G. Jones and Peter F. Carmeliet

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Early Registration Deadline: Jan. 17, 2019
Scholarship Deadline: Nov. 28, 2018
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Poster Abstract Deadline: Nov. 28, 2018
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# Cancer
# Immunology
In disease states, immune cells must compete for available resources to control tissue homeostasis or mediate protective functions. This is particularly true in cancer, where rapidly proliferating and metabolically dysregulated tumors exert metabolic pressure on cells within the tumor microenvironment. Understanding how immune and non-immune cells respond to these conditions and restrain tumor growth and metastasis is critical for developing new cancer therapies. Often cancer biologists and immunologists have little crossover, and this presents a significant barrier to furthering knowledge. This interdisciplinary conference brings together immunologists and scientists focusing on cancer to reveal novel and integrated mechanistic underpinnings that lead to cancer progression/regression and metastasis. Our goals are to: Integrate cancer biologists and immunologists who have a common interest in how cellular metabolism influences cell function; raise awareness of the metabolic intersection between tumor biology and immunology; and encourage junior researchers to actively participate at this interface. Attendees will leave the conference with a stronger understanding of how metabolism in immune cells and non-immune cells influence cell function in metastasis and the tumor microenvironment. We hope that researchers from cancer biology and immunology will, as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate. Given the resurgence that metabolism has seen in recent years, we think our conference will appeal broadly to many researchers across cancer biology and immunology, many of whom are interested in investigating metabolic changes in their particular systems.

March 17-21, 2019 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Cheryl Arrowsmith, Anne Schaefer and Mark A. Dawson

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Early Registration Deadline: Jan. 22, 2019
Scholarship Deadline: Nov. 29, 2018
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Poster Abstract Deadline: Nov. 29, 2018
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# Biochemistry, Structural and Cellular
# Cancer
# Genetics, Genomics and RNA
Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with a conference on “3D Genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this conference will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunological and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as they relate to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms.

March 24-27, 2019 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Marsha Wills-Karp, Donald Y.M. Leung and Kari Nadeau

Important Deadlines
Early Registration Deadline: Jan. 23, 2019
Scholarship Deadline: Dec. 4, 2018
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Poster Abstract Deadline: Dec. 4, 2018
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# Immunology
Allergic diseases have been on the rise globally in recent decades. Although it has long been known that IgE-mediated immune responses are associated with the manifestations of a wide spectrum of allergic disorders (asthma, atopic dermatitis, atopic rhinitis, food allergy, eosinophilic esophagitis), the exact factors leading to these aberrant immune responses are not well understood. Recent insights into disease origins support a broader realm of factors that may predispose, initiate or exacerbate altered immunity in allergic diseases such as inherent epithelial barrier dysfunction, loss of immune tolerance at central and specific sites, disturbances in gut and organ specific microbiomes, diet and age. However, these studies are in their infancy and have only been considered in a reductionist, disease or tissue-specific manner to date. Few studies have addressed the cross-talk between various organs leading to the concept of allergy as a system disease. A better understanding of the distinct or shared complex web of factors underlying the spectrum of allergic disorders and the successes/failures of the current armature of therapies may lead to the development of safer, disease-modifying interventions in the future. Thus the major goal of this meeting is to explore the potential microbial-epithelial-immune interactions underlying the etiology of allergic disorders in order to promote the development of novel disease prevention or intervention strategies.

March 24-28, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Nicholas D. Huntington, Eric Vivier, Caroline Robert and Lewis L. Lanier

Important Deadlines
Early Registration Deadline: Jan. 23, 2019
Scholarship Deadline: Dec. 4, 2018
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Poster Abstract Deadline: Dec. 4, 2018
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# Cancer
# Immunology
Immunotherapy has revolutionized the treatment of many cancer types over the past five years. T cell checkpoint inhibitors have led the way and are the focus of most immunotherapy trials. However innate and non-classical T cells contribute extensively to the tumor infiltrate and significantly impact on the tumor immune response in both the tumor microenvironment and in circulation. This symposium aims to bring together academic and industry opinion leaders in the fields of innate immune cells, natural killer cells, tumor microenvironment, tumor immune suppression, novel immunotherapeutic strategies and clinical cancer immunotherapy to define the next wave of immunotherapy breakthroughs that reach beyond the current T cell checkpoints. The conference offers a unique opportunity for an audience of diverse immunology and cancer research backgrounds to come together and share cutting edge insights into cancer immunology and rational approaches for therapeutic intervention that could be used as be standalone therapy or in combination with T cell checkpoint therapies. A key aim is to bring together experts with complementary interest in cancer immunotherapy that would not normally be drawn to common symposia and foster new dynamic collaborations to advance our understanding of tumor immunity.

March 24-28, 2019 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Nicole A. Doria-Rose, Thumbi Ndung'u and Gunilla B. Karlsson Hedestam

Important Deadlines
Early Registration Deadline: Jan. 24, 2019
Scholarship Deadline: Dec. 5, 2018
Global Health Award Deadline: Oct. 23, 2018
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Poster Abstract Deadline: Dec. 5, 2018
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# Immunology
# Infectious Diseases
Despite dramatic progress in prevention and treatment of HIV, the pandemic continues, and two million people are newly infected each year. Thus, the need for a preventive vaccine for HIV is as urgent as ever. Intensive research in basic immunology and virology as well as empirical clinical trial data continues to yield insights that inform vaccine efforts. The 2019 HIV Vaccines conference presents the latest results from human clinical studies of candidate vaccines as well as the use of monoclonal antibodies for prevention; novel HIV neutralizing antibodies and their developmental pathways; T cell functions in killing and B cell help; structural insights and immunogen design; and the intersection of research for HIV eradication/cure with research on HIV vaccines, including interventions after very early antiretroviral therapy. The program also includes a session on the process of bringing candidate vaccines to clinical trial, told from the diverse perspectives of laboratory investigators, industrial production, funders and clinical researchers on the front lines.

March 24-28, 2019 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Lynn Morris, Melanie M. Ott and Kevin V. Morris

Important Deadlines
Early Registration Deadline: Jan. 24, 2019
Scholarship Deadline: Dec. 5, 2018
Global Health Award Deadline: Oct. 23, 2018
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Poster Abstract Deadline: Dec. 5, 2018
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# Immunology
# Infectious Diseases
Human Immunodeficiency Virus type 1 (HIV) causes a persistent infection and results in acquired immunodeficiency syndrome (AIDS). AIDS has remained a global pandemic for over 40 years as HIV integrates into the genome of infected individuals and remains latent for years. Over the last decade, much emphasis has been centered on pathogenesis and vaccine development, but an emerging paradigm is taking place whereby targeted therapeutics are being developed to both control virus expression as well as possibly target viral infected cells for eradication. This conference for the first time brings together an interdisciplinary group of basic and applied scientists working on various aspects of HIV treatment and eradication strategies in an effort to translate our current understanding of HIV biology into meaningful therapeutics and/or eradication of HIV from infected individuals. To accomplish this goal, the conference aims to: 1) Introduce the state of the art in vaccine and neutralizing antibody strategies used to combat HIV; 2) Focus on transcriptional control and modulation of viral latency; and 3) Highlight synthetic biological approaches and genetic therapies currently being developed and clinically validated to combat HIV infection. The conference seeks to bring together an interdisciplinary mix of basic and applied scientists working on functional cures and eradication of HIV in an effort to better understand not only HIV treatment strategies but also the emerging technologies and approaches that will lead to the eventual eradication of HIV from infected individuals.

March 31-4, 2019 | Steamboat Grand, Steamboat Springs, CO, United States
Scientific Organizers: Sarah Spiegel, Charles N. Serhan and Valerie B. O'Donnell

Important Deadlines
Early Registration Deadline: Jan. 30, 2019
Scholarship Deadline: Dec. 11, 2018
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Poster Abstract Deadline: Dec. 11, 2018
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# Biochemistry, Structural and Cellular
Recently, our understanding of lipid metabolism has significantly advanced, at least in part through applying state-of-the-art lipidomic mass spectrometry approaches to cellular, cohort and animal models. A large body of evidence now exists demonstrating that bioactive lipids play key roles in regulation of biological processes important for health and disease. However, lipidomics also reveals major gaps in our knowledge, highlighting the enormous numbers and functional and structural diversity of bioactive lipids, their interactions, spatial and temporal changes and the complicated systems biology of lipid metabolism. This Keystone Symposia conference covers areas of bioactive lipid research that have been particularly impacted by these new technologies, which may have the potential to transform precision medicine. The conference covers recent progress and perspectives in the study of bioactive lipid metabolic pathways, how these interconnect and are cross-regulated, and their involvement in the regulation of disease. The conference brings together outstanding senior and junior scientists with expertise in functions of bioactive lipids as well as those with a background in mass spectrometry lipidomics, structural biology and systems biology of lipids. Goals and anticipated outcomes are: 1) To summarize new approaches and state-of-the-art mass spectrometry technology. combined with informatics and statistics, in bioactive lipid research and to gain broad understanding of their limitations and potential application to precision medicine; 2) To acquire a broader understanding of how lipidomics can be integrated with proteomics/genomics and other ‘omics technologies to develop a systems-wide view of the lipidome; 3) To gain new knowledge in spatial and temporal interactions of bioactive lipids in cellular and subcellular systems, to better understand their functions in health and diseases; and 4) To present recent findings on the biological importance of newly discovered lipids and their roles in immunity and inflammation.

April 7-10, 2019 | Steamboat Grand, Steamboat Springs, CO, United States
Scientific Organizers: Pad Chivukula, Jean Bennett and Paloma Giangrande

Important Deadlines
Early Registration Deadline: Feb. 5, 2019
Scholarship Deadline: Jan. 8, 2019
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Poster Abstract Deadline: Jan. 8, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Immunology
Protein replacement therapy based on recombinant protein has so far been limited to genetic diseases in which the mutated protein acts extracellularly. Nucleic acid therapies such as gene therapy and messenger RNA enable replacement of intracellular proteins, or extracellular proteins too complex to manufacture. This opens up the potential to treat many previously unapproachable diseases. After early setbacks in gene therapy, a new generation of therapeutics are showing progress in the clinic. Novel messenger RNA and RNA delivery technologies are also in development, the potential of which is only beginning to be demonstrated. These represent exciting areas of therapeutic development which also touch on fundamental questions about regulation of gene expression, protein production, and immunity. This conference brings these communities together to discuss common challenges and complementarities, providing an opportunity for cross-fertilization.

April 7-11, 2019 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Christian Klein, Mark S. Cragg and Germaine Fuh

Important Deadlines
Early Registration Deadline: Feb. 6, 2019
Scholarship Deadline: Dec. 11, 2018
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Poster Abstract Deadline: Dec. 11, 2018
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# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology
Over the last 20 years, recombinant antibodies have been established into clinical practice for the treatment of diseases ranging from cancer, to autoimmune and infectious diseases. While the first approved antibodies were native IgG antibodies, in recent years the field has rapidly advanced and therapeutic antibodies in preclinical and clinical development now include many non-canonical formats including Fc- engineered antibodies, antibody drug conjugates, bispecific antibodies and antibody-like scaffolds. This Keystone Symposia conference aims to bring together experts in antibody therapeutics, engineering and mechanisms of action from industry and academia to discuss and review the state-of-the-art in the field and discuss their future potential. The conference will foster cross-fertilization between different engineering technologies and scientists from different therapeutic areas. This conference can also help to initiate collaboration on the development of state-of-the-art antibody therapies with the aim to improve therapeutic options for patients. For trainees and early career researchers, this conference provides an opportunity to gain insight into various aspects of therapeutic antibodies and to discuss their projects and ideas face-to-face with experts in the field. A unique component to this conference that distinguishes it from other more commercial meetings in the field, is that this conference will include presentation and discussion of novel/unpublished data.

September 12-12, 2022 | 
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April 14-18, 2019 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Gökhan S. Hotamisligil, Ruslan Medzhitov and Karine Clément

Important Deadlines
Early Registration Deadline: Feb. 12, 2019
Scholarship Deadline: Dec. 18, 2018
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Poster Abstract Deadline: Dec. 18, 2018
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# Immunology
# Metabolism and Cardiovascular
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlie the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Understanding the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures has the potential to lead to tangible therapeutic advancements to promote health. This conference will engage scientists at the forefront of the efforts to translate this biology into clinical approaches, to discuss the successes and limitations of this work so far. This conference will cover the molecular mechanisms and physiological outcomes of immunometabolic interactions in the context of chronic metabolic diseases. Topics will range from the most evolutionarily conserved interactions studied in model organisms to human studies. There will be two sessions devoted to translational paths, covering both opportunities and challenges. Overall, this symposium will be an opportunity for experts in the fields of immunology and metabolism to come together to discuss and share their diverse perspectives on the integration of metabolism and immunity.

May 6-9, 2019 | Royal Dublin Society, Dublin 4Ireland
Scientific Organizers: David Brayden, Claus-Michael Lehr and Kathryn Whitehead

Important Deadlines
Early Registration Deadline: Mar. 6, 2019
Scholarship Deadline: Jan. 8, 2019
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Poster Abstract Deadline: Jan. 8, 2019
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# Drug Discovery, Bioengineering and Digital
The multi-disciplinary theme of crossing of biological barriers encompasses biology, chemistry, pharmaceutical formulation, polymeric and materials science, advanced cell biology, imaging, microfluidics, and drug-device combination research. This conference occurs at the interface between cell biology and the use of technologies to exploit such understanding in order to translate therapies to patients. The program comprises leading researchers from academia, institutes, as well as from the pharmaceutical and medical device industry. The goal of the conference is to profile cutting edge research in specific areas of achieving drug delivery across biological barriers where a large translational impact would result for both industry and patients. By inviting cell biologists, technology developers, and formulators to the same conference, this will provide in depth discussions and offer a thorough perspective on the tissue and cell barriers that must be crossed in order to help guide technology approaches to achieve these breakthrough treatments.

