RNAs are multifaceted molecules—serving as cellular regulators, genetic invaders, and, increasingly, as powerful therapeutic agents. Despite advances, key mechanistic questions remain unresolved, limiting the ability to improve RNA-based interventions. 

This Keystone Symposia conference on RNA Regulation: Mechanisms to Medicine explores the expanding landscape of regulatory RNAs to elucidate their mechanisms of action and biological roles. Sessions will cover coding and noncoding RNAs, extracellular RNAs, and emerging RNA-based therapeutics, including mRNAs and small RNAs, with a focus on moving beyond descriptive studies. The program will also highlight cutting-edge technologies that are transforming the field, including deep learning, high-throughput screening, and the latest in structural biology approaches that facilitate mechanistic studies. 

By bringing together RNA scientists, structural biologists, computational biologists, RNA therapeutics developers, and clinician-scientists, the meeting aims to foster cross-disciplinary dialogue that catalyzes new ideas and helps define the next frontiers of RNA biology and medicine. Interactive panel discussions will address the challenges and future directions of translational RNA research and explore how scientific results can be made more accessible to garner public trust and support. 

This meeting’s emphasis on linking mechanistic discovery to therapeutic innovation, along with exposure to cutting-edge tools and approaches that are shaping the field, distinguishes it as a timely and impactful forum in a rapidly evolving field.