Stroke and traumatic injury are common neurologic disorders and the leading causes for adult-onset disability. Development of therapeutics to improve recovery has been hindered due to a limited understanding of how circuits within the central nervous system (CNS) are affected by injury. Technological advances have enabled interrogation of the CNS with unprecedented resolution. These are being applied to stroke and trauma survivors and to animal models, allowing for a critical re-appraisal of proposed mechanisms of recovery. This knowledge is crucially important as neuromodulation therapies are available for clinical trials, but when and how to apply these to patients are not well understood. This conference will bring together scientists working across species, using diverse approaches, to understand the mechanisms underlying dysfunction and recovery after stroke or injury to the brain or spinal cord. The specific goals and aims of this meeting include:

• Identifying convergent mechanisms across CNS injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), at molecular, synaptic, cellular, and network scales
• Highlighting cutting edge methods and technologies for the interrogation and modulation of the CNS after injury
• Determining innovative emerging avenues for promoting neural repair and recovery after injury

The cross-disciplinary nature of our symposium will stimulate collaborations, spark insight, and generate avenues of investigation to transform our understanding of how the CNS reorganizes after an injury. This conference will be unique in its focus on basic and translational science of CNS recovery that brings together researchers working across many disease models and injury types.