May 13-16, 2019 | Herrenhausen Palace, HannoverGermany
Scientific Organizers: Julian I. Schroeder and Julia Bailey-Serres

Important Deadlines
Early Registration Deadline: Mar. 13, 2019
Scholarship Deadline: Jan. 15, 2019
Global Health Award Deadline: Dec. 18, 2018
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jan. 15, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
Current and anticipated impacts of climate change and atmospheric gases on water availability and weather extremes affect the production of crops that provide food and fiber to meet the growing needs of humanity. Innovative research on crops, related wild species and model plant species is enabling the identification of stress signaling, metabolic and developmental strategies that limit yield loss in zones with increased climate stress and variability. The use of functional genomics to dissect abiotic stress sensing and signaling networks and the downstream adjustments in metabolism and development continue to provide solutions for crop improvement. These advances are accelerated by tools such as genome editing and use of synthetic biology to fine-tune key pathways. Moreover, advances in genomics and GWAS approaches provide powerful platforms towards identifying new genes and mechanisms for increasing plant vigor while limiting yield losses in agriculture. New advances in physiological and molecular phenotyping and recognition of synergistic multigene combinations that provide stress resiliency without limiting productivity promise to enable rapid deployment of advantageous genetic combinations. This conference will bring together experts pursuing advances on the cutting edge of climate change-linked stress tolerance in plants and provide a dynamic interactive setting to map future challenges and solutions.

June 9-13, 2019 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Frank van Kuppeveld and Andrea Gamarnik

Important Deadlines
Early Registration Deadline: Apr. 9, 2019
Scholarship Deadline: Feb. 7, 2019
Global Health Award Deadline: Jan. 8, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 7, 2019
Meeting Summary
# Infectious Diseases
The Keystone Symposia conference on positive-strand RNA viruses provides an international forum for research on human, animal, insect, plant and bacterial viruses with positive-strand RNA genomes. This group of viruses contains many clinically relevant and well-known pathogens (e.g., poliovirus, hepatitis C virus, Dengue and West Nile virus). Furthermore, the enormous diversity of positive-strand RNA viruses in animals and insects, combined with their evolutionary and adaptive potential following a species-jump, poses a threat to the human population as demonstrated by the growing list of emerging viruses, including zoonotic as well as arbovirus-transmitted pathogens such as MERS-CoV, Chikungunya and Zika virus. Detailed insight into the “virosphere”, the “virome”, viral evolution, as well as in the molecular details of viral replication and spreading, tissue tropism, and viral recognition by the host immune system is critical to understand virus transmission, viral pathogenesis as well as to develop novel therapeutic and preventive measures. This conference brings together experienced and junior experts to discuss the latest developments in molecular biology, cell biology, vector biology, immunology, vaccinology, and antiviral drug development applied to the field of positive-strand RNA viruses.

June 16-20, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Richard Daneman, Dorothy Schafer, Michael V. Sofroniew and Vanda A. Lennon

Important Deadlines
Early Registration Deadline: Apr. 16, 2019
Scholarship Deadline: Feb. 13, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 13, 2019
Meeting Summary
# Immunology
# Neurobiology
The response of the central nervous system to injury and disease is a complex physiological process that involves the coordinated actions of many different cell types. The interplay of neural cells and vascular cells along with the innate and adaptive immune systems determines the response to different injury and disease stimuli and whether the central nervous system will repair or degenerate. Understanding this complex cellular environment is essential to understanding disease pathogenesis, elucidating underlying disease etiology, and developing treatments for neurological and psychiatric diseases. The goal of this conference will be to bring together people who study different aspects of neurological diseases and facilitate the interchange of ideas necessary for identifying new mechanisms underlying complex intercellular interactions in the diseased nervous system. This will include people who study resident neural cells (neurons, astrocytes, oligodendrocytes), vascular cells (blood-brain barrier, lymphatics, glymphatics) and immune cells (microglia, innate peripheral immune cells, adaptive immune cells) in the context of a variety of neurodegenerative, neuroinflammatory, and neuropsychiatric diseases. Further, we will also attract people who implement different techniques including genetic mouse models, human iPSCs, invertebrate models, imaging, cell biology, and behavior in their research which will further facilitate exchange of ideas and foster collaboration. With the combined expertise at this conference, we will accelerate our ability to understand the complex neural response to injury and disease, which is a necessary step towards developing novel therapeutics for complex neurological diseases.

June 16-20, 2019 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Valina L. Dawson, Joseph W. Lewcock and Fred H. Gage

Important Deadlines
Early Registration Deadline: Apr. 16, 2019
Scholarship Deadline: Feb. 13, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Feb. 13, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Drug Discovery, Bioengineering and Digital
# Genetics, Genomics and RNA
# Immunology
# Neurobiology
The global burden of neurodegenerative disease is staggering and growing at an alarming rate as the population ages. While Alzheimer’s disease and related dementias, as well as, Parkinson’s disease and related disorders, account for the majority of those afflicted, there are also less common but equally devastating diseases. Technical and conceptual advances are revealing disease mechanisms and providing new therapeutic opportunities. Misfolded proteins have been understood to be at the center of neurodegenerative diseases but recently there is an appreciation that these misfolded proteins may serve as seeds to template the misfolding of normal proteins, that transmission of these seeds may underlie disease progression, and that there may be different strains of these seeds with differential toxicities. Biophysical analysis of these proteins reveals a role for phase transition and liquid demixing of these intrinsically disordered proteins. Synaptic loss is an important feature of neurodegeneration which may occur long before neuronal loss, but be critically important in disease presentation and loss of function. Glia and immune activation contribute to neurodegeneration and synaptic loss, and must be understood and controlled if the disease process is to be tempered or stopped. This conference aims to address the current state of knowledge in these emerging area and to provide advanced discussion of these topics; the opportunity for interaction between scientists from different fields of research will foster new collaborations that may lead to new therapeutic opportunities to combat the coming crisis and provide medical care for those suffering from neurodegenerative diseases.

October 6-10, 2019 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Justin L. Sonnenburg, Fergus Shanahan and Suzanne Devkota

Important Deadlines
Early Registration Deadline: Aug. 7, 2019
Scholarship Deadline: Jun. 6, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jun. 6, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
# Immunology
# Infectious Diseases
# Metabolism and Cardiovascular
The microbial communities that inhabit the human body are connected to diverse aspects of our health. The plasticity and individuality of these communities promise great potential in the emerging vision of precision health, but formidable gaps to realizing this potential must be addressed. Critical challenges include the intrinsic complexity of dynamic microbial ecosystems, understanding how these microbes mechanistically connect to human biology, and identifying key therapeutic opportunities. This conference will bring together leaders across a range of disciplines from both academia and industry in microbiome sciences to present recent progress and innovative directions at addressing these gaps. This conference will provide a detailed view of the current status, future vision, and challenges of key modalities for predicting, diagnosing, and treating disease via the microbiome. In addition, there will be topics which augment the traditional biomedical paradigm of developing diagnostics and treatments with orthogonal approaches, such as pre-therapeutic prevention and health optimization strategies. Invited speakers will present key technologies and approaches for propelling the coming phases of basic and translational microbiome research. Finally, participants will receive key information about the current regulatory environment for microbial therapeutics. With the rapid expansion of translational microbiome efforts, this conference will enable synergies through the aggregation of knowledge and experiences from diverse body sites, disease states, and approaches. We combine facets of basic sciences including evolution, ecology, and technology development so an interdisciplinary collection of scientists can elucidate key steps for establishing a strong pipeline from fundamental understanding to therapeutic realization.

October 30-2, 2019 | Hilton Addis Ababa, Addis AbabaEthiopia
Scientific Organizers: Thierry T. Diagana, Philip Welkhoff and Flaminia Catteruccia

Important Deadlines
Early Registration Deadline: Aug. 29, 2019
Scholarship Deadline: Jul. 9, 2019
Global Health Award Deadline: Jun. 11, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jul. 9, 2019
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Infectious Diseases
Malaria is most prevalent in the tropical belt and many malaria endemic countries have now engaged in elimination programs. However, we are facing a public health crisis because we have lost many of the public health tools that enabled the progress we have made to date. Many drugs are useless in most areas and resistance is threatening even artemisinin-based combination therapy (ACT). Diagnostics, bed-nets and insecticides are also losing their effectiveness and the Plasmodium vivax (P. vivax) parasite is finding new ways to transmit in Duffy negative patients. At the same time, there are multiple emerging threats such as artemisinin drug resistance, the rise of P. vivax malaria prevalence, and the discovery of the parasite Plasmodium knowlesi (P. knowlesi) in humans. However, there are some interesting developments such as deploying older suboptimal drugs in new, innovative and targeted control approaches like seasonal malaria chemoprevention (SMC) or intermittent preventive treatment of pregnant women/ infants (PTi/p). There are new drugs on the horizon that have pharmacological properties compatible with single dose cures and could prove to be powerful tools in the fight against malaria. For example, mass drug administration has demonstrated substantial impact as an intervention for Plasmodium elimination. By learning from recent successes in malaria elimination, epidemiological models of malaria transmission can be updated, and the impact of new interventions will critically inform the malaria endgame strategy. The conference is organized around three themes: defeating resistance (both to drugs and to insecticides), leveraging data science to better understand disease transmission and innovation in vector control strategies. This program will assess the current threats and gaps in our malaria armamentarium to enable malaria elimination and discuss the emerging innovative approaches for antimalarial drug discovery and development.

November 19-23, 2019 | Casa Grande Hotel, Guarujá, SP, Brazil
Scientific Organizers: Karina R. Bortoluci, Vishva M. Dixit and Andreas E. Strasser

Important Deadlines
Early Registration Deadline: Sep. 19, 2019
Scholarship Deadline: Jul. 30, 2019
Global Health Award Deadline: Jul. 16, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Jul. 18, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Immunology
Cell death is linked to diverse physiological and pathological conditions. In addition to the well-defined apoptosis versus accidental necrosis paradigm, novel processes of programmed cell death, necroptosis and pyroptosis, in particular, have been described over the last years. Our knowledge about the molecular machineries that control these cell death processes has expanded substantially with the discovery of key regulators and effectors, such as the gasdermins, mixed-lineage kinase domain-like protein (MLKL), and receptor-interacting protein (RIP) kinases. We have learned that apoptosis, pyroptosis, necroptosis, ferroptosis, autophagic cell death and other cell death processes are all equipped with individual sets of regulatory and effector molecules but can also share constituents that can interconnect the distinct cell death pathways. Moreover, several alternative cell death programs may operate in any given circumstances with distinct consequences to the immune response and to the development of inflammatory disorders. Last, but not least, cell death may not be the sole or even the major fate/purpose of cells that engage inflammatory cell death pathways. Understanding of the role of the different regulators and effectors of each cell death processes is essential for the development of therapeutic tools for cancer, autoimmune diseases and inflammatory pathologies. Thus, this conference proposes to bring together specialists from diverse areas of cell death research from around world to explore these crucial issues to develop a better understanding of the relative, additive and/or redundant contributions of the distinct cell death pathways in health and disease.

December 8-12, 2019 | Southern Sun Cape Sun, Cape Town, WC, South Africa
Scientific Organizers: De' Broski R. Herbert, P'ng Loke, Nicola L. Harris and Frank Brombacher

Important Deadlines
Early Registration Deadline: Oct. 10, 2019
Scholarship Deadline: Aug. 8, 2019
Global Health Award Deadline: Jul. 9, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Aug. 8, 2019
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Infectious Diseases
Parasitic worms, or helminths, infect roughly one in five people on the planet and cause pathology in hundreds of millions. Given the global impact on human health and welfare, there is a great need to develop novel therapies and/or vaccines that target helminths. In addition, the unique nature of how these parasites interact with their hosts has brought tremendous insight into the mammalian immune system. Experimental studies of helminth infection have led to the identification of new cell types involved in type 2 immunity, including innate lymphoid cells, tuft cells, and new roles for neurons, in addition to revealing novel pathways of tissue repair and immune-modulation. The interactions of helminths with the microbiome has also come to light in recent years. This conference will highlight some of the most impactful advances in the fields of helminth genomics, helminth biology, vaccine design and host protective immunity, in addition to new discoveries highlighting the ability of these organisms to modulate the immune system, human disease and the microbiome.

January 12-16, 2020 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Howard Y. Chang, Frank Rigo and Lynne E. Maquat

Important Deadlines
Early Registration Deadline: Nov. 12, 2019
Scholarship Deadline: Sep. 24, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 24, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
A revolution is sweeping the RNA world. The human genome contains over 60,000 long noncoding RNA genes, three times the number of protein coding genes. Many important questions are outstanding, including physiologic functions of regulatory RNAs, their molecular mechanisms, and therapeutic potential. This conference will bring together leaders in RNA biology, technology, and medicine to present the latest findings in these respective areas. We anticipate that this conference will provide an integrated view of the cutting edge of this rapidly advancing scientific area and create many opportunities for synergy and cross fertilization.

January 16-20, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Joel D. Ernst, Jennifer Philips and Daniel L. Barber

Important Deadlines
Early Registration Deadline: Nov. 19, 2019
Scholarship Deadline: Sep. 24, 2019
Global Health Award Deadline: Aug. 13, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 24, 2019
Meeting Summary
# Immunology
# Infectious Diseases
Tuberculosis remains the most common fatal infectious disease worldwide due to the absence of a sufficiently effective vaccine. Two critical barriers to the development of an effective TB vaccine are the incomplete understanding of the mechanisms of protective immunity to TB, and of the mechanisms of immune evasion by M. tuberculosis. The interactions among speakers and attendees at this conference will promote collaborations between scientists with complementary expertise who work in geographically distinct institutions, including those in high TB burden regions. This conference will present new findings on mechanisms of protective immunity to M. tuberculosis, and promote dialogue between immunologists and scientists in different areas of expertise to fill gaps in knowledge. Participants will also discuss advances in TB vaccine development and vaccine immunology. Finally, this conference will cover advances in other fields of immunology and other infectious diseases characterized by pathogen persistence, which will help to inform development of effective TB vaccines.

