Presented in partnership with Open Rosetta Project at the Open Molecular Software Foundation

Keystone Symposia and Open Rosetta Project have come together to advance research in computational design and deep learning technology. Both partners invite contributions from scientists at all career stages across various fields.

The recent rapid progress in computational protein design promises to transform biotechnology, medicine, and sustainable chemistry, creating unprecedented opportunities to engineer proteins with novel, customized functions. At the same time, critical gaps remain such as the design of dynamic sensors, bespoke enzymes, and proteins with complex functions.

This Keystone Symposia meeting on Computational Design and Modeling of Biomolecules, developed in collaboration with Rosetta Commons, will catalyze collaborations that accelerate functional protein engineering. A defining feature of the program is its integrated focus covering data acquisition, automation, model development, and deployment. Attendees will learn about cutting-edge methods and applications in protein design, novel methods that combine deep learning with physical modeling, and emerging workflows for custom data collection and automated pipeline integration.

The meeting will foster collaboration across computational biologists, protein designers, AI and machine learning experts, small molecule chemists, and translational scientists creating opportunities for interdisciplinary exchange among academic researchers, industry scientists, technology developers, and trainees. Interactive program elements will include a hands-on AI model fine-tuning tutorial, career development panel, and manuscript-writing workshop designed to support both scientific innovation and professional growth.

The integrated focus on data generation, automation, and hybrid AI-physics modeling, combined with unique hands-on training and career-focused sessions sets this meeting apart. No existing forum simultaneously offers this comprehensive blend of technical depth, interdisciplinary networking, and professional development, making it the essential gathering for anyone seeking to lead the next wave of protein-design breakthroughs.

Check out the speaker highlights in the video below: