The study of somatic mosaicisms has provided new insight into our fundamental understanding of human development, aging, and diseases. The comprehensive analysis of somatic mosaicism allows us to trace lineage evolution from the fertilized egg to human embryo to adult organs, along with defining the developmental and aging process at single-cell resolution. Furthermore, somatic mosaicisms have been identified as the genetic source of many human diseases with previously unknown etiology.

This meeting will serve as a forum for exchange of emerging research concepts and directions in the field of somatic mosaicism, and provide an opportunity for new investigators to enter this exciting new field. The meeting will integrate diverse aspects of somatic mosaicism, from mechanisms to translational disease insights. Specifically, the program will cover:

1. the development of new sequencing and bioinformatic tools for accurately detecting somatic mosaicism;
2. the involvement of somatic mosaicism in human development and aging;
3. somatic mosaicisms in disease biology, and modeling thereof;
4. translational efforts to help patients with somatic mosaicism driven diseases.

This meeting will bring together scientists and clinicians from developmental and aging biology, bioinformatics, systems biology, molecular and genetic biology, medicine, and the pharmaceutical industry to collaboratively explore the intersection of these diverse fields and collectively advance our understanding of somatic mosaicism in health and disease.