January 19-23, 2020 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: José López-Barneó, Sarah R. Walmsley, Hesham A. Sadek and Jacques Pouysségur

Important Deadlines
Early Registration Deadline: Nov. 19, 2019
Scholarship Deadline: Sep. 25, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 25, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
Hypoxia research reflects a dynamic and rapidly expanding field with growing implications ranging from basic molecular biology to medicine. Changes in cellular oxygen availability secondary to environmental challenges or diseases, trigger a broad array of adaptive responses that can be rapid (seconds) or more protracted (weeks to months). The molecules and mechanisms involved in these versatile hypoxia signaling pathways are fundamental to the pathogenesis of highly prevalent medical conditions, among which are respiratory depression, hypertension, tumor progression and inflammation. Moreover, oxygen regulates cellular processes, which are essential to cell reprogramming, development and tissue/organ regeneration. In this conference on Hypoxia, the tenth in the series of Keystone Symposia, experts from basic, clinical and industrial backgrounds will gather to update the status of the field, to discuss the most relevant discoveries and their applications, and to envision the conceptual and technological trends for upcoming years. The conference is designed to provide a broad coverage of the hypoxia field, with emphasis in translational strategies and perspectives. It will also promote multidisciplinary collaborations between scientists from different research backgrounds and the interaction between new graduate students and postdocs with leaders in this discipline.

June 8-12, 2022 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: David M. Lee, Arlene H. Sharpe and William H. Robinson

Important Deadlines
Early Registration Deadline: Apr. 7, 2022
Scholarship Deadline: Oct. 21, 2021
Short Talk Abstract Deadline:
Poster Abstract Deadline: Apr. 20, 2022
Meeting Summary
# Cancer
# Immunology
# Infectious Diseases

This meeting is a reschedule of Advances in Checkpoints Immunology from Autoimmunity to Oncology to Infectious Diseases originally scheduled for February 2022.  PROGRAM NOW AVAILABLE!

Meeting Summary

Understanding of the mechanisms by which checkpoints regulate immune responses is burgeoning; molecular insights into checkpoint signaling, and complexities regarding degrees of checkpoint regulation in immune exhaustion vs. immune homeostasis are coming to light. The use of checkpoint antagonist therapeutics in Oncology has ushered in a transformation for treatment and led to major leaps in our understanding of checkpoint functions, both in health and in the context of immune responses to tumors. There are also rapidly emerging insights into the role of checkpoints in immune dysfunction seen in Autoimmune diseases, and checkpoint-targeted therapies for Autoimmune diseases are now in clinical studies. Further, treatment-associated autoimmunity syndromes comprise an important adverse event for cancer immunotherapy. While these syndromes are currently poorly understood, their analysis promises to shed new insights into improving tolerability of cancer treatment as well as into immune dysfunction in Autoimmune diseases. The meeting will provide a forum for cross-fertilization across disciplines, with a particular focus on Autoimmunity and will also include opportunities that stimulate new directions for investigation in Oncology and other diseases.

January 19-23, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: William R. Sellers, Charles Swanton and Lillian L. Siu

Important Deadlines
Early Registration Deadline: Nov. 20, 2019
Scholarship Deadline: Sep. 25, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 25, 2019
Meeting Summary
# Cancer
Progress in understanding the clonal and sub-clonal processes driving tumor evolution, tumor heterogeneity, the mechanisms of therapeutic resistance, and in defining new cancer dependencies have converged to help inform more rational approaches to achieving the development of transformative combination therapeutic regimens in cancer. Nonetheless, examples of highly effective rationally elucidated combinations remain rare and the pre-clinical and clinical development challenges to this goal are substantial. As an example, the emergent role of immunotherapeutics having curative potential has led to tremendous excitement, yet increased complexity. The broad swath of empiric based clinical trials attests to the continued and growing need for improved pre-clinical means by which transformative combinations can be identified. This conference will bring together evolutionary and computational biologists, experts in functional genomics, translational scientists, drug discovery researchers and physician leaders in clinical development. The conference program begins with how evolutionary processes drive the “natural” progression of cancer and how such processes lead to the measured heterogeneous populations of cells resident in all tumors. These two related forces, driven at least in part by ongoing mutational processes, then combine to give rise to therapeutic resistance, which enables researchers to robustly identify mechanisms relevant to humans in pre-clinical models. The deeper understanding of these forces can inform specific combination therapeutics, but combination hypotheses are now being discovered though genome-scale functional screening approaches (e.g. CRISPR, shRNA). Speakers have been invited to discuss the studies which are now taking place in both the targeted and immuno-oncology (I/O) therapeutic fields. These talks filter into sessions on understanding how I/O and targeted therapeutics are similar or distinct and to seek the lessons from the clinical trial outputs in the I/O field that will emerge over the next year. Finally, clinical development paradigms for more rapidly testing and developing combinations will be covered during the conference.

January 26-29, 2020 | Granlibakken Tahoe, Tahoe City, CA, United States
Scientific Organizers: Walid A. Houry, James Shorter, Antonina Roll-Mecak and Phyllis I. Hanson

Important Deadlines
Early Registration Deadline: Nov. 21, 2019
Scholarship Deadline: Sep. 26, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 26, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
AAA+ proteins are ATPases Associated with Diverse Cellular Activities. They form a large superfamily and have been found to carry out a very diverse range of functions including DNA replication, chromatin remodeling, rRNA processing, and membrane fusion. In recent years, there has been substantial progress in identifying the structure and cellular function of a large number of AAA+ proteins. However, little is known of the unique features underlying this mechano-chemical coupling mechanism used to apply forces to various substrates. There is also a lack of understanding for many AAA+ proteins regarding how substrates are recognized, regulation of their activities in vivo, and how their functions are coordinated with other competing and overlapping reactions. Recent findings demonstrate the importance of AAA+ proteins in the biology of cancer and neurodegeneration and as virulence factors in pathogenic microorganisms. However, we know very little of the biochemical pathways leading to diseases arising from mutations in these proteins. The conference will bring together an interdisciplinary group of scientists interested in understanding the structure, function, and disease aspects of these proteins. The conference comes at an opportune time of great developments in structural biology, especially cryoEM, and cell biology. We aim to provide a very interactive and collegial atmosphere to discuss the latest advances in this important field. In addition to having invited speakers, we will also provide the opportunity to many attendees to give an oral presentation about their research. Poster sessions will also be held for all attendees.

January 26-29, 2020 | Embassy Suites by Hilton Boulder, Boulder, CO, United States
Scientific Organizers: Bana Jabri, Daniel Mucida and Ramnik Xavier

Important Deadlines
Early Registration Deadline: Nov. 21, 2019
Scholarship Deadline: Sep. 26, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Sep. 26, 2019
Meeting Summary
# Immunology
How tissues integrate host-microbial signals and regulate immune responses has a critical impact on health and disease. However, our understanding of tissue immunity is limited because of difficulties in accessing the different organs and also due to the inherent complexity and individuality of the cellular circuits present in different tissues. This conference will bring together scientists in the fields of mucosal immunology, neurology, microbiology, metabolism and systems biology. The conference will discuss (i) the diversity of tissue resident T cell subsets and their function and regulation, (ii) the regulation and role of mucosal B cell responses, (iii) the role of the nervous system in the regulation of tissue immunity, (iii) how tissues integrate metabolic and microbial cues to determine which type of immune response to mount, (iv) the existence of innate memory and its role in pathophysiology, and (v) new approaches in the study of tissue immunity. Because of the interdisciplinary nature of the conference and its focus on tissue immunity across organs and cell types, the conference will give investigators a broad perspective on tissue immunity and encourage them to go beyond the traditional disciplinary boundaries. An interactive workshop engage will engage industrial partners to define new approaches to prevent and treat inflammatory disorders and cancer and will highlight new frontiers in tissue immunity, cellular networks and inter-tissue communication in health and disease.

January 26-30, 2020 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Karen Adelman and Patrick Cramer

Important Deadlines
Early Registration Deadline: Nov. 26, 2019
Scholarship Deadline: Oct. 1, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 1, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
Organismal development, homeostasis and healthy aging all rely on precise control of gene expression programs. Recent technological advances in structural biology, real-time imaging, and next generation sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions between transcriptional biologists and experts in single cell imaging and genomic approaches and spur conversations about how to interweave new techniques for structural biology with our growing appreciation that many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in most structural approaches). Participants will attend sessions that critically evaluate the impact of genome organization on gene expression. The conference will also expose trainees to the best science possible and instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene dysregulation in cancer. We plan two joint sessions to maximize interactions.

February 2-6, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Paul Carter, Janine Schuurman and Karl Dane Wittrup

Important Deadlines
Early Registration Deadline: Dec. 5, 2019
Scholarship Deadline: Oct. 17, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 17, 2019
Meeting Summary
# Cancer
# Drug Discovery, Bioengineering and Digital
# Immunology
Since the mid-1990s, antibodies have grown steadily into a clinically important pharmaceutical class with over 70 antibody-based drugs approved, predominantly in oncology, autoimmunity and inflammation. As the antibody drug field has expanded and matured in recent years, the field has moved from empirical strategies to deep knowledge-based, designer approaches for which understanding of mechanisms of action is critical; there has also been a trend toward increasingly specialized meetings with a narrow focus such as cancer immunotherapy, bispecifics or B cell biology. In contrast, we are proposing a scientifically diverse program that spans a broad range of different and cutting-edge topics relevant to antibody drug development, including antibodies for infectious disease and antibody pharmacology, topics which are often under-represented at major antibody conferences. Additionally, we have chosen a diverse collection of speakers from junior investigators to seasoned researchers from a wide range of institutions in at least eight different countries. We hope and expect that this approach will stimulate ‘cross-pollination’ between disciplines that span the gamut from basic to translational to clinical sciences with the common theme of antibody drugs for the benefit of patients.

February 8-12, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Crystal L. Mackall, Marina Cavazzana and Stanley R. Riddell

Important Deadlines
Early Registration Deadline: Dec. 10, 2019
Scholarship Deadline: Oct. 29, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 29, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Cancer
# Immunology
After many years of fundamental research, cell-based therapies are now recognized as effective medicines for treatment of a specific subset of cancers as well as a growing list of autoimmune, degenerative and infectious diseases. This clinical progress has been propelled by exponential growth in understanding of the underlying cell biology, and increasingly sophisticated techniques for genetic engineering and for using synthetic biology to control cellular therapeutics. Cellular therapeutics are now poised for increasing impact both in cancer medicine and in the treatment of genetic, autoimmune and degenerative diseases. This conference will bring together fundamental researchers and translational scientists to discuss recent successes and highlight challenges across the spectrum of emerging cellular therapeutics. Another innovative aspect of this conference is the joint pairing with the Keystone Symposia conference on “Engineering the Genome” organized by Drs. Vic Myer and Erik Sontheimer. This unique pairing will provide an outstanding opportunity to cross-fertilize ideas and to facilitate formation of new collaborations between experts in genome engineering and experts in cell biology, cell-based therapies and synthetic biology. The conference will provide an opportunity to report emerging preclinical and clinical insights, present novel platforms, and highlight challenges related to both safety and efficacy of cell therapies. The broad disease focus will enhance collaborations between the cancer immunotherapy communities and those focused on developing cell therapies for non-malignant disease.

February 8-12, 2020 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Vic E. Myer and Erik J. Sontheimer

Important Deadlines
Early Registration Deadline: Dec. 10, 2019
Scholarship Deadline: Oct. 29, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 29, 2019
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Genetics, Genomics and RNA
Genome editing is already transforming biological science and promises to do the same for human medicine. Technological capabilities are advancing rapidly and there are expected to be more than 30 genome editing therapies in clinical development by 2020. It is therefore important that practitioners in both academia and industry have the opportunity to learn about the latest improvements and applications. This conference will bridge that gap and provide an ideal environment for scientific exchange. In addition, participants will be educated on the growing roster and utility of genome engineering platforms. There will be sessions on genome editing’s clinical advancements and the evolution of thinking in the field regarding translational sciences. This meeting is being paired with Emerging Cellular Therapies so that participants can come together with researchers who focus on cell-based therapies. Therefore, we anticipate attendees will have a greater awareness of the full range of genome engineering tools, both established and emerging and knowledge of best practices and pitfalls in clinical advancement.

February 9-13, 2020 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Malene Hansen, Johan Auwerx and Heinrich Jasper

Important Deadlines
Early Registration Deadline: Dec. 11, 2019
Scholarship Deadline: Oct. 31, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 31, 2019
Meeting Summary
# Biochemistry, Structural and Cellular
# Genetics, Genomics and RNA
# Metabolism and Cardiovascular
# Neurobiology
Over the past three decades, studies have highlighted numerous cell-autonomous mechanisms that contribute to organismal aging. Specifically, changes in many genes, pathways, biomolecules and organelles have been shown to affect aging in a number of model organisms in a conserved fashion. However, it has become increasingly clear that these intracellular mechanisms are complemented by cell non-autonomous signaling events to influence aging on a tissue and organismal level. Understanding how an initial deregulation of intracellular functions are likely communicated to other cells, tissues, or organs to thereby impact the lifespan and healthspan of the organism will be key to our understanding of aging and age-related diseases. This conference will focus on intra- and intercellular mechanisms of aging, by highlighting current research on key cell-autonomous mechanisms such as DNA, protein and mitochondrial homeostasis, as well as inter-tissue signaling events relevant to aging and age-related diseases, in particular neurodegenerative disorders.

February 16-19, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza

Important Deadlines
Early Registration Deadline: Dec. 17, 2019
Scholarship Deadline: Oct. 29, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 29, 2019
Meeting Summary
# Drug Discovery, Bioengineering and Digital
# Neurobiology
CNS disorders represent a major unmet medical need. The associated societal burden is becoming unsustainable due to changing demographics (e.g., aging population). Despite major investments in basic and translational research by government and non-profit institutions world-wide, pharmaceutical companies and equity investors continue to view brain therapeutics as a relatively risky area of investment. This Keystone Symposia conference will highlight groundbreaking technologies and new approaches to de-risk CNS-targeted therapies and demonstrate how interdisciplinary integration has the potential to overcome the contemporary challenges of CNS drug development. One of the unique features of this conference is that it brings together a diversity of scientists, who rarely participate in the same meetings, in order to create an environment for disruptive innovation. Invited speakers will provide both general and technical presentations to engage participants in topics like disease biology-informed target selection, novel medicinal chemistry approaches, biomarkers, and clinical trial design. Advances in technologies such as genomics, imaging and brain delivery will be highlighted throughout. Our featured speakers hail from around the world and represent both public and private sector and young and established scientists. The aim of this conference is to create a space for collaboration that helps attendees address the unmet medical need of CNS disorders even after it has ended. Finally, this meeting will be paired with the Keystone Symposia conference on Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus. The goal of this paring is to stimulate cross-disciplinary thinking about CSF-based medicinal therapies.

February 16-19, 2020 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Edwin S. Monuki, Maria Lehtinen and Maiken Nedergaard

Important Deadlines
Early Registration Deadline: Dec. 17, 2019
Scholarship Deadline: Oct. 29, 2019
Short Talk Abstract Deadline:
Poster Abstract Deadline: Oct. 29, 2019
Meeting Summary
# Metabolism and Cardiovascular
# Neurobiology
The cerebrospinal fluid (CSF) has long been a 'missing link' in our understanding of brain form, function, and disease. However, recent work has begun to illuminate how the CSF regulates the brain in ways that extend far beyond its passive historical roles and provides unique opportunities for studying, diagnosing, and potentially treating brain disorders. This Keystone Symposia conference brings together an interdisciplinary group of new and established scientists to discuss this newfound excitement about CSF. Talks will feature discoveries about CSF sources (choroid plexus), routes (glymphatics), drainage (lymphatics) and clinical utilities. This conference aims to coalesce an international community that can propel CSF research forward by fostering new ideas, collaborations, and training opportunities. Held jointly with Keystone Symposia’s ‘Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development,’ the goal of this paring is to stimulate thinking about CSF-based medicinal therapies. CSF has therapeutic advantages over blood because it is 'behind' the blood-brain barrier and equilibrating with the interstitial fluid surrounding brain cells.

February 19-23, 2020 | Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Scientific Organizers: Scott N. Mueller, Jason G. Cyster, Reina E. Mebius and Theresa T. Lu

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# Immunology
Non-hematopoietic stromal cells play important roles in many tissues, constructing tissue microenvironments, contributing to tissue repair, defense and immune responses. Within lymphoid organs, stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration and interactions between antigen presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases, and in chronic infection. For instance, stromal cell dysregulation has been seen in HIV infection and in cancer patients. Furthermore, stromal cells are being harnessed for therapeutic applications in several diseases, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to increasingly sophisticated tools to dissect the fundamental biology and clinical importance of this cellular compartment. This conference is being held jointly with Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches. This joint pairing will bring together basic and clinical scientists with interdisciplinary interests in stromal cell biology and disease treatment to discuss critical fundamental and translational advances. The goals of this conference are to showcase cutting-edge results and new directions in the field, stimulate interactions and provide a forum for trainees and new investigators to present their work and interact with leaders in the field.

August 17-19, 2020 | Virtual at Your Computer
Scientific Organizers: Antoni Ribas and Priti Hegde

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# Cancer
Cancer immunotherapy by blocking immune inhibitory checkpoints or engineering T cells for adoptive cell transfer is providing an unprecedented level of long-term antitumor activity in patients with several metastatic cancers. However, the majority of patients with advanced cancers still do not experience sustained clinical benefit from immunotherapy. Understanding the mechanistic basis of response and resistance to these therapies and how therapeutic approaches could best be combined will be essential to continue progress. The largest human experiment is currently being conducted with over 1,000 agents and combinations. Understanding the results to date and determining what is working and what combinations are not working will be important to refine our understanding of immunity in patients with cancer. Questions that remain unanswered include: What is the rationale for the multiple immuno-oncology (IO) combinations being tested in the clinic, how do cancers adapt and resist T cell attack, and can we better understand the tumor microenvironment, thus paving the way for new approaches to cancer therapy. New analyses of patient-derived samples provide information on adaptive and genetic resistance mechanisms to immunotherapy. The conference program will include sessions which cover topics such as new analysis techniques, methodologies, and how to integrate high throughput data to provide a more comprehensive understanding of cancer and the immune system. Participants will leave the conference with an understanding of how the advancement of cancer biology will be influenced by a better comprehension of tumor immunology.

October 1-31, 2024 | 
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September 30-2, 2020 | Virtual at Your Computer
Scientific Organizers: Jin Billy Li, Stacy M. Horner and Michaela Frye

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# Genetics, Genomics and RNA
The biochemical modifications made to RNA after transcription, called the epitranscriptome, play a critical role in life. The development of new technologies has transformed the field in recent years. Our understanding of the reason for and regulation of RNA editing and modifications, as well as their roles in human infection and disease is deepening and therapeutic applications are emerging. This conference will bring together leading experts in RNA editing and modifications, technology development, and medicine to present and discuss cutting edge research. We anticipate that participants of this conference will benefit from learning the cutting edge of the rapidly advancing field and help move the field forward by creating collaboration opportunities.

February 18-21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Suzanne Devkota, Jeff F. Miller and Roberto G. Kolter

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Early Registration Deadline: Jan. 3, 2025
Scholarship Deadline: Nov. 21, 2024
Short Talk Abstract Deadline: Nov. 21, 2024
Poster Abstract Deadline: Jan. 28, 2025
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# Microbiota and Flora

Despite a longstanding appreciation of the species-level diversity of the human microbiome, and evidence for its role in health and disease, the true scale of its genetic diversity and dynamics of host microbial communities has only recently come to light. Indeed, recent studies suggest that half of every person's microbial gene content may be entirely unique. Our understanding of mechanisms that generate intraspecies genetic diversity in the human microbiome and its functional consequences for selection and adaptation have advanced considerably - to a point that justifies a dedicated conference on a topic.

This conference is of fundamental importance to understand the dynamics of human-microbe interactions, the shaping of microbial communities within the host and the future of the microbiome field. The goal is to bring together researchers studying hosts and microbiomes, with those studying fundamental microbiology, microbial genetics, and microbial ecology to spark deeper and more mechanistic research in the microbiome field. Pioneering tools and technologies to interrogate microbial genetics and microbial community composition will be featured, alongside innovative strategies to integrate these data with discoveries regarding host-microbe interactions, adaptations and impacts.

The conference will be held jointly with the Keystone Symposium on Host-Microbe Co-Evolution in Human Health: The Microbiome-Pathobiont Continuum to enable cross-disciplinary insights and collaborations towards a more comprehensive and integrative understanding of the holobiont.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Susan M. Kaech, Vishwa Deep Dixit and Dequina Angelina Nicholas

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# Immunology

'Immunometabolism across Scales: From Cells to Systems to Healthspan' focuses on the intersection between immunology and metabolism that contribute to longevity to pioneer advancements in health and disease treatment. This meeting aims to highlight the critical yet underexplored intersectionality of metabolic and immune processes at all biological levels. The sessions will address the intricacies of nutrient signaling, the immune system's adaptive mechanisms across varied metabolic ecosystems, and the pivotal role of microbial metabolites in modulation of nutrition and immunity. Further, we tackle neuro-immune interactions and their crucial functions in health, alongside the overarching control mechanisms governing aging and systemic metabolism. The conference's objectives are to: 1) Illuminate the uncharted territories of immunometabolism from cellular mechanisms to system-wide impacts; 2) Foster multidisciplinary collaborations that bridge current investigative silos; 3) Equip the next generation of scientists with the knowledge and tools necessary for innovation in this evolving field; and 4) Identify actionable strategies to translate research findings into clinical interventions aimed at enhancing healthspan. Anticipated outcomes include the dissemination of groundbreaking scientific knowledge, the development of novel methodologies, and the establishment of robust collaborative networks. Attendees will leave with enriched perspectives, ready to implement advanced techniques and new approaches to their own research. Upon conclusion of this meeting the field of immunometabolism will be poised to shift towards a more integrated approach to leveraging immunity and metabolism to ultimately pave the way for novel intervention to increase healthspan.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Alexander Hoffmann, Eicke Latz and Stacey D. Finley

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# Immunology

Immune responses rely on the dynamic coordination of diverse immune cell types. Each immune cell must sense and respond appropriately to signals while integrating information about the tissue context. Immune cells communicate with each other and with tissue cells enabling coordination at the physiological scale. Defective or over-active dysregulation of immune signaling processes underlie a majority human pathologies. Recent technological advances of next gen sequencing and mass spectrometry characterize top-down Systems Immunology approaches that enable statistical inference of signaling events within and between cells, and in space. At the same time, bottom-up systems biology approaches of Immune Signaling that leverage molecular mechanisms knowledge have advanced to dissect the non-linear and time-resolved dynamic interplay between molecular pathways and cells. This Keystone Symposia meeting offers a timely opportunity to explore the synergies between two complementary approaches that have made rapid progress in recent years: top-down Systems Immunology and bottom-up Systems Biology or Immune Signaling. Speakers will exemplify different approaches to study diverse physiological and pathological phenomena at different scales, thereby leading to the kind of cross-pollination and spirited discussions that inform future research.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Kim Good-Jacobson, Deepta Bhattacharya and Taras Kreslavsky

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# Immunology

Significance: B cells are critical to forming long-lived immunity, with plasma cells and memory B cells providing protection against reinfection. Yet, while so fundamental to human health and longevity, dysfunction of B cells during chronic infectious disease, autoimmunity and lymphomas can drive immunopathogenesis and disease. This conference will explore recent advances in understanding core determinants of the longevity and effectiveness of humoral responses. It will detail how these advances lay the foundation for understanding how to specifically target B cells for therapeutic intervention and utilize antibodies for diagnostics and immunotherapies. Understanding these mechanisms has become even more timely, given the focus on our ability to respond to newly emerging pathogens and their variants, the expanding portfolio of new vaccine platforms, and determining how to therapeutically engineer the B cell response. Thus, with this information the field can drive research into enhancing and prolonging vaccine-mediated protection, better understand disease pathogenesis, and identify new therapeutic targets for translational development. Innovation -Our meeting brings together global experts in the biology of B cells, plasma cells, and how to utilize and/or target antibody in disease. It is unique in its clear focus on the fundamental and translational biology of plasma cells and memory B cells. -We have designed the program to encompass ‘the instruction manual’ of building effective B cell responses, incorporating interdisciplinary talks on B cell repertoires in vaccine design, molecular mechanisms of promoting humoral memory longevity, understanding how ineffective and/or immunopathogenic antibody is produced, and new therapeutic strategies to ameliorate disease.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Stephanie C. Eisenbarth, Jason G. Cyster and Ziv Shulman

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# Immunology

Protective antibody-mediated immune responses typically depend on the generation of high-affinity antibodies with the capacity to neutralize pathogen activity and trigger effector functions of innate immune cells. Yet, antibody functions can be harmful in autoimmune diseases and allergic reactions. Thus, understanding how antibodies are generated is fundamental for the design of vaccination strategies and for the manipulation of B cell responses in these pathological conditions. The generation of most long-lived antibodies depends on collaboration between cognate T cells and B cells that interact with each other and exchange signals that promote B cell clonal expansion and differentiation into antibody-secreting cells, germinal center B cells and memory B cells. The current meeting will focus on the cellular dynamics of B-T cell interactions and the underlining molecular mechanisms that promote the differentiation of B cells both within and independent of germinal centers. Similar events that occur in non-lymphoid organs such as in mucosal tissues and tumors will be addressed as well. In addition, T-B collaborations that drive pathological conditions such as in autoimmunity, allergy, and their positive functions in cancer will be discussed. This meeting will be held in conjunction with the 'B cells and Plasma Cells in Health and Disease' meeting.

January 1-4, 2026 | Location to be Determined
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# Immunology

This KS Myeloid cell meeting aims to bring together key leaders in academia and industry to discuss recent insights regarding myeloid cell functional heterogeneity and how we should be thinking about targeting these cells for therapeutic interventions. It is clear that myeloid cells hold significant therapeutic promise, but at this moment, this largely remains to be realised. As such, previous meetings have typically focused on academic advances, however we firmly believe that by bringing together all actors we can further stimulate discussion, collaboration and ultimately move the field forward. Therefore with this meeting, we hope to provide both an update of ongoing academic research and the latest novel therapeutic approaches being applied in industry. One of the main areas of focus for the meeting will be on how we can translate recent seminal single cell studies into meaningful biology. Specifically, we will focus on how we can make sense of the recent single cell RNA-seq studies which have identified both unique and conserved myeloid cell populations across tissues and diseases. While these studies have moved the field forward, confusion has stemmed from the variety of names given to similar populations thus here we aim to start to align these studies. This will be achieved through a panel discussion and through the different invited talks and workshops covering selected abstracts. Finally, we hope to provide novel insight for junior scientists regarding how science is conducted in both industrial and academic settings as well as shedding light on the process of therapy discovery and development.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Doris Wagner, Xuehua Zhong, Toshiro Ito and Claudia Köhler

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# Genetics, Genomics and RNA
# Microbiota and Flora

Plants sustain all life on earth. Being immobile, plants tune their growth and development to the environment and frequently mount stress and defense responses. As the interface between the environment and the genome, the epigenome is critical for plant survival and adaptability. Indeed, plants have a large arsenal of epigenome regulators, which has led and continues to lead to new discoveries in the regulation and plasticity of the epigenome. However, understanding the contributions of epigenome modifiers to cellular and nuclear processes remains incomplete. Recent new technologies allow ever more precise insight into the epigenome of entire organisms at all scales, throughout their lifecycle, and in various conditions. This timely conference brings together international scientists from all career stages and research settings that develop and apply novel approaches to understand the role and regulation of the plant epigenome. The meeting will feature recent discoveries illuminating the contribution of non-histone chromatin proteins and regulators, histones, and DNA modification on gene regulation, genome organization, development, and environmental and species interactions, with particular emphasis on innovative epigenome technologies that help uncover fundamental epigenetic mechanisms in diverse plant species. A workshop by early career researcher talks followed by a panel discussion will focus on utilizing epigenome manipulation to enhance desirable traits in plants and foster interactions and collaborative investigations.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Florian Rieder, Tatiana Kisseleva and Marco Prunotto

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# Immunology

Fibrosis represents a pathophysiological condition intrinsic to chronic and progressive diseases, which is characterized by excessive tissue scarring. Diseases associated with fibrosis include cardiac fibrosis, metabolic dysfunction-associated steatotic liver disease (MASLD), inflammatory bowel diseases (IBD), chronic kidney disease (CKD), pulmonary fibrosis and scleroderma, collectively responsible for a large percentage of global morbidity and mortality. Significant progress has been made in our understanding of the mechanisms of fibrosis, different etiologies and therapeutic implications. Recently, several anti-fibrotic drugs have been approved for pulmonary and liver fibrosis. However, there remains a gap to identify effective treatments of fibrosis. This may be due to a the limited number of identified druggable putative targets, lack of translational research and insufficient disease models. This year’s Keystone Symposia Fibrosis Conference will discuss the viewpoint of biologists, physician-scientists and industry collaborators from around the globe on fibrosis and its intricacy to deterioration of organ function in multiple diseases. We propose the following specific goals: 1. Address gaps in knowledge in mechanisms of fibrosis across organs 2. Discuss challenges for diagnosis and monitoring of fibrosis progression in patients with chronic fibrotic diseases 3. Discuss models and pathways to effectively translate mechanisms of fibrogenesis into effective therapies 4. Train scientists of all levels of seniority in the area of fibrosis and provide opportunities for mentoring junior scientists. The goals of the symposium will be accomplished by putting together outstanding invited lectures, abstract presentations, workshops, poster-sessions and in-depth discussions between the scientists. Anticipated outcomes include a rich and unparalleled scientific exchange and discussion, provision of a forum for academic with industry interaction as well as interdisciplinary exchange and collaborations spanning multiple organ systems. We expect sharing of novel methods to translate novel therapies into patients, building connections for mentorship of the next generation of scientists and ultimately an acceleration of translation of novel anti-fibrotic therapies into clinical practice. This long-standing symposium series is the only conference of its kind to bring together interdisciplinary scientists and investigators from the bench to the bedside together with industry. Traditionally this meeting series functioned as the origin of novel research paradigms in fibrosis. The anticipated pairing with the stromal biology meeting represents a synergistic overlap and is very welcome.

January 1-4, 2026 | Location to be Determined
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# Immunology

SIGNIFICANCE Stromal immunology describes the influence of fibroblasts and endothelial cells on immune cells and immune-driven outcomes. It underpins immune development, function and major pathologies such as infection, cancer, autoimmunity and fibrosis. Meeting goals: 1. To expand scientific frontiers by bringing together outstanding researchers solving important biomedical problems 2. To promote new breakthroughs in thought and practice by exposing siloed researchers to new findings that may be cross-disciplinary 3. To nurture emerging scientific leaders by providing a stimulating, inclusive environment to learn from and share with leaders in academia, clinical medicine and industry. We anticipate important knowledge gains including breakthroughs in understanding; the application of existing knowledge to new research frontiers; the emergence of new testing and technical modalities; and creation of collaborative and training opportunities. We want attendees to leave this meeting with exciting new ideas, and a topographical view of how stromal cells impact immunity across disciplines. INNOVATION The emerging collective identity of stromal immunology is already yielding transformative advances, reflected in the rapid increase in stromal-targeting therapies undergoing clinical experimentation. However, many efforts remain siloed in discrete disciplines, and our meeting will bring these scientists together. Career development and networking events are built into the program to foster collaboration and mentorship. Our pairing with the immune-driven fibrosis meeting is outstanding and unique. Both programs deal extensively with fibroblast function in homeostasis, inflammation, and immunity, including disease pathogenesis and therapeutic targeting. Our program covers emerging mechanism-driven insights in fibroblast development and function across a range of disease states dovetailed with fibrosis and matrix biology. Both meetings have strong relevance to a majority of attendees; thus we expect extensive interaction and cross-fertilization of ideas.

January 1-4, 2026 | Location to be Determined
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# Immunology

Autoimmune and autoinflammatory diseases result from complex interplay of genetic, environmental, and immunological factors and affect millions of people worldwide. Advances in genetics, disease modeling, immune monitoring and drug development are contributing to the identification of effective drug targets. Therapeutic choices still rely, however, on clinical phenotypes that may not reflect underlying molecular heterogeneity of disease. This results in “trial and error” strategies that delay disease remission, contribute to cumulative tissue damage, and inflate health care costs. We envision a Symposium that will bring together a multidisciplinary group of experts in basic science, translational research, and clinical studies and will address the following themes: 1. Basic mechanisms, with a focus on nucleic acid sensing-dependent inflammation, advances in the study of innate and adaptive immune cells and of multi-cellular platforms and tissues. 2. Systems biology and immune monitoring approaches towards patient stratification and disease-specific target identification. 3. Pre-clinical studies, with an emphasis on organoid biology towards human disease modeling, as well as murine models tailored to reproduce human disease. 4. The latest approaches to design and deliver effective and safe targeted therapies. Through the conference, we expect to gain new scientific knowledge and foster collaborations towards developing quality preclinical research models, recognizing disease subtypes, and identifying biomarkers for early diagnosis, all of which remain significant challenges. This meeting will feature a Career Roundtable, where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities.

January 1-4, 2026 | Location to be Determined
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# Immunology

The innate immune system serves to detect perturbations in organismal physiology and orchestrate responses that aim to reinstate homeostasis. Such perturbations sensed by innate immunity are diverse – including dangers such as infection, tissue injury and metabolic stress – and require a diversity of cells, receptors, and effector pathways to sense and interpret such signals, mount an appropriate innate immune response, and orchestrate inflammation resolution and wound healing. While such innate immune mechanisms are often host-protective, if they become unbalanced this can lead to infection or pathology. In this rapidly developing field, it is increasingly clear that maladaptive innate immune responses contribute to a myriad of diseases, including many human diseases associated with lifestyle and ageing (e.g. metabolic syndrome, neurodegeneration). This conference will bring together multidisciplinary perspectives on innate immunity, covering the fundamental science of innate immune mechanisms and the integration of immune diversity, including recent advances in innate immune danger-sensing and effector mechanisms across diverse cell types including macrophages, dendritic cells and epithelial barrier cells. As a joint meeting with the Keystone Aging Symposium, this meeting will allow valuable exchange and world-leading expertise in the fields of Ageing and Inflammation, to discuss the clinical aspects of inflammatory diseases associated with ageing, as well as industry approaches and emerging therapeutic opportunities for targeting inflammatory mechanisms in such diseases.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

January 1-4, 2026 | Location to be Determined
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# Immunology

Inflammation is a fundamental component of the immune response, playing a vital role in defending the body against pathogens and promoting tissue repair. However, unresolved or chronic inflammation is implicated in the pathogenesis of numerous diseases, including autoimmune disorders, cardiovascular diseases, neurodegenerative diseases, cancer, and the aging process. The Keystone Symposium on “Emerging Concepts in Inflammation Resolution” will explore recent advances in inflammation resolution, offering deeper insights into underlying mechanisms and opening new avenues for therapeutic intervention in inflammatory diseases. Our interdisciplinary program covers a broad spectrum of mechanisms contributing to inflammation resolution, including signals from dying cells and damaged tissues, the function of sentinel myeloid cells, the role of T cells in immunosuppression and tissue repair, the neural control of inflammation and its resolution, and the impact of aging on these processes. Additionally, the Symposium is designed to complement the concurrent Symposium on “Tumor Microenvironment: Identifying Drivers of Progression and Resistance.” The pairing of these Keystone Symposia underscores the intricate link between the tumor microenvironment and the failure to resolve inflammation, which promotes tumor growth and progression through maladaptation of the very mechanisms meant to restore tissue homeostasis. Insights gained from studying resolution mechanisms are expected to inform strategies to mitigate the detrimental effects of unresolved inflammation on tissue function and overall health. This knowledge offers novel therapeutic targets and interventions to improve clinical outcomes in cancer and other inflammatory conditions. The combined focus on inflammation resolution and tumor microenvironment is poised to drive innovative strategies in combating chronic inflammation and its associated diseases, making these symposia pivotal for researchers and clinicians alike.

January 1-4, 2026 | Location to be Determined
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# Cancer

Cancers are heterogeneous multicellular enterprises whose growth is dependent upon reciprocal interactions between genetically altered ‘initiated’ cells and the dynamic microenvironments in which they live. This meeting on TUMOR MICROENVIRONMENT (TME) will embrace tumor cell-intrinsic and -extrinsic communication programs regulating neoplastic progression, systemic aspects of host response to cancer (aging, cachexia, obesity, tumor immunity) impacting disease progression and response to therapy, and feature presentations discussing innovative experimental and computational tools designed to identify tumor vulnerabilities amenable for therapeutic targeting or patient stratification. Also included will be a workshop/data jamboree leveraging analytical tools developed by the NCI Human Tumor Atlas Data (HTAN) to study the TME.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

Emerging and re-emerging viruses remain a persistent threat, causing widespread illness and death, from localized outbreaks to global pandemics. Our struggles with recent pandemics and outbreaks of viruses such as SARS, avian influenza, MERS, Ebola, and more recently Monkeypox, highlight critical gaps in our understanding and emphasize the urgent need to rethink our preparedness strategies for future viral threats. This meeting aims to address gaps in knowledge regarding emerging and re-emerging viral diseases. Specifically, one session will focus on understanding the mechanisms of virus-host interactions, including how viruses evade host immune responses and cause severe disease and explore countermeasures to these. Additionally, discussions will cover gaps in knowledge related to the pathogenesis of zoonotic influenza and Middle East Respiratory Syndrome (MERS), as well as the development of effective vaccines against these viruses. The meeting will also explore gaps in our understanding of surveillance methodologies, predictive modelling approaches, and pandemic preparedness strategies. The goals of this conference are: 1. Address critical gaps in understanding virus-host interactions to inform the development of effective countermeasures against emerging and re-emerging viral diseases. 2. Advance knowledge of the pathogenesis of zoonotic viruses and accelerate progress in vaccine development for these diseases. 3. Foster collaboration and knowledge sharing to enhance surveillance methodologies, predictive modelling approaches, and pandemic preparedness strategies. 4. Identify and prioritize important research questions and critical barriers in the field of virology, immunology, epidemiology, and public health. 5. Provide networking opportunities for researchers, clinicians, and public health professionals to strengthen global efforts in preventing, detecting, and responding to viral threats. The anticipated outcomes of this meeting include the generation of new scientific knowledge regarding virus-host interactions, pathogenesis of zoonotic diseases, and innovative approaches to vaccine development. Attendees will gain insights into cutting-edge methods and technical capabilities for surveillance, predictive modelling, and pandemic preparedness. Collaboration among experts from diverse disciplines will foster the exchange of ideas and facilitate the development of multidisciplinary solutions to address viral threats. Additionally, attendees will benefit from training and educational opportunities, enhancing their skills and expertise in the field. As a result of this meeting, the field of virology, immunology, epidemiology, and public health will be better equipped to prevent, detect, and respond to emerging and re-emerging viral diseases, ultimately leading to improved global health outcomes.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

This symposium intends to provide a discussion platform for all scientists interested in the biology of virus infection and antiviral immunity as well as countermeasure development, which is urgently needed for a range of viral pathogens. The meeting will promote the exchange of novel and conceptual ideas in this fast evolving field, and will foster interdisciplinary collaborations that are essential to sustain the rapid progress our field has seen over the past several years. We intent to engage a diverse group of scientists from academia, industry, and government to discuss a broad range of topics related to viral immunology, pathogenesis, evolution, prevention, and treatment. The meeting will comprise the following six sessions: 1) Host-virus interactions in innate immunity; 2) Species expansion of (re)emerging viruses and associated immunity; 3) Success and failures of adaptive immunity to acute and persistent virus infections; 4) Genetic and acquired immune factors modulating viral susceptibility; 5) Novel approaches of host-directed and immune-based therapies to virus infections; and 6) New approaches to optimizing vaccine-induced immunity to viral pathogens. To attract a broad audience, we will have a balanced representation of cutting-edge fundamental research discoveries. A focus here will be on host-directed, immune-based therapies and vaccines, which are increasingly appreciated by the field. Providing virologists and immunologists with this opportunity to discuss their recent research findings including major successes and challenges in therapeutics/vaccines development is expected to facilitate interdisciplinary collaborations and, ultimately, promote scientific advancement for combating (re)emerging and persistent viral infections.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

Once considered entirely elusive, the search for a cure for HIV infection has now transformed into a global health priority that attracts and engages a community of scientists with interdisciplinary interests in genomics, epigenetics, single-cell analytic techniques, clinical medicine, immunological engineering, vaccinology, and global health research. Faced with daunting scientific challenges, high societal expectations, and not a single widely applicable intervention that can reduce or destabilize the highly durable pool of HIV-1 reservoir cells, HIV cure research critically depends on advances in understanding the fundamental mechanisms that promote life-long viral persistence and resistance to immune-mediated elimination. This meeting will focus on highlighting recent conceptual and technical advances in understanding the biological behavior and immunological vulnerabilities of HIV reservoir cells, and present progress in designing, testing and evaluating novel approaches for targeting HIV reservoir cells in model systems and human clinical trials. Specific areas of programmatic emphasis will focus on single-cell evaluations of viral reservoir cells, development of gene- and cell-based therapeutic modalities, testing of combinatorial immunological treatment interventions, and investigations of HIV reservoir cell persistence across the continuum of the human lifespan.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

The HIV vaccine field is at a critical juncture with immunological and virological discoveries from HIV infection having resulted in the generation of highly engineered vaccines, many now in advanced clinical trials in humans. These clinical insights are paired with detailed immunological analyses resulting in unparalleled depth of understanding of vaccine responses. Allied with ongoing studies of the natural history of HIV infection across diverse geographies, and innovations in protein engineering, adjuvant design and novel vaccine platforms, this intersection between clinical and basic sciences is accelerating the pace of HIV vaccines. This Keystone meeting, joint with an HIV Cure meeting, will bring together basic scientists and clinical trialists at a moment when experimental medicine trials will provide novel insights into HIV prevention and treatment.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

Every year, 10 million people fall ill with tuberculosis (TB). Despite being a preventable and curable disease, 1.5 million people die from TB each year. TB is the leading cause of death of people with HIV and a major contributor to antimicrobial resistance. Most of the people who fall ill with TB live in low- and middle-income countries, but TB is present all over the world. This meeting aims to bring together microbiologists, cell biologists, immunologists, and clinicians to collectively tackle the public health challenge that TB presents worldwide. The meeting will showcase new technologies and approaches that will allow us to understand the disease across scales, from bacteria to the human host and their interactions. The meeting will engage and feature the next generation of TB researchers to drive the field forward and foster cross-disciplinary insights and collaborations. TB mostly affects the Global South, but its research is poorly represented in scientific meetings. We aim to enable early-career researchers from the Global South to exchange ideas and discuss research approaches and resources that are needed for future research with leading experts in the TB field.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

Antimicrobial resistance is an urgent public health threat that represents the single greatest challenge in infectious disease across the globe. The objective of this Keystone Symposium is to bring together a diverse group of world leaders focused on new and innovative strategies for combating antimicrobial resistant bacterial infections. The meeting will focus on emerging concepts for treating antimicrobial resistance across a wide array of clinically relevant bacterial pathogens. Specific focus will be given to three primary areas: i.) bacteriophage therapy, ii.) microbiome-based medicine, and iii.) harnessing of host immunity for treatment of bacterial infections. The symposium will fill a major need in the scientific community by integrating both basic and applied research with the goal of bringing together broad experts at various stages of the scientific process and creating an environment for building interactions and collaborations that will push the field forward. The meeting will hold unique and interactive sessions addressing the opportunities and challenges facing scientists, clinicians, and regulatory agencies in this rapidly evolving space. Speakers and attendees will represent leaders in academic research, industry, and government agencies from across the globe. The design of the symposium will encourage new collaborations and start conversations about the future of medicine without antibiotics.

January 1-4, 2026 | Location to be Determined
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# Infectious Diseases

Human pathogenic fungi have emerged as significant causes of morbidity and mortality in patients with acquired immunodeficiency conditions such as HIV/AIDS and receipt of myeloablative chemotherapy and targeted immunosuppressive therapies for autoimmune disorders, neoplastic diseases, and hematopoietic stem cell and solid organ transplantation. In recent years, emerging multidrug resistant Candida auris is responsible for life-threatening outbreaks in healthcare facilities and raises serious concerns to global public health. A recent explosion in the discovery and characterization of novel monogenic inborn errors of immunity that predispose to mucocutaneous and/or invasive tissue-specific fungal disease and the development of clinically relevant animal models of mucocutaneous and invasive fungal infections have collectively enhanced our understanding of cell type-, tissue-, and fungus-specific recognition, effector pathways, and adaptive immune responses. Our improved molecular understanding of fungal virulence traits shows promise for the development of targeted treatment strategies against fungal pathogens. The goal of this Keystone meeting will be build on the 2024 meeting and bring together scientists who study both fungal virulence and fungal immunology, thus helping to synthesize our current understanding of the cellular and molecular determinants of fungal pathogenesis and mammalian antifungal immunity, which will provide the foundation for informing precision risk stratification, prophylactic, therapeutic and vaccination strategies to combat life-threatening fungal infections in vulnerable patient populations.

January 1-4, 2026 | Location to be Determined
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# Metabolism and Cardiovascular

Obesity, a condition that is becoming a leading cause of human morbidity and mortality, is among the global healthcare challenges of the 21st century. Specifically, obesity is a major risk factor for cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease and some forms of cancer. New and emerging medicines show unprecedented efficacy in promoting weight loss. This symposium will fuse existing knowledge with the latest discoveries in the underpinning mechanisms of obesity drug action, potential health benefits beyond weight loss, improving the quality of weight loss and minimizing side effects, and preserving muscle mass during weight loss. Recent advances in diverse combination therapies, new biology discoveries of glucagon and amylin and in leveraging enteroendocrine cell secretion will also be presented. The application of cutting-edge drug discovery approaches and the clinical relevance of basic science discoveries to obesity research will also be highlighted. In combination with a joint symposium on Cardiometabolism in Health and Disease, this exciting program will bring together breaking research from both basic science and translational realms on the treatment of obesity and cardiometabolic disease to foster cross-disciplinary insights, discovery and collaborations.

January 1-4, 2026 | Location to be Determined
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# Metabolism and Cardiovascular

We are witnessing an explosion of new information related to the intersecting health problems of obesity and cardiovascular disease. A flurry of cardiovascular outcomes trials have demonstrated a remarkable, yet poorly understood, cardioprotective benefit of diabetes and obesity drugs. In parallel, recent breakthrough technologies and experimental approaches allow deep real-time interrogation of systemic, organ, and cellular metabolism. We propose a symposium designed to address a series of topics relevant to cardiometabolism in health and disease including: 1) the metabolic bases for heart and vascular health/disease; 2) organ-organ crosstalk relevant to the synergism between obesity, insulin resistance, and cardiovascular disease; 3) the mechanisms whereby new drugs such as SGLT2 inhibitors and GLP-1r agonists reduce cardiovascular events; and 4) the impact of environmental factors such as feeding and diurnal behavior on cardiovascular health and disease. A successful Symposium focused on these topics requires participants with expertise across an array of disciplines and themes including cellular and organismal metabolism, heart and vascular biology/physiology/disease, clinical and data science, clinical trial design, and new drug seekers. The proposed 'Cardiometabolism in Health and Disease' symposium will be most appealing if partnered with a symposium centered around obesity and its complications. It is envisioned that this conference will bring together basic and translational scientists in academia with industry partners engaged in the development and assessment of new treatments for the worldwide health problem of cardiometabolic diseases. Such a meeting will be timely and of significant interest to a wide range of participants.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Olov Andersson, Barak Blum, Amelia K. Linnemann and Erica B. Nishimura

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# Metabolism and Cardiovascular

The islets of Langerhans are critical for glucose homeostasis but fail in diabetes, accompanied by autoimmune destruction of beta-cells in type 1 diabetes and increased insulin demand and beta-cell exhaustion in type 2 diabetes. During the last decade, there have been major advances not only in the molecular understanding of beta-cell stress, unfolded protein response, dedifferentiation, aging and failure, but also in counteracting mechanisms, such as beta-cell maturation, compensation, redifferentiation, autophagy and recovery. This meeting will address unresolved gaps in how these mechanisms intersect and how to shift fundamental insights into possible approaches to reverse type 2 diabetes. In parallel, this meeting will address how we can combine primary islets, differentiated stem cells or regenerative mechanisms with immune-evasive strategies for beta-cell replacement in type 1 diabetes. In development, the different niches that enable beta-cells to develop, mature and function are another important aspect of islet biology. In the adult, progression and reversal of either type of diabetes can be affected by inter-organ crosstalk, e.g. between the islet and the gut or brain. This Keystone meeting welcomes presentations on all aspects of islet biology, as well as from researchers at any career stage and from both academia and industry. A fusion of technical advances and novel biological concepts will encourage interdisciplinary collaborations of global nature to accelerate diabetes research.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers

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# Metabolism and Cardiovascular

The gut and brain interact to control a host of behaviors (including feeding), gut function, the perception of gastrointestinal malaise, and many autonomic responses. Most of these responses are mediated at the level of the brainstem, which also represents the site for many feeding-related actions of incretin-mimetics. Understanding the systems that sense gut status and respond to incretin mimetics, as well as the defining circuits that process and relay these signals to promote specific behavioral and autonomic outputs may reveal potential targets for therapeutic intervention in obesity. This meeting will focus on the gut systems and neural circuits by which the gut and brain communicate to effect behavioral and physiologic changes. The conference will provide a venue to learn about, discuss, and integrate the latest research advances regarding the sensing of information by the gut, the relay of this information to the brain, the mechanisms and circuits that mediate ensuing behavioral and physiologic changes, and the systems that mediate anti-obesity actions of incretin-mimetics, as well as examining the integration of gut-brain signaling with islet biology. The conference will integrate academic and industry perspectives, providing the opportunity for interdisciplinary discussions that can drive therapeutic advances. Workshops will focus on emerging areas of research and technology, as well as career development. The meeting will engage researchers from diverse areas of expertise, integrating neuroscience, gut biology, metabolism, behavior, physiology, nutrition, and pharmacology, allowing participants to comprehensively understand mechanisms of gut-brain communication and the importance of these mechanisms for physiology, pathophysiology, and therapy.

January 1-4, 2026 | Location to be Determined
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# Metabolism and Cardiovascular

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most prevalent complications of obesity. MASH is already the most common chronic liver disease, and is predicted to soon be the leading cause for liver transplant worldwide. Understanding mechanisms underlying MASH initiation and progression is likely to lead to novel and sorely needed therapy for a significant at-risk patient population. The proposed meeting will address several key knowledge gaps, including: •Does hepatocyte lipid accumulation affect cell-autonomous metabolic and regenerative processes? •What hepatocyte and systemic pathways determine liver inflammation and fibrosis? •Are there novel approaches to study MASH in vitro or in animal models? •Can we monitor MASH in patients using non-invasive biomarkers and imaging tools? We anticipate that attendees of this meeting will be exposed to the most current science in MASH pathogenesis, which in turn may lead to new academic collaborations with potential translational impact. Industry colleagues will in turn inform current and planned therapeutic approaches. This crosstalk will certainly lead to new insights into actionable mechanisms in MASH and may lead to novel therapies. Another distinguishing feature of the proposed meeting is the convergence of interdisciplinary expertise from bioengineering, metal biology and metabolism, which when coupled to talks from expert liver-focused clinicians, is likely to result in new in silico, in vitro and in vivo approaches to model MASH with eventual goal for novel treatment strategies.

January 1-4, 2026 | Location to be Determined
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# Metabolism and Cardiovascular

Research in chronic kidney diseases (CKD) has reached a tipping point not seen in our field for a generation. We finally can develop a comprehensive understanding of the convergence of disease mechanisms driving both the progression to organ failure as well as cardiovascular morbidity and mortality. The Keystone conference will be a critical accelerator for our efforts to save kidneys and lives, by aligning the rapidly progressing knowledge streams within CKD research. We will explore a fundamentally novel view of the kidney’s cellular architecture through the lens of multi-scalar data generated by global kidney tissue atlas networks. We will discuss how the unprecedented deep tissue-level understanding of CKD biology in humans is driving a precision medicine drug discovery pipeline forward, from systems level target identification to definition of appropriate model systems. The impact of pursuing these emerging therapeutic targets will be examined from a molecular and societal level through the interplay of kidney failure with environmental and social determinants of health. We will evaluate successes and failures in the current CKD drug development pipeline and present innovative strategies for next generation trial design. For the first time, CKD trials will be used as discovery engines to define the mode of action of the targeted intervention in humans, using the kidney atlas knowledgebase to close the discovery loop. Immersing investigators in a diverse, rapidly expanding CKD knowledgebase in the Keystone conference setting is expected to generate cross-cutting interventional strategies impacting how we treat kidney disease for years to come.

January 1-4, 2026 | Location to be Determined
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# Microbiota and Flora

Despite the critical role of microbiota-derived molecules, the structural characterization and functional understanding of such molecules remain limited. A significant portion of metabolites undergo changes, irrespective if they are aquatic, soil, plant, animal, and human microbiome ecosystems, when the microbiome is altered. Typically, only about 10% of the data can be attributed to a molecular structure, with merely 1-2% traceable to microbial origins. However, sequencing indicates that microbiomes often possess 100-150 times the metabolic capacity compared to host ecosystems. Understanding the microbiome mechanistically and gaining control over microbiomes necessitate novel tools to discover all microbiota-derived metabolites and elucidate their functional roles. Humans, along with other ecosystems, are comprised of microbial-derived metabolites via three primary sources: 1) microbial metabolism of host-derived metabolites; 2) microbial digestion of molecules from food and beverages; and 3) microbial synthesis of metabolites using proteins encoded by genetic elements, often organized as gene clusters across bacteria, archaea, fungi, and recently discovered to be widespread in phages. Furthermore, microbial metabolites can stem from the microbial processing of xenobiotics beyond food, including plasticizers, pollutants, medications, and potentially environmental molecules absorbed through the skin or inhalation. This conference aims to explore the latest technological advancements for discovering new microbiome-derived metabolites, identifying the genes responsible for their production, and understanding of their functional roles. These insights hold promise for various applications in managing health and disease in agriculture, environment and medicine.

January 1-4, 2026 | Location to be Determined
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# Neurobiology

SIGNIFICANCE: A challenge of studying human neurodevelopmental conditions involves its heterogeneity in terms of etiologies, symptoms, disease course, and outcomes. As live human brain tissue is inaccessible, most studies involving the analysis of cellular function have been restricted to the examination of human postmortem tissues or animal models. While these approaches have yielded important insights, there are limitations regarding the transferability of these results to human physiology and psychiatry. Considering that, human induced pluripotent stem cells (iPSCs) appear as powerful models for studying predisposition to neurodevelopmental conditions with complex etiology as they allow researchers to uncover the idiosyncratic developmental deficits that arise from an individual's genetic landscape in combination with environmental disturbances. The goals of this symposium are: to discuss novel approaches for studying neurodevelopmental disorders; to connect scientists investigating global gene expression, neural patterning, maturation, inflammation, and synaptic function on neurons and astrocytes; to provide an interdisciplinary, stimulating, and high-level scientific environment related to psychiatric conditions or with a mutation related to brain development; to build knowledge in a two or tridimensional (brain organoids) culture systems. ANTICIPATED OUTCOMES: This meeting will promote the bringing of complementary expertise, providing an in-depth overview of the basis for neurodevelopmental conditions, the status of the art, cutting-edge technologies, and innovative approaches, benefiting attendees and fostering collaboration in science. INNOVATION: The meeting will narrow panels that will consider a variety of innovative techniques for generating neural cell types and analyzing cellular phenotypes relevant to psychiatric/ neurodevelopmental conditions, including glial-induced neuroinflammation and single-cell transcriptomics. The panels will also discuss the advantages and limitations of case/control studies and CRISPR-mediated gene editing for isogenic comparisons. The joining of our meeting with “developmental mechanisms and insights into disease” will favor an interdisciplinary, but somehow related scientific environment.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

The 2025/26 Keystone Meeting “The Ubiquitin Family in Biology and Disease” will bring together researchers from the broad areas of ubiquitin biology and ubiquitin-like proteins and connect them to scientists actively working on exploiting these posttranslational modifications for therapeutic benefit. Topics of particular interest will be novel ubiquitin-dependent signaling pathways that play roles in disease and are amenable to small-molecule intervention; new functions of ubiquitin-like proteins, such as those providing ribosomal quality control; the study of catalytic mechanisms of ubiquitylation enzymes and their implications for drug discovery; and exploiting ubiquitylation enzymes for novel induced proximity therapies. Just as basic biology continues to inform drug discovery, clinical trials have recently shed light on the cellular function of ubiquitylation enzymes and their targets. Building a tightly knit community that includes scientists from both discovery and translational ubiquitin biology is critical for discovering new biology and developing new induced proximity modalities that will benefit patients in decades to come. Thus, this meeting will highlight interdisciplinary science with an emphasis on disease treatment. As interdisciplinary science often requires increased focus on effective communication, this meeting will include workshops that expand interactions between academic and biotech scientists through career roundtables, meet the editors, or drug discovery workshops.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

Drug discovery has traditionally relied on low-throughput experimentation and trial and error. Computational methods, including machine learning or AI approaches, are transforming drug discovery by enabling more computer-based experiments and simulation-informed decision-making at an increasingly unprecedented scale. With access to extensive computer-aided insights and simulations, scientists can now explore a vastly expanded set of potential interactions and outcomes at atomistic, DNA, protein, and cellular levels, thereby significantly improving the precision with which we design drugs for the right cellular and disease context and the right patient. This symposium aims to bring together experts from connected disciplines in drug discovery who are leveraging computational methods in therapeutic compound and protein design, protein structure and protein-protein interaction predictions, disease model systems, and computational predictive toxicology. Speakers in each session will cover how computation and advanced machine-learning methods aid hypothesis generation and exemplify how the convergence of data and technology is accelerating medicine discovery and development.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Giulio Superti-Furga, David Drew and Kathleen M. Giacomini

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# Biochemistry, Structural and Cellular

Membrane transporters facilitate the uptake of nutrients, ions, hormones, neurotransmitters, vitamins, and xenobiotics required for cell function and energetics as well as the export of toxic or excess molecules. Solute Carrier transporters make up the second-largest fraction of the membrane proteome, but have been under-utilized as drug targets. Although there are a few success stories of drugs targeting SLCs, we need to better determine their transport function, mechanism, regulation and physiological connection to biological processes to properly evaluate their therapeutic potential in drug discovery. In parallel, we need better tool compounds, computational modelling and high-throughput technologies to improve on their pharmacological control and diagnostic value. This conference brings together researchers focused on SLC transporter pharmacology, physiology and structure-function-mechanism in an effort to facilitate and promote a coordinated effort and understanding of these important proteins, with a strong emphasis on transporters as emerging drug targets. As outcome of the meeting we expect the creation of a cohesive research community on the medical and pharmacological exploitation of human membrane transporters as emerging drug targets and gates to drug access. New solutions and recommendations for the interpretation of genomic variants. Identification of new paths to transporter drug discovery.

January 1-4, 2026 | Location to be Determined
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# Cancer

Cancer immunotherapy strategies are highly effective, though target just a few immunoregulatory pathways, and only benefit a subset of patients; most patients either fail to respond or respond transiently and develop resistance. Mechanisms of primary or secondary resistance are poorly understood, and a variety of immunotherapeutic strategies are in development to harness alternative immune pathways to overcome barriers to clinical response. This meeting will bring together a diverse group of basic, translational and clinical researchers including those from academia, industry and government to cooperatively discuss the mechanistic basis of failed immunotherapy, and novel approaches to activating the immune system, in order to provide insight for future clinical applications of novel approaches and optimal combination therapies. This program will highlight the failures and successes of cancer immunotherapy, explore therapeutic targets within our understanding of host immunity, and discuss challenges of current combination immunotherapy approaches. Alongside a discussion of the status quo—and current barriers—this program will highlight novel approaches to targeting stroma and myeloid cells, novel insights on tumor recognition by multiple lymphoid lineages, and overcoming resistance. We will discuss some of the most promising technologies in development to unravel the complexity of the tumor microenvironment using spatial imaging and AI technology. We will hear from experts on optimal clinical trial design and clinically relevant endpoints. This interdisciplinary meeting will spark new collaborations and inspire new research directions toward identifying novel immunotherapy approaches to benefit patients.

January 1-4, 2026 | Location to be Determined
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# Cancer

Systemic metabolism plays a critical role in controlling tumor development and provides several new opportunities to improve cancer therapy. The symposium will address topics that go beyond the impact of metabolic changes in the cancer cells themselves – the subject of many meetings – and explore the reciprocal relationship between tumors and whole-body metabolism. While systemic metabolism is important in the control of the immune system, this meeting is designed to explore other aspects of this important, but complex, area of research. The Symposium will cover diverse topics that impact will impact systemic metabolism and cancer, including the microbiome, diet (including obesity, cachexia and antioxidants), aging and other metabolic diseases. The aims of the meeting are to bring together fields that are only now beginning to intersect, to inspire a cohort of trainees to develop projects that span different disciplines and establish new collaborations, and to consider how progress in this area is being translated into clinical utility. The meeting will help to broaden the scope and complexity of cancer metabolism to consider the tumor in the context of the entire organism.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Anwesha Dey, Laura D. Attardi and Mariam Jamal-Hanjani

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# Cancer

This meeting is focused on the tumor cell and the tumor intrinsic mechanisms involved in cancer. The sessions are intended to cover broad topics from cancer evolution, tumor heterogenity, metabolic rewiring and plasticity to drugging tumor intrinsic pathways and cancer cell vulnerabilities. Given the timeline for the meeting, we have included a session to focus on forward looking topics to discuss emerging topics and questions in the field from both academia and industry. Attendees will take away a broad based overview of the field that is uniquely focused on the tumor cell itself. The aim is for this meeting to complement the cancer immunotherapy focused meeting.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

The field of membrane repair has exploded in the past five years. Membrane repair has been closely linked to Parkinson's disease and other diseases. The mechanistic cell biology of membrane repair has taken off just as fast as the disease implications. Hundreds of laboratories working on this new topic have been drawn from the older fields of autophagy, cell death, lysosome biology, membrane traffic, neurodegeneration, and beyond. While recent meetings on the topics of autophagy and lysosome biology have included individual sessions on membrane repair, there has been no single international forum dedicated to the topic. The topic is particularly close to the vibrant field of autophagy, with many traditional autophagy researchers drawn into the topic of membrane repair by the common role of ATG8/LC3 conjugation. A joint symposium with Autophagy is therefore a natural fit.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

Autophagy dysregulation has been linked to a wide range of diseases, such as cancer, neurodegenerative disorders, metabolic disorders, and infections. However, further research is needed to fully understand the precise roles and mechanisms of autophagy in different disease contexts and its therapeutic potential. This meeting aims to address gaps in knowledge regarding the regulation, mechanisms, and therapeutic potential of selective autophagy in disease contexts. A further understanding of selective autophagy is critical for developing targeted therapeutic interventions and understanding disease mechanisms, as selective autophagy allows cells to specifically target and remove damaged organelles, misfolded proteins, and intracellular pathogens. This meeting will showcase ongoing basic research advances in the field, but also focus on translational research and industry developments in the area. A joint meeting with “Membrane Dynamics, Repair and Disease” is an excellent opportunity for engaging joint sessions of shared interest, in particular with the pathology. We also plan to organize a workshop on tools and strategies to study and target autophagy, which may also include lessons learned from clinical trials. The translational sessions in this meeting provide a forum for exchange of knowledge between academic and industry researchers which is not an element in on-going meetings such as Gordon Research conferences, or the International Symposium for Autophagy.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

For decades, mitochondria were cast in the limited, yet essential role as powerhouse of the cell. In the past 25 years, this view has changed as mitochondria have emerged as a major signaling hub that dictates cellular fate and function to control cellular physiology. Aberrant mitochondrial signaling can cause diseases and for the longest time the common perception of the etiology of mitochondrial disease was a lack of ATP within cells that had mitochondrial dysfunction. Recent work outlined novel conceptual framework for the role of mitochondria in the cellular physiology, yet, the mechanistic details are not fully understood of how signals emerging from mitochondria dictate cell fate and function. These include (1) how mtDNA, known to cause inflammation, is released from mitochondria into the cytosol; (2) how mitochondrial metabolites control epigenetics; (3) how mitochondria ROS levels are regulated and control cell function and fate by cysteine oxidation; 4) what mitochondria dependent mechanisms control neurodegenerative diseases; 5) how mitochondria integrate to activate stress responses; 6) which mitochondrial metabolites control cell fate and function. Beside these questions aimed to broaden our basic understanding of the role of mitochondria as central signaling hub in the cell,, the conference will address whether mitochondria can be targeted for variety of diseases including ischemia-reperfusion, hair growth, inflammation, and neurodegeneration. These topics will be addressed in this conference that brings a diverse group of biologists, clinicians, and pharmaceutical scientists. We don’t think our meeting is good link for ongoing cancer metabolism or immunometabolism meeting as we have don’t have speakers that address mitochondrial bioenergetics or mitochondria function in metabolism for growth/proliferation. These are main topics covered by those meetings. We are worried their presence will “dwarf” our meeting. If there is an aging meeting, then we could imagine that it could much better link with our conference.

January 1-4, 2026 | Location to be Determined
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# Biochemistry, Structural and Cellular

Significance: Proximity Based Modalities are a rapidly developing field at the intersection of biology, chemical biology, drug discovery and development, across a range of therapeutic areas. This rapid evolution requires collaboration and knowledge sharing amongst scientists in academic, non-profit and industry sectors to bring early induced proximity ideas from concept to chemical biology validation and ultimately into clinical development. The goals of this conference are to 1) foster connection between academic, industry and non-profit scientists, 2) provide perspective on the early discoveries of induced proximity, 3) provide a working knowledge of induced proximity mechanism of action, 4) inform on approaches to discover and develop induced proximity agents and 5) discuss the most recent advancements in the clinic. Innovation: Induced proximity (IP) is a rapidly evolving field that is includes protein degradation and other novel IP approaches that have significant therapeutic potential. New therapeutic modalities and paradigms do not arise often, and it is critical that academic, industry and non-profit scientist are regularly interacting to drive quality research, drug discovery and translation to clinical development. Providing a comprehensive perspective from concept and chemical biology to drug discovery and development will aid the field in realizing the scientific and medical opportunity that induced proximity approaches represent.

January 1-4, 2026 | Location to be Determined
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# Genetics, Genomics and RNA

January 1-4, 2026 | Location to be Determined
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# Genetics, Genomics and RNA

Significance. Nucleic acid therapeutics (NATs) represent a transformative frontier in medicine, with numerous drugs already approved. This clinical success has been achieved through persistent technological innovation and successful adherence to two pivotal principles: understanding the molecular mechanisms of nucleic acid action and cellular interactions, and ensuring robust delivery systems. The clinical success of nucleic acid therapeutics in treating liver diseases is now a reality. The next frontiers in this field will emerge from several areas: advancements in chemistry and targeted delivery, exploration of novel mechanisms of therapeutic gene regulation, and the integration of informatics and AI-based design. Innovation. The diversity of nucleic acid molecular mechanisms—ranging from semi-permanent gene regulation and gene activation to readthrough codon skipping—profoundly enhances the possibilities for application and innovative treatments. Shared chemistry, fundamental delivery principles, and commonalities in intracellular interactions are consistent across various RNA-based drugs. While the potential of these emerging mechanisms is immense, there is a redundancy of learning within the community, necessitating a concerted effort to break these cycles. Thus, it is imperative to convene a diverse audience comprising experts in chemistry, cellular and molecular biology, and pharmacology to foster interdisciplinary exchange and cross-pollination of ideas. The overarching objective of the Keystone meeting is to catalyze such interactions, thereby providing the foundation for the next wave of transformative discoveries in the field. The co-organization with the precision genome editing session aims to further this agenda, recognizing the shared questions and solutions that transcend disciplinary boundaries. Together, we aim to chart a course towards a future where NATs realize their full potential in reshaping the landscape of medicine.

January 1-4, 2026 | Location to be Determined
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# Neurobiology

Neurodegenerative disorders are a leading cause of disability and the second leading cause of death, therefore disease modifying therapeutics and biomarkers for early diagnosis and monitoring of target engagement during treatment are desperately required. Neurodegenerative diseases share many disease overarching mechanisms. These not only include the deposition of insoluble prion-like proteins but also strong non-neuronal contributions. Vascular and neuro-immunological risk factors are described for numerous neurodegenerative disorders. Moreover, peripheral modifiers of disease progression have been identified. A systemic view of neurodegeneration, which includes all non-neuronal brain cells and influences from peripheral organs, will open new avenues for the identification of diagnostic biomarkers and targeted disease overarching interventions. The conference will therefore cover a broad spectrum of neurodegenerative disorders and include targeted sessions to discuss system-wide mechanistic research and the exciting possibility to identify unexpected disease overarching therapeutic targets.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Michael V. Sofroniew, Malu G. Tansey and Robyn S Klein

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# Neurobiology

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January 1-4, 2026 | Location to be Determined
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# Developmental, Reproductive and Regenerative

This meeting seeks to cover the latest advances in how blood and immune cells are produced through the process of hematopoiesis. The molecular regulation of hematopoiesis and relevance to diseases are covered, along with cutting-edge technological advances in this field. Through this meeting, attendees will gain a deeper understanding of the process of hematopoiesis and gain new knowledge on recent advances. No other meeting covers the same breadth and depth on this topic, as this meeting does.

January 1-4, 2026 | Location to be Determined
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# Developmental, Reproductive and Regenerative

Since the advent of the iPSC technology, enormous progress has been made. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development. Novel mechanisms have been elucidated, drugs have started to enter clinical trials, and increasing number of clinical trials have been initiated. The combination of iPSC technology with gene editing and organoids makes it even more powerful. We propose to have an iPSC symposium in 2026 to celebrate achievements we have made in the iPSC field, reflect on lessons we have learnt, and identify challenges and opportunities for moving forward. The important concepts for the symposium include iPSC-based disease modeling and drug discovery, iPSC-based cell therapy development (autologous and universal donors), clinical trials of iPSC-derived products, 3D modeling using organoids or organs-on-a-chip, and AI and machine learning in iPSC research and applications, as well as bioethics. Such a meeting on iPSCs will provide a great opportunity for researchers, clinicians, industrial experts, and investors to interact, creating unusual collaborative prospects. It could transform the field through sharing knowledge from different disciplines, leading to the development of new cellular platforms and therapeutic products, which will ultimately impact clinical practice positively. This symposium will appeal to a wide community, including researchers, clinicians, industrial partners, and venture capitalists.

January 1-3, 2026 | Location to be Determined
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# Developmental, Reproductive and Regenerative

Stem-cell-based embryo models (SCBEMs) are structures formed by culturing pluripotent stem cells in either two-dimentional (2D) or three-dimensional (3D) environments, using mechanical and chemical cues to guide their lineage differentiation, self-organization and morphogenesis. Given that SCBEMs can mimic different aspects of early embryonic development, they are invaluable tools for advancing our understanding of early development and enhancing disease modeling, drug screening, and regenerative and reproductive medicine. The field of SCBEMs is rapidly evolving, with new models of increasing complexity and fidelity being reported continuously. Recent advances in deriving bona fide human extraembryonic stem cells and developing in vitro implantation models with endometrial cells have facilitated the development of more advanced SCBEMs that incorporate embryonic, extraembryonic, and/or maternal components. Continuous innovation, especially the integration of bioengineering, synthetic biology tools, and cell-instructive biomaterial systems, is crucial for precisely modulating dynamic niche signals for SCBEMs. These new developments will enable the creation of more accurate SCBEMs that properly exhibit progressive development and even organogenesis processes, with enhanced efficiency and controllability. Furthermore, the applications of SCBEMs for understanding human development are beginning to be explored. The purpose of this meeting is to present the latest advancements in SCBEMs, highlight innovative bioengineering and synthetic biology tools that enhance these models, and discuss how SCBEMs can be utilized to gain insights into early human development. We expect this meeting to broaden the SCBEM community and foster interdisciplinary collaborations. Additionally, we aim to use this meeting to emphasize the significance of SCBEMs in uncovering new insights into early development and their potential for translational applications. This meeting stands out as it comprehensively covers all major aspects of the emerging field of embryo modeling using stem cells, which has significant implications for both basic research and translational applications. It brings together interdisciplinary groups of scientists and investigators who typically do not have the opportunity to interact. As the field is still in its early stages, this meeting will play a crucial role in consolidating the field and advancing it further.

January 1-4, 2026 | Location to be Determined
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# Drug Discovery, Bioengineering and Digital

Vaccination is estimated to prevent more than 4 million deaths annually, representing one of the most effective public health tools to prevent death and disease. Yet vaccines remain enigmatic against some of the most deadly pathogens and diseases globally, in part due to our incomplete understanding of the immune responses associated with disease control and clearance. However, over the past 3 decades , we have experienced an explosion in immunological tools, that have effectively revolutionized our understanding of immunological mechanisms involved in the control of the host-pathogen interaction. Linked to new vaccine platforms, adjuvants, and antigen design, the ability to strategically shape immunity is emerging. This meeting will focus on defining key vaccine associated immunological obstacles and discuss current and future immunological solutions that may lead to the development of next generation vaccines able to straetically harness immunity to fight disease. Significance: The COVID-19 pandemic catalyzed an extraordinary revolution in vaccinology, accelerating the development of novel antigen design/discovery strategies, clinical trial conduct, as well as novel vaccine platforms/tools. However, vaccines are still lacking for some of our most lethal pathogens, partly due to our incomplete understanding of immune correlates of protection. Moreover, additional vaccine gaps exist that continue to limit the universal efficacy of some of our most critical vaccines. Thus, this keystone meeting aims to take a deep look at the current immunological gaps in vaccinology. This meeting will bring together international immunological leaders in vaccinology and infectious disease to define the challenges and discuss creative new solutions to fully leverage the immune response to maximize the potential of vaccines. Immunologists and vaccinologists from across virology, bacteriology, and oncology will come together to tackle 4 fundamental questions: 1. How are T/B cells trained in inductive sites and how can these responses be engineered for breadth, full potency, and durability 2. How can vaccines drive long-lived tissue resident immunity able to provide maximal protection against infection and disease 3. How can immune correlates help advance vaccine development 4. Will therapeutic vaccines fully leverage immunity to chronic pathogens and tumors. Collectively, interaction of leaders from disparate areas of vaccinology and immunology will create a new dialogue, catalyze new collaborations, inspire new approaches to overcome immunological obstacles and accelerate discovery of vaccines across a wide range of diseases. Attendees will learn about the common challenges across vaccine development efforts and find converging opportunities to overcome and improve immunogenicity and vaccine efficacy. Innovation: While vaccine development often focuses on the pathogen, this meeting will uniquely approach vaccine design and development with an immunological lens. The meeting will focus on key challenges and approaches to leverage immunology in vaccine development and raise opportunities to re-engineer and train the immune system to fight a broad range of infections and diseases. The meeting will bring together academic and industry vaccinologists and immunologists, strategically catalyzing discussions around common challenges across vaccine development fields. The structure and selection of speakers will enable attendees to not only rapidly appreciate the common immunological obstacles faced across vaccine development efforts, but also appreciate the rapidly evolving new technologies and immune mechanistic understanding that will help solve these challenges. The venue and arrangement of sessions will further support the growth of new collaborations and inspire the next generation of vaccinologists to take a new vantage point in leveraging the host:disease axis. Thus, ultimately, the meeting will bridge fields of vaccinology through common immunological struggles and create new networks of vaccinologists and immunologists apt to take vaccinology to the next frontier.

January 1-4, 2026 | Location to be Determined
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# Drug Discovery, Bioengineering and Digital

Antibody drugs have been remarkably successful in recent decades with more than 150 approved, providing major benefits to patients across multiple different disease areas. Looking to the future, artificial intelligence (AI) has the potential, albeit largely unrealized, to transform antibody discovery and optimization. This meeting will explore progress and challenges in the application of AI to the design of antibody drugs including immunogenicity risk assessment and mitigation. Additional goals of this meeting include: i) identifying opportunities and challenges with emerging antibody-based modalities, ii) exploring the therapeutic potential of antibody-conjugates with novel payloads including oligonucleotides, iii) evaluating conditional activation of antibodies for example to improve therapeutic index for cancer, iv) harnessing the immune system more optimally with bispecific and multispecific antibodies as well as through and engineered effector functions. We anticipate that the meeting attendees will span a broad range of different disciplines that impact antibody drugs including basic, translational and medical sciences. Participants are expected to gain a deeper understanding of some of the key emerging areas with antibody drugs. Our hope is that we can help the community to identify and begin to tackle some of the most critical challenges with antibody drugs. Fostering innovation can only bring even greater benefits to patients in the future with antibody-based drugs.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Wendell A. Lim, Ashley K. Koegel and Robbie G. Majzner

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# Drug Discovery, Bioengineering and Digital

January 1-4, 2026 | Location to be Determined
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# Genetics, Genomics and RNA

Recent artificial intelligence (AI) breakthroughs in understanding and generating complex data have immense potential to accelerate biological research, but key gaps remain in applying these advances to the life sciences. This meeting will explore how AI can help decipher biological codes, uncover patterns in large-scale biological data, and develop foundation models and domain-specific methods to drive biological discovery. Scientific inquiry presents unique challenges for AI. Ensuring widespread benefit requires careful consideration of training data acquisition and inclusion, as well as model design. Understanding what our models have learned is essential to: * Verify that biological relationships, rather than experimental artifacts, are being used. * Enable exploratory analysis via visualization interfaces. * Establish solid generalizable principles that can inform experimental validation. Specific meeting goals include: * Showcase cutting-edge applications of AI to biological problems. * Identify challenges and best practices for biological data acquisition and inclusion in AI. * Discuss interpretability approaches to understand what biological relationships AI models learn. * Foster collaboration between AI and biology experts to develop innovative solutions. * Train the next generation of scientists at the interface of AI and biology. Anticipated outcomes include new interdisciplinary research directions, technical capabilities, and collaborations. Attendees will gain insight into leveraging AI to advance their research. The meeting will explore how to move this nascent field forward, highlighting research projects exploring the interface of AI and biology from visionary experts building the future of the life sciences.

January 1-4, 2026 | Location to be Determined
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# Genetics, Genomics and RNA

A multidisciplinary collection of studies performed over the past decade has highlighted the critical roles for disrupted chromatin and gene regulatory mechanisms in human diseases, ranging from cancer to immune conditions and neurodevelopmental disorders. These findings have prompted the development of a wide range of new mechanistic investigations and discovery efforts toward the development of targeted therapeutics. However, the effective translation of basic mechanisms remains both slow and challenged, owing in large part to a significant gap in understanding regarding the connectivity between epigenetic factors and gene expression and cellular functions. This meeting seeks to address this gap by bringing together academic experts in chromatin and gene regulatory mechanisms with clinicians and industry experts. Collaborating and combining diverse expertise will enable us to develop more effective strategies to combat major health challenges rooted in epigenetic mechanisms. Significance This meeting will concentrate on new insights into established and emerging mechanisms of disease-related chromatin and gene regulatory proteins and protein complexes. Among the areas of emphasis will include the contrast between catalytic and non-catalytic functions of chromatin modifying factors, roles for structured and intrinsically disordered regions, the interplay between key chromatin regulatory and transcriptional complexes and other proteins that govern their stability and/or targeting and direct relationships between chromatin states and gene expression. A special focus will be given to cutting-edge and emerging technologies that further our understanding of these intricate mechanisms as well as new approaches in drug discovery and development that can accelerate translation to new medicines. Innovation Despite rapidly evolving, high-throughput genomics-centered strategies that enable intricate characterization of chromatin landscape and gene regulatory states, there remains a notable gap in understanding the mechanistic underpinnings of chromatin dysfunction and their impact on gene expression in normal and disease states. This meeting seeks to connect timely observations identified by large-scale cell fitness, gene and chromatin profiling, and proteomics efforts with biochemical, biophysical, 3D structural, and sequence-function centered work. Such a linkage is expected to maximally inform intricate mechanisms of chromatin and its associated dysfunctions in diseases, and further, to inspire new basic research and therapeutic discovery efforts in this area. By way of the topics and approaches covered, this meeting will convene a highly interdisciplinary group of basic and translationally-oriented scientists, stimulating new discussions between groups of investigators who are not routinely placed in the same meetings.

January 1-4, 2026 | Location to be Determined
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# Genetics, Genomics and RNA

The purpose of this symposium is to share best practice and knowledge about the potential impact on global health from large-scale population-based prospective studies. It will showcase scientific discoveries that have been made from well-established longitudinal research studies and the importance of having such studies located in strategic parts of the world to better understand the genomic, lifestyle and environmental determinants of a wide range of diseases. Beyond understanding the impact of genomic diversity on health, this symposium will also discuss the huge advances in our understanding of how data from wearables, imaging scans and blood biomarkers can be used to predict, diagnose and monitor disease. The symposium will seek to address the challenges faced in different populations when collecting, curating, accessing and analyzing such large-scale, complex data and how such data are being translated in improvements in the diagnosis, treatment and prevention of disease.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Ami S. Bhatt, Tami Lieberman and Harry Sokol

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# Microbiota and Flora

Microbiomes exist in various niches of the human body and play some known and likely many unknown roles in human health and disease. Nearly two decades of research have laid the groundwork for this field, and we are now at a point where sophisticated tools and cutting-edge approaches can be applied to the microbiome to build models, understand mechanisms and ultimately impact medicine. This meeting will address important gaps in our knowledge as it relates to (Aim 1) understanding the microbiome in an ecological context, (Aim 2) dissecting the mechanisms by which microbes and microbial products modulate microbial and host biology, and (Aim 3) important new clinical breakthroughs in microbiome science. Anticipated outcomes of the meeting include enhancing international collaborations, providing exposure to unpublished microbiome research, exposing trainees to a broad range of science and potential future mentors, and giving trainees an opportunity to present their work in poster and oral formats in an international conference. This meeting innovates by being a strongly human microbiome-focused meeting (as opposed to other environmental microbiome or mixed host-associated and environmental microbiome meetings), by encouraging strong participation from trainees, and by encouraging sharing of unpublished information in an intimate format that enables deep and meaningful connections to be made. This meeting will be paired with a Microbiome and metabolites meeting, which will be strongly complementary to the program that is presented in this meeting.

January 1-4, 2026 | Location to be Determined
Scientific Organizers: Michaela Frye, Schraga Schwartz and Yunsun Nam

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# Genetics, Genomics and RNA

The rapid increase in RNA modification studies in higher organisms now established that chemical modifications of nucleotides regulate RNA metabolism, modulate cell functions and contribute to severe human diseases including cancer and metabolic disorders. Moreover, the power of single chemically modified nucleotides to alter the electrostatic charge, base pairing and stability of RNA molecules is exploited for clinical use of stable artificial RNA transcripts such as mRNA vaccines or synthetic small RNA molecules to increase or decrease the expression of therapeutic proteins. The meeting will highlight recent developments and focus on future aspects and current challenges of the field: 1. Novel molecular function of RNA modifications in regulating RNA metabolism 2. Critical evaluation of language models predicing RNA modifications & function 3. Discuss medicinal chemistry advances and bioengineering technologies (function in RNA-based treatment regimens) 4. Advances in RNA modification function in immune related diseases 5. Advances in RNA modification function in metabolic diseases and cancer 6. Highlight novel RNA therapeutics (RNA modifications as prognostic marker in disease) In summary, the meeting will provide a broad overview how basic science discoveries have unraveled the molecular and cellular functions of RNA modifications, provided new prospects for therapeutic manipulation and led to a range of innovative clinical approaches. Our program will bring together field-leading experts from across the globe covering multidisciplinary aspects of RNA modification research from chemistry, clinical applications, bioengineering and industry. Our comprehensive program provides young scientists with a broad view of state-of-the-art research in the field that is not available in other meetings or workshop centered around RNA more generally. Pairing the meeting with a meeting focusing on regulatory RNAs is highly beneficial as it provides an overview of not in depth covered emerging novel mechanisms how RNA regulate gene expression and cellular functions that could involve RNA modifications.

Organized in Collaboration with ShanghaiTech University

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